scholarly journals Ultra Sensitivity Silicon-Based Photonic Crystal Microcavity Biosensors for Plasma Protein Detection in Patients with Pancreatic Cancer

Micromachines ◽  
2020 ◽  
Vol 11 (3) ◽  
pp. 282 ◽  
Author(s):  
Chun-Ju Yang ◽  
Hai Yan ◽  
Naimei Tang ◽  
Yi Zou ◽  
Yas Al-Hadeethi ◽  
...  

Defect-engineered photonic crystal (PC) microcavities were fabricated by UV photolithography and their corresponding sensitivities to biomarkers in patient plasma samples were compared for different resonant microcavity characteristics of quality factor Q and biomarker fill fraction. Three different biomarkers in plasma from pancreatic cancer patients were experimentally detected by conventional L13 defect-engineered microcavities without nanoholes and higher sensitivity L13 PC microcavities with nanoholes. 8.8 femto-molar (0.334 pg/mL) concentration of pancreatic cancer biomarker in patient plasma samples was experimentally detected which are 50 times dilution than ELISA in a PC microcavity with high quality factor and high analyte fill fraction.

2018 ◽  
Vol 8 (9) ◽  
pp. 1552 ◽  
Author(s):  
Youngsoo Kim ◽  
Young Lee ◽  
Seokhyeon Hong ◽  
Kihwan Moon ◽  
Soon-Hong Kwon

The development of an efficient silicon-based nanolight source is an important step for silicon-based photonic integrated circuits. We propose a high quality factor photonic crystal nanocavity consisting of silicon and silica, which can be used as a silicon-compatible nanolight source. We show that this cavity can effectively confine lights in a low-index silica layer with a high confinement factor of 0.25, in which rare-earth dopants can be embedded as gain materials. The cavity is optimized to have a high quality factor of 15,000 and a mode volume of 0.01 μm3, while the resonance has a wavelength of 1537 nm. We expect that the high confinement factor in the thin silica layer and the high quality factor of the proposed cavity enable the cavity to be a good candidate for silicon-compatible nanolight sources for use in nanolasers or light-emitting diodes in the telecommunication wavelength region.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
J. P. Vasco ◽  
V. Savona

AbstractWe optimize a silica-encapsulated silicon L3 photonic crystal cavity for ultra-high quality factor by means of a global optimization strategy, where the closest holes surrounding the cavity are varied to minimize out-of-plane losses. We find an optimal value of $$Q_c=4.33\times 10^7$$ Q c = 4.33 × 10 7 , which is predicted to be in the 2 million regime in presence of structural imperfections compatible with state-of-the-art silicon fabrication tolerances.


2014 ◽  
Vol 22 (3) ◽  
pp. 3724 ◽  
Author(s):  
Jeongwon Lee ◽  
Bo Zhen ◽  
Song-Liang Chua ◽  
Ofer Shapira ◽  
Marin Soljačić

2017 ◽  
Vol 56 (9) ◽  
pp. 090304 ◽  
Author(s):  
Masahiro Nakadai ◽  
Ryotaro Konoike ◽  
Yoshinori Tanaka ◽  
Takashi Asano ◽  
Susumu Noda

2012 ◽  
Vol 21 (3) ◽  
pp. 034215
Author(s):  
Nai-Di Cui ◽  
Jing-Qiu Liang ◽  
Zhong-Zhu Liang ◽  
Wei-Biao Wang

2014 ◽  
Vol 556-562 ◽  
pp. 6-10 ◽  
Author(s):  
Ding Wei ◽  
Xian Wang ◽  
Ze Kun Feng ◽  
Rong Zhou Gong

The variation of soft magnetic properties of Sendust powder cores as a function of annealing temperature has been investigated. Toroid-shaped Sendust powder cores were prepared from Fe-Si-Al powder by machine pulverizing and subsequent cold pressing using inorganic insulating layer and organic binders, respectively. The influence of different compaction pressures and various annealing temperature on effective permeability and quality factor was investigated. Sendust powder cores using inorganic salt as insulating layer exhibit high effective permeability ( μe>110) up to 1 MHz, showing excellent frequency stable characteristics and high quality factor (Q>80) at 50 kHz. The optimized annealing temperature is 953K.


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