scholarly journals Dietary Docosahexaenoic Acid and Eicosapentaenoic Acid Influence Liver Triacylglycerol and Insulin Resistance in Rats Fed a High-Fructose Diet

Marine Drugs ◽  
2015 ◽  
Vol 13 (4) ◽  
pp. 1864-1881 ◽  
Author(s):  
Gabriela Salim de Castro ◽  
Rafael Deminice ◽  
Livia Cordeiro Simões-Ambrosio ◽  
Philip C. Calder ◽  
Alceu A. Jordão ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Docosahexaenoic Acid ◽  
Eicosapentaenoic Acid ◽  
High Fructose Diet ◽  
High Fructose ◽  
Dietary Docosahexaenoic Acid

Eicosapentaenoic acid (EPA) vs. Docosahexaenoic acid (DHA): Effects in epididymal white adipose tissue of mice fed a high-fructose diet

2017 ◽  
Vol 123 ◽  
pp. 14-24 ◽  
Author(s):  
Thereza Cristina Lonzetti Bargut ◽  
Larissa Pereira Santos ◽  
Daiana Guimarães Lopes Machado ◽  
Marcia Barbosa Aguila ◽  
Carlos Alberto Mandarim-de-Lacerda
Keyword(s):  
Adipose Tissue ◽  
Docosahexaenoic Acid ◽  
Eicosapentaenoic Acid ◽  
White Adipose Tissue ◽  
High Fructose Diet ◽  
High Fructose ◽  
Epididymal White Adipose Tissue

Favorable effects of Globularia alypum on cardiometabolic markers in high fructose-fed rats

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Yasmina Bahlil ◽  
Djamil Krouf ◽  
Zoheir Mellouk ◽  
Nawal Taleb-Dida ◽  
Akila Guenzet
Keyword(s):  
Insulin Resistance ◽  
Lipid Peroxidation ◽  
Low Density Lipoproteins ◽  
Standard Diet ◽  
Low Density ◽  
Content Type ◽  
High Fructose Diet ◽  
Globularia Alypum ◽  
High Fructose ◽  
Antioxidant Defense Systems

Purpose This study aims to examine whether Globularia alypum (Ga) lyophilized aqueous leaves extract treatment improves cardiometabolic syndromes such as hyperglycemia, lipid profiles and oxidative damage resulting from a high-fructose diet induced in hypertriglyceridemic rats. Design/methodology/approach A total of 24 male Wistar rats weighing 80 ± 5 g were first randomly divided into 2 groups. A total of 12 control rats (C) were fed a standard-diet (St-D) and 12 high fructose (HF) rats were fed a high-fructose diet (HF-D) containing St-D in which cornstarch was substituted by fructose (61.4%). After 15 weeks of feeding, body weight (BW) was about 320 ± 20 g and hypertriglyceridemia was noted in HF vs C group (2.69 ± 0.49 mmol/L) vs (1.25 ± 0.33 mmol/L). Each group of rats was then divided into two equal groups (n = 6) and fed during four weeks either a St-D or HF-D, treated or not with 1% of Ga extract (C-Ga) and (HF-Ga). After 28 days, fasting rats were anesthetized and blood and tissues were removed to measure biochemical parameters. Findings The results showed no significant differences in BW and insulinemia between all groups. Ga extract supplementation reduced glycemia (−36%), glycosylated hemoglobin (−37%), Homeostasis Model of Assessment-Insulin Resistance index (−34%) and triacylglycerol’s contents in plasma (−33%), very low density lipoproteins–low density lipoproteins (VLDL-LDL) (−48%), liver (−52%) and aorta (−39%); total cholesterol concentrations in aorta was 3.7-fold lower in HF-Ga vs HF group. Ga treatment reduced lipid peroxidation in plasma, VLDL-LDL, red blood cells (RBC), liver, muscle and kidney by improving superoxide dismutase (SOD) activity and glutathione peroxidase (GPx) in RBC and catalase (CAT) activity in kidney (p < 0.05). Moreover, Ga ameliorates glutathione (GSH) production in RBC (+41%) and kidney tissues (+35%). Originality/value Ga extract ameliorated cardiometabolic syndrome by its hypotriglyceridemic effect and prevented development of insulin resistance. It reduces lipid peroxidation by enhancing non-enzymatic (GSH) and enzymatic (SOD, GPx and CAT) antioxidant defense systems in high-fructose hypertriglyceridemic rats. Therefore, supplementation of Ga leaves extract as an adjuvant could be used for the treatment of hypertriglyceridemia and the prevention and/or the management of cardio-metabolic adverse effects.

Sea cucumbers-derived sterol sulfate alleviates insulin resistance and inflammation in high-fat-high-fructose diet-induced obese mice

2020 ◽  
Vol 160 ◽  
pp. 105191
Author(s):  
Hui-Juan Zhang ◽  
Cheng Chen ◽  
Lin Ding ◽  
Hao-Hao Shi ◽  
Cheng-Cheng Wang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Obese Mice ◽  
High Fat ◽  
Sea Cucumbers ◽  
High Fructose Diet ◽  
High Fructose
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