scholarly journals Antimicrobial Chlorinated 3-Phenylpropanoic Acid Derivatives from the Red Sea Marine Actinomycete Streptomyces coelicolor LY001

Marine Drugs ◽  
2020 ◽  
Vol 18 (9) ◽  
pp. 450 ◽  
Author(s):  
Lamiaa A. Shaala ◽  
Diaa T. A. Youssef ◽  
Torki A. Alzughaibi ◽  
Sameh S. Elhady
Keyword(s):  
Streptomyces Coelicolor ◽  
Acid Methyl Ester ◽  
Propanoic Acid ◽  
Ionization Mass ◽  
Acid Methyl ◽  
Marine Actinomycete ◽  
Actinomycete Strain ◽  
Derivatives Of ◽  
And Staphylococcus Aureus ◽  
Insight Into

The actinomycete strain Streptomyces coelicolor LY001 was purified from the sponge Callyspongia siphonella. Fractionation of the antimicrobial extract of the culture of the actinomycete afforded three new natural chlorinated derivatives of 3-phenylpropanoic acid, 3-(3,5-dichloro-4-hydroxyphenyl)propanoic acid (1), 3-(3,5-dichloro-4-hydroxyphenyl)propanoic acid methyl ester (2), and 3-(3-chloro-4-hydroxyphenyl)propanoic acid (3), together with 3-phenylpropanoic acid (4), E-cinnamic acid (5), and the diketopiperazine alkaloids cyclo(l-Phe-trans-4-OH-l-Pro) (6) and cyclo(l-Phe-cis-4-OH-d-Pro) (7) were isolated. Interpretation of nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HRESIMS) data of 1–7 supported their assignments. Compounds 1–3 are first candidates of the natural chlorinated phenylpropanoic acid derivatives. The production of the chlorinated derivatives of 3-phenylpropionic acid (1–3) by S. coelicolor provides insight into the biosynthetic capabilities of the marine-derived actinomycetes. Compounds 1–3 demonstrated significant and selective activities towards Escherichia. coli and Staphylococcus aureus, while Candida albicans displayed more sensitivity towards compounds 6 and 7, suggesting a selectivity effect of these compounds against C. albicans.

An insight into the estimation of fatty acid methyl ester based biodiesel properties using a LSSVM model

Fuel ◽  
2019 ◽  
Vol 243 ◽  
pp. 133-141 ◽  
Author(s):  
Razieh Razavi ◽  
Amin Bemani ◽  
Alireza Baghban ◽  
Amir H. Mohammadi ◽  
Sajjad Habibzadeh
Keyword(s):  
Fatty Acid ◽  
Methyl Ester ◽  
Fatty Acid Methyl Ester ◽  
Acid Methyl Ester ◽  
Biodiesel Properties ◽  
Acid Methyl ◽  
Insight Into

Derivate des Benzo[1.3]dioxols, 431 Über Benzo [1.3] dioxolcarbonsäuren / Derivatives of 1,3-Benzodioxoles, 43 1,3-Benzodioxolecarboxylic Acids

1978 ◽  
Vol 33 (7-8) ◽  
pp. 465-471
Author(s):  
Franz Daliacker ◽  
Volker Mues ◽  
In-O Kim
Keyword(s):  
Carboxylic Acid ◽  
Methyl Ester ◽  
Benzoic Acid ◽  
Myristic Acid ◽  
Good Yield ◽  
Acid Ester ◽  
Acid Methyl Ester ◽  
Acid Methyl ◽  
Derivatives Of

Abstract We describe the possibilities of formation and preparation of the “natural” 1,3-benzodioxolecarboxylic acids 1, 2, 4, 6 b, and 7, already mentioned in literature. Myristic acid (3e) was prepared in good yield from 3-methoxy-4,5-dihydroxy-benzoic acid ester (3c) , which could be easily made from 3-methoxy-2,3-carbonyldioxy-benzoic acid methylester (3b). Myristicic acid methylester (3d) could be subjected to methylation and hydrolysis leading to 3e without any difficulties. 4.6-dimethoxy-1,3-benzodioxole-5-carboxylic acid (5b) was prepared in good yields by oxidation of 4,6-dimethoxy-1,3-benzodioxole-5-aldehyde (5a). 5.7-dimethoxy-1,3-benzodioxole-carboxylic acid (13f), one of the “unnatural” 1,3-benzodioxolecarboxylic acids, derivatives of o-ipiperonylic acid (8), was prepared from 5-amino-7-methoxy-1,3- benzodioxole-4carboxylic acid methyl ester (13b) by diazotisation, elimination of nitrogen, methylation, and hydrolysis. A comparison of our measured pkA-values showed the strongest acidity belonging to 5,6-dimethoxy-1,3-benzodioxole-4-carbocylic acid (11).

Potential of electrospray ionization mass spectrometry (ESI-MS), using direct infusion, to quantify fatty acid methyl esters (FAMEs) in biodiesel

2017 ◽  
Vol 9 (26) ◽  
pp. 3949-3955
Author(s):  
Rodrigo V. P. Leal ◽  
Gabriel F. Sarmanho ◽  
Luiz H. Leal ◽  
Bruno C. Garrido ◽  
Lucas J. Carvalho ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Fatty Acid ◽  
Methyl Ester ◽  
Fatty Acid Methyl Esters ◽  
Methyl Esters ◽  
Acid Methyl Ester ◽  
Ionization Mass ◽  
Direct Infusion ◽  
Esi Ms ◽  
Acid Methyl

Fatty acid methyl ester (FAME) intensities, by ESI-MS, used to their quantification in biodiesel.

Differentiation of 2-Alkylthioorotic Acids, Methyl and Ethyl 2-Alkylthioorotates and Hydrazides of 2-Alkylthioorotic Acids by Using Electron Ionization Mass Spectra

2008 ◽  
Vol 14 (1) ◽  
pp. 27-35 ◽  
Author(s):  
Grazyna Bartkowiak
Keyword(s):  
Molecular Mass ◽  
Mass Spectra ◽  
Chemical Species ◽  
Molecular Ions ◽  
Electron Ionization ◽  
Relative Molecular Mass ◽  
Ionization Mass ◽  
Acid Methyl ◽  
Electron Ionization Mass Spectra ◽  
Derivatives Of

Electron ionization mass spectra of 12 derivatives of 2-thioorotic acid have been discussed and general fragmentation routes of their molecular ions have been proposed. The compounds under discussion were three groups of four chemical species (2-alkylthioorotic acid, methyl 2-alkylthioorotate, ethyl 2-alkylthioorotate and 2-alkylthioorotic hydrazide) each with the same relative molecular mass. The comparison of selected ions relative abundances and their correlation with the abundance of molecular ions enable differentiation between isomeric or isobaric species in this class of compounds.

scholarly journals The metabolic interconversion of arecoline and arecoline 1-oxide in the rat

1971 ◽  
Vol 122 (4) ◽  
pp. 503-508 ◽  
Author(s):  
R. Nery
Keyword(s):  
Aqueous Media ◽  
Specific Radioactivity ◽  
Acid Methyl Ester ◽  
Peroxyacetic Acid ◽  
Acid Methyl ◽  
High Specific Radioactivity ◽  
Derivatives Of ◽  
Catalytic Exchange ◽  
Metabolic Interconversion ◽  
Unidentified Metabolite

1. Tritiation of arecoline hydrochloride by catalytic exchange in aqueous media (done by The Radiochemical Centre) gave arecaidine hydrochloride of high specific radioactivity; this on treatment with diazomethane gave [3H]arecoline, which was oxidized with peroxyacetic acid to [3H]arecoline 1-oxide. 2. Arecoline 1-oxide gave arecaidine 1-oxide on acid hydrolysis and 1,2-dihydro-1-methylnicotinic acid methyl ester on thermal decomposition. 3. [3H]Arecoline hydrochloride was metabolized in the rat into the 3H-labelled derivatives of arecoline 1-oxide, arecaidine 1-oxide, arecaidine, N-acetyl-S-(3-carboxy-1-methylpiperid-4-yl)-l-cysteine and an unidentified metabolite; some unchanged arecoline was also excreted. [3H]Arecoline 1-oxide gave the same metabolities, but in different amounts. 4. The possible relevance of these findings to betel-nut carcinogenesis is discussed.

Synthesis of 2-Cyanoethoxy and 2-(1H-Tetrazol-5-yl)ethoxy Derivatives of Glycyrrhetic Acid Methyl Ester

2018 ◽  
Vol 54 (12) ◽  
pp. 1868-1870
Author(s):  
A. D. Zorina ◽  
V. L. Polozova ◽  
S. A. Marchenko ◽  
S. I. Selivanov ◽  
R. E. Trifonov
Keyword(s):  
Methyl Ester ◽  
Acid Methyl Ester ◽  
Glycyrrhetic Acid ◽  
Acid Methyl ◽  
Derivatives Of
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