scholarly journals On-Chip Construction of Multilayered Hydrogel Microtubes for Engineered Vascular-Like Microstructures

Micromachines ◽  
2019 ◽  
Vol 10 (12) ◽  
pp. 840 ◽  
Author(s):  
Tao Yue ◽  
Na Liu ◽  
Yuanyuan Liu ◽  
Yan Peng ◽  
Shaorong Xie ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Efficient Method ◽  
High Efficiency ◽  
Flow Conditions ◽  
Artificial Blood ◽  
Assembly Method ◽  
Artificial Blood Vessels ◽  
Direct Fabrication ◽  
Potential Applications ◽  
On Chip

Multilayered and multicellular structures are indispensable for constructing functional artificial tissues. Engineered vascular-like microstructures with multiple layers are promising structures to be functionalized as artificial blood vessels. In this paper, we present an efficient method to construct multilayer microtubes embedding different microstructures based on direct fabrication and assembly inside a microfluidic device. This four-layer microfluidic device has two separate inlets for fabricating various microstructures. We have achieved alternating-layered microtubes by controlling the fabrication, flow, and assembly time of each microstructure, and as well, double-layered microtubes have been built by a two-step assembly method. Modifications of both the inner and outer layers was successfully demonstrated, and the flow conditions during the on-chip assembly were evaluated and optimized. Each microtube was successfully constructed within several minutes, showing the potential applications of the presented method for building engineered vascular-like microstructures with high efficiency.

scholarly journals High-Efficiency All-Dielectric Metasurfaces for the Generation and Detection of Focused Optical Vortex for the Ultraviolet Domain

2020 ◽  
Vol 10 (16) ◽  
pp. 5716
Author(s):  
Ziheng Zhang ◽  
Tong Li ◽  
Xiaofei Jiao ◽  
Guofeng Song ◽  
Yun Xu
Keyword(s):  
High Performance ◽  
High Efficiency ◽  
Dielectric Material ◽  
Optical Vortex ◽  
Magnetic Dipoles ◽  
Half Wave ◽  
Potential Applications ◽  
On Chip ◽  
High Flexibility ◽  
Meta Atom

The optical vortex (OV) has drawn considerable attention owing to its tremendous advanced applications, such as optical communication, quantum entanglement, and on-chip detectors. However, traditional OV generators suffer from a bulky configuration and limited performance, especially in the ultraviolet range. In this paper, we utilize a large bandgap dielectric material, niobium pentoxide (Nb2O5), to construct ultra-thin and compact transmission-type metasurfaces to generate and detect the OV at a wavelength of 355 nm. The meta-atom, which operates as a miniature half-wave plate and demonstrates a large tolerance to fabrication error, manipulates the phase of an incident right-handed circular polarized wave with high cross-polarized conversion efficiency (around 86.9%). The phase delay of π between the orthogonal electric field component is attributed to the anti-parallel magnetic dipoles induced in the nanobar. Besides, focused vortex generation (topological charge l from 1 to 3) and multichannel detection (l from −2 to 2) are demonstrated with high efficiency, up to 79.2%. We envision that our devices of high flexibility may have potential applications in high-performance micron-scale integrated ultraviolet nanophotonics and meta-optics.

scholarly journals Microfluidic on-chip Production of Alginate Hydrogels Using Double Co-flow Geometry

2021 ◽  
Author(s):  
Amirmohammad Sattari ◽  
Sajad Janfaza ◽  
Mohsen Mashhadi Keshtiban ◽  
Nishat Tasnim ◽  
Pedram Hanafizadeh ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Precursor Solution ◽  
Average Diameter ◽  
Continuous Phase ◽  
Solution Viscosity ◽  
Flow Conditions ◽  
External Gelation ◽  
Flow Geometry ◽  
On Chip ◽  
Spherical Droplets

Abstract Microfluidic on-chip production of microgels employing external gelation has numerous biological and pharmaceutical applications, particularly for the encapsulation of delicate cargos, however, the on-chip production of microgels in microfluidic devices can be challenging due to problems such as clogging caused by accelerated progress in precursor solution viscosity. Here, we introduce a novel microfluidic design incorporating two consecutive co-flow geometries for microfluidic droplet generation. A shielding oil phase is employed to avoid emulsification and gelation stages from occurring simultaneously, thereby preventing clogging. The results revealed that the microfluidic device could generate highly monodispersed spherical droplets (coefficient of variation < 3%) with an average diameter in the range of 60–200 μm. Additionally, it was demonstrated that the device could appropriately create a shelter of the oil phase around the inner aqueous phase regardless of the droplet formation regime and flow conditions. The ability of the proposed microfluidic device in the generation of microgels was validated by producing alginate microgels utilizing an aqueous solution of calcium chloride as the continuous phase.

Ultra-robust Superhydrophobic/superoleophilic Stainless Mesh Coated by PTFE/SiO2 for Oil/water Separation

MRS Advances ◽  
2018 ◽  
Vol 4 (07) ◽  
pp. 359-367 ◽  
Author(s):  
Chaolang Chen ◽  
Ding Weng ◽  
Awais Mahmood ◽  
Jiadao Wang
Keyword(s):  
Contact Angle ◽  
Self Assembly ◽  
High Efficiency ◽  
Water Contact ◽  
Water Separation ◽  
Low Surface Energy ◽  
Assembly Method ◽  
Potential Applications ◽  
Oil Water Separation ◽  
Oil Water

AbstractIn this study, a superhydrophobic and superoleophilic stainless mesh coated with polytetrafluoroethylene/silicon dioxide (PTFE/SiO2) was fabricated through electrostatic self-assembly method followed by sintering treatment. The PTFE was utilized to construct low-surface-energy surface and the SiO2 nanoparticles were added to enhance its surface roughness. The as-prepared stainless mesh exhibited desirable superhydrophobicity and superoleophilicity with a water contact angle of 152° and oil contact angle of 0°. The coated stainless mesh could separate a variety of oil/water mixtures with high efficiency and it also exhibited good recyclability. Moreover, the corrosion-resistance of stainless mesh was greatly improved by coating it with PTFE. The thermogravimetric analysis (TGA) measurements showed that the coated mesh could withstand high temperature of up to 430°C, indicating excellent thermal-resistance. It is believed that this ultra-robust stainless mesh would have significant potential applications in industry.

Microbubble Array as a Versatile Tool for On-Chip Worm Processing

2012 ◽  
Author(s):  
Gan Yu ◽  
Ali Hashmi ◽  
Yuhao Xu ◽  
Hyuck-Jin Kwon ◽  
Xiaolin Chen ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Trapping Efficiency ◽  
Flow Conditions ◽  
C Elegans ◽  
Novel Technique ◽  
Versatile Tool ◽  
On Chip ◽  
First Time

In this study, we present a novel technique for achieving precise trapping, enrichment and manipulation of C. elegans using an array of oscillating microbubbles in a simple microfluidic device. We demonstrate a high trapping efficiency and enrichment of C. elegans characterized by the flow conditions. We also demonstrate for the first time an on-chip manipulation of the pathways of a single C. elegans through temporal actuation of bubbles.

Electrochemical Oxidative Esterification of Thiophenols: Efficient Access to Sulfinic Esters

2020 ◽  
Vol 17 (7) ◽  
pp. 540-547
Author(s):  
Chun-Hui Yang ◽  
Cheng Wu ◽  
Jun-Ming Zhang ◽  
Xiang-Zhang Tao ◽  
Jun Xu ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Efficient Method ◽  
High Efficiency ◽  
Building Blocks ◽  
Constant Current ◽  
Good Efficiency ◽  
Oxidative Esterification ◽  
Efficient Access ◽  
New Applications ◽  
Sulfinic Esters

Background: The sulfinic esters are important and useful building blocks in organic synthesis. Objective: The aim of this study was to develop a simple and efficient method for the synthesis of sulfinic esters. Materials and Methods: Constant current electrolysis from thiols and alcohols was selected as the method for the synthesis of sulfinic esters. Results and Discussion: A novel electrochemical method for the synthesis of sulfinic esters from thiophenols and alcohols has been developed. Up to 27 examples of sulfinic esters have been synthesized using the current methods. This protocol shows good functional group tolerance as well as high efficiency. In addition, this protocol can be easily scaled up with good efficiency. Notably, heterocycle-containing substrates, including pyridine, thiophene, and benzothiazole, gave the desired products in good yields. A plausible reaction mechanism is proposed. Conclusion: This research not only provides a green and efficient method for the synthesis of sulfinic esters but also shows new applications of electrochemistry in organic synthesis. It is considered that this green and efficient synthetic protocol used to prepare sulfinic esters will have good applications in the future.

scholarly journals Design and Manufacturing of a Disposable, Cyclo-Olefin Copolymer, Microfluidic Device for a Biosensor †

Sensors ◽  
2019 ◽  
Vol 19 (5) ◽  
pp. 1178 ◽  
Author(s):  
Jorge Prada ◽  
Christina Cordes ◽  
Carsten Harms ◽  
Walter Lang
Keyword(s):  
Microfluidic Device ◽  
Heating Temperature ◽  
Low Cost ◽  
Reaction Chamber ◽  
Microfluidic System ◽  
Heating Process ◽  
Design And Manufacturing ◽  
On Chip ◽  
Working Parameters ◽  
Auto Fluorescence

This contribution outlines the design and manufacturing of a microfluidic device implemented as a biosensor for retrieval and detection of bacteria RNA. The device is fully made of Cyclo-Olefin Copolymer (COC), which features low auto-fluorescence, biocompatibility and manufacturability by hot-embossing. The RNA retrieval was carried on after bacteria heat-lysis by an on-chip micro-heater, whose function was characterized at different working parameters. Carbon resistive temperature sensors were tested, characterized and printed on the biochip sealing film to monitor the heating process. Off-chip and on-chip processed RNA were hybridized with capture probes on the reaction chamber surface and identification was achieved by detection of fluorescence tags. The application of the mentioned techniques and materials proved to allow the development of low-cost, disposable albeit multi-functional microfluidic system, performing heating, temperature sensing and chemical reaction processes in the same device. By proving its effectiveness, this device contributes a reference to show the integration potential of fully thermoplastic devices in biosensor systems.

scholarly journals On-chip trans-dimensional plasmonic router

Nanophotonics ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 3357-3365 ◽  
Author(s):  
Shaohua Dong ◽  
Qing Zhang ◽  
Guangtao Cao ◽  
Jincheng Ni ◽  
Ting Shi ◽  
...  
Keyword(s):  
High Speed ◽  
High Efficiency ◽  
Incident Angle ◽  
Reciprocal Lattice ◽  
Plasmonic Waveguide ◽  
Optical Diffraction ◽  
Local Dynamic ◽  
Phase Gradient ◽  
On Chip ◽  
Plasmon Polaritons

AbstractPlasmons, as emerging optical diffraction-unlimited information carriers, promise the high-capacity, high-speed, and integrated photonic chips. The on-chip precise manipulations of plasmon in an arbitrary platform, whether two-dimensional (2D) or one-dimensional (1D), appears demanding but non-trivial. Here, we proposed a meta-wall, consisting of specifically designed meta-atoms, that allows the high-efficiency transformation of propagating plasmon polaritons from 2D platforms to 1D plasmonic waveguides, forming the trans-dimensional plasmonic routers. The mechanism to compensate the momentum transformation in the router can be traced via a local dynamic phase gradient of the meta-atom and reciprocal lattice vector. To demonstrate such a scheme, a directional router based on phase-gradient meta-wall is designed to couple 2D SPP to a 1D plasmonic waveguide, while a unidirectional router based on grating metawall is designed to route 2D SPP to the arbitrarily desired direction along the 1D plasmonic waveguide by changing the incident angle of 2D SPP. The on-chip routers of trans-dimensional SPP demonstrated here provide a flexible tool to manipulate propagation of surface plasmon polaritons (SPPs) and may pave the way for designing integrated plasmonic network and devices.

scholarly journals Development of a Mobile Analytical Chemistry Workstation Using a Silicon Electrochromatography Microchip and Capacitively Coupled Contactless Conductivity Detector

Micromachines ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 239
Author(s):  
Yineng Wang ◽  
Xi Cao ◽  
Walter Messina ◽  
Anna Hogan ◽  
Justina Ugwah ◽  
...  
Keyword(s):  
Capillary Electrochromatography ◽  
High Efficiency ◽  
Device Fabrication ◽  
Capacitively Coupled ◽  
Packaging Design ◽  
Design And Optimization ◽  
Nanofabrication Technique ◽  
On Chip ◽  
Silicon Based ◽  
Rapid Separations

Capillary electrochromatography (CEC) is a separation technique that hybridizes liquid chromatography (LC) and capillary electrophoresis (CE). The selectivity offered by LC stationary phase results in rapid separations, high efficiency, high selectivity, minimal analyte and buffer consumption. Chip-based CE and CEC separation techniques are also gaining interest, as the microchip can provide precise on-chip control over the experiment. Capacitively coupled contactless conductivity detection (C4D) offers the contactless electrode configuration, and thus is not in contact with the solutions under investigation. This prevents contamination, so it can be easy to use as well as maintain. This study investigated a chip-based CE/CEC with C4D technique, including silicon-based microfluidic device fabrication processes with packaging, design and optimization. It also examined the compatibility of the silicon-based CEC microchip interfaced with C4D. In this paper, the authors demonstrated a nanofabrication technique for a novel microchip electrochromatography (MEC) device, whose capability is to be used as a mobile analytical equipment. This research investigated using samples of potassium ions, sodium ions and aspirin (acetylsalicylic acid).

An uncoordinatedly tertiary nitrogen based tricarboxylate Calcium network with Lewis acid-base dual catalytic sites for cyanosilylation of aldehydes

2020 ◽  
Author(s):  
Xian-Ming Zhang ◽  
Ying-Xia Wang ◽  
Hui-Min Wang ◽  
Pan Meng ◽  
Dong-Xia Song ◽  
...  
Keyword(s):  
Lewis Acid ◽  
Efficient Method ◽  
High Efficiency ◽  
Acid Base ◽  
Catalytic Sites ◽  
Tertiary Nitrogen

The design and utilization of dual sites for synergistic catalysts has been recognised as an efficient method towards high-efficiency catalysis in the cyanosilylation of aldehydes, which gives the key intermediates...

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