scholarly journals Nanomaterials-Based Electrochemical Immunosensors

Micromachines ◽  
2019 ◽  
Vol 10 (6) ◽  
pp. 397 ◽  
Author(s):  
Zhenguo Zhang ◽  
Yulin Cong ◽  
Yichun Huang ◽  
Xin Du
Keyword(s):  
Carbon Nanomaterials ◽  
Low Cost ◽  
High Sensitivity ◽  
Detection Methods ◽  
Sensor Technology ◽  
Time Analysis ◽  
Real Time Analysis ◽  
Electrochemical Immunosensors ◽  
Recent Developments ◽  
Metal Nanomaterials

With the development of nanomaterials and sensor technology, nanomaterials-based electrochemical immunosensors have been widely employed in various fields. Nanomaterials for electrode modification are emerging one after another in order to improve the performance of electrochemical immunosensors. When compared with traditional detection methods, electrochemical immunosensors have the advantages of simplicity, real-time analysis, high sensitivity, miniaturization, rapid detection time, and low cost. Here, we summarize recent developments in electrochemical immunosensors based on nanomaterials, including carbon nanomaterials, metal nanomaterials, and quantum dots. Additionally, we discuss research challenges and future prospects for this field of study.

scholarly journals Electrochemical Biosensors for Detection of Foodborne Pathogens

Micromachines ◽  
2019 ◽  
Vol 10 (4) ◽  
pp. 222 ◽  
Author(s):  
Zhenguo Zhang ◽  
Jun Zhou ◽  
Xin Du
Keyword(s):  
Foodborne Pathogens ◽  
Low Cost ◽  
Public Health Problem ◽  
High Sensitivity ◽  
Global Public Health ◽  
Real Time Analysis ◽  
Electrochemical Biosensing ◽  
Recent Developments ◽  
Global Public Health Problem

Foodborne safety has become a global public health problem in both developed and developing countries. The rapid and precise monitoring and detection of foodborne pathogens has generated a strong interest by researchers in order to control and prevent human foodborne infections. Traditional methods for the detection of foodborne pathogens are often time-consuming, laborious, expensive, and unable to satisfy the demands of rapid food testing. Owing to the advantages of simplicity, real-time analysis, high sensitivity, miniaturization, rapid detection time, and low cost, electrochemical biosensing technology is more and more widely used in determination of foodborne pathogens. Here, we summarize recent developments in electrochemical biosensing technologies used to detect common foodborne pathogens. Additionally, we discuss research challenges and future prospects for this field of study.

scholarly journals Optical Fiber Sensor for Heavy Chemical Detection: An Overview

2021 ◽  
Vol 2075 (1) ◽  
pp. 012010
Author(s):  
Nurul Athirah Mohamad Abdul Ghafar ◽  
Arni Munira Markom ◽  
Marni Azira Markom ◽  
Ahmad Razif Muhammad
Keyword(s):  
Optical Fiber ◽  
Electromagnetic Interference ◽  
Low Cost ◽  
Optical Fiber Sensor ◽  
High Sensitivity ◽  
Electrochemical Analysis ◽  
Detection Methods ◽  
Fiber Sensor ◽  
Sensor Technology ◽  
Compact Size

Abstract Heavy metal contaminations such as mercury, lead, arsenic, cadmium, and zinc are becoming more serious and have become a hazard to human health. Due to their non-biodegradable nature, they can easily accumulate in the environment and cause toxicity even at low concentrations. Therefore, detecting the presence of these metal ions requires a highly sensitive sensing method. Traditional detection methods, such as electrochemical analysis, require complicated sample preparation, are costly, and typically require a lengthy measurement period. These days, optical fiber sensors have been acknowledged due to their unique characteristics such as compact size, high sensitivity, low cost, high flexibility, and immunity to electromagnetic interference. An overview of an optical fiber sensor technology for heavy chemical measurement is discussed in this paper. The sensing mechanisms are summarized, as well as the chemical water quality parameters and sensitivities.

scholarly journals Application of Electrochemical Sensors Based on Carbon Nanomaterials for Detection of Flavonoids

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 2020
Author(s):  
Jinchun Hu ◽  
Zhenguo Zhang
Keyword(s):  
Carbon Nanomaterials ◽  
Electrochemical Sensors ◽  
Graphene Quantum Dots ◽  
High Sensitivity ◽  
Research Field ◽  
Electrochemical Sensing ◽  
Detection Methods ◽  
Health Issues ◽  
Fast Detection ◽  
Anti Cancer

Flavonoids have a variety of physiological activities such as anti-free radicals, regulating hormone levels, antibacterial factors, and anti-cancer factors, which are widely present in edible and medicinal plants. Real-time detection of flavonoids is a key step in the quality control of diverse matrices closely related to social, economic, and health issues. Traditional detection methods are time-consuming and require expensive equipment and complicated working conditions. Therefore, electrochemical sensors with high sensitivity and fast detection speed have aroused extensive research interest. Carbon nanomaterials are preferred material in improving the performance of electrochemical sensing. In this paper, we review the progress of electrochemical sensors based on carbon nanomaterials including carbon nanotubes, graphene, carbon and graphene quantum dots, mesoporous carbon, and carbon black for detecting flavonoids in food and drug homologous substances in the last four years. In addition, we look forward to the prospects and challenges of this research field.

scholarly journals Emerging Optical Materials in Sensing and Discovery of Bioactive Compounds

Sensors ◽  
2021 ◽  
Vol 21 (17) ◽  
pp. 5784
Author(s):  
Raquel Vaz ◽  
Beatriz Valpradinhos ◽  
Manuela F. Frasco ◽  
Maria Goreti F. Sales
Keyword(s):  
Drug Discovery ◽  
Bioactive Compounds ◽  
High Throughput Screening ◽  
High Sensitivity ◽  
Optical Biosensors ◽  
Chemical Compositions ◽  
Bioactive Natural Products ◽  
Real Time Analysis ◽  
Technological Advances ◽  
Recent Developments

Optical biosensors are used in numerous applications and analytical fields. Advances in these sensor platforms offer high sensitivity, selectivity, miniaturization, and real-time analysis, among many other advantages. Research into bioactive natural products serves both to protect against potentially dangerous toxic compounds and to promote pharmacological innovation in drug discovery, as these compounds have unique chemical compositions that may be characterized by greater safety and efficacy. However, conventional methods for detecting these biomolecules have drawbacks, as they are time-consuming and expensive. As an alternative, optical biosensors offer a faster, simpler, and less expensive means of detecting various biomolecules of clinical interest. In this review, an overview of recent developments in optical biosensors for the detection and monitoring of aquatic biotoxins to prevent public health risks is first provided. In addition, the advantages and applicability of these biosensors in the field of drug discovery, including high-throughput screening, are discussed. The contribution of the investigated technological advances in the timely and sensitive detection of biotoxins while deciphering the pathways to discover bioactive compounds with great health-promoting prospects is envisaged to meet the increasing demands of healthcare systems.

scholarly journals Recent advances of fluorescent biosensors based on cyclic signal amplification technology in biomedical detection

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Hongke Qu ◽  
Chunmei Fan ◽  
Mingjian Chen ◽  
Xiangyan Zhang ◽  
Qijia Yan ◽  
...  
Keyword(s):  
Signal Amplification ◽  
Low Cost ◽  
Rolling Circle Amplification ◽  
High Sensitivity ◽  
High Specificity ◽  
Detection Methods ◽  
Research Progress ◽  
Rolling Circle ◽  
Displacement Reactions ◽  
Short Time

AbstractThe cyclic signal amplification technology has been widely applied for the ultrasensitive detection of many important biomolecules, such as nucleic acids, proteins, enzymes, adenosine triphosphate (ATP), metal ions, exosome, etc. Due to their low content in the complex biological samples, traditional detection methods are insufficient to satisfy the requirements for monitoring those biomolecules. Therefore, effective and sensitive biosensors based on cyclic signal amplification technology are of great significance for the quick and simple diagnosis and treatment of diseases. Fluorescent biosensor based on cyclic signal amplification technology has become a research hotspot due to its simple operation, low cost, short time, high sensitivity and high specificity. This paper introduces several cyclic amplification methods, such as rolling circle amplification (RCA), strand displacement reactions (SDR) and enzyme-assisted amplification (EAA), and summarizes the research progress of using this technology in the detection of different biomolecules in recent years, in order to provide help for the research of more efficient and sensitive detection methods. Graphical Abstract

scholarly journals Metal nanoparticles-based nanoplatforms for colorimetric sensing: A review

2020 ◽  
Vol 40 (1) ◽  
pp. 1-11
Author(s):  
Ning Xu ◽  
Shuang Jin ◽  
Li Wang
Keyword(s):  
Analytical Chemistry ◽  
Metal Nanoparticles ◽  
Low Cost ◽  
Colorimetric Detection ◽  
Colorimetric Method ◽  
High Sensitivity ◽  
Detection Methods ◽  
Practical Application ◽  
Colorimetric Sensing ◽  
Research Hotspots

Abstract With the progress of analysis technology and nanotechnology, colorimetric detection has become one of the research hotspots in the field of analytical chemistry. Compared with traditional detection methods, the colorimetric method has many advantages, such as high sensitivity, good selectivity, convenience and fast, as well as low cost. In recent years, metal nanoparticles have been introduced into colorimetry, making the research and application of colorimetry develop rapidly. In this work, we summarize the usual colorimetric detection methods based on metal nanoparticles-based nanozymes and their applications in the last five years. We hope that this work will help readers understand the mechanism and practical application value of nanozyme-based colorimetric biosensors. Meanwhile, this work may give some hints and references for future colorimetric detection research to promote the application and development of nanozyme-based colorimetry in biomedical and environmental analysis.

scholarly journals State-of-the-Art Optical Devices for Biomedical Sensing Applications—A Review

Electronics ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 973
Author(s):  
N. L. Kazanskiy ◽  
S. N. Khonina ◽  
M. A. Butt ◽  
A. Kaźmierczak ◽  
R. Piramidowicz
Keyword(s):  
Optical Sensors ◽  
Low Cost ◽  
High Sensitivity ◽  
Sensor Technology ◽  
Biomedical Sensors ◽  
Plasmonic Sensors ◽  
Biomedical Sensing ◽  
Sensing Applications ◽  
Compact Size ◽  
Pros And Cons

Optical sensors for biomedical applications have gained prominence in recent decades due to their compact size, high sensitivity, reliability, portability, and low cost. In this review, we summarized and discussed a few selected techniques and corresponding technological platforms enabling the manufacturing of optical biomedical sensors of different types. We discussed integrated optical biosensors, vertical grating couplers, plasmonic sensors, surface plasmon resonance optical fiber biosensors, and metasurface biosensors, Photonic crystal-based biosensors, thin metal films biosensors, and fiber Bragg grating biosensors as the most representative cases. All of these might enable the identification of symptoms of deadly illnesses in their early stages; thus, potentially saving a patient’s life. The aim of this paper was not to render a definitive judgment in favor of one sensor technology over another. We presented the pros and cons of all the major sensor systems enabling the readers to choose the solution tailored to their needs and demands.

scholarly journals Optical Detection Methods for High-Throughput Fluorescent Droplet Microflow Cytometry

Micromachines ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 345
Author(s):  
Kaiser Pärnamets ◽  
Tamas Pardy ◽  
Ants Koel ◽  
Toomas Rang ◽  
Ott Scheler ◽  
...  
Keyword(s):  
High Throughput ◽  
Focal Point ◽  
Low Cost ◽  
Fluorescent Microscopy ◽  
Detection Methods ◽  
Sensor Technology ◽  
Portable Devices ◽  
Light Sources ◽  
Microscopy Techniques ◽  
Massive Parallelization

High-throughput microflow cytometry has become a focal point of research in recent years. In particular, droplet microflow cytometry (DMFC) enables the analysis of cells reacting to different stimuli in chemical isolation due to each droplet acting as an isolated microreactor. Furthermore, at high flow rates, the droplets allow massive parallelization, further increasing the throughput of droplets. However, this novel methodology poses unique challenges related to commonly used fluorometry and fluorescent microscopy techniques. We review the optical sensor technology and light sources applicable to DMFC, as well as analyze the challenges and advantages of each option, primarily focusing on electronics. An analysis of low-cost and/or sufficiently compact systems that can be incorporated into portable devices is also presented.

scholarly journals Graphene and its Derivatives-Based Optical Sensors

2021 ◽  
Vol 9 ◽  
Author(s):  
Xiao-Guang Gao ◽  
Ling-Xiao Cheng ◽  
Wen-Shuai Jiang ◽  
Xiao-Kuan Li ◽  
Fei Xing
Keyword(s):  
Optical Sensors ◽  
Low Cost ◽  
High Sensitivity ◽  
Fast Response ◽  
Cell Detection ◽  
Single Cell Detection ◽  
Sensing Applications ◽  
Wide Range ◽  
Surface Enhanced Raman ◽  
Recent Developments

Being the first successfully prepared two-dimensional material, graphene has attracted extensive attention from researchers due to its excellent properties and extremely wide range of applications. In particular, graphene and its derivatives have displayed several ideal properties, including broadband light absorption, ability to quench fluorescence, excellent biocompatibility, and strong polarization-dependent effects, thus emerging as one of the most popular platforms for optical sensors. Graphene and its derivatives-based optical sensors have numerous advantages, such as high sensitivity, low-cost, fast response time, and small dimensions. In this review, recent developments in graphene and its derivatives-based optical sensors are summarized, covering aspects related to fluorescence, graphene-based substrates for surface-enhanced Raman scattering (SERS), optical fiber biological sensors, and other kinds of graphene-based optical sensors. Various sensing applications, such as single-cell detection, cancer diagnosis, protein, and DNA sensing, are introduced and discussed systematically. Finally, a summary and roadmap of current and future trends are presented in order to provide a prospect for the development of graphene and its derivatives-based optical sensors.

scholarly journals RECENT TRENDS IN DENGUE DETECTION METHODS USING BIOSENSORS

2018 ◽  
Vol 19 (2) ◽  
pp. 134-153 ◽  
Author(s):  
AHMAD ANWAR ZAINUDDIN ◽  
ANIS NURASHIKIN NORDIN ◽  
ROSMINAZUIN AB RAHIM
Keyword(s):  
Low Cost ◽  
New Technology ◽  
High Sensitivity ◽  
Hemorrhagic Fever ◽  
Laboratory Diagnosis ◽  
Optical Biosensor ◽  
Ease Of Use ◽  
Detection Methods ◽  
Rt Pcr ◽  
Minimal Sample

ABSTRACT: Dengue illness is an infectious tropical disease, transmitted by Aedes mosquitos, that poses a serious health threat to the tropical world. This disease causes widespread infection worldwide, with about 50 million cases of dengue occurring per annum out of which 500,000 recorded cases of dengue hemorrhagic fever and 22,000 deaths.  Currently, there are no effective vaccines available to prevent the spread of the infection. Accurate and rapid laboratory diagnostic tests are required for early detection to reduce patient mortality rate. In this paper,  common laboratory diagnosis methods for detecting dengue virus infection are discussed. Currently, virus isolation, RT-PCR and serology methods provide the most direct and accurate response for detection of dengue. However, these methods require tedious steps, expensive requirements and expert staffs. Recent research have proposed the usage of biosensors as an alternative new technology for detection of dengue. In this work, various types of biosensors such as electrochemical, piezoelectric, and optical biosensor have been described and compared to evaluate their effectiveness in dengue detection.  It is observed that the optical biosensor offers the best detection due to its high sensitivity as compared to others, although it is popularly known as an expensive method. Alternatively, the use of electrochemical and piezoelectric biosensors (QCM) is highly recommended for detection of dengue due to their ease-of-use, low cost, low reagent consumption, disposability, and minimal sample preparation. These approaches have the potential to improve the rate of survival, particularly in resource-limited countries. ABSTRAK: Virus denggi adalah penyakit berjangkit tropika bawaan nyamuk Aedes yang menimbulkan ancaman serius kepada kesihatan global. Penyakit ini menyebabkan jangkitan yang meluas di seluruh dunia, dengan kira-kira 50 juta kes denggi yang berlaku setiap tahun di mana 500,000 kes demam denggi berdarah dan 22,000 kematian direkodkan. Buat masa ini, tiada vaksin yang berkesan untuk mencegah penyebaran jangkitan ini. Ujian diagnostik makmal yang cepat dan tepat diperlukan untuk pengesanan denggi awal untuk mengurangkan kadar kematian pesakit. Dalam artikel ini, kaedah diagnosis makmal yang biasa dilakukan untuk mengesahkan jangkitan virus denggi akan dibincangkan. Pada masa kini, kaedah pengasingan virus, RT-PCR dan serologi adalah tindak balas yang paling cepat dan tepat untuk mengesan denggi. Walau bagaimanapun, kaedah-kaedah ini memerlukan langkah-langkah yang melecehkan, kos penyelenggaraan yang tinggi dan kakitangan  yang terlatih.  Penyelidikan terkini telah mencadangkan penggunaan biosensor sebagai teknologi baru alternatif untuk mengesan denggi.  Dalam artikel  ini juga pelbagai jenis biosensor seperti biosensor elektrokimia, piezoelektrik, dan biosensor optik telah dijelaskan dan dibandingkan untuk menilai keberkesanannya dalam pengesanan denggi. Difahamkan bahawa biosensor optik menawarkan pengesanan terbaik kerana kepekaannya yang tinggi berbanding dengan yang lain, walaupun ia dikenali sebagai kaedah berkos tinggi. Sebaliknya, biosensor elektrokimia dan piezoelektrik (QCM) sangat disyorkan untuk mengesan denggi kerana ia mudah digunakan, berkos rendah, penggunaan bahan uji yang terhad, boleh dipakai buang, dan mempunyai penyediaan sampel yang minima. Pendekatan-pendekatan ini berpotensi untuk meningkatkan kadar kemandirian di kawasan-kawasan sumber terhad.

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