scholarly journals Review on Fabrication Technologies for Optical Mold Inserts

Micromachines ◽  
2019 ◽  
Vol 10 (4) ◽  
pp. 233 ◽  
Author(s):  
Marcel Roeder ◽  
Thomas Guenther ◽  
André Zimmermann
Keyword(s):  
Surface Quality ◽  
Selection Process ◽  
Fabrication Process ◽  
Optical Surface ◽  
Fabrication Technology ◽  
High Quality ◽  
Replication Process ◽  
Optical Components ◽  
Polymer Optics ◽  
Optical Mold

Polymer optics have gained increasing importance in recent years. With advancing requirements for the optical components, the fabrication process remains a challenge. In particular, the fabrication of the mold inserts for the replication process is crucial for obtaining high-quality optical components. This review focuses on fabrication technologies for optical mold inserts. Thereby, two main types of technologies can be distinguished: fabrication methods to create mold inserts with optical surface quality and methods to create optical microstructures. Since optical mold inserts usually require outstanding form accuracies and surface qualities, a focus is placed on these factors. This review aims to give an overview of available methods as well as support the selection process when a fabrication technology is needed for a defined application. Furthermore, references are given to detailed descriptions of each technology if a deeper understanding of the processes is required.

MICRO CAPILLARY ARRAY ELECTROPHORESIS CHIP BY MOVING MASK LIGA TECHNOLOGY

2004 ◽  
Vol 01 (01) ◽  
pp. 39-46
Author(s):  
HUI YOU ◽  
SHOUJI SHINOHARA ◽  
KENNICHI ENAMI ◽  
SHINSUKE SHIBATA ◽  
OSAMU TABATA ◽  
...  
Keyword(s):  
Adhesive Bonding ◽  
Dna Analysis ◽  
Adhesive Layer ◽  
Fabrication Process ◽  
Optical Components ◽  
X Ray ◽  
Laser Induced Fluorescence Detection ◽  
Capillary Array Electrophoresis ◽  
Liga Technology ◽  
Capillary Array

The concept and the fabrication process of a micro capillary array electrophoresis (μ-CAE) for DNA analysis were stated. The chip was mainly made of plastic and fabricated by the innovatory LIGA technology which included moving mask deep X-ray lithography, electroplating and hot embossing, and assembled by an adhesive bonding, in which the adhesive layer solidified and formed firm bond under UV exposure. The micro channel array with high aspect ratio is the key part, whose wall should have a slight inclination to ensure the demoulding. It was demonstrated that moving mask deep X-ray lithography (M2DXL) technology could successfully control the inclination and enabled to integrate micro optical components such as micro lens into the chip, which improved detection performance greatly. The fabrication process was experimented and some initial prototype chips have been obtained. Fluidic test and electrophoresis test with laser-induced fluorescence detection has been done on the prototype. The results confirm that the μ-CAE by moving mask LIGA process is realizable and it has great potential in high-throughput, which may lead to ultra-fast DNA analysis.

scholarly journals DEVELOPMENT OF FIELD CROP SEED PRODUCTION IN RUSSIA

2020 ◽  
Vol 8 (3) ◽  
pp. 81-85
Author(s):  
Artem Lukomec
Keyword(s):  
Food Security ◽  
Seed Production ◽  
Production System ◽  
Selection Process ◽  
Biological Properties ◽  
Field Crop ◽  
High Quality ◽  
Main Condition ◽  
Field Crops ◽  
High Quality Seed

Seed production of field crops plays a key role in ensuring food security of the country and is a continuation of the selection process, a necessary link for the development and maintenance of the variety. In seed production, the main object is a variety that is genetically close to each other a certain group of plants, homogeneous in morphological and biological properties. The finish of high-quality seed production is seeds with good varietal and sowing qualities. The main condition for effective production of field crops is a well-established seed production system, which is a set of functionally interconnected structures engaged in the production of elite and reproductive seeds. Seed production of field crops solves two main tasks: variety exchange and variety renewal. When a variety is changed, one zoned variety is replaced by another with more valuable economic characteristics. During variety renewal, varietal seeds in farms are replaced with seeds of the same varieties, but of higher reproductions. Usually, seeds for cereals and legumes are updated every 3-4 years, for millet - every 2 years, for sunflower - annually. The main goal of seed production of field crops is to maintain a set of characteristics of the variety, its most valuable qualities and economic indicators.

A NEW METHOD OF LENS CENTERING IN THE OPTICAL SYSTEM BY USING SPECIAL MOUNT

2021 ◽  
pp. 137-144
Author(s):  
Bao Bui Dinh
Keyword(s):  
Optical System ◽  
Optical Axis ◽  
Assembly Process ◽  
Optical Surface ◽  
Lens System ◽  
High Quality ◽  
Manufacturing Equipment ◽  
Influence Coefficients ◽  
Process Solutions

Decentration in lens systems (for example objectives) significantly degrades the quality of image, such as the coma. In order to reduce lens decentration, the lenses are centered while manufacturing, while gluing, while attachment in the mounts. Significant decrease in the lenses decentering in the mounts is achieved by using a special manufacturing equipment, which allow combining the optical axis of the lens with the base axis of the mount in assembly process. Solutions for coma's alignment by shifting, tilting and rotation their components are also provided in the construction of high-quality objectives (microscopes [1-7], photolithographic, aerophotographic). For optimization of methods for such adjustment the influence coefficients of decentering of each optical surface of the lens system on the value and sign of coma must be calculated and taken into account. In this paper, we propose a special mounting which combined with the Opticentric of Trioptics device to center the lenses. The results show that the decentering is significantly reduced (0.9µm) compared to (44.2µm) with using a reference mount.

scholarly journals Budgeting of non-commercial clinical trials: development of a budget tool by a public funding agency

Trials ◽  
2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Hilde Nevens ◽  
Jillian Harrison ◽  
France Vrijens ◽  
Leen Verleye ◽  
Nelle Stocquart ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Selection Process ◽  
Necessary Condition ◽  
Funding Agency ◽  
Published Data ◽  
Close Monitoring ◽  
High Quality ◽  
Cost Drivers ◽  
Pragmatic Clinical Trials

Abstract Background Investigator-led multicentre randomised trials are essential to generate evidence on the optimal use of medical interventions. These non-commercial trials are often hampered by underfunding, which may lead to difficulties in gathering a team with the necessary expertise, a delayed trial start, slow recruitment and even early trial discontinuation. As a new public funder of pragmatic clinical trials, the KCE Trials programme was committed to correctly pay all trial activities in order to assure timely delivery of high-quality trial results. As no appropriate trial budget tool was readily publicly available that took into account the costs for the sponsor as well as the costs for participating sites, we developed a tool to make the budgeting of a clinical trial efficient, transparent and fair across applicants. Methods All trial-related activities of the sponsor and sites were categorised, and cost drivers were identified. All elements were included in a spreadsheet tool allowing the sponsor team to calculate in detail the various activities of a clinical trial and to appreciate the budget impact of specific cost drivers, e.g. a delay in recruitment. Hourly fees by role were adapted from published data. Fixed amounts per activity were developed when appropriate. Results This publicly available tool has already been used for 17 trials funded since the start of the KCE Trials programme in 2016, and it continues to be used and improved. This budget tool is used together with additional risk-reducing measures such as a multistep selection process with advance payments, a recruitment feasibility check by sponsor and funder, a close monitoring of study progress and a milestone-based payment schedule with the last payment made when the manuscript is submitted. Conclusions The budget tool helps the KCE Trials programme to answer relevant research questions in a timely way, within budget and with high quality, a necessary condition to achieve impact of this programme for patients, clinical practice and healthcare payers.

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