scholarly journals Osirisynes G-I, New Long-Chain Highly Oxygenated Polyacetylenes from the Mayotte Marine Sponge Haliclona sp.

Marine Drugs ◽  
2020 ◽  
Vol 18 (7) ◽  
pp. 350 ◽  
Author(s):  
Pierre-Eric Campos ◽  
Gaëtan Herbette ◽  
Christophe Chendo ◽  
Patricia Clerc ◽  
Florent Tintillier ◽  
...  
Keyword(s):  
Marine Sponge ◽  
Active Compound ◽  
Nmr Spectra ◽  
Proteasome Inhibition ◽  
Chemical Study ◽  
2D Nmr ◽  
Sirtuin 1 ◽  
Fyn Kinase ◽  
2D Nmr Spectra ◽  
Long Chain

Chemical study of the CH2Cl2−MeOH (1:1) extract from the sponge Haliclona sp. collected in Mayotte highlighted three new long-chain highly oxygenated polyacetylenes, osirisynes G-I (1–3) together with the known osirisynes A (4), B (5), and E (6). Their structures were elucidated by 1D and 2D NMR spectra and HRESIMS and MS/MS data. All compounds were evaluated on catalase and sirtuin 1 activation and on CDK7, proteasome, Fyn kinase, tyrosinase, and elastase inhibition. Five compounds (1; 3–6) inhibited proteasome kinase and two compounds (5–6) inhibited CDK7 and Fyn kinase. Osirisyne B (5) was the most active compound with IC50 on FYNB kinase, CDK7 kinase, and proteasome inhibition of 18.44 µM, 9.13 µM, and 0.26 µM, respectively.

scholarly journals New Antimalarial and Antimicrobial Tryptamine Derivatives from the Marine Sponge Fascaplysinopsis reticulata

Marine Drugs ◽  
2019 ◽  
Vol 17 (3) ◽  
pp. 167 ◽  
Author(s):  
Pierre-Eric Campos ◽  
Emmanuel Pichon ◽  
Céline Moriou ◽  
Patricia Clerc ◽  
Rozenn Trépos ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Minimum Inhibitory Concentration ◽  
Marine Sponge ◽  
Nmr Spectra ◽  
Inhibitory Concentration ◽  
Chemical Study ◽  
2D Nmr ◽  
Antimicrobial Activities ◽  
2D Nmr Spectra ◽  
Ic50 Values

Chemical study of the CH2Cl2-MeOH (1:1) extract of the sponge Fascaplysinopsis reticulata collected in Mayotte highlighted three new tryptophan derived alkaloids, 6,6′-bis-(debromo)-gelliusine F (1), 6-bromo-8,1′-dihydro-isoplysin A (2) and 5,6-dibromo-8,1′-dihydro-isoplysin A (3), along with the synthetically known 8-oxo-tryptamine (4) and the three known molecules from the same family, tryptamine (5), (E)-6-bromo-2′-demethyl-3′-N-methylaplysinopsin (6) and (Z)-6-bromo-2′-demethyl-3′-N-methylaplysinopsin (7). Their structures were elucidated by 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their antimicrobial and their antiplasmodial activities. Regarding antimicrobial activities, the best compounds are (2) and (3), with minimum inhibitory concentration (MIC) of 0.01 and 1 µg/mL, respectively, towards Vibrio natrigens, and (5), with MIC values of 1 µg/mL towards Vibrio carchariae. In addition the known 8-oxo-tryptamine (4) and the mixture of the (E)-6-bromo-2′-demethyl-3′-N-methylaplysinopsin (6) and (Z)-6-bromo-2′-demethyl-3′-N-methylaplysinopsin (7) showed moderate antiplasmodial activity against Plasmodium falciparum with IC50 values of 8.8 and 8.0 µg/mL, respectively.

scholarly journals Salaramides A and B; Two α-Oxoamides Isolated from the Marine Sponge Hippospongia sp. (Porifera, Dictyoceratida)

2010 ◽  
Vol 5 (2) ◽  
pp. 1934578X1000500
Author(s):  
Julia Bensemhoun ◽  
Amira Rudi ◽  
Yoel Kashman ◽  
Emile M. Gaydou ◽  
Jean Vacelet ◽  
...  
Keyword(s):  
Chemical Transformation ◽  
Marine Sponge ◽  
Mass Spectra ◽  
Nmr Spectra ◽  
2D Nmr ◽  
2D Nmr Spectra

Two novel α-oxoamides, salaramide A (1) and its homologue salaramide B (2), were isolated from the Madagascar marine sponge, Hippospongia sp., collected in Salary Bay, north of Tulear. The structures of 1 and 2 were elucidated by interpretation of mass spectra, 1D and 2D NMR spectra, and confirmed by chemical transformation.

A Green Synthesis and a Chemical Study of the Coumarin, 1-(2-Hydroxy- 2-methyl-2H-chromen-3yl)ethanone

2019 ◽  
Vol 16 (2) ◽  
pp. 128-133
Author(s):  
Emerson Teixeira da Silva ◽  
Ligia Souza da Silveira Pinto ◽  
Solange Maria Silva Veloso Wardell ◽  
James Lewis Wardell ◽  
Marcus Vinícius Nora de Souza
Keyword(s):  
Green Synthesis ◽  
Nmr Spectra ◽  
Chemical Study ◽  
2D Nmr ◽  
Mechanistic Study ◽  
X Ray ◽  
X Ray Crystallography ◽  
General Importance ◽  
2D Nmr Spectra ◽  
Coumarin 1

Coumarins are a class of natural and synthetic products with a wide variety of applications in different fields. Due to the general importance of coumarins, the objective of this work is to further develop the chemistry of 1-(2-hydroxy-2-methyl-2H-chromen-3yl)ethanone, 1, a potentially useful and versatile coumarin but an under-reported compound in the literature. This work describes a green preparation of 1 in the absence of solvents and acids, thereby eliminating byproducts, normally obtained in classical procedures, and a mechanistic study of the reactions of 1 with nucleophiles. In addition, we report the characterisation of 1-(2-ethoxy-2-methyl-2H-chromen-3-yl)ethanone 2, via X-ray crystallography and 2D NMR spectra.

scholarly journals A New Meroterpene, A New Benzofuran Derivative and Other Constituents from Cultures of the Marine Sponge-Associated Fungus Acremonium persicinum KUFA 1007 and Their Anticholinesterase Activities

Marine Drugs ◽  
2019 ◽  
Vol 17 (6) ◽  
pp. 379 ◽  
Author(s):  
Ana J. S. Alves ◽  
José A. Pereira ◽  
Tida Dethoup ◽  
Sara Cravo ◽  
Sharad Mistry ◽  
...  
Keyword(s):  
Marine Sponge ◽  
Nmr Spectra ◽  
2D Nmr ◽  
Electronic Circular Dichroism ◽  
Benzofuran Derivative ◽  
Extensive Analysis ◽  
Stereogenic Centers ◽  
2D Nmr Spectra ◽  
Inhibitory Activities

Previously unreported meroterpene, acremine S (1), and benzopyran derivative, acremine T (2), were isolated, together with lumichrome (3), ergosterol (4) and ergosterol 5,8-endoperoxide, from cultures of the marine sponge-associated fungus Acremonium persicinum KUF1007. The structure of the previously unreported compounds was established based on an extensive analysis of 1D and 2D NMR spectra as well as HRMS data. The absolute configurations of the stereogenic centers of 1 were established, unambiguously, based on NOESY correlations and comparison of calculated and experimental electronic circular dichroism (ECD) spectra. Compounds 1–3 were tested for their in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activities.

Differential Analysis of 2D NMR Spectra: New Natural Products from a Pilot-Scale Fungal Extract Library

2007 ◽  
Vol 46 (6) ◽  
pp. 901-904 ◽  
Author(s):  
Frank C. Schroeder ◽  
Donna M. Gibson ◽  
Alice C. L. Churchill ◽  
Punchapat Sojikul ◽  
Eric J. Wursthorn ◽  
...  
Keyword(s):  
Natural Products ◽  
Nmr Spectra ◽  
2D Nmr ◽  
Pilot Scale ◽  
Differential Analysis ◽  
Fungal Extract ◽  
2D Nmr Spectra

scholarly journals Advanced solvent signal suppression for the acquisition of 1D and 2D NMR spectra of Scotch Whisky

2017 ◽  
Vol 55 (9) ◽  
pp. 785-796 ◽  
Author(s):  
Will Kew ◽  
Nicholle G.A. Bell ◽  
Ian Goodall ◽  
Dušan Uhrín
Keyword(s):  
Nmr Spectra ◽  
2D Nmr ◽  
Signal Suppression ◽  
2D Nmr Spectra ◽  
Solvent Signal Suppression ◽  
Scotch Whisky

scholarly journals Hierarchical Alignment and Full Resolution Pattern Recognition of 2D NMR Spectra: Application to Nematode Chemical Ecology

2011 ◽  
Vol 83 (5) ◽  
pp. 1649-1657 ◽  
Author(s):  
Steven L. Robinette ◽  
Ramadan Ajredini ◽  
Hasan Rasheed ◽  
Abdulrahman Zeinomar ◽  
Frank C. Schroeder ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Chemical Ecology ◽  
Nmr Spectra ◽  
2D Nmr ◽  
Full Resolution ◽  
2D Nmr Spectra
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