scholarly journals Microfluidic Systems Applied in Solid-State Nanopore Sensors

Micromachines ◽  
2020 ◽  
Vol 11 (3) ◽  
pp. 332 ◽  
Author(s):  
Jiye Fu ◽  
Linlin Wu ◽  
Yi Qiao ◽  
Jing Tu ◽  
Zuhong Lu
Keyword(s):  
Experimental Study ◽  
Solid State ◽  
Microfluidic System ◽  
Detection Methods ◽  
Electrical Detection ◽  
Microfluidic Systems ◽  
Novel Device ◽  
Device Structures ◽  
Nanopore Sensors

Microfluidic system, as a kind of miniature integrated operating platform, has been applied to solid-state nanopore sensors after many years of experimental study. In the process of introducing microfluidic into solid-state nanopore sensors, many novel device structures are designed due to the abundance of analytes and the diversity of detection methods. Here we review the fundamental setup of nanopore-based microfluidic systems and the developments and advancements that have been taking place in the field. The microfluidic systems with a multichannel strategy to elevate the throughput and efficiency of nanopore sensors are then presented. Multifunctional detection represented by optical-electrical detection, which is realized by microfluidic integration, is also described. A high integration microfluidic system with nanopore is further discussed, which shows the prototype of commercialization.

scholarly journals Application of microfluidic systems for neural differentiation of cells

2019 ◽  
Vol 2 (4) ◽  
pp. 370-381
Author(s):  
Zahra Hesari ◽  
Fatemeh Mottaghitalab ◽  
Akram Shafiee ◽  
Masoud Soleymani ◽  
Rasoul Dinarvand ◽  
...  
Keyword(s):  
Stem Cells ◽  
Small Molecules ◽  
Neuronal Differentiation ◽  
Neural Differentiation ◽  
Three Dimensional ◽  
Microfluidic System ◽  
Microfluidic Systems ◽  
Cell Culture Systems ◽  
Novel Model ◽  
Dimensional Cell

Neural differentiation of stem cells is an important issue in development of central nervous system. Different methods such as chemical stimulation with small molecules, scaffolds, and microRNA can be used for inducing the differentiation of neural stem cells. However, microfluidic systems with the potential to induce neuronal differentiation have established their reputation in the field of regenerative medicine. Organization of microfluidic system represents a novel model that mimic the physiologic microenvironment of cells among other two and three dimensional cell culture systems. Microfluidic system has patterned and well-organized structure that can be combined with other differentiation techniques to provide optimal conditions for neuronal differentiation of stem cells. In this review, different methods for effective differentiation of stem cells to neuronal cells are summarized. The efficacy of microfluidic systems in promoting neuronal differentiation is also addressed.

Development of Planar Microfluidic Systems Using Conventional and Low Temperature Assembling Schemes for Components

1999 ◽  
Author(s):  
Nihat Okulan ◽  
Shekhar Bhansali ◽  
Arum Han ◽  
Saman Dharmatilleke ◽  
Jin-Woo Choi ◽  
...  
Keyword(s):  
Low Temperature ◽  
Electrochemical Detection ◽  
Biochemical Analysis ◽  
Magnetic Particle ◽  
Lab On A Chip ◽  
Microfluidic System ◽  
Microfluidic Systems ◽  
Detection Techniques

Abstract This center is currently working on the development of a remotely accessible generic microfluidic system (“lab on a chip”) for biological and biochemical analysis, based on electrochemical detection techniques. Modular microfluidic components, including micro reservoirs, microvalves, micropumps, filterless magnetic particle separators, biosensors and flowsensors, were fabricated and tested, and integrated on a system motherboard. Other air-to-liquid measurand concentrators and integrated sieve/filters are being explored in related efforts. The fabrication of these microfluidic components and the utilization of wax for low temperature assembly and even bonding is discussed.

Design and Experimental Study of Two-Cavity Dual-Frequency All-Solid-State Laser with Large Frequency Difference

2010 ◽  
Vol 37 (11) ◽  
pp. 2784-2789
Author(s):  
焦明星 Jiao Mingxing ◽  
邢俊红 Xing Junhong ◽  
刘芸 Liu Yun ◽  
杨云 Yang Yun ◽  
马少华 Ma Shaohua
Keyword(s):  
Experimental Study ◽  
Solid State ◽  
Solid State Laser ◽  
Frequency Difference ◽  
Dual Frequency ◽  
State Laser ◽  
Large Frequency

scholarly journals Author Correction: Solid-state nanopore sensors

2020 ◽  
Vol 5 (12) ◽  
pp. 952-952
Author(s):  
Liang Xue ◽  
Hirohito Yamazaki ◽  
Ren Ren ◽  
Meni Wanunu ◽  
Aleksandar P. Ivanov ◽  
...  
Keyword(s):  
Solid State ◽  
Nanopore Sensors

scholarly journals The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review

Micromachines ◽  
2020 ◽  
Vol 11 (3) ◽  
pp. 297 ◽  
Author(s):  
Kena Song ◽  
Guoqiang Li ◽  
Xiangyang Zu ◽  
Zhe Du ◽  
Liyu Liu ◽  
...  
Keyword(s):  
High Throughput ◽  
New Technologies ◽  
Biomedical Application ◽  
Raw Materials ◽  
Physical Structure ◽  
Microfluidic System ◽  
Microfluidic Chips ◽  
Microfluidic Systems ◽  
Microfluidic Technology

Microfluidic systems have been widely explored based on microfluidic technology, and it has been widely used for biomedical screening. The key parts are the fabrication of the base scaffold, the construction of the matrix environment in the 3D system, and the application mechanism. In recent years, a variety of new materials have emerged, meanwhile, some new technologies have been developed. In this review, we highlight the properties of high throughput and the biomedical application of the microfluidic chip and focus on the recent progress of the fabrication and application mechanism. The emergence of various biocompatible materials has provided more available raw materials for microfluidic chips. The material is not confined to polydimethylsiloxane (PDMS) and the extracellular microenvironment is not limited by a natural matrix. The mechanism is also developed in diverse ways, including its special physical structure and external field effects, such as dielectrophoresis, magnetophoresis, and acoustophoresis. Furthermore, the cell/organ-based microfluidic system provides a new platform for drug screening due to imitating the anatomic and physiologic properties in vivo. Although microfluidic technology is currently mostly in the laboratory stage, it has great potential for commercial applications in the future.

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