scholarly journals Analysis of the Toxicity and Histopathology Induced by the Oral Administration of Pseudanabaena galeata and Geitlerinema splendidum (Cyanobacteria) Extracts to Mice

Marine Drugs ◽  
2014 ◽  
Vol 12 (1) ◽  
pp. 508-524 ◽  
Author(s):  
Marisa Rangel ◽  
Joyce Martins ◽  
Angélica Garcia ◽  
Geanne Conserva ◽  
Adriana Costa-Neves ◽  
...  
Keyword(s):  
Oral Administration ◽  
Pseudanabaena Galeata

scholarly journals Loss of toxicity by Pseudanabaena galeata in culture

Hoehnea ◽  
2017 ◽  
Vol 44 (2) ◽  
pp. 269-276
Author(s):  
Angelica Nunes Garcia ◽  
Fernando Pipole ◽  
Luciana Castro da Cunha ◽  
Fabiana Elias ◽  
Silvana Lima Górniak ◽  
...  
Keyword(s):  
Oral Administration ◽  
Lethal Dose ◽  
Oral Exposure ◽  
Reductive Evolution ◽  
Renal Lesions ◽  
Intestinal Lesions ◽  
Toxicological Studies ◽  
Severe Intoxication ◽  
Potential Risks ◽  
Pseudanabaena Galeata

ABSTRACT Pseudanabaena galeata, a well-known toxin-producer, is commonly found in water supplies. In order to assess potential risks associated with oral exposure to this cyanobacterium, mouse toxicological studies were carried out with the monoespecific strain P. galeata CCIBt 3082, which has been kept in culture since 1996. In our studies, the acute oral lethal dose has been estimated to be 5,000 mg kg-1 bw and, in the oral sub-chronic assays, the animals showed a decrease in weight and presented microscopic intestinal lesions, results that did not correspond to statements by other authors. In their studies, oral administration of the extract, whose acute lethal dose has been established to be 1,000 mg kg-1 bw, led to severe intoxication and promoted hepatic and renal lesions. Toxicity loss of this strain may be the result of reductive evolution that can occur in organisms that remain in static environments for long periods.

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