scholarly journals Balancing Porosity and Mechanical Properties of Titanium Samples to Favor Cellular Growth against Bacteria

Metals ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 1039 ◽  
Author(s):  
Ana Civantos ◽  
Ana M. Beltrán ◽  
Cristina Domínguez-Trujillo ◽  
Maria D. Garvi ◽  
Julián Lebrato ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Mammalian Cells ◽  
Biomechanical Properties ◽  
Titanium Implants ◽  
Cellular Growth ◽  
Space Holder ◽  
Suitable Material ◽  
Biomechanical Behavior ◽  
Cell Biocompatibility ◽  
The Relationship

Two main problems limit the success of titanium implants: bacterial infection, which restricts their osseointegration capacity; and the stiffness mismatch between the implant and the host cortical bone, which promotes bone resorption and risk of fracture. Porosity incorporation may reduce this difference in stiffness but compromise biomechanical behavior. In this work, the relationship between the microstructure (content, size, and shape of pores) and the antibacterial and cellular behavior of samples fabricated by the space-holder technique (50 vol % NH4HCO3 and three ranges of particle sizes) is established. Results are discussed in terms of the best biomechanical properties and biofunctional activity balance (cell biocompatibility and antibacterial behavior). All substrates achieved suitable cell biocompatibility of premioblast and osteoblast in adhesion and proliferation processes. It is worth to highlighting that samples fabricated with the 100–200 μm space-holder present better mechanical behavior—in terms of stiffness, microhardness, and yield strength—which make them a very suitable material to replace cortical bone tissues. Those results exposed the relationship between the surface properties and the race of bacteria and mammalian cells for the surface with the aim to promote cellular growth over bacteria.

scholarly journals Regulation of the tumour suppressor Fbw7α by PKC-dependent phosphorylation and cancer-associated mutations

2010 ◽  
Vol 432 (1) ◽  
pp. 77-87 ◽  
Author(s):  
Joanne Durgan ◽  
Peter J. Parker
Keyword(s):  
Mammalian Cells ◽  
Tumour Suppressor ◽  
Dependent Manner ◽  
Serine Threonine Kinase ◽  
Threonine Kinase ◽  
Pkc Protein Kinase C ◽  
Specific Regulation ◽  
The Relationship ◽  
Substrate Binding Domain

Fbw7 (F-box WD40 protein 7) is a major tumour suppressor, which mediates the degradation of several potent oncogenes. PKC (protein kinase C) comprises a serine/threonine kinase family that can promote transformation when dysregulated. In the present study, we investigated the relationship between Fbw7 and PKC. Multiple members of the PKC superfamily interact with the substrate-binding domain of Fbw7. However, we find no evidence for Fbw7-mediated degradation of PKC. Instead, we demonstrate that Fbw7 is a novel substrate for PKC. Two residues within the isoform-specific N-terminus of Fbw7α are phosphorylated in a PKC-dependent manner, both in vitro and in mammalian cells (Ser10 and Ser18). Mutational analyses reveal that phosphorylation of Fbw7α at Ser10 can regulate its nuclear localization. Cancer-associated mutations in nearby residues (K11R and the addition of a proline residue at position 16) influence Fbw7α localization in a comparable manner, suggesting that mislocalization of this protein may be of pathological significance. Together these results provide evidence for both physical and functional interactions between the PKC and Fbw7 families, and yield insights into the isoform-specific regulation of Fbw7α.

Thyroid Hormones May Influence Cortical Bone Healing Around Titanium Implants: A Histometric Study in Rats

2008 ◽  
Vol 79 (5) ◽  
pp. 881-887 ◽  
Author(s):  
Daniela da Silva Feitosa ◽  
Beatriz de Brito Bezerra ◽  
Gláucia Maria Bovi Ambrosano ◽  
Francisco Humberto Nociti ◽  
Márcio Zaffalon Casati ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Cortical Bone ◽  
Bone Healing ◽  
Titanium Implants

COMPARATIVE STRESS ANALYSIS OF LINGUALIZED AND CONVENTIONAL BALANCED OCCLUSION SCHEMES IN A FULL-ARCH FIXED IMPLANT PROSTHESIS USING FINITE ELEMENT ANALYSIS

2017 ◽  
Vol 17 (04) ◽  
pp. 1750074
Author(s):  
MD ABU HASAN ◽  
PANOS S. SHIAKOLAS
Keyword(s):  
Cortical Bone ◽  
Acrylic Resin ◽  
Element Analysis ◽  
Posterior Teeth ◽  
Failure Index ◽  
Biomechanical Behavior ◽  
Denture Teeth ◽  
Implant Prosthesis ◽  
Von Mises ◽  
Von Mises Stresses

This study compares the biomechanical behavior of a mandibular full-arch fixed implant prosthesis with four implants under lingualized and conventional balanced occlusion schemes. The acrylic resin denture was supported by four titanium cylindrical implants and connected via a titanium prosthetic rectangular bar. Orthotropic material was used for the cortical and cancellous bones. The applied loadings were vertical and bilateral: 100[Formula: see text]N on first molar and 50[Formula: see text]N on first and second premolars each. For the lingualized balanced occlusion, the loadings were applied in central fossae of the posterior teeth, whereas for the conventional balanced occlusion the loadings were applied in central fossae and buccal cusps. The maximum von-Mises stresses for the lingualized and conventional balanced schemes were 301[Formula: see text]MPa and 25[Formula: see text]MPa, respectively, and were located at the neck of the posterior implants. In the denture teeth, the highest stress was located at the beginning of the cantilever extension. In the cortical bone, according to Tsai–Wu criterion, the failure index for the lingualized balanced occlusion was 1.10 and for the conventional balanced occlusion was 0.83. Thus, the conventional balanced occlusion demonstrated more favorable stress distribution in the implants and the cortical bone than the lingualized balanced occlusion.

Relationship between novel intraocular pressure measurement from Corvis ST and central corneal thickness and corneal hysteresis

2019 ◽  
Vol 104 (4) ◽  
pp. 563-568 ◽  
Author(s):  
Masato Matsuura ◽  
Hiroshi Murata ◽  
Yuri Fujino ◽  
Mieko Yanagisawa ◽  
Yoshitaka Nakao ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Central Corneal Thickness ◽  
Linear Regression Analysis ◽  
Corneal Thickness ◽  
Biomechanical Properties ◽  
Applanation Tonometry ◽  
Corneal Hysteresis ◽  
Corneal Resistance Factor ◽  
Corvis St ◽  
The Relationship

AimsCorvis ST (CST) yields biomechanical corrected IOP (bIOP) which is purported to be less dependent on biomechanical properties. In our accompanied paper, it was suggested that the repeatability of bIOP is high. The purpose of the current study was to assess the relationship between intraocular pressure (IOP) measured with CST and central corneal thickness (CCT) and corneal hysteresis (CH), in comparison with IOP measured with Goldmann applanation tonometry (GAT) and the ocular response analyzer (ORA).MethodsA total of 141 eyes from 141 subjects (35 healthy eyes and 106 glaucomatous eyes) underwent IOP measurements with GAT, CST and ORA. The relationships between IOP measurements (ORA-IOPg, ORA-IOPcc, CST-bIOP and GAT IOP) and biomechanical properties (CCT, CH and corneal resistance factor (CRF)) were analysed using the linear regression analysis.ResultsIOPg, IOPcc and GAT IOP were significantly associated with CCT (p<0.001), whereas bIOP was not significantly associated with CCT (p=0.19). IOPg, bIOP and GAT IOP were significantly associated with CH (IOPg: p<0.001; bIOP: p<0.001; GAT IOP: p=0.0054), whereas IOPcc was not significantly associated with CH (p=0.18). All of IOP records were associated with CRF (p<0.001).ConclusionThe bIOP measurement from CST is independent from CCT, but dependent on CH and CRF.

Sign in / Sign up

Export Citation Format

Share Document