scholarly journals 4-Acetoxydolastane Diterpene from the Brazilian Brown Alga Canistrocarpus cervicornis as Antileishmanial Agent

Marine Drugs ◽  
2011 ◽  
Vol 9 (11) ◽  
pp. 2369-2383 ◽  
Author(s):  
Adriana Oliveira dos Santos ◽  
Elizandra Aparecida Britta ◽  
Everson Miguel Bianco ◽  
Tania Ueda-Nakamura ◽  
Benedito Prado Dias Filho ◽  
...  
Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
AO Santos ◽  
EA Britta ◽  
T Ueda-Nakamura ◽  
BP Dias Filho ◽  
EM Bianco ◽  
...  

ChemInform ◽  
2016 ◽  
Vol 47 (14) ◽  
Author(s):  
Everson Miguel Bianco ◽  
Thiago Martins Francisco ◽  
Carlos Basilio Pinheiro ◽  
Rodrigo Bagueira de Vasconcellos Azer ◽  
Valeria Laneuville Teixeira ◽  
...  

Author(s):  
Laura De Andrade Moura ◽  
Eládio Florez Sanchez ◽  
Éverson Miguel Bianco ◽  
Renato Crespo Pereira ◽  
Valéria Laneuville Teixeira ◽  
...  

2008 ◽  
Vol 3 (9) ◽  
pp. 1934578X0800300
Author(s):  
Aline Santos De Oliveira ◽  
Diana Negrão Cavalcanti ◽  
Έverson Miguel Bianco ◽  
Joel Campos De Paula ◽  
Renato Crespo Pereira ◽  
...  

Specimens of two populations of Canistrocarpus cervicornis were collected from two different localities on the Brazilian coast about 2000 kilometers apart. The CH2Cl2 extracts were analyzed by 1H NMR and HRGC-MS techniques. A total of fourteen diterpenes were detected, eight dolastanes (1–8) and five secodolastanes (9–13). The results obtained revealed a typical pattern for C. cervicornis, which did not vary according to the geographical region.


2011 ◽  
Vol 21 (2) ◽  
pp. 234-238 ◽  
Author(s):  
Thaisa Francielle S. Domingos ◽  
Magui Aparecida Vallim ◽  
Carla Carvalho ◽  
Eladio Flores Sanchez ◽  
Valéria Laneuville Teixeira ◽  
...  

2011 ◽  
Vol 1 (1) ◽  
pp. 61-66 ◽  
Author(s):  
Laura De Andrade Moura ◽  
Eládio Florez Sanchez ◽  
Éverson Miguel Bianco ◽  
Renato Crespo Pereira ◽  
Valéria Laneuville Teixeira ◽  
...  

2017 ◽  
Vol 41 (2) ◽  
pp. 296-304
Author(s):  
Fredy A. Ortiz-Ramírez ◽  
Magui Aparecida Vallim ◽  
Diana Negrão Cavalcanti ◽  
Valéria Laneuville Teixeira

Marine organisms are rich sources of natural products that, among other activities, help to maintain the species equilibrium. Samples of the marine brown alga Canistrocarpus cervicornis (Kützing) De Paula & De Clerck were collected in Búzios, Rio de Janeiro, Brazil, in June 2006. The extract was obtained in CH2Cl2 and subjected to fractionation by chromatographic methods in order to isolate and purify the compound (4R, 7R, 14S)-4α, 7α-diacethoxy-14-hydroxydolastane-1(15), 8-dien. Then, the effects of the extract and the dolastane diterpene on zygotes and gametes of the sea urchin Lytechinus variegatus were evaluated. The exposure of male and female gametes to the C. cervicornis extract promoted, respectively, a reduction of 10-30% in fertilization and a 20 to 70% decrease in the number of eggs. Furthermore, the exposure of zygotes to the extract inhibited their development up to 86.7 ± 1.6% (at a concentration of 250 µg mL-1), as well as generating abnormalities in 39-50% of zygotes. The results of the dolastane diterpene showed no evidence of inhibition in the zygotes’ development, thought it was proved to induce anomalies. At higher concentrations (25 and 50 µg mL-1), it was possible to observe cell lyses.


2011 ◽  
Vol 31 (2) ◽  
pp. 235-240 ◽  
Author(s):  
Laura de Andrade Moura ◽  
Éverson Miguel Bianco ◽  
Renato Crespo Pereira ◽  
Valéria Laneuville Teixeira ◽  
André Lopes Fuly

Author(s):  
A.V. Prazukin ◽  
◽  
Yu.K. Firsov ◽  
A.A. Latushkin ◽  
A.I. Chepyzhenko ◽  
...  
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