scholarly journals Methods in Microbial Biodiscovery

Marine Drugs ◽  
2021 ◽  
Vol 19 (9) ◽  
pp. 503
Author(s):  
Angela A. Salim ◽  
Zeinab G. Khalil ◽  
Ahmed H. Elbanna ◽  
Taizong Wu ◽  
Robert J. Capon
Keyword(s):  
Natural Products ◽  
Terrestrial Fungi ◽  
The University

This review presents an account of the microbial biodiscovery methodology developed and applied in our laboratory at The University of Queensland, Institute for Molecular Bioscience, with examples drawn from our experiences studying natural products produced by Australian marine-derived (and terrestrial) fungi and bacteria.

scholarly journals Tom J. Mabry's Natural Products Chemistry Program: 1960–2007

2007 ◽  
Vol 2 (10) ◽  
pp. 1934578X0700201
Author(s):  
Lalita M. Calabria ◽  
Tom J. Mabry
Keyword(s):  
Biological Sciences ◽  
Developmental Biology ◽  
Natural Products ◽  
Faculty Member ◽  
Natural Product ◽  
University Of Texas ◽  
Natural Products Chemistry ◽  
University Of Zurich ◽  
The University ◽  
Natural Product Chemist

This paper presents an overview of Dr. Mabry's accomplishments in his career as a natural product chemist, first at the University of Zürich as a post-doctoral fellow, and from 1962, as a faculty member at the University of Texas at Austin in the Department of Botany until the late 1990s, when the Biological Sciences programs at UT-Austin were completely reorganized. From then until his retirement in 2006, he was a member of the Molecular Cell and Developmental Biology faculty.

C–O Containing Natural Products

2015 ◽  
Author(s):  
Tristan H. Lambert
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Natural Product ◽  
Biological Activities ◽  
Max Planck ◽  
Penicillium Species ◽  
Antimitotic Agent ◽  
Berkelic Acid ◽  
Metal Catalyzed ◽  
The University

It is thought that the pseudopterane class of diterpenoid natural products, of which 11-gorgiacerol is a member, arises biosynthetically by a photo-ring contraction of the related furanocembranes. Johann Mulzer at the University of Vienna has applied (Org. Lett. 2012, 14, 2834) this logic to realize the total synthesis of 11-gorgiacerol. Ringclosing metathesis of the butenolide 1 using the Grubbs second generation catalyst produced the tricycle 2. When irradiated, 2 undergoes a 1,3-rearrangement to furnish the natural product in good yield. Whether this rearrangement is concerted, or occurs stepwise via a diradical intermediate, is not known. Although ring-closing metathesis has become a reliable method for macrocycle construction, its use here to set what then becomes an extracyclic olefin is notable. Berkelic acid is produced by an extremophile bacterium penicillium species that lives in the toxic waters of an abandoned copper mine, and this natural product has been found to possess some very intriguing biological activities. Not surprisingly, berkelic acid has attracted significant attention from synthetic chemists, including Francisco J. Fañanás of Universidad de Oviedo in Spain, who has developed (Angew. Chem. Int. Ed. 2012, 51, 4930) a scalable, protecting-group free total synthesis. The key step in this route is the remarkable silver(I)-catalyzed coupling of alkyne 3 and aldehyde 4 to produce, after hydrogenation, the structural core 5 of (–)-berkelic acid on a gram scale. Some tools from the field of organocatalysis have been brought to bear (Angew. Chem. Int. Ed. 2012, 51, 5735) on a new total synthesis of the macrolide (+)-dactylolide by Hyoungsu Kim of Ajou University in Korea and Jiyong Hong of Duke University. The bridging tetrahydropyranyl ring is fashioned by way of an intramolecular 1,6-oxa conjugate addition of dienal 6 to produce 8 under catalysis by the secondary amine 7. Following some synthetic manipulations, the macrocyclic ring 12 is subsequently forged by an NHC-catalyzed oxidative macrolactonization using the carbene catalyst 10 and diphenoquinone 11 as the oxidant. A new approach to the nanomolar antimitotic agent spirastrellolide F methyl ester has been reported (Angew. Chem. Int. Ed. 2012, 51, 8739) by Alois Fürstner of the Max-Planck-Institut, Mülheim. Two elegant metal-catalyzed processes form the key basis of this strategy.

Preface

2012 ◽  
Vol 84 (6) ◽  
pp. iv
Author(s):  
Anthony R. Carroll
Keyword(s):  
Natural Products ◽  
Cross Section ◽  
Marine Invertebrates ◽  
Early Career ◽  
Neglected Diseases ◽  
Rich Diversity ◽  
Broad Cross Section ◽  
Poster Presentations ◽  
The University ◽  
New Metabolites

The IUPAC-sponsored joint meeting of the 27th International Symposium on the Chemistry of Natural Products (ISCNP-27) and the 7th International Conference on Biodiversity (ICOB-7) was held in Brisbane, Australia from 10 to 15 July 2011. The meeting was co-chaired by Prof. Ron Quinn from Griffith University and Prof. Mary Garson from the University of Queensland.The meeting brought together a broad cross-section of highly renowned scientists from academia, government, and industry, who presented their findings in 42 plenary and invited talks. An excellent diversity of contributed short talks were provided by a further 20 speakers. Three successful sessions were devoted to short (3 min) oral poster presentations given by 18 early-career scientists describing the research presented in their posters. A total of 76 posters were also presented. Scientists from 24 countries presented their research at the conference. Topics covered at the symposia included: discovery of new metabolites, isolation and structure elucidation, synthesis, neglected diseases, biosynthesis, engineered biosynthesis, chemical ecology, new methodology, and biodiversity. The chemistry from a rich diversity of sources was covered, including marine invertebrates, insects, plants, fungi, bacteria, myxobacteria, cyanobacteria, and even mammalian venoms.The 14 papers included in this issue of Pure and Applied Chemistry are based upon lectures presented at ISCNP-27/ICOB-7. The papers represent a good cross-section of the major themes in natural products research presented during the meeting and demonstrate the multidisciplinary nature and extensive breadth of applications that natural products research can provide to the wider community. The next meeting in this series is scheduled to take place in Shanghai in 2013.Anthony R. CarrollConference Editor

scholarly journals Drugs from the Cloudforest: The Search for New Medicines from Monteverde, Costa Rica

2011 ◽  
Vol 6 (10) ◽  
pp. 1934578X1100601
Author(s):  
William N. Setzer
Keyword(s):  
Natural Products ◽  
Costa Rica ◽  
Anticancer Agents ◽  
Antimicrobial Agents ◽  
Tropical Rainforest ◽  
Higher Plants ◽  
University Of Alabama ◽  
The Past ◽  
The University ◽  
Antiparasitic Agents

The University of Alabama in Huntsville Natural Products Research Group has been investigating the phytopharmaceutical potential of tropical rainforest higher plants from the Monteverde region of northwestern Costa Rica for the past twenty years. The group has focused primarily on anticancer agents, antimicrobial agents, and antiparasitic agents. This review presents an overview of some of our efforts in natural products drug discovery from Monteverde, Costa Rica.

scholarly journals Natural Products in the Prevention of Metabolic Diseases: Lessons Learned from the 20th KAST Frontier Scientists Workshop

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1881
Author(s):  
Seung J. Baek ◽  
Bruce D. Hammock ◽  
In-Koo Hwang ◽  
Qingxiao Li ◽  
Naima Moustaid-Moussa ◽  
...  
Keyword(s):  
Natural Products ◽  
Metabolic Diseases ◽  
Current Knowledge ◽  
Analytical Techniques ◽  
Lessons Learned ◽  
Bioactive Components ◽  
Underlying Causes ◽  
The University ◽  
And Oxidative Stress

The incidence of metabolic and chronic diseases including cancer, obesity, inflammation-related diseases sharply increased in the 21st century. Major underlying causes for these diseases are inflammation and oxidative stress. Accordingly, natural products and their bioactive components are obvious therapeutic agents for these diseases, given their antioxidant and anti-inflammatory properties. Research in this area has been significantly expanded to include chemical identification of these compounds using advanced analytical techniques, determining their mechanism of action, food fortification and supplement development, and enhancing their bioavailability and bioactivity using nanotechnology. These timely topics were discussed at the 20th Frontier Scientists Workshop sponsored by the Korean Academy of Science and Technology, held at the University of Hawaii at Manoa on 23 November 2019. Scientists from South Korea and the U.S. shared their recent research under the overarching theme of Bioactive Compounds, Nanoparticles, and Disease Prevention. This review summarizes presentations at the workshop to provide current knowledge of the role of natural products in the prevention and treatment of metabolic diseases.

scholarly journals Current Trends in Natural Products Research from the CBNP10 Symposium at Warwick

2016 ◽  
Vol 4 (1) ◽  
pp. 158-166
Author(s):  
Fabrizio Alberti ◽  
Fabrizio Alberti
Keyword(s):  
Natural Products ◽  
Structural Diversity ◽  
Early Career ◽  
New Drugs ◽  
Common Source ◽  
Natural Product Research ◽  
Leading Position ◽  
Living Organisms ◽  
The University ◽  
New Compounds

Natural products are compounds that are produced by living organisms. They have numerous applications in our everyday life, from antibiotics to herbicides. They possess great chemical and structural diversity, which gives them a leading position as a source of new drugs. Many institutions worldwide are focusing more and more on natural product research, with microorganisms and plants being the most common source for discovery of new compounds. On the 30th June and 1st July 2016, early-career scientists working in the field of natural products gathered at the University of Warwick for the 10th edition of the Chemistry and Biology of Natural Products Symposium (CBNP10). This critical reflection reviews, in the context of the current research in the field, the major considerations that arose from this meeting.

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