scholarly journals Donghaecyclinones A–C: New Cytotoxic Rearranged Angucyclinones from a Volcanic Island-Derived Marine Streptomyces sp.

Marine Drugs ◽  
2020 ◽  
Vol 18 (2) ◽  
pp. 121
Author(s):  
Munhyung Bae ◽  
Joon Soo An ◽  
Seong-Heon Hong ◽  
Eun Seo Bae ◽  
Beomkoo Chung ◽  
...  
Keyword(s):  
Human Cancer ◽  
Human Cancer Cell ◽  
Volcanic Island ◽  
Streptomyces Sp ◽  
Human Cancer Cell Lines ◽  
Chemical Profiling ◽  
Stereogenic Centers ◽  
Marine Sediment Sample ◽  
Shielding Tensor ◽  
New Metabolites

Chemical profiling of the Streptomyces sp. strain SUD119, which was isolated from a marine sediment sample collected from a volcanic island in Korea, led to the discovery of three new metabolites: donghaecyclinones A–C (1–3). The structures of 1–3 were found to be rearranged, multicyclic, angucyclinone-class compounds according to nuclear magnetic resonance (NMR) and mass spectrometry (MS) analyses. The configurations of their stereogenic centers were successfully assigned using a combination of quantum mechanics–based computational methods for calculating the NMR shielding tensor (DP4 and CP3) as well as electronic circular dichroism (ECD) along with a modified version of Mosher’s method. Donghaecyclinones A–C (1–3) displayed cytotoxicity against diverse human cancer cell lines (IC50: 6.7–9.6 μM for 3).

Chemical profiling, antiviral and antiproliferative activities of the essential oil of Phlomis aurea Decne

2021 ◽  
Author(s):  
Zeinab Torky ◽  
Ashaimaa Yehia Mohammed Mohammed Moussa ◽  
Eman Abd El-Ghffar ◽  
Usama Abdel-Hameed ◽  
Omayma Eldahshan
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Antiviral Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Chemical Profiling ◽  
Antiproliferative Activities

Here, we investigated the chemical composition of the edible Phlomis aurea oil and its anticancer potential on four human cancer cell lines, as well as its antiviral activity against Herpes...

scholarly journals Diaportones A–C: Three New Metabolites From Endophytic Fungus Diaporthe foeniculina BZM-15

2021 ◽  
Vol 9 ◽  
Author(s):  
Fenghua Kang ◽  
Xiuxiang Lu ◽  
Sha Zhang ◽  
Dekun Chen ◽  
Min Kuang ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Human Cancer ◽  
Human Cancer Cell ◽  
Quantum Chemistry Calculation ◽  
Antiproliferative Effects ◽  
Human Cancer Cell Lines ◽  
Phytochemical Investigation ◽  
Chemistry Calculation ◽  
Mcf 7 ◽  
New Metabolites

Phytochemical investigation of Diaporthe foeniculina BZM-15 led to one new γ-butyrolactone derivative, diaportone A (1), one cyclopentenone derivative, diaportone B (3), and one monoterpene derivative, diaportone C (5), along with six known compounds (2, 4, and 6–9). Their structures as well as the absolute configurations were characterized by means of NMR, HRESIMS, and ECD spectroscopy and quantum chemistry calculation, respectively. Furthermore, all compounds were evaluated for their cytotoxic activity and antibacterial activity, and compounds 7 and 8 displayed significant antiproliferative effects on three human cancer cell lines (SF-268, MCF-7, and HepG2) with IC50 values ranging from 3.6 to 15.8 μM.

Constituents of Polyalthia jucunda and their cytotoxic effect on human cancer cell lines

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
IO Mondranondra ◽  
A Suedee ◽  
A Kijjoa ◽  
M Pinto ◽  
N Nazareth ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cytotoxic Effect ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines
Sign in / Sign up

Export Citation Format

Share Document