scholarly journals Microbial Oligosaccharides with Biomedical Applications

Marine Drugs ◽  
2021 ◽  
Vol 19 (6) ◽  
pp. 350
Author(s):  
Jian-Lin Xu ◽  
Zhi-Feng Liu ◽  
Xiao-Wei Zhang ◽  
Hai-Li Liu ◽  
Yong Wang
Keyword(s):  
Type Ii Diabetes ◽  
Biomedical Applications ◽  
Bacterial Infections ◽  
Biological Activities ◽  
Type Ii Diabetes Mellitus ◽  
Chemical Structures ◽  
Activity Inhibition ◽  
Naturally Occurring ◽  
Current Review ◽  
Cellular Recognition

Microbial oligosaccharides have been regarded as one of the most appealing natural products attributable to their potent and selective bioactivities, such as antimicrobial activity, inhibition of α-glucosidases and lipase, interference of cellular recognition and signal transduction, and disruption of cell wall biosynthesis. Accordingly, a handful of bioactive oligosaccharides have been developed for the treatment of bacterial infections and type II diabetes mellitus. Given that naturally occurring oligosaccharides have increasingly gained recognition in recent years, a comprehensive review is needed. The current review highlights the chemical structures, biological activities and divergent biosynthetic origins of three subgroups of oligomers including the acarviosine-containing oligosaccharides, saccharomicins, and orthosomycins.

scholarly journals Bioactive Pigments from Marine Bacteria: Applications and Physiological Roles

2011 ◽  
Vol 2011 ◽  
pp. 1-17 ◽  
Author(s):  
Azamjon B. Soliev ◽  
Kakushi Hosokawa ◽  
Keiichi Enomoto
Keyword(s):  
Marine Bacteria ◽  
Review Paper ◽  
Biological Activities ◽  
Pharmacological Activities ◽  
Chemical Structures ◽  
The Past ◽  
Unique Color ◽  
Current Review ◽  
Marine Compounds ◽  
Commercial Applications

Research into natural products from the marine environment, including microorganisms, has rapidly increased over the past two decades. Despite the enormous difficulty in isolating and harvesting marine bacteria, microbial metabolites are increasingly attractive to science because of their broad-ranging pharmacological activities, especially those with unique color pigments. This current review paper gives an overview of the pigmented natural compounds isolated from bacteria of marine origin, based on accumulated data in the literature. We review the biological activities of marine compounds, including recent advances in the study of pharmacological effects and other commercial applications, in addition to the biosynthesis and physiological roles of associated pigments. Chemical structures of the bioactive compounds discussed are also presented.

scholarly journals An Update on Oligosaccharides and Their Esters from Traditional Chinese Medicines: Chemical Structures and Biological Activities

2015 ◽  
Vol 2015 ◽  
pp. 1-23 ◽  
Author(s):  
Xiang-Yang Chen ◽  
Ru-Feng Wang ◽  
Bin Liu
Keyword(s):  
Medicinal Plants ◽  
Biological Activities ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Chemical Structures ◽  
Naturally Occurring ◽  
Prevention And Treatment ◽  
Chinese Medicinal Plants

A great number of naturally occurring oligosaccharides and oligosaccharide esters have been isolated from traditional Chinese medicinal plants, which are used widely in Asia and show prominent curative effects in the prevention and treatment of kinds of diseases. Numerousin vitroandin vivoexperiments have revealed that oligosaccharides and their esters exhibited various activities, including antioxidant, antidepressant, cytotoxic, antineoplastic, anti-inflammatory, neuroprotective, cerebral protective, antidiabetic, plant growth-regulatory, and immunopotentiating activities. This review summarizes the investigations on the distribution, chemical structures, and bioactivities of natural oligosaccharides and their esters from traditional Chinese medicines between 2003 and 2013.

The Importance of Rhodanine Scaffold in Medicinal Chemistry: A Comprehensive Overview

2020 ◽  
Vol 21 ◽  
Author(s):  
Arif Mermer
Keyword(s):  
Type Ii Diabetes ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Type Ii Diabetes Mellitus ◽  
Mechanisms Of Action ◽  
Type Ii ◽  
Pharmacological Activities ◽  
Comprehensive Overview ◽  
Structure Activity ◽  
Privileged Scaffold

: After the clinical use of epalrestat that contains a rhodanine ring, in type II diabetes mellitus and diabetic complications, rhodanin-based compounds have become an important class of heterocyclic in the field of medicinal chemistry. Various modifications to the rhodanine ring have led to a broad spectrum of biological activity of these compounds. Synthesis of rhodanine derivatives, depended on advenced throughput scanning hits, frequently causes to potent and selective modulators of targeted enzymes or receptors, which apply their pharmacological activities through different mechanisms of action. Rhodanine-based compounds will likely stay a privileged scaffold in drug discovery because of different probability of chemical modifications of the rhodanine ring. We have therefore reviewed their biological activities and structure activity relationship.

Therapeutic potential of naturally occurring benzofuran derivatives and hybrids of benzofurans with other pharmacophores as antibacterial agents

2021 ◽  
Vol 21 ◽  
Author(s):  
Zhi Xu ◽  
Dan Xu ◽  
Wei Zhou ◽  
Xiaoyan Zhang
Keyword(s):  
Bacterial Infections ◽  
Antibacterial Agents ◽  
Therapeutic Potential ◽  
Severe Disease ◽  
Host Immune System ◽  
Chemical Structures ◽  
Naturally Occurring ◽  
Pharmacologically Active ◽  
Pharmacologically Active Compounds ◽  
World Development

: Gram-positive and Gram-negative pathogens are able to evade the host immune system, persist within the human host, and lead to severe disease and even death. At present, bacterial infections are one of the leading causes of morbidity and mortality across the world. Development of novel antibacterial agents still represents a challenging endeavor, which is mainly attributed to the continuous emergence of more virulent and drug-resistant pathogens. Benzofuran constitutes the core of diverse pharmacologically active compounds, and there are a variety of approved benzofuran-based drugs in the market or currently going through different clinical phases or registration statuses. Benzofurans could exert antibacterial activity through various mechanisms and possess pronounced activity, so benzofuran is a useful skeleton for the discovery of novel antibacterial agents. This review focuses on the recent advancement of naturally occurring benzofuran derivatives and hybrids of benzofurans with other pharmacophores as antibacterial agents, covering articles published between January 2015 and July 2021. The chemical structures and structure-activity relationships are also discussed.

scholarly journals Natural Polypropionates in 1999–2020: An Overview of Chemical and Biological Diversity

Marine Drugs ◽  
2020 ◽  
Vol 18 (11) ◽  
pp. 569
Author(s):  
Zhaoming Liu ◽  
Hongxin Liu ◽  
Weimin Zhang
Keyword(s):  
Biological Diversity ◽  
Biological Activities ◽  
Structural Features ◽  
Chemical Diversity ◽  
Research Papers ◽  
Chemical Structures ◽  
The Past ◽  
Current Review ◽  
Large Subgroup ◽  
The Relationship

Natural polypropionates (PPs) are a large subgroup of polyketides with diverse structural features and bioactivities. Most of the PPs are discovered from marine organisms including mollusks, fungi and actinomycetes, while some of them are also isolated from terrestrial resources. An increasing number of studies about PPs have been carried out in the past two decades and an updated review is needed. In this current review, we summarize the chemical structures and biological activities of 164 natural PPs reported in 67 research papers from 1999 to 2020. The isolation, structural features and bioactivities of these PPs are discussed in detail. The chemical diversity, bioactive diversity, biodiversity and the relationship between chemical classes and the bioactivities are also concluded.

Structure, Biological Activities and Metabolism of Flavonoid Glucuronides

2021 ◽  
Vol 21 ◽  
Author(s):  
Min Chen ◽  
Xueyang Ren ◽  
Siqi Sun ◽  
Xiuhuan Wang ◽  
Xiao Xu ◽  
...  
Keyword(s):  
Natural Product ◽  
Biological Activities ◽  
Cerebrovascular Diseases ◽  
Diverse Range ◽  
Chemical Structures ◽  
The Past ◽  
Naturally Occurring ◽  
Notable Effect ◽  
Natural Product Research ◽  
Glycoside Bond

Background: Flavonoid glucuronides are a kind of natural products which present a flavone linked directly with one or several glucuronides through O-glycoside bond. They had become of interest in natural product research in the past decades for their antioxidant, anti-inflammatory, and anti-bacteria activities. In particular, the compound breviscapine has a notable effect on cardio-cerebrovascular diseases. Several other compounds even have antitumor activity. Methods: Through searching the database and reading a large number of documents, we summarized the related findings of flavonoid glucuronides. Results: We summarized 211 naturally occurring flavonoid glucuronides in 119 references with their chemical structures, biological activities, and metabolism. A total of 220 references from 1953 to 2020 were cited in this paper according to literature databases such as CNKI, Weipu, Wanfang data, Elsevier, Springer, Wiley, NCBI, PubMed, EmBase, etc. Conclusion : Flavonoid glucuronides are a class of compounds with various chemical structures and a diverse range of biological activities. And they are thought to be potential candidates for drug discovery, but the specific study on their mechanisms is still limited until now. We hope this article can provide references for natural product researchers and draw more attention to flavonoid glucuronides’ biological activities and mechanisms.

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