scholarly journals Application-Oriented Marine Isomerases in Biocatalysis

Marine Drugs ◽  
2020 ◽  
Vol 18 (11) ◽  
pp. 580
Author(s):  
Antonio Trincone
Keyword(s):  
Marine Environment ◽  
Literature Search ◽  
General View ◽  
Positional Isomers ◽  
Literature Analysis ◽  
Scientific Interest ◽  
Marine Origin ◽  
Future Studies ◽  
Depth Analysis ◽  
Synthetic Medicinal

The class EC 5.xx, a group of enzymes that interconvert optical, geometric, or positional isomers are interesting biocatalysts for the synthesis of pharmaceuticals and pharmaceutical intermediates. This class, named “isomerases,” can transform cheap biomolecules into expensive isomers with suitable stereochemistry useful in synthetic medicinal chemistry, and interesting cases of production of l-ribose, d-psicose, lactulose, and d-phenylalanine are known. However, in two published reports about potential biocatalysts of marine origin, isomerases are hardly mentioned. Therefore, it is of interest to deepen the knowledge of these biocatalysts from the marine environment with this specialized in-depth analysis conducted using a literature search without time limit constraints. In this review, the focus is dedicated mainly to example applications in biocatalysis that are not numerous confirming the general view previously reported. However, from this overall literature analysis, curiosity-driven scientific interest for marine isomerases seems to have been long-standing. However, the major fields in which application examples are framed are placed at the cutting edge of current biotechnological development. Since these enzymes can offer properties of industrial interest, this will act as a promoter for future studies of marine-originating isomerases in applied biocatalysis.

scholarly journals Morphoanatomical and histochemical studies of the seed development of Euterpe oleracea (Arecaceae)

Rodriguésia ◽  
2021 ◽  
Vol 72 ◽  
Author(s):  
João Alves Ferreira Pereira ◽  
Ítalo Antônio Cotta Coutinho ◽  
Emanoella Lima Soares ◽  
Arlete Aparecida Soares ◽  
Ana Paula de Souza Caetano ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Seed Development ◽  
Cell Walls ◽  
Palm Tree ◽  
Euterpe Oleracea ◽  
Scientific Interest ◽  
Vast Array ◽  
Future Studies ◽  
Seed Biology ◽  
Fruit Pericarp

Abstract Although the consumption of açaí (Euterpe oleracea) pulp has long been an important component of the diet of the peoples from the Amazon, the açaí palm tree has recently attracted economic and scientific interest because of its vast array of bioactive compounds found in the fruit pericarp. The açaí seeds are the largest byproduct after pulp extraction and have potential for use in ethanol production, but this process is hindered by limited knowledge of seed biology, chemical composition and pattern reserve deposition during seed development. The aim of this work was to describe the morphoanatomical development of the seeds, as well as to identify the main organic compounds stored in the seeds. To achieve this goal, histological and histochemical analyses were performed on developing seeds. Results showed the seed is albuminous, bitegmic and that ingrowths of the seed coat give rise to a ruminate endosperm. Moreover, the nutritive reserves of açaí seeds are found in the endosperm thickened cell walls as reserve polysaccharides. Our findings provide information for future studies dealing with reproductive biology, propagation and the improvement of this profitable crop.

scholarly journals Phytochemistry and Biological Activities of Amburana cearensis (Allemão) ACSm

Molecules ◽  
2022 ◽  
Vol 27 (2) ◽  
pp. 505
Author(s):  
Zildene de Sousa Silveira ◽  
Nair Silva Macêdo ◽  
Suieny Rodrigues Bezerra ◽  
Abolghasem Siyadatpanah ◽  
Henrique Douglas Melo Coutinho ◽  
...  
Keyword(s):  
Chemical Composition ◽  
High Performance ◽  
Biological Activities ◽  
Literature Analysis ◽  
Future Studies ◽  
Analytical Technique ◽  
Popular Medicine ◽  
Brazilian Semiarid ◽  
Wide Range ◽  
Internet Searches

Amburana cearensis (Allemão) ACSm. belongs to the Fabaceae family and occurs in the Brazilian semiarid, Argentina, Paraguay, Bolivia, and Peru. Numerous studies that portray its ethnobotany, use in popular medicine, chemical composition, and biological activities exist in the literature. This review aimed to provide an overview of the chemical composition, ethnopharmacology, and biological activities associated with A. cearensis and its isolated constituents. Information was collected from internet searches in the Scopus, Medline, PubMed, Google Scholar, and ScienceDirect databases were performed covering publications from 1997–2020. An ethnopharmacological literature analysis revealed that A. cearensis is used to treat a wide range of respiratory disorders in addition to intestinal, circulatory, and inflammatory problems. Coumarins, flavonoids, phenolic glycosides, phenolic acids, phenylpropanoid derivatives, and triterpenoids, among others, have been reported as active compounds, with High-Performance Liquid Chromatography (HPLC) being the main analytical technique used. The A. cearensis extracts and compounds presented several biological activities, including antimicrobial, antinociceptive, anti-inflammatory, antioxidant, neuroprotective, and myorelaxant activities, among others. This review provides a useful bibliography for future investigations and A. cearensis applications; however, future studies should focus on its toxic effects and the mechanisms of action of its extracts and isolated constituents to guide clinical applications.

scholarly journals The Ethnopharmacological and Nutraceutical Relevance of Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Michael Buenor Adinortey ◽  
Justice Kwabena Sarfo ◽  
Jeffery Kwarteng ◽  
Cynthia Ayefoumi Adinortey ◽  
William Ekloh ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Literature Search ◽  
Metabolic Diseases ◽  
Search Process ◽  
Pharmacological Effects ◽  
Tropical Africa ◽  
Medicinal Uses ◽  
Future Studies ◽  
One Stop ◽  
Phytochemical Constituents

Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey is a herb found mostly in tropical Africa. The plant, commonly found in West Africa, is used in the management of many diseases including cardiovascular, respiratory, haematological, endocrine, and metabolic diseases in Ghana, Nigeria, Benin, Serra Leone, and Senegal. This piece provides comprehensive and updated information on the traditional uses, phytochemical constituents, and pharmacological and toxicological information available on Launaea taraxacifolia to support its medicinal uses and also unearth knowledge gaps for future studies. An electronic literature search using search engines, namely, Google Scholar, ScienceDirect, and PubMed, was carried out to obtain information on the plant. Both common and scientific names of the plant were used as keywords for the search process. This paper captured information on Launaea taraxacifolia from 1985 to 2018. The search revealed that the leaves of the plant possess nutritional/pharmacological effects on diseases such as diabetes mellitus, hypertension, cancer, malaria, bacterial infections, and arthritis. The leaf has been shown to be a rich source of phytoconstituents such as flavonoids, phenolic acids, tannins, alkaloids, glycosides, coumarins, triterpenoids, ascorbic acid, lycopene, and β-carotene. Also, isolated phytoconstituents as well as the safety profile of the plant have been documented. This review on Launaea taraxacifolia has provided a one-stop documentation of information in support of the several purported ethnopharmacological uses of the plant. It also reveals information gaps such as the need to research into its pharmacokinetics, interactions with drugs of importance, and its development into a plant-based drug in order to expand its clinical use.

scholarly journals Conclusion: the road ahead: where should we go now to improve healthcare quality in acute settings?

2019 ◽  
Vol 32 (Supplement_1) ◽  
pp. 99-103 ◽  
Author(s):  
Jeffrey Braithwaite ◽  
Natalie Taylor ◽  
Robyn Clay-Williams ◽  
Hsuen P Ting ◽  
Gaston Arnolda
Keyword(s):  
Quality Improvement ◽  
Healthcare Quality ◽  
Quality And Safety ◽  
Future Studies ◽  
The Road ◽  
The Core ◽  
Depth Analysis ◽  
No Gold Standard ◽  
Main Message ◽  
Over Time

Abstract This final article in our 12-part series articulating a suite of quality improvement studies completes our report on the Deepening our Understanding of Quality in Australia (DUQuA) program of work. Here, we bring the Supplement’s key findings and contributions together, tying up loose ends. Traversing the DUQuA articles, we first argued the case for the research, conducted so that an in-depth analysis of one country’s health system, completed 5 years after the landmark Deepening our Understanding of Quality Improvement in Europe (DUQuE), was available. We now provide a digest of the learning from each article. Essentially, we have contributed an understanding of quality and safety activities in 32 of the largest acute settings in Australia, developed a series of scales and tools for use within Australia, modifiable for other purposes elsewhere, and provided a platform for future studies of this kind. Our main message is, despite the value of publishing an intense study of quality activities in 32 hospitals in one country, there is no gold standard, one-size-fits-all methodology or guarantee of success in quality improvement activities, whether the initiatives are conducted at departmental, organization-wide or whole-of-systems levels. Notwithstanding this, armed with the tools, scales and lessons from DUQuA, we hope we have provided many more options and opportunities for others going about strengthening their quality improvement activities, but we do not claim to have solved all problems or provided a definitive approach. In our view, quality improvement initiatives are perennially challenging, and progress hard-won. Effective measurement, evaluating progress over time, selecting a useful suite of quality methods and having the persistence to climb the improvement gradient over time, using all the expertise and tools available, is at the core of the work of quality improvement and will continue to be so.

Co-authorship networks: a review of the literature

2015 ◽  
Vol 67 (1) ◽  
pp. 55-73 ◽  
Author(s):  
Sameer Kumar
Keyword(s):  
Design Methodology ◽  
Research Collaboration ◽  
Research Output ◽  
Knowledge Networks ◽  
Review Of The Literature ◽  
Research Gaps ◽  
Content Type ◽  
Future Studies ◽  
Depth Analysis ◽  
Structure Patterns

Purpose – The purpose of this paper is to attempt to provide a review of the growing literature on co-authorship networks and the research gaps that may be investigated for future studies in this field. Design/methodology/approach – The existing literature on co-authorship networks was identified, evaluated and interpreted. Narrative review style was followed. Findings – Co-authorship, a proxy of research collaboration, is a key mechanism that links different sets of talent to produce a research output. Co-authorship could also be seen from the perspective of social networks. An in-depth analysis of such knowledge networks provides an opportunity to investigate its structure. Patterns of these relationships could reveal, for example, the mechanism that shapes our scientific community. The study provides a review of the expanding literature on co-authorship networks. Originality/value – This is one of the first comprehensive reviews of network-based studies on co-authorship. The field is fast evolving, opening new gaps for potential research. The study identifies some of these gaps.

Data Base of Studies on Prenatal Cocaine Exposure and Child Outcome

1997 ◽  
Vol 27 (3) ◽  
pp. 487-499 ◽  
Author(s):  
Barry M. Lester ◽  
Lyn LaGasse ◽  
Susan Brunner
Keyword(s):  
Data Base ◽  
Literature Search ◽  
Cocaine Exposure ◽  
Child Outcome ◽  
Prenatal Cocaine Exposure ◽  
Future Studies ◽  
Prenatal Cocaine ◽  
Final Data ◽  
Objective Understanding ◽  
Methodological Problems

A computerized data base of characteristics and findings of the literature on prenatal exposure and child outcome was developed. The data base can be used to summarize and describe the literature resulting in a more objective understanding of the findings as well as to determine methodological problems that can shape the direction of future studies. Based on a literature search 99 studies were identified, 76 of which met methodological criteria and were included in the final data base. The data base shows that our knowledge base is limited, scattered, and compromised by methodological problems that mitigate any conclusions about whether or not or how prenatal cocaine exposure affects child outcome. Only a few studies have followed children beyond age 3. In addition, the cocaine problem is more complicated than first envisioned. It is a multifactorial problem including the use of other drugs and parenting and environmental lifestyle issues.

scholarly journals On the Possibility of Using Succinate in Hypoxia Developing in COVID-19

2021 ◽  
Vol 17 (3) ◽  
pp. 78-98
Author(s):  
Yu. P. Orlov ◽  
N. V. Govorova ◽  
O. V. Korpacheva ◽  
V. V. Afanasyev ◽  
I. A. Khilenko
Keyword(s):  
Clinical Studies ◽  
Literature Search ◽  
Positive Impact ◽  
Central Element ◽  
Multiple Organ ◽  
Tissue Hypoxia ◽  
Literature Analysis ◽  
Diaphragmatic Dysfunction ◽  
Pathogenetic Role

Aim. To provide a rationale for the feasibility of using the succinate-containing drugs to treat hypoxia associated with COVID-19 based on the analysis of experimental and clinical studies.Materials and methods. 84 Russian and international literature sources concerning the pathogenesis of COVID-19 and the pathogenetic role of succinate in the management of COVID-19 associated hypoxia, oxidative stress and diaphragmatic dysfunction were analyzed. The literature search was performed using Pubmed and ELIBRARY.ru databases.Results. The literature analysis showed that tissue hypoxia, triggering the pathomorphological cascade of events and resulting in multiple organ failure is a central element of COVID-19 pathogenesis. Experimental and clinical studies show the positive impact of tissue hypoxia correction using succinate in both adult patients and children with various conditions associated with acute respiratory failure.Conclusion. The literature data provide a rationale for using succinate-containing drugs in the treatment of severe COVID-19.

scholarly journals Ai4Truth: An In-depth Analysis on Misinformation using Machine Learning and Data Science

2021 ◽  
Author(s):  
Kevin Qu ◽  
Yu Sun
Keyword(s):  
Machine Learning ◽  
Data Science ◽  
Social Issues ◽  
Fake News ◽  
Future Studies ◽  
The Public ◽  
Applied Machine Learning ◽  
Depth Analysis ◽  
Real Challenge ◽  
The Way

A number of social issues have been grown due to the increasing amount of “fake news”. With the inevitable exposure to this misinformation, it has become a real challenge for the public to process the correct truth and knowledge with accuracy. In this paper, we have applied machine learning to investigate the correlations between the information and the way people treat it. With enough data, we are able to safely and accurately predict which groups are most vulnerable to misinformation. In addition, we realized that the structure of the survey itself could help with future studies, and the method by which the news articles are presented, and the news articles itself also contributes to the result.

scholarly journals Petrology and Genesis of the Bhainskati Iron Ore Deposit of Palpa District, Western Nepal

2013 ◽  
Vol 28 (1-2) ◽  
pp. 153-160
Author(s):  
Lalu Poudel ◽  
Sujan Devkota
Keyword(s):  
Marine Environment ◽  
Mineral Assemblage ◽  
Iron Ore ◽  
Ore Deposit ◽  
Marine Origin ◽  
Shallow Marine ◽  
Long Time ◽  
Iron Ore Deposit ◽  
Petrographic Study ◽  
Oolitic Ironstone

The Bhainskati Formation of the Tansen Group in Palpa area is known for hematite iron ore deposit for long time. A prominent band of hematite of about 1-2 km thickness extending >5 km was identified in the upper part of the Bhainskati Formation in the present study and the band is repeated three times in the area by folding and faulting. Petrographic study shows that it is oolitic ironstone of sedimentary shallow marine origin. Main minerals in the band are hematite, goethite, quartz, calcite, siderite and albite. Hematite content varies considerably among samples and occurs mainly as oolite and cement. The Bhainskati ironstone with its ferrous mineral assemblage and well-rounded texture of the ooids suggests prodeltaicto estuarine with shallow marine environment reduced clastic input.

scholarly journals In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function

2017 ◽  
Vol 1 (14) ◽  
pp. 918-932 ◽  
Author(s):  
Tom N. Durrant ◽  
James L. Hutchinson ◽  
Kate J. Heesom ◽  
Karen E. Anderson ◽  
Len R. Stephens ◽  
...  
Keyword(s):  
Platelet Activation ◽  
Platelet Function ◽  
Binding Proteins ◽  
Thrombus Formation ◽  
Negative Regulator ◽  
Valuable Resource ◽  
Future Studies ◽  
Glycoprotein Vi ◽  
Key Points ◽  
Depth Analysis

Key Points We present the first in-depth analysis of platelet PtdIns(3,4,5)P3-binding proteins, providing a valuable resource for future studies. The PtdIns(3,4,5)P3-binding protein, DAPP1, negatively regulates glycoprotein VI–driven platelet activation and thrombus formation.

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