scholarly journals In Vitro Antioxidant Activities of Enzymatic Hydrolysate from Schizochytrium sp. and Its Hepatoprotective Effects on Acute Alcohol-Induced Liver Injury In Vivo

Marine Drugs ◽  
2017 ◽  
Vol 15 (4) ◽  
pp. 115 ◽  
Author(s):  
Xixi Cai ◽  
Ana Yan ◽  
Nanyan Fu ◽  
Shaoyun Wang
Keyword(s):  
Liver Injury ◽  
Antioxidant Activities ◽  
Enzymatic Hydrolysate ◽  
Hepatoprotective Effects

The Proton Pump Inhibitor Lansoprazole Has Hepatoprotective Effects in In Vitro and In Vivo Rat Models of Acute Liver Injury

2019 ◽  
Vol 64 (10) ◽  
pp. 2854-2866 ◽  
Author(s):  
Richi Nakatake ◽  
Hidehiko Hishikawa ◽  
Masaya Kotsuka ◽  
Morihiko Ishizaki ◽  
Kosuke Matsui ◽  
...  
Keyword(s):  
Liver Injury ◽  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Acute Liver Injury ◽  
Rat Models ◽  
Hepatoprotective Effects

Pharmacokinetics in Vitro and in Vivo of Two Novel Prodrugs of Oleanolic Acid in Rats and Its Hepatoprotective Effects against Liver Injury Induced by CCl4

2016 ◽  
Vol 13 (5) ◽  
pp. 1699-1710 ◽  
Author(s):  
Zongjiang Yu ◽  
Weizhi Sun ◽  
Weibing Peng ◽  
Rilei Yu ◽  
Guoqiang Li ◽  
...  
Keyword(s):  
Liver Injury ◽  
Oleanolic Acid ◽  
Hepatoprotective Effects

Phenolic-rich lychee (Litchi chinensis Sonn.) pulp extracts offer hepatoprotection against restraint stress-induced liver injury in mice by modulating mitochondrial dysfunction

2016 ◽  
Vol 7 (1) ◽  
pp. 508-515 ◽  
Author(s):  
Dongxiao Su ◽  
Ruifen Zhang ◽  
Cuilan Zhang ◽  
Fei Huang ◽  
Juan Xiao ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Liver Injury ◽  
Mitochondrial Dysfunction ◽  
Restraint Stress ◽  
Antioxidant Activities ◽  
Litchi Chinensis ◽  
Subtropical Fruit

The pulp from lychee, a tropical to subtropical fruit, contains large quantities of phenolic compounds and exhibits antioxidant activities both in vitro and in vivo.

scholarly journals Antioxidant and Preventive Effects of Extract fromNymphaea candidaFlower onIn VitroImmunological Liver Injury of Rat Primary Hepatocyte Cultures

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Jun Zhao ◽  
Tao Liu ◽  
Long Ma ◽  
Ming Yan ◽  
Zhengyi Gu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Antioxidant Capacity ◽  
Antioxidant Activities ◽  
Reducing Power ◽  
Rat Hepatocytes ◽  
Butylated Hydroxytoluene ◽  
Traditional Uighur Medicine ◽  
Cultured Rat Hepatocytes

Nymphaea candidais traditional Uighur medicine that is commonly used to treat head pains, cough, hepatitis and hypertension in Xinjiang of China. In this article, the extract ofN. candidawas measured for antioxidant activity, using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals scavenging assay and reducing power determination, and compared with those of the positive controls of butylated hydroxytoluene (BHT) and gallic acid (GA). The active extract was further purified by liquid-liquid partition to afford four fractions, of which the ethyl acetate-soluble (EA) fraction (NCE) exhibited the strongest antioxidant capacity with IC50value of 12.6 g/mL for DPPH. Thirteen phenolic compounds were isolated from this fraction, and they all showed significant antioxidant activities in DPPH model system. Furthermore, NCE showed potent antioxidant capacity with IC50value of 59.32 g/mL, 24.48 g/mL and 86.85 g/mL, for ,·OH and H2O2radicals, respectively. Moreover, NCE on BCG plus LPS-induced immunological liver injury was evaluated using primary cultured rat hepatocytes. NCE produced significant hepatoprotective effects as evidenced by decreased supernatant enzyme activities (AST—aspartate transaminase,P<  .01; ALT—alanine transferase,P<  .01) and nitric oxide (NO,P<  .01) production. These results revealed thein vitroantioxidant and hepatoprotective activities of NCE against immunological liver injury. Further investigations are necessary to verify these activitiesin vivo.

scholarly journals Antioxidant activities of anastatin A & B derivatives and compound 38c's protective effect in a mouse model of CCl4-induced acute liver injury

RSC Advances ◽  
2020 ◽  
Vol 10 (24) ◽  
pp. 14337-14346 ◽  
Author(s):  
Cen Xiang ◽  
Menglin Cao ◽  
Ai Miao ◽  
Feng Gao ◽  
Xuzhe Li ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Liver Injury ◽  
Mouse Model ◽  
Protective Effect ◽  
Acute Liver Injury ◽  
Antioxidant Activities

Anastatins B derivative 38c both had good antioxidant activity in vitro and in vivo.

In vitro and in vivo antioxidant activities of the leaves of Chrysophyllum albidum

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
AH Adebayo ◽  
AO Abolaji ◽  
OO Ayepola ◽  
TB Olorunfemi ◽  
OS Taiwo
Keyword(s):  
Antioxidant Activities

Hepatoprotective Effects of Hovenia dulcis Fruit on Ethanol-Induced Liver Damage in vitro and in vivo

2009 ◽  
Vol 38 (2) ◽  
pp. 154-159 ◽  
Author(s):  
Yang-Hee You ◽  
Kuk-Yung Jung ◽  
Yoo-Hyun Lee ◽  
Woo-Jin Jun ◽  
Boo-Yong Lee
Keyword(s):  
Liver Damage ◽  
Hepatoprotective Effects ◽  
Hovenia Dulcis

scholarly journals 5-O-Demethylnobiletin Alleviates CCl4-Induced Acute Liver Injury by Equilibrating ROS-Mediated Apoptosis and Autophagy Induction

2021 ◽  
Vol 22 (3) ◽  
pp. 1083
Author(s):  
Sukkum Ngullie Chang ◽  
Se Ho Kim ◽  
Debasish Kumar Dey ◽  
Seon Min Park ◽  
Omaima Nasif ◽  
...  
Keyword(s):  
Liver Injury ◽  
Acute Liver Injury ◽  
Elevated Serum ◽  
In Vitro Study ◽  
Biological Properties ◽  
Autophagic Flux ◽  
Serum Aminotransferase ◽  
Ccl4 Treatment

Polymethoxyflavanoids (PMFs) have exhibited a vast array of therapeutic biological properties. 5-O-Demethylnobiletin (5-DN) is one such PMF having anti-inflammatory activity, yet its role in hepatoprotection has not been studied before. Results from in vitro study revealed that 5-DN did not exert a high level of cytotoxicity on HepG2 cells at 40 μM, and it was able to rescue HepG2 cell death induced by carbon tetrachloride (CCl4). Subsequently, we investigated acute liver injury on BALB/c mice induced by CCl4 through the intraperitoneal injection of 1 mL/kg CCl4 and co-administration of 5-DN at (1 and 2 mg/kg) by oral gavage for 15 days. The results illustrated that treatment with 5-DN attenuated CCl4-induced elevated serum aminotransferase (AST)/alanine aminotransferase (ALT) ratio and significantly ameliorated severe hepatic damage such as inflammation and fibrosis evidenced through lesser aberrations in the liver histology of 5-DN dose groups. Additionally, 5-DN efficiently counteracted and equilibrated the production of ROS accelerated by CCl4 and dramatically downregulated the expression of CYP2E1 vitally involved in converting CCl4 to toxic free radicals and also enhanced the antioxidant enzymes. 5-DN treatment also inhibited cell proliferation and inflammatory pathway abnormally regulated by CCl4 treatment. Furthermore, the apoptotic response induced by CCl4 treatment was remarkably reduced by enhanced Bcl-2 expression and noticeable reduction in Bax, Bid, cleaved caspase 3, caspase 9, and apaf-1 expression. 5-DN treatment also induced the conversion of LC3 and promoted the autophagic flux. Conclusively, 5-DN exhibited hepatoprotective effects in vitro and in vivo and prevented liver fibrosis induced by CCl4.

Sign in / Sign up

Export Citation Format

Share Document