scholarly journals Marine Organisms from the Yucatan Peninsula (Mexico) as a Potential Natural Source of Antibacterial Compounds

Marine Drugs ◽  
2020 ◽  
Vol 18 (7) ◽  
pp. 369 ◽  
Author(s):  
Dawrin Pech-Puch ◽  
Mar Pérez-Povedano ◽  
Patricia Gómez ◽  
Marta Martínez-Guitián ◽  
Cristina Lasarte-Monterrubio ◽  
...  
Keyword(s):  
Marine Organism ◽  
Yucatan Peninsula ◽  
Antibacterial Activities ◽  
Multidrug Resistant ◽  
Marine Sponges ◽  
Marine Organisms ◽  
Human Pathogens ◽  
Yucatán Peninsula ◽  
Bioassay Guided Fractionation ◽  
Agelasine B

A total of 51 sponges (Porifera) and 13 ascidians (Chordata) were collected on the coast of the Yucatan Peninsula (Mexico) and extracted with organic solvents. The resulting extracts were screened for antibacterial activity against four multidrug-resistant (MDR) bacterial pathogens: the Gram-negative Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa and the Gram-positive Staphylococcus aureus. The minimum inhibitory concentrations (MICs) of the organic extracts of each marine organism were determined using a broth microdilution assay. Extracts of eight of the species, in particular the Agelas citrina and Haliclona (Rhizoniera) curacaoensis, displayed activity against some of the pathogens tested. Some of the extracts showed similar MIC values to known antibiotics such as penicillins and aminoglycosides. This study is the first to carry out antimicrobial screening of extracts of marine sponges and ascidians collected from the Yucatan Peninsula. Bioassay-guided fractionation of the active extracts from the sponges Amphimedon compressa and A. citrina displayed, as a preliminary result, that an inseparable mixture of halitoxins and amphitoxins and (-)-agelasine B, respectively, are the major compounds responsible for their corresponding antibacterial activities. This is the first report of the antimicrobial activity of halitoxins and amphitoxins against major multidrug-resistant human pathogens. The promising antibacterial activities detected in this study indicate the coast of Yucatan Peninsula as a potential source of a great variety of marine organisms worthy of further research.

scholarly journals Antimicrobial Activities of Marine Sponge-Associated Bacteria

2021 ◽  
Vol 9 (1) ◽  
pp. 171
Author(s):  
Yitayal S. Anteneh ◽  
Qi Yang ◽  
Melissa H. Brown ◽  
Christopher M. M. Franco
Keyword(s):  
Pathogenic Bacteria ◽  
South Australia ◽  
Multidrug Resistant ◽  
Antimicrobial Activities ◽  
Marine Sponges ◽  
Bioactive Metabolites ◽  
Human Pathogens ◽  
Sponge Associated Bacteria ◽  
Microbial Symbionts ◽  
Bacteria And Fungi

The misuse and overuse of antibiotics have led to the emergence of multidrug-resistant microorganisms, which decreases the chance of treating those infected with existing antibiotics. This resistance calls for the search of new antimicrobials from prolific producers of novel natural products including marine sponges. Many of the novel active compounds reported from sponges have originated from their microbial symbionts. Therefore, this study aims to screen for bioactive metabolites from bacteria isolated from sponges. Twelve sponge samples were collected from South Australian marine environments and grown on seven isolation media under four incubation conditions; a total of 1234 bacterial isolates were obtained. Of these, 169 bacteria were tested in media optimized for production of antimicrobial metabolites and screened against eleven human pathogens. Seventy bacteria were found to be active against at least one test bacterial or fungal pathogen, while 37% of the tested bacteria showed activity against Staphylococcus aureus including methicillin-resistant strains and antifungal activity was produced by 21% the isolates. A potential novel active compound was purified possessing inhibitory activity against S. aureus. Using 16S rRNA, the strain was identified as Streptomyces sp. Our study highlights that the marine sponges of South Australia are a rich source of abundant and diverse bacteria producing metabolites with antimicrobial activities against human pathogenic bacteria and fungi.

scholarly journals Marine Natural Products from the Yucatan Peninsula

Marine Drugs ◽  
2020 ◽  
Vol 18 (1) ◽  
pp. 59 ◽  
Author(s):  
Dawrin Pech-Puch ◽  
Mar Pérez-Povedano ◽  
Oscar A. Lenis-Rojas ◽  
Jaime Rodríguez ◽  
Carlos Jiménez
Keyword(s):  
Natural Products ◽  
Biological Diversity ◽  
Yucatan Peninsula ◽  
Marine Species ◽  
Marine Organisms ◽  
Marine Resources ◽  
Yucatán Peninsula ◽  
Organic Extracts ◽  
Long Time ◽  
Medicinal Flora

Mexico is one of the three areas of the world with the greatest terrestrial and cultural biological diversity. The diversity of Mexican medicinal flora has been studied for a long time and several bioactive compounds have been isolated. The investigation of marine resources, and particularly the potential of Mexican marine resources, has not been intensively investigated, even though the Yucatan Peninsula occupies 17.4% of the total of the Mexican coast, with great biological diversity in its coasts and the ocean. There are very few studies on the chemistry of natural products from marine organisms that were collected along the coasts of the Yucatan Peninsula and most of them are limited to the evaluation of the biological activity of their organic extracts. The investigations carried out on marine species from the Yucatan Peninsula resulted in the identification of a wide structural variety of natural products that include polyketides, terpenoids, nitrogen compounds, and biopolymers with cytotoxic, antibacterial, antifouling, and neurotoxic activities. This review describes the literature of bioprospecting and the exploration of the natural product diversity of marine organisms from the coasts of the Yucatan Peninsula up to mid-2019.

scholarly journals Antibacterial activities of Rhazya stricta leaf extracts against multidrug-resistant human pathogens

2016 ◽  
Vol 30 (5) ◽  
pp. 1016-1025 ◽  
Author(s):  
Raziuddin Khan ◽  
Mohammed N. Baeshen ◽  
Kulvinder S. Saini ◽  
Roop S. Bora ◽  
Ahmed M. Al-Hejin ◽  
...  
Keyword(s):  
Antibacterial Activities ◽  
Multidrug Resistant ◽  
Human Pathogens ◽  
Leaf Extracts ◽  
Rhazya Stricta

scholarly journals Antiviral and Antiproliferative Potential of Marine Organisms From the Yucatan Peninsula, Mexico

2020 ◽  
Vol 7 ◽  
Author(s):  
Dawrin Pech-Puch ◽  
Judith Berastegui-Cabrera ◽  
Mar Pérez-Povedano ◽  
Harold Villegas-Hernández ◽  
Sergio Guillén-Hernández ◽  
...  
Keyword(s):  
Yucatan Peninsula ◽  
Marine Organisms ◽  
Yucatán Peninsula

Cytotoxic activity against breast cancer cells of two species of marine sponges from shallows of Yucatan peninsula

2020 ◽  
pp. 1-5
Author(s):  
Jasmín Salazar-Mendoza ◽  
Lorena V. León-Deniz ◽  
Gumersindo Mirón-López ◽  
Rosa E. Moo-Puc ◽  
Juan Chalé-Dzul ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Yucatan Peninsula ◽  
Marine Sponges ◽  
Yucatán Peninsula

Octopus maya parasites off the Yucatán Peninsula, Mexico. II. Salivary gland damage by cestodes

2018 ◽  
Vol 130 (1) ◽  
pp. 45-50 ◽  
Author(s):  
S Guillén-Hernández ◽  
C González-Salas ◽  
D Pech-Puch ◽  
H Villegas-Hernández
Keyword(s):  
Salivary Gland ◽  
Yucatan Peninsula ◽  
Yucatán Peninsula ◽  
Octopus Maya

Production of Novel Bioactive Compounds by the Bacteria Associated with Some Marine Sponges of Gulf of Mannar and Palk Bay, Southeast Coast of India

2018 ◽  
Vol 6 (8) ◽  
pp. 183
Author(s):  
V. Ramadas ◽  
G. Chandralega
Keyword(s):  
Bioactive Compounds ◽  
Bacterial Species ◽  
Marine Sponges ◽  
Marine Organisms ◽  
Gulf Of Mannar ◽  
Bacterial Symbionts ◽  
Palk Bay ◽  
Excellent Source

Sponges, exclusively are aquatic and mostly marine, are found from the deepest oceans to the edge of the sea. There are approximately 15,000 species of sponges in the world, of which, 150 occur in freshwater, but only about 17 are of commercial value. A total of 486 species of sponges have been identified in India. In the Gulf of Mannar and Palk Bay a maximum of 319 species of sponges have been recorded. It has been proved that marine organisms are excellent source of bioactive secondary metabolites and number of compounds of originated from marine organisms had been reported to possess in-vitro and in-vivo immuno stimulatory activity. Extracts from 20 sponge species were tested for bacterial symbionts and bioactive compounds were isolated from such associated bacterial species in the present study.

COASTAL CARBONATE CRITICAL ZONES: AN EXAMPLE FROM THE YUCATAN PENINSULA

2019 ◽  
Author(s):  
Jonathan B. Martin ◽  
◽  
Andrea J. Pain ◽  
Caitlin Young ◽  
Arnoldo Valle-Levinson
Keyword(s):  
Yucatan Peninsula ◽  
Yucatán Peninsula ◽  
Critical Zones
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