scholarly journals Chemical Synthesis of Marine-Derived Sulfoglycolipids, a New Class of Molecular Adjuvants

Marine Drugs ◽  
2017 ◽  
Vol 15 (9) ◽  
pp. 288 ◽  
Author(s):  
Emiliano Manzo ◽  
Laura Fioretto ◽  
Dario Pagano ◽  
Genoveffa Nuzzo ◽  
Carmela Gallo ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
New Class ◽  
Molecular Adjuvants

scholarly journals C–H-Functionalization logic guides the synthesis of a carbacyclopamine analog

2014 ◽  
Vol 10 ◽  
pp. 1564-1569 ◽  
Author(s):  
Sebastian Rabe ◽  
Johann Moschner ◽  
Marina Bantzi ◽  
Philipp Heretsch ◽  
Athanassios Giannis
Keyword(s):  
Chemical Synthesis ◽  
New Class ◽  
Metal Catalyzed ◽  
Acid Stable

The chemical synthesis of carbacyclopamine analog 2, a cyclopamine analog with an all-carbon E-ring, is reported. The use of C–H-functionalization logic and further metal-catalyzed transformations allows for a concise entry to this new class of acid-stable cyclopamine analogs.

Phosphonolipids. XV. Synthesis of a dihydroceramide aminoethylphosphonate

1968 ◽  
Vol 46 (3) ◽  
pp. 525-532 ◽  
Author(s):  
Erich Baer ◽  
Bimal C. Pal
Keyword(s):  
Chemical Synthesis ◽  
Acid Chloride ◽  
Phosphonic Acid ◽  
Steam Distillation ◽  
Free Acid ◽  
Reaction Products ◽  
New Class ◽  
Naturally Occurring ◽  
Benzoyl Group ◽  
Complex Lipids

The first chemical synthesis of a dihydroceramide aminoethylphosphonate is described. It is a saturated representative of a new class of recently discovered, naturally occurring complex lipids derived from phosphonic acid. The compound, viz. erythro-N-palmitoyl-DL-dihydrosphingosyl-1-(2-aminoethyl)-phosphonate, was obtained by two procedures: phosphonylation of erythro-N-palmitoyl-3-O-benzoyl-DL-dihydrosphingosine with (2-N,N-dibenzylammoethyl)phosphonic acid chloride (hydrochloride) and triethylamine, or with (2-phthalimidoethyl)phosphonic acid monochloride and triethylamine, and freeing the reaction products of both procedures, viz. erythro-N-palmitoyl-3-O-benzoyl-DL-dihydrosphingosyl-1-(2-N,N-dibenzylaminoethyl)phosphonate and erythro-N-palmitoyl-3-O-benzoyl-DL-dihydrosphingosyl-1-(2-phthalimidoethyl)phosphonate, from their protective benzyl or phthaloyl group by hydrogenolysis or hydrazinolysis, respectively, followed in both cases by removal of the benzoyl group by saponification.The (2-N,N-dibenzylaminoethyl)phosphonic acid was obtained by treating (2-bromoethyl)phosphonic acid with N,N-dibenzylamine and converting the reaction product, viz. the dibenzylammonium salt of (2-N,N-dibenzylaminoethyl)phosphonic acid, into the free acid by steam distillation.

A new class of HIV-1 protease inhibitor: The crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere

1996 ◽  
Vol 4 (9) ◽  
pp. 1545-1558 ◽  
Author(s):  
Earl E. Rutenber ◽  
Fiona McPhee ◽  
Alan P. Kaplan ◽  
Steven L. Gallion ◽  
Joseph C. Hogan ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Protease Inhibitor ◽  
Crystallographic Structure ◽  
New Class ◽  
Hiv 1

scholarly journals Chemical synthesis and purification of a non-hydrolyzable CTP analog CTPγS

2021 ◽  
Author(s):  
M Rejzek ◽  
Tung B. K. Le
Keyword(s):  
Chemical Synthesis ◽  
New Class ◽  
Founding Member ◽  
Commercial Sources

AbstractSlowly- or non-hydrolyzable analogs of ATP and GTP, for example adenosine 5’-(γ-thio)triphosphate (ATPγS) and guanosine 5’-(γ-thio)triphosphate (GTPγS), have been widely employed to probe the roles of ATP and GTP in biosystems, and these compounds are readily available from commercial sources. In contrast, cytosine 5’-(γ-thio)triphosphate (CTPγS) is not widely available commercially. The recent discovery of ParB as the founding member of a new class of CTPase enzyme (Osorio-Valeriano et al., 2019; Soh et al., 2019) and the possibility of multiple other undiscovered CTPases necessitate the use of the CTPγS to elucidate the roles of CTP hydrolysis in these systems. Here, we adapt a procedure for the synthesis of modified phosphoanhydrides (Hofer et al., 2015) to chemically synthesize and purify a milligram-scale of CTPγS.

Chemical synthesis and functional characterization of a new class of ceramide analogues as anti-cancer agents

2019 ◽  
Vol 27 (8) ◽  
pp. 1489-1496
Author(s):  
Qianqian Liu ◽  
Xia Li ◽  
Yong-Sheng Bao ◽  
Jingxin Lu ◽  
Hua Li ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Functional Characterization ◽  
New Class ◽  
Anti Cancer
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