scholarly journals The Structural Characteristics of Seaweed Polysaccharides and Their Application in Gel Drug Delivery Systems

Marine Drugs ◽  
2020 ◽  
Vol 18 (12) ◽  
pp. 658
Author(s):  
Haowei Zhong ◽  
Xiaoran Gao ◽  
Cui Cheng ◽  
Chun Liu ◽  
Qiaowen Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Recent Literature ◽  
Alginic Acid ◽  
Biological Activities ◽  
Structural Characteristics ◽  
Delivery Systems ◽  
Polymer Materials ◽  
Component Mixture ◽  
Anticancer Drug Delivery

In recent years, researchers across various fields have shown a keen interest in the exploitation of biocompatible natural polymer materials, especially the development and application of seaweed polysaccharides. Seaweed polysaccharides are a multi-component mixture composed of one or more monosaccharides, which have the functions of being anti-virus, anti-tumor, anti-mutation, anti-radiation and enhancing immunity. These biological activities allow them to be applied in various controllable and sustained anti-inflammatory and anticancer drug delivery systems, such as seaweed polysaccharide-based nanoparticles, microspheres and gels, etc. This review summarizes the advantages of alginic acid, carrageenan and other seaweed polysaccharides, and focuses on their application in gel drug delivery systems (such as nanogels, microgels and hydrogels). In addition, recent literature reports and applications of seaweed polysaccharides are also discussed.

Advances in the use of MOFs for Cancer Diagnosis and Treatment: An Overview

2020 ◽  
Vol 26 (33) ◽  
pp. 4174-4184
Author(s):  
Marina P. Abuçafy ◽  
Bruna L. da Silva ◽  
João A. Oshiro-Junior ◽  
Eloisa B. Manaia ◽  
Bruna G. Chiari-Andréo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Rational Design ◽  
Gas Adsorption ◽  
Drug Loading ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Academic Community ◽  
Anticancer Drug Delivery ◽  
Diagnostic Agents

Nanoparticles as drug delivery systems and diagnostic agents have gained much attention in recent years, especially for cancer treatment. Nanocarriers improve the therapeutic efficiency and bioavailability of antitumor drugs, besides providing preferential accumulation at the target site. Among different types of nanocarriers for drug delivery assays, metal-organic frameworks (MOFs) have attracted increasing interest in the academic community. MOFs are an emerging class of coordination polymers constructed of metal nodes or clusters and organic linkers that show the capacity to combine a porous structure with high drug loading through distinct kinds of interactions, overcoming the limitations of traditional drug carriers explored up to date. Despite the rational design and synthesis of MOFs, structural aspects and some applications of these materials like gas adsorption have already been comprehensively described in recent years; it is time to demonstrate their potential applications in biomedicine. In this context, MOFs can be used as drug delivery systems and theranostic platforms due to their ability to release drugs and accommodate imaging agents. This review describes the intrinsic characteristics of nanocarriers used in cancer therapy and highlights the latest advances in MOFs as anticancer drug delivery systems and diagnostic agents.

Development and Evaluation of Sustained Release Lipid Nanocarriers for Curcumin

2020 ◽  
Vol 5 (3) ◽  
pp. 224-235
Author(s):  
Harshal A. Pawar ◽  
Bhagyashree D. Bhangale
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery Systems ◽  
Biological Activities ◽  
Curcuma Longa ◽  
Research Work ◽  
Elimination Rate ◽  
Delivery Systems ◽  
Physicochemical Stability ◽  
Wide Range

Background: Lipid based excipients have increased acceptance nowadays in the development of novel drug delivery systems in order to improve their pharmacokinetic profiles. Drugs encapsulated in lipids have enhanced stability due to the protection they experience in the lipid core of these nano-formulations. Phytosomes are newly discovered drug delivery systems and novel botanical formulation to produce lipophilic molecular complex which imparts stability, increases absorption and bioavailability of phytoconstituent. Curcumin, obtained from turmeric (Curcuma longa), has a wide range of biological activities. The poor solubility and wettability of curcumin are responsible for poor dissolution and this, in turn, results in poor bioavailability. To overcome these limitations, the curcumin-loaded nano phytosomes were developed to improve its physicochemical stability and bioavailability. Objective: The objective of the present research work was to develop nano-phytosomes of curcumin to improve its physicochemical stability and bioavailability. Methods: Curcumin-loaded nano phytosomes were prepared by using phospholipid Phospholipon 90 H using a modified solvent evaporation method. The developed curcumin nano phytosomes were evaluated by particle size analyzer and differential scanning calorimetry (DSC). Results: Results indicated that phytosomes prepared using curcumin and lipid in the ratio of 1:2 show good entrapment efficiency. The obtained curcumin phytosomes were spherical in shape with a size less than 100 nm. The prepared nano phytosomal formulation of curcumin showed promising potential as an antioxidant. Conclusion: The phytosomal complex showed sustained release of curcumin from vesicles. The sustained release of curcumin from phytosome may improve its absorption and lowers the elimination rate with an increase in bioavailability.

Micro/nanomachines: what is needed for them to become a real force in cancer therapy?

Nanoscale ◽  
2019 ◽  
Vol 11 (14) ◽  
pp. 6519-6532 ◽  
Author(s):  
Lucie Reinišová ◽  
Soňa Hermanová ◽  
Martin Pumera
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Anticancer Drug ◽  
Future Development ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Anticancer Drug Delivery

A biomedical perspective is used to assess micro/nanomotor-based anticancer drug delivery systems with recommendations for their effective future development.

Anticancer Drug Delivery Systems Based on Curcumin Nanostructures: A Review

2020 ◽  
Vol 54 (4) ◽  
pp. 353-360
Author(s):  
Zahra Mirzaie ◽  
Mohammad Barati ◽  
Mohammad Asadi Tokmedash
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Anticancer Drug Delivery

Dendritic chitosan as a magnetic and biocompatible nanocarrier for the simultaneous delivery of doxorubicin and methotrexate to MCF-7 cell line

2017 ◽  
Vol 41 (8) ◽  
pp. 3177-3189 ◽  
Author(s):  
Mahdi Rahimi ◽  
Kazem D. Safa ◽  
Effat Alizadeh ◽  
Roya Salehi
Keyword(s):  
Drug Delivery ◽  
Cell Line ◽  
Anticancer Drug ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ph Responsive ◽  
Anticancer Drug Delivery ◽  
Line P ◽  
Simultaneous Delivery ◽  
Mcf 7

A novel smart, biocompatible, and pH-responsive magnetic highly branched chitosan was synthesized efficiently for use in dual-anticancer drug delivery systems.

Development of curcumin–cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems

2016 ◽  
Vol 26 (3) ◽  
pp. 941-945 ◽  
Author(s):  
Gautier M.A. Ndong Ntoutoume ◽  
Robert Granet ◽  
Jean Pierre Mbakidi ◽  
Frédérique Brégier ◽  
David Y. Léger ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Cellulose Nanocrystals ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Anticancer Drug Delivery

Anticancer drug delivery systems based on noncovalent interactions between carbon nanotubes and linear–dendritic copolymers

Soft Matter ◽  
2011 ◽  
Vol 7 (8) ◽  
pp. 4062 ◽  
Author(s):  
Mohsen Adeli ◽  
Farahman Hakimpoor ◽  
Masoumeh Ashiri ◽  
Roya Kabiri ◽  
Masoumeh Bavadi
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Anticancer Drug ◽  
Drug Delivery Systems ◽  
Noncovalent Interactions ◽  
Delivery Systems ◽  
Anticancer Drug Delivery
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