scholarly journals New Furanocembranoids from Briareum violaceum

Marine Drugs ◽  
2019 ◽  
Vol 17 (4) ◽  
pp. 214 ◽  
Author(s):  
Pin-Chang Huang ◽  
Wen-Sou Lin ◽  
Bo-Rong Peng ◽  
Yu-Chia Chang ◽  
Lee-Shing Fang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Inducible Nitric Oxide Synthase ◽  
In Vitro Study ◽  
Raw 264.7 ◽  
Spectroscopic Methods ◽  
Macrophage Cell Line ◽  
Macrophage Cell ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Three new furanocembranoids—briaviodiol F (1) and briaviotriols A (2) and B (3)—along with a known analogue, briaviodiol A (4), were obtained from a cultured-type octocoral Briareum violaceum. The structures of cembranoids 1–3 were elucidated by using spectroscopic methods. In vitro study demonstrated that compounds 2 and 4 exerted inhibition effects on inducible nitric oxide synthase (iNOS) release from RAW 264.7, a macrophage cell line that originated from a mouse monocyte macrophage, stimulated with lipopolysaccharides.

scholarly journals Briarenols I—K, New Anti-inflammatory 8,17-Epoxybriaranes from the Octocoral Briareum excavatum (Briareidae)

Molecules ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 1405 ◽  
Author(s):  
Thanh-Hao Huynh ◽  
Lee-Shing Fang ◽  
Yu-Hsin Chen ◽  
Bo-Rong Peng ◽  
You-Ying Chen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Inducible Nitric Oxide Synthase ◽  
2D Nmr ◽  
Raw 264.7 ◽  
Spectroscopic Methods ◽  
Nmr Studies ◽  
Cox 2 ◽  
New Compounds ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Five 8,17-epoxybriaranes, including three new compounds—briarenols I–K (1–3), along with two known analogues, briaexcavatolide P (4) and briaexcavatin P (5), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1–3 were elucidated by spectroscopic methods, including 1D and 2D NMR studies and (+)-HRESIMS. Briarane 4 exerted inhibition effects on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) release from RAW 264.7.

scholarly journals Briarenols Q–T: Briaranes from A Cultured Octocoral Briareum stechei (Kükenthal, 1908)

Marine Drugs ◽  
2020 ◽  
Vol 18 (8) ◽  
pp. 383
Author(s):  
Yi-Lin Zhang ◽  
Chih-Chao Chiang ◽  
Yi-Ting Lee ◽  
Zhi-Hong Wen ◽  
Yang-Chang Wu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Chemical Study ◽  
Raw 264.7 ◽  
Spectroscopic Methods ◽  
Oxide Synthase ◽  
Continuous Chemical ◽  
Inducible Nitric Oxide ◽  
New Metabolites

Our continuous chemical study of a cultured octocoral Briareum stechei led to the isolation of four new briarane diterpenoids, briarenols Q–T (1–4). The structures of new metabolites 1–4 were established by spectroscopic methods, and compounds 3 and 4 were found to inhibit the generation of inducible nitric oxide synthase (iNOS) from RAW 264.7 stimulated by lipopolysaccharides (LPS).

Prostaglandin E2 regulates inducible nitric oxide synthase in the murine macrophage cell line J774

1995 ◽  
Vol 49 (2) ◽  
pp. 105-115 ◽  
Author(s):  
Salvatore Milano ◽  
Francesco Arcoleo ◽  
Mariella Dieli ◽  
Rita D'Agostino ◽  
Pietro D'Agostino ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Prostaglandin E2 ◽  
Cell Line ◽  
Inducible Nitric Oxide Synthase ◽  
Murine Macrophage ◽  
Macrophage Cell Line ◽  
Macrophage Cell ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

scholarly journals Briarane-Related Diterpenoids from Octocoral Briareum stechei

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6861
Author(s):  
Thanh-Hao Huynh ◽  
Choo-Aun Neoh ◽  
Yu-Chi Tsai ◽  
Zhi-Kang Yao ◽  
Li-Guo Zheng ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Raw 264.7 ◽  
Spectroscopic Methods ◽  
Mouse Macrophage ◽  
Inos Protein ◽  
New Compounds ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

A known polyoxygenated briarane, briaexcavatolide P (1), was isolated from a Formosan octocoral Briareum stechei. Moreover, the same species B. stechei, collected from Okinawan waters, yielded three chlorine-containing briaranes, including two new compounds, briastecholides B (2) and C (3) as well as a known analogue, briarenol R (4). The structures of 1–4 were established using spectroscopic methods. In addition, briarane 1 demonstrated anti-inflammatory activity in lipo-polysaccharide-induced RAW 264.7 mouse macrophage cells by suppressing the expression of inducible nitric oxide synthase (iNOS) protein.

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