scholarly journals Transcriptome of the Australian Mollusc Dicathais orbita Provides Insights into the Biosynthesis of Indoles and Choline Esters

Marine Drugs ◽  
2016 ◽  
Vol 14 (7) ◽  
pp. 135 ◽  
Author(s):  
Abdul Baten ◽  
Ajit Ngangbam ◽  
Daniel Waters ◽  
Kirsten Benkendorff
Keyword(s):  
Choline Esters

OCULAR EFFECTS OF THE CHOLINE ESTERS

1949 ◽  
Vol 42 (6) ◽  
pp. 709-725 ◽  
Author(s):  
K. C. SWAN
Keyword(s):  
Choline Esters

The identification of acetyl-l-carnitylcholine in rat brain extracts and the comparison of its cholinomimetic properties with acetylcholine

1970 ◽  
Vol 48 (10) ◽  
pp. 709-722 ◽  
Author(s):  
E. A. Hosein ◽  
A. Kato ◽  
E. Vine ◽  
A. M. Hill
Keyword(s):  
Guinea Pig ◽  
Rat Brain ◽  
Total Activity ◽  
Guinea Pig Ileum ◽  
Molar Basis ◽  
Choline Esters ◽  
Brain Extracts

Acetyl-l-carnitylcholine (l-ACCh) was identified in rat brain extracts on paper chromatograms developed in butanol–water for 138 h. l-ACCh was also identified in brain extracts fractionated on t.l.c. plates and on Sephadex G-10 columns. In every instance l-ACCh was separated from the acetylcholine (ACh) present and the ACh-like activity of l-ACCh was about 20% of the total activity in the extract. Both l-ACCh and ACh were found to be inseparable in a variety of chromatographic systems including electrophoresis. Treatment of these choline esters with cholinesterases showed that while true acetylcholinesterase hydrolyzed both l-ACCh and ACh, pseudocholinesterase destroyed only ACh. On a molar basis, the ACh-like activity of ACCh is one-half that of ACh on both the guinea pig ileum and frog rectus preparations. Like ACh, the ratio of the nicotinic to muscarinic potency of l-ACCh is unity. Mixtures of l-ACCh and ACh show summation of ACh-like activity on both the guinea pig ileum and frog rectus preparations.

Choline esters of N-substituted amino acids. IX. Synthesis and cholinergic properties of β-dimethylaminoethyl esters of N-substituted amino acids

1997 ◽  
Vol 31 (1) ◽  
pp. 23-26
Author(s):  
V. O. Topuzyan ◽  
G. Yu. Khachvakyan ◽  
L. V. Shakhbazyan ◽  
D. A. Gerasimyan
Keyword(s):  
Amino Acids ◽  
Choline Esters

scholarly journals Potentiation effect of choline esters on choline-catalysed decarbamoylation of dimethylcarbamoyl-acetylcholinesterase

1992 ◽  
Vol 284 (1) ◽  
pp. 153-160 ◽  
Author(s):  
Y B Kim ◽  
C H Jung ◽  
S J Choi ◽  
W J Seo ◽  
S H Cha ◽  
...  
Keyword(s):  
Ionic Strength ◽  
Quaternary Ammonium ◽  
Acyl Chain ◽  
Requirement Analysis ◽  
Ester Bond ◽  
Choline Ester ◽  
Anionic Sites ◽  
Structural Requirement ◽  
Potentiation Effect ◽  
Choline Esters

The choline esters potentiated the choline-catalysed decarbamoylation of dimethylcarbamoyl-acetylcholinesterase in proportion to the length of acyl group, although esters containing an acyl chain longer than the hexanoyl group exhibited a corresponding decrease in the potentiation. In structural requirement analysis it was found that both the quaternary ammonium moiety and the ester bond were important for the effective acceleration of choline-catalysed decarbamoylation. In general, the respective thiocholine ester was found to be more effective than the corresponding choline ester. Whereas the binding affinity (Ka) of choline in the decarbamoylation was not significantly altered, the maximum decarbamoylation rate (kr(max.)) of choline was greatly enhanced in the presence of choline esters or thiocholine esters. Along with the above observation, the isotope solvent effect, the effect of ionic strength and the antagonism studies demonstrate that the choline esters or thiocholine esters may interact with one of peripheral anionic sites, and thereby make the choline-catalysed decarbamoylation more favourable.

scholarly journals The Separation of Choline Esters by Paper Chromatography.

1953 ◽  
Vol 7 ◽  
pp. 906-912 ◽  
Author(s):  
Klas-Bertil Augustinsson ◽  
Margareta Grahn ◽  
H. Fex ◽  
B. Högberg ◽  
T. Linderot ◽  
...  
Keyword(s):  
Paper Chromatography ◽  
Choline Esters

Parallel mechanisms in acetylcholinesterase-catalyzed hydrolysis of choline esters

1993 ◽  
Vol 115 (23) ◽  
pp. 10477-10482 ◽  
Author(s):  
Trevor Selwood ◽  
Shawn R. Feaster ◽  
Michael J. States ◽  
Alton N. Pryor ◽  
Daniel M. Quinn
Keyword(s):  
Parallel Mechanisms ◽  
Choline Esters ◽  
Hydrolysis Of
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