scholarly journals 4-Hydroxy-2,3-Dimethyl-2-Nonen-4-Olide Has an Inhibitory Effect on Pro-Inflammatory Cytokine Production in CpG-Stimulated Bone Marrow-Derived Dendritic Cells

Marine Drugs ◽  
2016 ◽  
Vol 14 (5) ◽  
pp. 88 ◽  
Author(s):  
Zahid Manzoor ◽  
Jung-Eun Koo ◽  
Irshad Ali ◽  
Jung-Eun Kim ◽  
Sang-Hee Byeon ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Dendritic Cells ◽  
Inflammatory Cytokine ◽  
Cytokine Production ◽  
Inhibitory Effect ◽  
Inflammatory Cytokine Production

scholarly journals Inhibitory Effects of Cucurbitane-Type Triterpenoids from Momordica charantia Fruit on Lipopolysaccharide-Stimulated Pro-Inflammatory Cytokine Production in Bone Marrow-Derived Dendritic Cells

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4444
Author(s):  
Thao Quyen Cao ◽  
Nguyen Viet Phong ◽  
Jang Hoon Kim ◽  
Dan Gao ◽  
Hoang Le Tuan Anh ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Dendritic Cells ◽  
Inflammatory Cytokine ◽  
Cytokine Production ◽  
Momordica Charantia ◽  
Ionization Mass ◽  
Inflammatory Cytokine Production ◽  
Chemical Structures ◽  
Tnf Α ◽  
Anti Inflammatory

The bitter melon, Momordica charantia L., was once an important food and medicinal herb. Various studies have focused on the potential treatment of stomach disease with M. charantia and on its anti-diabetic properties. However, very little is known about the specific compounds responsible for its anti-inflammatory activities. In addition, the in vitro inhibitory effect of M. charantia on pro-inflammatory cytokine production by lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs) has not been reported. Phytochemical investigation of M. charantia fruit led to the isolation of 15 compounds (1−15). Their chemical structures were elucidated spectroscopically (one- and two-dimensional nuclear magnetic resonance) and with electrospray ionization mass spectrometry. The anti-inflammatory effects of the isolated compounds were evaluated by measuring the production of the pro-inflammatory cytokines interleukin IL-6, IL-12 p40, and tumor necrosis factor α (TNF-α) in LPS-stimulated BMDCs. The cucurbitanes were potent inhibitors of the cytokines TNF-α, IL-6, and IL-12 p40, indicating promising anti-inflammatory effects. Based on these studies and in silico simulations, we determined that the ligand likely docked in the receptors. These results suggest that cucurbitanes from M. charantia are potential candidates for treating inflammatory diseases.

Dendritic cells sub-sets are associated with inflammatory cytokine production in progressive vitiligo disease

2021 ◽  
Author(s):  
Niharika Srivastava ◽  
Anuradha Bishnoi ◽  
Davinder Parsad ◽  
Muthu Sendhil Kumaran ◽  
Keshavamurthy Vinay ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Inflammatory Cytokine ◽  
Cytokine Production ◽  
Inflammatory Cytokine Production
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