scholarly journals Identification and Biochemical Characterization of Halisulfate 3 and Suvanine as Novel Inhibitors of Hepatitis C Virus NS3 Helicase from a Marine Sponge

Marine Drugs ◽  
2014 ◽  
Vol 12 (1) ◽  
pp. 462-476 ◽  
Author(s):  
Atsushi Furuta ◽  
Kazi Salam ◽  
Idam Hermawan ◽  
Nobuyoshi Akimitsu ◽  
Junichi Tanaka ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Marine Sponge ◽  
Biochemical Characterization

scholarly journals Morphological and Biochemical Characterization of the Membranous Hepatitis C Virus Replication Compartment

2013 ◽  
Vol 87 (19) ◽  
pp. 10612-10627 ◽  
Author(s):  
D. Paul ◽  
S. Hoppe ◽  
G. Saher ◽  
J. Krijnse-Locker ◽  
R. Bartenschlager
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Replication ◽  
Biochemical Characterization ◽  
Replication Compartment

scholarly journals Newly Synthesized Hepatitis C Virus Replicon RNA Is Protected from Nuclease Activity by a Protease-Sensitive Factor(s)

2004 ◽  
Vol 78 (18) ◽  
pp. 10202-10205 ◽  
Author(s):  
Guang Yang ◽  
Daniel C. Pevear ◽  
Marc S. Collett ◽  
Srinivas Chunduru ◽  
Dorothy C. Young ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Lipid Membranes ◽  
Biochemical Characterization ◽  
Buoyant Density ◽  
Nuclease Activity ◽  
Replication Complex ◽  
Sensitive Factor ◽  
Protease Treatment

ABSTRACT Biochemical characterization of hepatitis C virus (HCV) replication using purified, membrane-associated replication complexes is hampered by the presence of endogenous nuclease activity that copurifies with the replication complex. In this study, pulse-chase analyses were used to demonstrate that newly synthesized replicon RNA was protected from nuclease activity by a factor(s) that was sensitive to 0.5% NP-40 or protease treatment. Nuclease susceptibility was not related to disruption of lipid membranes, since NP-40 did not significantly affect the buoyant density of HCV replication complexes or protease susceptibility of HCV NS3 and NS5A proteins. These results suggest that a protease-sensitive factor(s) protects newly synthesized RNA from nuclease degradation.

scholarly journals Functional and Biochemical Characterization of Hepatitis C Virus (HCV) Particles Produced in a Humanized Liver Mouse Model

2015 ◽  
Vol 290 (38) ◽  
pp. 23173-23187 ◽  
Author(s):  
Sara Calattini ◽  
Floriane Fusil ◽  
Jimmy Mancip ◽  
Viet Loan Dao Thi ◽  
Christelle Granier ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Mouse Model ◽  
Biochemical Characterization

scholarly journals Biochemical characterization of a hepatitis C virus RNA-dependent RNA polymerase mutant lacking the C-terminal hydrophobic sequence

2000 ◽  
Vol 81 (3) ◽  
pp. 759-767 ◽  
Author(s):  
Licia Tomei ◽  
Alessandra Vitelli ◽  
Raffaele De Francesco ◽  
Rosa Letizia Vitale ◽  
Ilario Incitti ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Polymerase ◽  
Biochemical Characterization ◽  
Hepatitis C Virus Rna ◽  
Rna Dependent Rna Polymerase ◽  
Virus Rna

scholarly journals Characterization of a hepatitis C virus genotype 1 divergent isolate from an HIV-1 coinfected individual in Germany assigned to a new subtype 1o

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Bo Wang ◽  
Luise Krüger ◽  
Patrycja Machnowska ◽  
Amare Eshetu ◽  
Barbara Gunsenheimer-Bartmeyer ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Genotype 1 ◽  
Virus Genotype ◽  
Hiv 1

scholarly journals Characterization of Resistance to Non-obligate Chain-terminating Ribonucleoside Analogs That Inhibit Hepatitis C Virus Replicationin Vitro

2003 ◽  
Vol 278 (49) ◽  
pp. 49164-49170 ◽  
Author(s):  
Giovanni Migliaccio ◽  
Joanne E. Tomassini ◽  
Steven S. Carroll ◽  
Licia Tomei ◽  
Sergio Altamura ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C
Sign in / Sign up

Export Citation Format

Share Document