scholarly journals Sinulariolide Suppresses Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 and Urokinase through the PI3K/AKT/mTOR Signaling Pathway in Human Bladder Cancer Cells

Marine Drugs ◽  
2017 ◽  
Vol 15 (8) ◽  
pp. 238 ◽  
Author(s):  
Te-Chih Cheng ◽  
Zhong-Hao Din ◽  
Jui-Hsin Su ◽  
Yu-Jen Wu ◽  
Chih-I Liu
Keyword(s):  
Bladder Cancer ◽  
Cell Migration ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 2 ◽  
Migration And Invasion ◽  
Human Bladder Cancer ◽  
Mtor Signaling Pathway ◽  
Human Bladder ◽  
Bladder Cancer Cells ◽  
Human Bladder Cancer Cells

scholarly journals Suppressions of Migration and Invasion by Cantharidin in TSGH-8301 Human Bladder Carcinoma Cells through the Inhibitions of Matrix Metalloproteinase-2/-9 Signaling

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Yi-Ping Huang ◽  
Chien-Hang Ni ◽  
Chi-Cheng Lu ◽  
Jo-Hua Chiang ◽  
Jai-Sing Yang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Cells ◽  
Cancer Metastasis ◽  
Gelatin Zymography ◽  
Matrix Metalloproteinase 2 ◽  
Migration And Invasion ◽  
Dependent Manner ◽  
Human Bladder Cancer ◽  
Human Bladder

Cancer metastasis becomes an initial cause of cancer death in human population. In many cancers, it has been shown that the high levels of matrix metalloproteinase (MMP)-2 and/or MMP-9 are associated with the invasive phenotypes of cancer cells. In this study, we investigated the effects of cantharidin, a derivative ofblister beetleswhich is one of the traditional Chinese medicines, on the adhesion, migration, and invasion of human bladder cancer TSGH-8301 cells. Cantharidin effectively suppressed TSGH-8301 cell adhesion, migration, and invasion in a concentration-dependent manner. Results from Western blotting, RT-PCR, and gelatin zymography assays indicated that cantharidin blocked the protein levels, gene expression (mRNA), and activities of MMP-2 and -9 in TSGH-8301 cells. Cantharidin also significantly suppressed the protein expressions of p-p38 and p-JNK1/2 in TSGH-8301 cells. Taken together, cantharidin was suggested to present antimetastatic potentialviasuppressing the levels of MMP-2 and MMP-9 expression that might be mediated by targeting the p38 and JNK1/2 MAPKs pathway in TSGH-8301 human bladder cancer cells.

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