scholarly journals Occlusal Scheme Effect on the Biomechanical Response of Full-Arch Dental Prosthesis Supported by Titanium Implants: A Systematic Review

Metals ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1574
Author(s):  
Laís Carolina Landim Gomes ◽  
Fernanda Zapater Pierre ◽  
João Paulo Mendes Tribst ◽  
Nathália de Carvalho Ramos ◽  
Eduardo Bresciani ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trial ◽  
Clinical Success ◽  
Scientific Evidence ◽  
Titanium Implants ◽  
Cochrane Library ◽  
Laboratory Studies ◽  
Biomechanical Response ◽  
Edentulous Patients

Dental implant-supported prosthesis are widely used in oral reconstruction of totally edentulous patients. Nonetheless, one of the most common failures in these cases is caused by overloading from improper occlusion. The aim of this work was to determine if the occlusal scheme influences the biomechanical response in implant-supported dental prostheses. Searches were conduct is several databases (PubMed/MEDLINE, The Cochrane Library, Web of Science, Scopus, LILACS, and Opengrey). We found 632 publications and 521 studies remained after removing duplicates. After applying the inclusion criteria, five studies were used in this systematic review: one clinical trial, one retrospective clinical trial, one in vitro and two in silico. The results show the lack of clinical and laboratory studies about occlusion in implant-supported prostheses. Although there are several studies regarding implant occlusion schemes, there remains a lack of scientific evidence to support that one specific occlusal scheme is superior to another, or to help define the ideal occlusal scheme that improves the clinical outcome. It can be concluded, however, that the proper distribution of loads and the absence of occlusal interferences can increase implant longevity. Thus, more clinical and laboratory studies must be carried out to obtain an occlusal scheme that favors the clinical success of implant rehabilitation.

scholarly journals Effect of Cavity Disinfectants on Dentin Bond Strength and Clinical Success of Composite Restorations—A Systematic Review of In Vitro, In Situ and Clinical Studies

2020 ◽  
Vol 22 (1) ◽  
pp. 353
Author(s):  
Ana Coelho ◽  
Inês Amaro ◽  
Beatriz Rascão ◽  
Inês Marcelino ◽  
Anabela Paula ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bond Strength ◽  
Clinical Studies ◽  
Antimicrobial Agents ◽  
Clinical Success ◽  
Scientific Evidence ◽  
Cochrane Library ◽  
The Cochrane Library

Cavity disinfection becomes an important step before a dental restorative procedure. The disinfection can be obtained cleaning the dental cavity with antimicrobial agents before the use of adhesive systems. The aim of this study was to conduct a systematic review on the effect of different cavity disinfectants on restorations’ adhesion and clinical success. A search was carried out through the Cochrane Library, PubMed, and Web of Science. In vitro and in situ studies reporting results on dentin bond strength tests, and clinical studies published until August 2020, in English, Spanish and Portuguese were included. The methodological quality assessment of the clinical studies was carried out using the Revised Cochrane risk-of-bias tool. Chlorhexidine could preserve adhesion to dentin. EDTA and ethanol had positive results that should be further confirmed. Given the significant lack of scientific evidence, the use of lasers, fluoridated agents, sodium hypochlorite, or other products as cavity disinfectants should be avoided. Chlorhexidine is a safe option for cavity disinfection with adequate preservation of adhesion to dentin. Moreover, future researches should be focused on the efficacy of these disinfectants against cariogenic bacteria and their best application methods.

scholarly journals Effect of phytosterols in the treatment of hypercholesterolemia in adults – systematic review with meta-analysis / Efeitos dos fitoesteróis no tratamento da hipercolesterolemia em adultos – revisão sistemática com metanálise

2021 ◽  
Vol 4 (4) ◽  
pp. 16317-16338
Author(s):  
Rebeca Cirilo De Lima ◽  
Vanessa Souza Mendonça ◽  
Grazielle Vilas Bôas Huguenin
Keyword(s):  
Systematic Review ◽  
Randomized Clinical Trials ◽  
Ldl Cholesterol ◽  
Meta Analysis ◽  
Scientific Evidence ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cochrane Library ◽  
Web Of Service

 Increased plasma total cholesterol (TC) and LDL-cholesterol (low-density lipoprotein) are considered risk factors for coronary disease. Phytosterols are among the dietary options for decreasing serum concentrations of TC and LDL-c by up to 15%.To evaluate the scientific evidence on the use of phytosterols in the treatment of hypercholesterolemia in adults.A systematic meta-analysis of the Medline, Embase, Web of Service, VHL, PUBMED, Scopus, Cochrane Library and LILACS databases was performed between November and December 2016. The PICO strategy was used. Inclusion criteria were randomized clinical trials with adults of both sexes using phytosterols longer than 4 weeks intervention. Exclusion criteria were animal and in vitro studies, humans less than 18 years old and individuals with other diseases (cancer, metabolic syndromes, diabetes mellitus, hypertension, renal disease, liver diseases). The risk of bias was assessed by two reviewers. The primary outcomes investigated were TC and LDL-cholesterol. Statistical analyses were conducted using the RevMan 5.3. The standardized effect size was used to estimate the standardized mean difference and 95% CI of TC and LDL-c.Twenty-seven randomized controlled trials were included in this systematic review and 26 studies in the meta-analysis of TC and LDL-cholesterol. The meta-analyzes showed an association with the reduction in plasma TC (-2.54 [-3.04; -2.03]) and LDL-c (-2.8 [-2.63; -1.53]) after intervention with the vegetable esters.The consumption of 1.5 to 2.0 g/day of phytosterols promotes reduction of TC and LDL-c in hypercholesterolemic individuals, regardless of the way they are consumed.

scholarly journals Effect of Cavity Disinfectants on Adhesion to Primary Teeth—A Systematic Review

2021 ◽  
Vol 22 (9) ◽  
pp. 4398
Author(s):  
Ana Coelho ◽  
Inês Amaro ◽  
Ana Apolónio ◽  
Anabela Paula ◽  
José Saraiva ◽  
...  
Keyword(s):  
Primary Teeth ◽  
Clinical Success ◽  
Dental Materials ◽  
In Vitro Study ◽  
In Vitro Studies ◽  
Cochrane Library ◽  
Promising Alternative

Some authors have been proposing the use of cavity disinfectants in order to reduce, or even eliminate, the effect of the microorganisms present in a dental cavity before a restoration is placed. The aim of this study was to evaluate the effect of different cavity disinfectants on bond strength and clinical success of composite and glass ionomer restorations on primary teeth. The research was conducted using Cochrane Library, PubMed/MEDLINE, SCOPUS, and Web of Science for articles published up to February 2021. The search was performed according to the PICO strategy. The evaluation of the methodological quality of each in vitro study was assessed using the CONSORT checklist for reporting in vitro studies on dental materials. Sixteen in vitro studies and one in situ study fulfilled the inclusion criteria and were analyzed. Chlorhexidine was the most studied cavity disinfectant, and its use does not compromise dentin bonding. Sodium hypochlorite is a promising alternative, but more research on its use is required to clearly state that it can safely be used as a cavity disinfectant for primary teeth. Although other disinfectants were studied, there is a low-level evidence attesting their effects on adhesion, therefore their use should be avoided.

scholarly journals Dance as treatment therapy in breast cancer patients – a systematic review

2017 ◽  
Vol 22 (4) ◽  
pp. 319-331 ◽  
Author(s):  
Leonessa Boing ◽  
Aline Dandara Rafael ◽  
Helena de Oliveira Braga ◽  
Alan de Jesus Pires De Moraes ◽  
Fabiana Flores Sperandio ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Dance Therapy ◽  
Scientific Evidence ◽  
Well Being ◽  
Disease Stage ◽  
Cochrane Library ◽  
Breast Cancer Patients ◽  
Psychological Benefits ◽  
Classical Ballet

This systematic review aimed to identify and analyse articles which investigated the influence of dance as adjuvant therapy in breast cancer. The selected databases were PsycInfo, PubMed, The Cochrane Library, ScienceDirect and the Virtual Health Library (VHL). The following descriptors were considered for the selection of articles: [dance therapy] OR [movement therapy] OR [complementary therapies] AND [breast cancer] OR [cancer neoplasms] OR [breast tumor] OR [breast carcinoma] present in the titles or abstracts of the articles. The quality of the data was evaluated by means of the methodological criteria proposed by Downs and Black. Eleven articles were found. The approach followed in methodologies were dance therapy movement, Greek dance, Sacred dance, ballroom dance, classical ballet and jazz. Favorable results were found for self-image, femininity, mood, self-esteem, physical well-being, perceived stress, pain, consciousness, depression, couples trust, anxiety and fear. It was observed better range of motion and strength in upper limp, and also improvement in functional capacity. The authors pointed dance as an effective alternative adjuvant treatment in breast cancer. Dance promotes psychological benefits in women in breast cancer, as well as improvements in upper limbs. Future studies are recommended with best scientific evidence, in order to investigate interventions with dance during other treatment and disease stage and with other forms of dance.

scholarly journals The Role of Physiotherapy in Pediatric Palliative Care: A Systematic Review

Children ◽  
2021 ◽  
Vol 8 (11) ◽  
pp. 1043
Author(s):  
Silvia Ortiz-Campoy ◽  
Cristina Lirio-Romero ◽  
Helena Romay-Barrero ◽  
David Martín-Caro Álvarez ◽  
Purificación López-Muñoz ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Palliative Care ◽  
Scientific Evidence ◽  
Pediatric Palliative Care ◽  
Cochrane Library ◽  
Her Family ◽  
Life Threatening ◽  
Respiratory Physiotherapy

Pediatric palliative care (PPC) is a set of actions aimed at children who suffer from a severe or life-threatening disease to alleviate the symptoms of the disease and improve the quality of life of both the child and his/her family. One of the tools used to control symptoms is physiotherapy; however, its application in the child population has not been thoroughly studied. The main objective of this study was to gather, analyze, and critically evaluate the available scientific evidence on physiotherapy in children who require palliative care through a systematic review of the studies published in the last 10 years in the following databases: PubMed, Cochrane Library, PEDro, CINAHL, and Scopus. Of a total of 622 studies, the inclusion criteria were only met by seven articles, which were focused on the relationship between physiotherapy and PPC. This study analyzed: (1) the main pathologies treated, with a predominance of cerebral palsy and cancer; (2) the interventions applied, such as respiratory physiotherapy, neurological physiotherapy, therapeutic massage, and virtual reality; (3) the effects achieved in the child and his/her family, highlighting the control of symptoms and the improvement of the quality of life; and (4) the knowledge of the physiotherapists on PPC, observing that most of the professionals had not received training in this scope. The findings of this review indicate a lack of an adequate evidence foundation for physiotherapy in PPC.

scholarly journals Enhancement of Chondrogenesis in Hypoxic Precondition Culture: A Systematic Review

2021 ◽  
Vol 9 (F) ◽  
pp. 492-504
Author(s):  
Sholahuddin Rhatomy ◽  
Riky Setyawan ◽  
Michael Aaron Romulo
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Stem Cell ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Oxygen Level ◽  
Hypoxic Precondition ◽  
Online Library

BACKGROUND: Cartilage tear has begun to be treated with stem cells. However, stem cell oxygen level culture has not been evaluated for the best environment to enhance chondrogenesis. AIM: The purpose of this review is to focus on the hypoxic oxygen level of stem cells culture as a treatment for cartilage tear. METHODS: A literature search was systemically conducted on PubMed (MEDLINE), OVID, EMBASE, the Cochrane Library, Scopus, Web of Science, Science Direct, Wiley Online Library, Google Scholar, and bibliography of selected articles with the terms (“culture”) AND (“stem cell” OR “mesenchymal stem cell” OR “MSC”) AND (“hypoxic” OR “hypoxia”) AND (“cartilage” OR “chondro*”) as the main keywords. A total of 438 articles were reviewed. Thirty-six articles were considered relevant for this systematic review. RESULTS: The result of this review supports stimulation effects of hypoxic oxygen level stem cell culture in chondrogenesis process. Most studies used 5% oxygen concentration for culture, both of in vivo and in vitro studies. Due to the heterogeneity nature of the included studies, meta-analysis was unable to be conducted. CONCLUSION: Hypoxia state seems to play an important role in chondrocytes proliferation, differentiation, and matrix production.

scholarly journals Anticancer Effects of Disulfiram: A Systematic Review of in Vitro, Animal, and Human Studies

2021 ◽  
Author(s):  
ling wang ◽  
yang yu ◽  
cong zhou ◽  
run wan ◽  
Yumin Li
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Animal Models ◽  
Human Studies ◽  
Cochrane Library ◽  
Future Research ◽  
Tumor Inhibition ◽  
Anti Tumor Activity

Abstract Background and objectives: Cancer morbidity and mortality rates remain high, and thus, at present, considerable efforts are focused on finding drugs with higher sensitivity against tumor cells and fewer side effects. Several preclinical and clinical studies have examined the potential of repurposing disulfiram (DSF) as an anticancer treatment. This systematic review aimed to assess evidence regarding the antineoplastic activity of DSF in in vitro and in vivo models, as well as in humans.Methods: Two authors independently conducted this systematic review of English and Chinese articles from the PubMed, Embase, and the Cochrane Library databases up to July 2019. Eligible in vitro studies needed to include assessments of the apoptosis rate by flow cytometry using annexin V/propidium iodide, and studies in animal models and clinical trials needed to examine tumor inhibition rates, and progression-free survival (PFS) and overall survival (OS), respectively. Data were analyzed using descriptive statistics.Results: Overall, 35 studies, i.e., 21 performed in vitro, 11 based on animal models, and three clinical trials, were finally included. In vitro and animal studies indicated that DSF was associated with enhanced apoptosis and tumor inhibition rates. Human studies showed that DSF prolongs PFS and OS. The greatest anti-tumor activity was observed when DSF was used as combination therapy or as a nanoparticle-encapsulated molecule.Conclusions: This systematic review provides evidence regarding the anti-tumor activity of DSF in vitro, in animals, and in humans and indicates the optimal forms of treatment to be evaluated in future research.

scholarly journals EFFECT OF Mucuna pruriens ON SPERM PARAMETERS WITH IDIOPATHIC INFERTILITY: A SYSTEMATIC REVIEW

2021 ◽  
Vol p5 (03) ◽  
pp. 2802-2810
Author(s):  
Deepthika S. H. K ◽  
Karunagoda K. P. K. R
Keyword(s):  
Systematic Review ◽  
Sperm Count ◽  
Sperm Parameters ◽  
Google Scholar ◽  
Mucuna Pruriens ◽  
Cochrane Library ◽  
Idiopathic Infertility ◽  
Vitro Effect

In Ayurveda Mucuna pruriens (M. pruriens) is considered as a medicine for male subfertility. There are in vitro, in vivo and literature reviews to demonstrate beneficial medicinal effects of M. pruriens in worldwide. This study aims to systematically review the scientific literature and provide a comprehensive summary on the effect of M. pruriens on sperm parameters with idiopathic infertility. A comprehensive systematic review was conducted in the following databases: PubMed, Google scholar and Cochrane library for research articles published in between 2000 and 2020. The keywords that were used in combination to search for articles included, "Mucuna pruriens","idio- pathic infertility" and "sperm parameters". The literature search done by using keywords and identified following number of articles in the respective databases; PubMed (n=13), Google scholar (n= 116), and Cochrane library (n=4). After removing duplications, the total number of articles included in the present review is 124. 114 studies were omitted due to exclusion criteria and use of combine M. pruriens with other medicinal herbs, due to the im- possibility of determining the net effect of M. pruriens. Included articles were screened in the final stage by reading the full article. There were 10 different studies evaluating the in vitro effect of M. pruriens on sperm parameters with idiopathic infertility. The results of this study showed that consumption of M. pruriens significantly improves sperm count and motility. According to studies (n=2) M. pruriens can improve morphological defects of sperms to some extents and none of those studies recorded any adverse effects. Keywords: Mucuna pruriens, Sperm parameters, Idiopathic infertility, Motility, Morphology

scholarly journals Evidence Based Dentistry among Dentists in Low and Middle Income Countries: A Systematic Review

2021 ◽  
Vol 5 (2) ◽  
pp. 129-136
Author(s):  
Irene Kida Minja ◽  
Edda Tandi Lwoga
Keyword(s):  
Systematic Review ◽  
Scientific Evidence ◽  
Grey Literature ◽  
Cochrane Library ◽  
Evidence Based ◽  
Middle Income ◽  
Hand Search ◽  
Middle Income Countries ◽  
Evidence Based Dentistry ◽  
Low And Middle Income

Purpose of this systematic review was to bring together studies of evidence-based practice among dentists in low- and middle-income countries, where its use has been reported to be limited. The protocol was registered in PROSPERO. Methodology: We searched the evidence (in English only) from medical databases including PubMed, EBSCO, The Cochrane Library, CINAHL, ScienceDirect, HINARI summon, and SCOPUS and Web of Science via Research4Life, grey literature, hand search from relevant articles, and augmented results on Google scholar.Published reports were retrieved from relevant websites and organizations. Studies included those that looked at key factors that facilitate or hinder Evidence Based Dentistry (EBD), as well as outcomes in terms of: knowledge, attitudes and skills of EB practice among dentists; and the methodology used and their relevance in future EBD strategies.Main focus was on dentists, as practitioners and faculty members. Studies on students and non-dental personnel were excluded.Findings:A total of 4568 records were retrieved and five potentially relevant articles were selected after title/abstract screening. Two articles were excluded after full text screening, and therefore Three papers were included in this review. The studies report limited knowledge,unsatisfactory attitude towards EBD and lowpractice of EBD and use of scientific evidence databases. None of the studies reported implementation of EBD nor evaluation thereof. The main barriers that constrained application of EBD ranged from lack of interest to infrastructural limitations. Originality: The current review showed that there is a need to strategised implementation of EBD in this region.

scholarly journals Supplementation with Curcuma longa Reverses Neurotoxic and Behavioral Damage in Models of Alzheimer’s Disease: A Systematic Review

2019 ◽  
Vol 17 (5) ◽  
pp. 406-421 ◽  
Author(s):  
Ianara Mendonça da Costa ◽  
Marco Aurelio de Moura Freire ◽  
José Rodolfo Lopes de Paiva Cavalcanti ◽  
Dayane Pessoa de Araújo ◽  
Bianca Norrara ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Symptoms ◽  
Curcuma Longa ◽  
Senile Plaques ◽  
Experimental Models ◽  
Cochrane Library

Background: The formation of senile plaques and neurofibrillary tangles of the tau protein are the main pathological mechanism of Alzheimer’s disease (AD). Current therapies for AD offer discrete benefits to the clinical symptoms and do not prevent the continuing degeneration of neuronal cells. Therefore, novel therapeutic strategies have long been investigated, where curcumin (Curcuma longa) has shown some properties that can prevent the deleterious processes involved in neurodegenerative diseases. Objective: The aim of the present work is to review studies that addressed the effects of curcumin in experimental models (in vivo and in vitro) for AD. Method: This study is a systematic review conducted between January and June 2017, in which a consultation of scientific articles from indexed periodicals was carried out in Science Direct, United States National Library of Medicine (PubMed), Cochrane Library and Scielo databases, using the following descriptors: “Curcuma longa”, “Curcumin” and “Alzheimer’s disease”. Results: A total of 32 studies were analyzed, which indicated that curcumin supplementation reverses neurotoxic and behavioral damages in both in vivo and in vitro models of AD. Conclusion: The administration of curcumin in experimental models seems to be a promising approach in AD, even though it is suggested that additional studies must be conducted using distinct doses and through other routes of administration.

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