scholarly journals Marine Indole Alkaloids—Isolation, Structure and Bioactivities

Marine Drugs ◽  
2021 ◽  
Vol 19 (12) ◽  
pp. 658
Author(s):  
Yong Hu ◽  
Siling Chen ◽  
Fang Yang ◽  
Shuai Dong
Keyword(s):  
High Pressure ◽  
Natural Products ◽  
Low Temperature ◽  
Indole Alkaloids ◽  
Structural Diversity ◽  
Marine Microorganisms ◽  
Pharmacological Activities ◽  
Lead Compounds ◽  
Indole Compounds ◽  
Clinical Drugs

Indole alkaloids are heterocyclic natural products with extensive pharmacological activities. As an important source of lead compounds, many clinical drugs have been derived from natural indole compounds. Marine indole alkaloids, from unique marine environments with high pressure, high salt and low temperature, exhibit structural diversity with various bioactivities, which attracts the attention of drug researchers. This article is a continuation of the previous two comprehensive reviews and covers the literature on marine indole alkaloids published from 2015 to 2021, with 472 new or structure-revised compounds categorized by sources into marine microorganisms, invertebrates, and plant-derived. The structures and bioactivities demonstrated in this article will benefit the synthesis and pharmacological activity study for marine indole alkaloids on their way to clinical drugs.

scholarly journals Plant-Based Indole Alkaloids: A Comprehensive Overview from a Pharmacological Perspective

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2297
Author(s):  
Faisal Omar ◽  
Abu Montakim Tareq ◽  
Ali M. Alqahtani ◽  
Kuldeep Dhama ◽  
Mohammed Abu Sayeed ◽  
...  
Keyword(s):  
Indole Alkaloids ◽  
Lipid Lowering ◽  
Moderate Activity ◽  
Pharmacological Activities ◽  
Comprehensive Overview ◽  
Scientific Databases ◽  
Lead Compounds ◽  
Indole Compounds ◽  
Pharmacological Potential ◽  
Online Library

Plant-based indole alkaloids are very rich in pharmacological activities, and the indole nucleus is considered to contribute greatly to these activities. This review’s fundamental objective is to summarize the pharmacological potential of indole alkaloids that have been derived from plants and provide a detailed evaluation of their established pharmacological activities, which may contribute to identifying new lead compounds. The study was performed by searching various scientific databases, including Springer, Elsevier, ACS Publications, Taylor and Francis, Thieme, Wiley Online Library, ProQuest, MDPI, and online scientific books. A total of 100 indole compounds were identified and reviewed. The most active compounds possessed a variety of pharmacological activities, including anticancer, antibacterial, antiviral, antimalarial, antifungal, anti-inflammatory, antidepressant, analgesic, hypotensive, anticholinesterase, antiplatelet, antidiarrheal, spasmolytic, antileishmanial, lipid-lowering, antimycobacterial, and antidiabetic activities. Although some compounds have potent activity, some only have mild-to-moderate activity. The pharmacokinetic profiles of some of the identified compounds, such as brucine, mitragynine, 7-hydroxymitragynine, vindoline, and harmane, were also reviewed. Most of these compounds showed promising pharmacological activity. An in-depth pharmacological evaluation of these compounds should be performed to determine whether any of these indoles may serve as new leads.

scholarly journals Natural Indole Alkaloids from Marine Fungi: Chemical Diversity and Biological Activities

2021 ◽  
Author(s):  
Jiao Li ◽  
Chun-Lin Zhuang
Keyword(s):  
Marine Fungi ◽  
Biological Activities ◽  
Indole Alkaloids ◽  
Structural Diversity ◽  
Heterocyclic Ring ◽  
Chemical Diversity ◽  
Pharmaceutical Development ◽  
Chemical Structures ◽  
Clinical Drugs ◽  
Unique Chemical

The indole scaffold is one of the most important heterocyclic ring systems for pharmaceutical development, and serves as an active moiety in several clinical drugs. Fungi derived from marine origin are more liable to produce novel indole-containing natural products due to their extreme living environments. The indole alkaloids from marine fungi have drawn considerable attention for their unique chemical structures and significant biological activities. This review attempts to provide a summary of the structural diversity of marine fungal indole alkaloids including prenylated indoles, diketopiperazine indoles, bisindoles or trisindoles, quinazoline-containing indoles, indole-diterpenoids, and other indoles, as well as their known biological activities, mainly focusing on cytotoxic, kinase inhibitory, antiinflammatory, antimicrobial, anti-insecticidal, and brine shrimp lethal effects. A total of 306 indole alkaloids from marine fungi have been summarized, covering the references published from 1995 to early 2021, expecting to be beneficial for drug discovery in the future.

scholarly journals Chemical Diversity and Biological Activities of Marine Sponges of the Genus Suberea: A Systematic Review

Marine Drugs ◽  
2019 ◽  
Vol 17 (2) ◽  
pp. 115 ◽  
Author(s):  
Amr El-Demerdash ◽  
Atanas G. Atanasov ◽  
Olaf K. Horbanczuk ◽  
Mohamed A. Tammam ◽  
Mamdouh Abdel-Mogib ◽  
...  
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Biological Activities ◽  
Structural Diversity ◽  
Marine Sponges ◽  
Chemical Diversity ◽  
Molecular Scaffolds ◽  
Pharmacological Activities ◽  
Chemotaxonomic Markers ◽  
Novel Drug

Marine natural products (MNPs) continue to be in the spotlight in the global drug discovery endeavor. Currently, more than 30,000 structurally diverse secondary metabolites from marine sources have been isolated, making MNPs a profound, renewable source to investigate novel drug compounds. Marine sponges of the genus Suberea (family: Aplysinellidae) are recognized as producers of bromotyrosine derivatives, which are considered distinct chemotaxonomic markers for the marine sponges belonging to the order Verongida. This class of compounds exhibits structural diversity, ranging from simple monomeric molecules to more complex molecular scaffolds, displaying a myriad of biological and pharmacological potentialities. In this review, a comprehensive literature survey covering the period of 1998–2018, focusing on the chemistry and biological/pharmacological activities of marine natural products from marine sponges of the genus Suberea, with special attention to the biogenesis of the different skeletons of halogenated compounds, is presented.

scholarly journals Natural Products Repertoire of the Red Sea

Marine Drugs ◽  
2020 ◽  
Vol 18 (9) ◽  
pp. 457 ◽  
Author(s):  
Ebaa M. El-Hossary ◽  
Mohammad Abdel-Halim ◽  
Eslam S. Ibrahim ◽  
Sheila Marie Pimentel-Elardo ◽  
Justin R. Nodwell ◽  
...  
Keyword(s):  
Natural Products ◽  
Red Sea ◽  
Great Success ◽  
Ecological Role ◽  
Pharmacological Activities ◽  
Lead Compounds ◽  
Biological Potential ◽  
Bioactive Secondary Metabolites ◽  
Domains Of Life ◽  
Comprehensive Study

Marine natural products have achieved great success as an important source of new lead compounds for drug discovery. The Red Sea provides enormous diversity on the biological scale in all domains of life including micro- and macro-organisms. In this review, which covers the literature to the end of 2019, we summarize the diversity of bioactive secondary metabolites derived from Red Sea micro- and macro-organisms, and discuss their biological potential whenever applicable. Moreover, the diversity of the Red Sea organisms is highlighted as well as their genomic potential. This review is a comprehensive study that compares the natural products recovered from the Red Sea in terms of ecological role and pharmacological activities.

Spiropyrazolines: A Worthy Insight into the Recent Strategies and Synthetic Applications

2019 ◽  
Vol 16 (5) ◽  
pp. 357-391
Author(s):  
Zubi Sadiq ◽  
Sadia Naz ◽  
Erum Akbar Hussain ◽  
Umbreen Aslam
Keyword(s):  
Natural Products ◽  
Structural Diversity ◽  
Dipolar Cycloaddition ◽  
Molecular Architecture ◽  
Pharmacological Activities ◽  
Insight Into ◽  
Biological And Pharmacological Activities

The structural diversity of spiro heterocycles has achieved an extensive attention of organic chemists due to their vast synthetic applications. Among these, spiropyrazolines are gaining considerable prominence due to their biological and pharmacological activities, electrophotographic photosensitivity as well as their application as beneficial synthons for spirocyclopropanes, cyclobutanes, pyrrolidinones, pyrazoles, 3-amino oxindoles and several natural products molecular architecture. In view of all these, this review aims to provide the classical and advanced regioselective approaches as well as synthetic applications of spiropyrazolines. The key reactions for its synthesis are 1,3-dipolar cycloaddition and condensations that are described completely in this piece of work.

scholarly journals The Structural Diversity of Marine Microbial Secondary Metabolites Based on Co-Culture Strategy: 2009–2019

Marine Drugs ◽  
2020 ◽  
Vol 18 (9) ◽  
pp. 449
Author(s):  
Jianwei Chen ◽  
Panqiao Zhang ◽  
Xinyi Ye ◽  
Bin Wei ◽  
Mahmoud Emam ◽  
...  
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Biological Activities ◽  
Structural Diversity ◽  
Marine Microorganisms ◽  
Future Prospects ◽  
Marine Microbes ◽  
Cultivation Strategy ◽  
Culture Strategy ◽  
Bioactive Natural Product

Marine microorganisms have drawn great attention as novel bioactive natural product sources, particularly in the drug discovery area. Using different strategies, marine microbes have the ability to produce a wide variety of molecules. One of these strategies is the co-culturing of marine microbes; if two or more microorganisms are aseptically cultured together in a solid or liquid medium in a certain environment, their competition or synergetic relationship can activate the silent biosynthetic genes to produce cryptic natural products which do not exist in monocultures of the partner microbes. In recent years, the co-cultivation strategy of marine microbes has made more novel natural products with various biological activities. This review focuses on the significant and excellent examples covering sources, types, structures and bioactivities of secondary metabolites based on co-cultures of marine-derived microorganisms from 2009 to 2019. A detailed discussion on future prospects and current challenges in the field of co-culture is also provided on behalf of the authors’ own views of development tendencies.

scholarly journals Antifouling Indole Alkaloids from Two Marine Derived Fungi

2013 ◽  
Vol 8 (3) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Fei He ◽  
Zhuang Han ◽  
Jiang Peng ◽  
Pei-Yuan Qian ◽  
Shu-Hua Qi
Keyword(s):  
Natural Products ◽  
Mass Spectra ◽  
Chemical Constituents ◽  
Indole Alkaloids ◽  
Antibacterial Activities ◽  
Aspergillus Sydowii ◽  
Marine Microorganisms ◽  
Penicillium Sp ◽  
Antifouling Agent

In order to find non-toxic antifouling natural products from marine microorganisms, the chemical constituents of two marine derived fungi Penicillium sp. and Aspergillus sydowii have been investigated under bio-guided fractionation. A new indolyl diketopiperazine compound, penilloid A (1), together with 15 known ones were isolated from these two strains. The structure of 1 was elucidated on the basis of NMR and mass spectra. Some alkaloids showed significant antifouling and antibacterial activities. The results indicate that indole alkaloids could be a potential antifouling agent resource.

scholarly journals Marine-Derived Indole Alkaloids and Their Biological and Pharmacological Activities

Marine Drugs ◽  
2021 ◽  
Vol 20 (1) ◽  
pp. 3
Author(s):  
Joko Tri Wibowo ◽  
Peni Ahmadi ◽  
Siti Irma Rahmawati ◽  
Asep Bayu ◽  
Masteria Yunovilsa Putra ◽  
...  
Keyword(s):  
Indole Alkaloids ◽  
Structural Features ◽  
New Drugs ◽  
Pharmacological Activities ◽  
Biological Targets ◽  
Scientific Databases ◽  
Lead Compounds ◽  
Wide Range ◽  
Review Reports ◽  
Biological And Pharmacological Activities

Novel secondary metabolites from marine macroorganisms and marine-derived microorganisms have been intensively investigated in the last few decades. Several classes of compounds, especially indole alkaloids, have been a target for evaluating biological and pharmacological activities. As one of the most promising classes of compounds, indole alkaloids possess not only intriguing structural features but also a wide range of biological/pharmacological activities including antimicrobial, anti-inflammatory, anticancer, antidiabetic, and antiparasitic activities. This review reports the indole alkaloids isolated during the period of 2016–2021 and their relevant biological/pharmacological activities. The marine-derived indole alkaloids reported from 2016 to 2021 were collected from various scientific databases. A total of 186 indole alkaloids from various marine organisms including fungi, bacteria, sponges, bryozoans, mangroves, and algae, are described. Despite the described bioactivities, further evaluation including their mechanisms of action and biological targets is needed to determine which of these indole alkaloids are worth studying to obtain lead compounds for the development of new drugs.

scholarly journals Osthole: A Promising Lead Compound for Drug Discovery from a Traditional Chinese Medicine (TCM)

2009 ◽  
Vol 4 (2) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Lisha You ◽  
Song Feng ◽  
Rui An ◽  
Xinhong Wang
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Pharmaceutical Compounds ◽  
Therapeutic Agents ◽  
Biological Information ◽  
Lead Compound ◽  
Pharmacological Activities ◽  
Lead Compounds

Natural products have always been important resources either as therapeutic agents or as lead compounds for the production of pharmaceutical compounds. Osthole, 7-methoxy-8-(3-methyl-2-butenyl) coumarin, an ingredient of a Traditional Chinese Medicine(TCM), has received considerable attention recently because of its significant and diverse pharmacological activities, including anticancer, antisteoporotic, and antiproliferative, which make it a very promising natural lead compound for new drug discovery. The present work summarizes the related biological information on osthole and its analogues and proposes the possibility of its development as a promising lead compound for drug discovery.

scholarly journals Exploring Marine Cyanobacteria for Lead Compounds of Pharmaceutical Importance

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Bushra Uzair ◽  
Sobia Tabassum ◽  
Madiha Rasheed ◽  
Saima Firdous Rehman
Keyword(s):  
Bioactive Compounds ◽  
Biological Activities ◽  
Structural Diversity ◽  
Marine Cyanobacteria ◽  
Pharmacological Activities ◽  
Lead Compounds ◽  
Acquired Immunodeficiency ◽  
Living Organisms ◽  
Immunodeficiency Syndrome ◽  
Excellent Source

The Ocean, which is called the “mother of origin of life,” is also the source of structurally unique natural products that are mainly accumulated in living organisms. Cyanobacteria are photosynthetic prokaryotes used as food by humans. They are excellent source of vitamins and proteins vital for life. Several of these compounds show pharmacological activities and are helpful for the invention and discovery of bioactive compounds, primarily for deadly diseases like cancer, acquired immunodeficiency syndrome (AIDS), arthritis, and so forth, while other compounds have been developed as analgesics or to treat inflammation, and so forth. They produce a large variety of bioactive compounds, including substances with anticancer and antiviral activity, UV protectants, specific inhibitors of enzymes, and potent hepatotoxins and neurotoxins. Many cyanobacteria produce compounds with potent biological activities. This paper aims to showcase the structural diversity of marine cyanobacterial secondary metabolites with a comprehensive coverage of alkaloids and other applications of cyanobacteria.

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