scholarly journals Glycol Chitosan-Docosahexaenoic Acid Liposomes for Drug Delivery: Synergistic Effect of Doxorubicin-Rapamycin in Drug-Resistant Breast Cancer

Marine Drugs ◽  
2019 ◽  
Vol 17 (10) ◽  
pp. 581 ◽  
Author(s):  
Min Woo Kim ◽  
Takuro Niidome ◽  
Ruda Lee
Keyword(s):  
Drug Delivery ◽  
Docosahexaenoic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Colloidal Stability ◽  
Therapeutic Potential ◽  
Cell Model ◽  
Drug Resistant ◽  
Glycol Chitosan ◽  
Physiological Conditions

Marine ecosystems are the most prevalent ecosystems on the planet, providing a diversity of living organisms and resources. The development of nanotechnology may provide solutions for utilizing these thousands of potential compounds as marine pharmaceuticals. Here, we designed a liposomal glycol chitosan formulation to load both doxorubicin (DOX) and rapamycin (RAPA), and then evaluated its therapeutic potential in a prepared drug-resistant cell model. We explored the stability of the drug delivery system by changing the physiological conditions and characterized its physicochemical properties. The electrostatic complexation between DOX-glycol chitosan and docosahexaenoic acid RAPA-liposomes (GC-DOX/RAPA ω-liposomes) was precisely regulated, resulting in particle size of 131.3 nm and zeta potential of −14.5 mV. The well-characterized structure of GC-DOX/RAPA ω-liposomes led to high loading efficiencies of 4.1% for DOX and 6.2% for RAPA. Also, GC-DOX/RAPA ω-liposomes exhibited high colloidal stability under physiological conditions and synergistic anti-cancer effects on DOX-resistant MDA-MB-231 cells, while showing pH-sensitive drug release behavior. Our results provided a viable example of marine pharmaceuticals with therapeutic potential for treating drug-resistant tumors using an efficient and safe drug delivery system.

Herbal Liposomes: Natural Network for Targeted Drug Delivery System

2021 ◽  
pp. 31-41
Author(s):  
Vijay R. Salunkhe ◽  
Prasanna S. Patil ◽  
Ganesh H. Wadkar ◽  
Somnath D. Bhinge
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Therapeutic Potential ◽  
Herbal Medicines ◽  
Lipid Solubility ◽  
Liposomal Formulations ◽  
Novel Drug ◽  
Herbal Formulations

Herbal medicines have tremendous therapeutic potential that can explored across various effective drug delivery system. Decoctions, herbal teas, tinctures, glyceritum, oxymel, and use much soap, herbal tablets, herbal capsules, and herbal cream, herbal books, and prepared the confection of the most commonly available forms of dosage. The less use of herbal formulations in recent decades due to their lack of standardization. It is possible to use plant extract and isolated constituents to overcome this problem. But these phytoconstituents are suffering from drawbacks, mostly due to problems with stability and low lipid solubility. Novel drug delivery such as liposomes plays an important role in problem solving. Infact, compliance with the patient also improves. The review article discusses the recent status of new herbal liposomal formulations and describes the different ways in which these formulations are prepared.

scholarly journals DFT study of the therapeutic potential of phosphorene as a new drug-delivery system to treat cancer

RSC Advances ◽  
2019 ◽  
Vol 9 (42) ◽  
pp. 24325-24332 ◽  
Author(s):  
Amina Tariq ◽  
Sidra Nazir ◽  
Ahmad Wahab Arshad ◽  
Faisal Nawaz ◽  
Khurshid Ayub ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Electron Transfer ◽  
Drug Delivery System ◽  
Delivery System ◽  
Therapeutic Potential ◽  
Dft Study ◽  
New Drug ◽  
System P ◽  
Photo Induced Electron Transfer

Therapeutic potential of phosphorene as drug delivery system for chlorambucil to treat cancer is evaluated. The photo-induced electron transfer suggests that phosphorene possess significant therapeutic potential as drug delivery system.

scholarly journals Encapsulation of Quercetin in Tri-Block-Copolymer/Tween 80 Mixed Nanomicelles to Enhance its Cytotoxicity Against Breast Cancer Cells

2021 ◽  
Author(s):  
Reza Davarnejad ◽  
Kiyana Layeghy ◽  
Meysam Soleymani ◽  
Arvin Ayazi
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Breast Cancer Cells ◽  
Therapeutic Potential ◽  
Tween 80 ◽  
Prolonged Release

Abstract Quercetin, a natural polyphenolic compound, has attracted much attention due to its great therapeutic potential against various types of diseases. But clinical applications of quercetin are limited due to its poor aqueous solubility and low bioavailability. The main purpose of this research was to evaluate the therapeutic potential of quercetin-loaded Pluronic F127 (PF127)/Tween 80 mixed nanomicelles as a passive targeted drug delivery system for breast cancer therapy. To this end, quercetin-loaded mixed nanomicelles with different mass ratios of drug:PF127:Tween 80 were prepared by the thin-film hydration method. The highest drug loading and entrapment efficiency were obtained to be 2.3% and 98.0%, respectively, for mixed micelles with drug:PF127:Tween 80 ratio of 1:40:15. The physical interactions of quercetin with PF127 and Tween 80 at optimized ratio was investigated by XRD and FTIR analyses. The mean hydrodynamic size and surface charge of prepared nanomicelles, measured by DLS and zeta potential analyses, were 22.1 nm and -7.63 mV, respectively. The results of in-vitro drug release experiments showed that, the mixed micellar system has a prolong and sustained release behavior compared to the solution of free quercetin. Moreover, the in-vitro cytotoxicity studies of quercetin-loaded mixed nanomicelles on breast cancer cells (MCF-7) revealed that, the encapsulated drug have a lower IC50 value (8.9 µg/mL) compared to the free drug (49.2 µg/mL). Our results suggest that, quercetin-loaded mixed nanomicelles can be considered as a promising drug delivery system with prolonged release and potentiated cytotoxicity against breast cancer cells.

A CD44-Targeting Programmable Drug Delivery System for Enhancing and Sensitizing Chemotherapy to Drug-Resistant Cancer

2019 ◽  
Vol 11 (6) ◽  
pp. 5851-5861 ◽  
Author(s):  
Min Zhang ◽  
Yi Ma ◽  
Zhaohui Wang ◽  
Zhihao Han ◽  
Weidong Gao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Resistant ◽  
Cd44 Targeting

scholarly journals Therapeutic potential of Cymbopogon schoenanthus (L.) developed into nanoparticle technology

2021 ◽  
pp. 210-214
Author(s):  
Lutfi Chabib ◽  
Adnan Muhammad Uno J Hidayat ◽  
A.M. Bagas Trianloka ◽  
Muhammad Iqbal Pangestu ◽  
Arman Suryani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Essential Oil ◽  
Drug Delivery System ◽  
Delivery System ◽  
Therapeutic Potential ◽  
Potential Effectiveness ◽  
Comprehensive Information ◽  
Anti Inflammatory ◽  
Cymbopogon Schoenanthus

Introduction: One of plants that may have therapeutic potential is the Cymbopogon schoenanthus (L.) Spreng, also known as camel grass. Aim: This review aims to investigate and gather comprehensive information about camel grass plants and their potential to be developed into a nanotechnology drug delivery system. Methods: This review examined a variety of online literature. Results: It was found that camel grass contains essential oil such as piperitone. Piperitone is efficacious as an antioxidant, antimicrobial and anti-inflammatory, in addition to other properties . The development of camel grass essential oil into lipid-based nanotechnology preparations can improve its bioavailability, solubility, and stability, thereby improving its potential effectiveness.

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