scholarly journals Anti-Obesity and Anti-Diabetic Effects of Ishige okamurae

Marine Drugs ◽  
2019 ◽  
Vol 17 (4) ◽  
pp. 202 ◽  
Author(s):  
Hye-Won Yang ◽  
K.H.N. Fernando ◽  
Jae-Young Oh ◽  
Xining Li ◽  
You-Jin Jeon ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Biological Activities ◽  
Therapeutic Effects ◽  
Cellular Mechanisms ◽  
Ishige Okamurae ◽  
Obesity And Diabetes ◽  
Health Complications ◽  
Nutritional Benefits

Obesity is associated with several health complications and can lead to the development of metabolic syndrome. Some of its deleterious consequences are related to insulin resistance, which adversely affects blood glucose regulation. At present, there is a growing concern regarding healthy food consumption, owing to awareness about obesity. Seaweeds are well-known for their nutritional benefits. The brown alga Ishige okamurae (IO) has been studied as a dietary supplement and exhibits various biological activities in vitro and in vivo. The bioactive compounds isolated from IO extract are known to possess anti-obesity and anti-diabetic properties, elicited via the regulation of lipid metabolism and glucose homeostasis. This review focuses on IO extract and its bioactive compounds that exhibit therapeutic effects through several cellular mechanisms in obesity and diabetes. The information discussed in the present review may provide evidence to develop nutraceuticals from IO.

scholarly journals Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2506
Author(s):  
Wamidh H. Talib ◽  
Ahmad Riyad Alsayed ◽  
Alaa Abuawad ◽  
Safa Daoud ◽  
Asma Ismail Mahmod
Keyword(s):  
Clinical Trials ◽  
Current Knowledge ◽  
Biological Activities ◽  
Experimental Studies ◽  
Therapeutic Effects ◽  
Cell Proliferation Inhibition ◽  
Different Types ◽  
Solid Foundation

Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and experimental studies have documented that melatonin could inhibit different types of cancer in vitro and in vivo. Results showed the involvement of melatonin in different anticancer mechanisms including apoptosis induction, cell proliferation inhibition, reduction in tumor growth and metastases, reduction in the side effects associated with chemotherapy and radiotherapy, decreasing drug resistance in cancer therapy, and augmentation of the therapeutic effects of conventional anticancer therapies. Clinical trials revealed that melatonin is an effective adjuvant drug to all conventional therapies. This review summarized melatonin biosynthesis, availability from natural sources, metabolism, bioavailability, anticancer mechanisms of melatonin, its use in clinical trials, and pharmaceutical formulation. Studies discussed in this review will provide a solid foundation for researchers and physicians to design and develop new therapies to treat and prevent cancer using melatonin.

scholarly journals Extraction of bioactive compounds from Curcuma longa L. using deep eutectic solvents: In vitro and in vivo biological activities

2021 ◽  
pp. 102697
Author(s):  
Grazielle Oliveira ◽  
Caroline Marques ◽  
Anielle de Oliveira ◽  
Amanda de Almeida dos Santos ◽  
Wanderlei do Amaral ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Biological Activities ◽  
Curcuma Longa ◽  
Deep Eutectic Solvents

scholarly journals Characterization of Andean Blueberry in Bioactive Compounds, Evaluation of Biological Properties and in vitro Bioaccessibility

2020 ◽  
Author(s):  
Nieves Baenas ◽  
Jenny Ruales ◽  
Diego A. Moreno ◽  
Daniel Alejandro Barrio ◽  
Carla M. Stinco ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
In Vitro Digestion ◽  
Biological Properties ◽  
Wide Range ◽  
Zebrafish Embryogenesis

Andean blueberries are wild berries grown and consumed in Ecuador which contain high values of bioactive compounds, mainly anthocyanins, with powerful antioxidant activity. The aim of this study was to evaluate the profile and contents of (poly)phenols and carotenoids in Andean blueberry by HPLC-DAD-MSn and determine a wide range of its biological activities. The antioxidant capacity of this fruit was evaluated in vitro by three different methods and in vivo using the zebrafish animal model, also the toxicity effect was determined by the zebrafish embryogenesis test. Besides, the antimicrobial activity and the capacity of Andean blueberry to produce hemagglutination in blood cells were evaluated. Finally, the bioaccessibility of (poly)phenols and related antioxidant capacity were determined in the different phases of an in vitro digestion. The global results indicated no toxicity of Andean blueberry, weakly bacteriostatic activity, and high contents of anthocyanins and antioxidant capacity, which were partially bioaccesible in vitro (~ 50 % at the final intestinal step), contributing to the knowledge of its health benefits for consumers and its potential use in the food and pharmaceutical industry as functional ingredient.

scholarly journals Therapeutic Applications of Solid Dispersions for Drugs and New Molecules: In Vitro and In Vivo Activities

Pharmaceutics ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 933
Author(s):  
Verônica da Silva Oliveira ◽  
Amanda Silva de Almeida ◽  
Ingrid da Silva Albuquerque ◽  
Fernanda Ílary Costa Duarte ◽  
Bárbara Cristina Silva Holanda Queiroz ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Solid Dispersions ◽  
Polymeric Matrices ◽  
Therapeutic Applications ◽  
Biological Potential ◽  
New Applications

This review aims to provide an overview of studies that address the use, in therapeutic applications, of solid dispersions (SDs) with biological activities in vitro and/or in vivo mainly made up of polymeric matrices, as well as to evaluate the bioactive activity of their constituents. This bibliographic survey shows that the development of solid dispersions provides benefits in the physicochemical properties of bioactive compounds, which lead to an increase in their biological potential. However, despite the reports found on solid dispersions, there is still a need for biological assay-based studies, mainly in vivo, to assist in the investigation and to devise new applications. Therefore, studies based on such an approach are of great importance to enhance and extend the use of solid dispersions in the most diverse therapeutic applications.

scholarly journals Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

Molecules ◽  
2019 ◽  
Vol 24 (10) ◽  
pp. 2001 ◽  
Author(s):  
Ana Karković Marković ◽  
Jelena Torić ◽  
Monika Barbarić ◽  
Cvijeta Jakobušić Brala
Keyword(s):  
Phenolic Compounds ◽  
Olive Oil ◽  
Biological Activities ◽  
In Vivo Studies ◽  
Therapeutic Effects ◽  
Endocrine Effects ◽  
Pharmacological Potential ◽  
A Minor

The Mediterranean diet and olive oil as its quintessential part are almost synonymous with a healthy way of eating and living nowadays. This kind of diet has been highly appreciated and is widely recognized for being associated with many favorable effects, such as reduced incidence of different chronic diseases and prolonged longevity. Although olive oil polyphenols present a minor fraction in the composition of olive oil, they seem to be of great importance when it comes to the health benefits, and interest in their biological and potential therapeutic effects is huge. There is a growing body of in vitro and in vivo studies, as well as intervention-based clinical trials, revealing new aspects of already known and many new, previously unknown activities and health effects of these compounds. This review summarizes recent findings regarding biological activities, metabolism and bioavailability of the major olive oil phenolic compounds—hydroxytyrosol, tyrosol, oleuropein, oleocanthal and oleacein—the most important being their antiatherogenic, cardioprotective, anticancer, neuroprotective and endocrine effects. The evidence presented in the review concludes that these phenolic compounds have great pharmacological potential, however, further studies are still required.

scholarly journals Biomedical Effects of Popular Phytonutrients and Their Phytochemicals: A Comprehensive Review

2021 ◽  
Author(s):  
Yamixa Delgado ◽  
Céline Cassé ◽  
Yancy Ferrer-Acosta ◽  
Ivette J. Suárez-Arroyo ◽  
José Rodríguez-Zayas ◽  
...  
Keyword(s):  
Health Care ◽  
Immune Response ◽  
Secondary Metabolites ◽  
Biological Activities ◽  
Therapeutic Effects ◽  
Primary Metabolites ◽  
Comprehensive Review ◽  
Plant Foods

Phytonutrients are plant foods that contain many natural bioactive compounds, called phytochemicals, which expose specific biological activities. These phytonutrients and their phytochemicals may play an important role in health care maintaining normal organism functions (as preventives) and fighting against diseases (as therapeutics). Phytonutrient’s components are the primary metabolites (i.e., proteins, carbohydrates, and lipids) and phytochemicals or secondary metabolites (i.e., phenolics, alkaloids, organosulfides, and terpenes). For years, several phytonutrients and their phytochemicals have demonstrated specific pharmacological and therapeutic effects in human health such as anticancer, antioxidant, antiviral, anti-inflammatory, antibacterial, antifungal, and immune response. This review summarizes the effects of the most studied or the most popular phytonutrients (i.e., turmeric, garlic, cinnamon, graviola, and oregano), and any contraindication found. This article also calculated the physicochemical properties of the main phytochemicals in the selected phytonutrients using Lipinski’s, Veber’s and Ghose’s rules. Based on our revisions for this article, all these phytonutrients have consistently shown several in vitro, in vivo, and clinical studies with great potential as preventives and therapeutics on many diseases.

scholarly journals Ethnopharmacology, Phytochemistry, and Pharmacological Properties of Thymus satureioides Coss.

2021 ◽  
Vol 2021 ◽  
pp. 1-23
Author(s):  
Naoufal El Hachlafi ◽  
Abderrahim Chebat ◽  
Kawtar Fikri-Benbrahim
Keyword(s):  
Essential Oils ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Chemical Characterization ◽  
Pharmacokinetic Studies ◽  
Pharmacological Studies ◽  
Thymus Satureioides

Thymus satureioides Coss. (Lamiaceae) is a Moroccan medicinal plant locally known as “Azkouni” or “Zaitra.” It is widely used in traditional medicine to treat various ailments, including hypertension, diabetes, cold, fever, dermatological and circulatory disorders, immune problems, bronchitis, nociception, cooling, pharyngitis, cough, and influenza. The current review aims to critically summarize the literature on ethnopharmacological uses, chemical profile, and pharmacological investigations of T. satureioides in order to provide data support and scientific evidences for further investigations. Electronic databases such as Scopus, PubMed, Web of Science, SciFinder, ScienceDirect, Google Scholar, and Medline were used to gather data on T. satureioides. Chemical characterization of T. satureioides essential oils (EOs) and extracts allowed to identify a total of 139 bioactive compounds, mainly belonging to the terpenoids, phenolic acids, and flavonoids classes. T. satureioides especially its essential oils exhibited numerous biological activities such as antibacterial, antifungal, anti-inflammatory, antioxidant, antidiabetic, anticancer, antiparasitic, and hypolipedemic activities. In light of these findings, further studies to transmute the traditional application of T. satureioides into scientific-based information are strongly required. Additional in vivo pharmacological studies are recommended to validate the results of the in vitro studies. Moreover, comprehensive preclinical and clinical trials on the pharmacological mechanisms of action of this plant and its bioactive compounds on molecular targets should be performed. Finally, more efforts must be focused on toxicological assessments and pharmacokinetic studies, in order to ensure the safety and the efficiency of T. satureioides.

scholarly journals Ethnomedicinal Use, Phytochemistry, Pharmacology, and Toxicology of Salvia verbenaca L. : A Review

2021 ◽  
Vol 12 (2) ◽  
pp. 1437-1469
Keyword(s):  
Essential Oils ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Traditional Use ◽  
Toxicological Effects ◽  
Stomach Pain ◽  
Toxicological Investigation ◽  
Phytochemical Compounds

Salvia verbenaca L. is a Mediterranean medicinal plant used traditionally to treat several diseases such as burns, ocular wounds, contusion, stomach pain, eye diseases, dermal inflammation. This review highlighted previous reports, including the botanical, taxonomical, geographical distribution, traditional use, phytochemical, biological, and toxicological effects of S. verbenaca. The data were gathered from scientific databases PubMed, Scopus, Web of Science, Google Scholar, ScienceDirect, SpringerLink. The presented data on S. verbenaca were organized according to ethnomedicinal use, bioactive compounds, pharmacology, and toxicological investigation. Ethnobotanical studies reported that many folk medicines use S. verbenaca, especially against wounds, burns, and cicatrization. The phytochemical compounds in different parts of S. verbenaca belonged to different classes of chemical compounds, including terpenoids, flavonoids, phenolic acids, phenolic diterpenoids, and fatty acids. The extracts and essential oils from S. verbenaca have a wide variety of in vitro and in vivo pharmacological activities, i.e., antioxidant, antifungal, antidiabetic, anti-inflammatory, antitumor, antihemolytic, antihypertensive, antileishmanial, and immunomodulatory activities. This research suggests that the biological activities of S. verbenaca prove its traditional uses. However, in-depth investigations are required, such as pharmacokinetic, pharmacodynamic, and toxicological experiments, to prove the efficacy and safety of S. verbenaca extracts and essential oils and their bioactive compounds.

scholarly journals Diplazium esculentum (Retz.) Sw.: Ethnomedicinal, Phytochemical, and Pharmacological Overview of the Himalayan Ferns

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Prabhakar Semwal ◽  
Sakshi Painuli ◽  
Kartik M. Painuli ◽  
Gizem Antika ◽  
Tugba Boyunegmez Tumer ◽  
...  
Keyword(s):  
Web Of Science ◽  
Biological Activities ◽  
Therapeutic Effects ◽  
Sustainable Utilization ◽  
Action Mechanism ◽  
Pharmacological Activities ◽  
Therapeutic Properties ◽  
Cns Stimulant

The genus Diplazium (family: Athyriaceae) comprises approximately 350 species of pteridophytes. Diplazium esculentum (Retz.) Sw. is an important member of this genus and commonly known as a wild vegetable in the Himalayan and sub-Himalayan communities. According to the literature analysis, D. esculentum was traditionally used for the prevention or treatment of several diseases such as diabetes, smallpox, asthma, diarrhea, rheumatism, dysentery, headache, fever, wounds, pain, measles, hypertension, constipation, oligospermia, bone fracture, and glandular swellings. Various extracts of D. esculentum were evaluated to elucidate their phytochemical and pharmacological activities. A wide array of pharmacological properties such as antioxidant, antimicrobial, antidiabetic, immunomodulatory, CNS stimulant, and antianaphylactic activities have been recognized in different parts of D. esculentum. The review covers a systematic examination of pharmacognosy, phytochemistry, and pharmacological applications of D. esculentum, but scientifically, it is not fully assessed regarding complete therapeutic effects, toxicity, and safety in the human body. The published literature on D. esculentum and its therapeutic properties were collected from different search engines including Wiley online, PubMed, Springer Link, Scopus, Science Direct, Web of Science, Google Scholar, and ACS publications by using specific terms such as “Diplazium esculentum, bioactive compounds, biological activities and health benefits” from 1984 to 2021 (March). Therefore, further studies are required to identify the detailed action mechanism of D. esculentum in vitro/in vivo, and also, more studies should focus on conservation, cultivation, and sustainable utilization of the species.

scholarly journals Therapeutic Effects of Fucoidan: A Review on Recent Studies

Marine Drugs ◽  
2019 ◽  
Vol 17 (9) ◽  
pp. 487 ◽  
Author(s):  
Sibusiso Luthuli ◽  
Siya Wu ◽  
Yang Cheng ◽  
Xiaoli Zheng ◽  
Mingjiang Wu ◽  
...  
Keyword(s):  
Theoretical Basis ◽  
Biological Activities ◽  
In Vivo Studies ◽  
Therapeutic Effects ◽  
Biological Functions ◽  
Biological Structure ◽  
Anti Oxidant ◽  
Future Therapy

Fucoidan is a polysaccharide largely made up of l-fucose and sulfate groups. Fucoidan is favorable worldwide, especially amongst the food and pharmaceutical industry as a consequence of its promising therapeutic effects. Its applaudable biological functions are ascribed to its unique biological structure. Classical bioactivities associated with fucoidan include anti-oxidant, anti-tumor, anti-coagulant, anti-thrombotic, immunoregulatory, anti-viral and anti-inflammatory effects. More recently, a variety of in vitro and in vivo studies have been carried out to further highlight its therapeutic potentials. This review focuses on the progress towards understanding fucoidan and its biological activities, which may be beneficial as a future therapy. Hence, we have summarized in vitro and in vivo studies that were done within the current decade. We expect this review and a variety of others can contribute as a theoretical basis for understanding and inspire further product development of fucoidan.

Sign in / Sign up

Export Citation Format

Share Document