The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells

Georgios Kallifatidis; Dominic Hoepfner; Tiphaine Jaeg; Esther Guzmán; Amy Wright

doi:10.3390/md11093500

The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells

Marine Drugs ◽

10.3390/md11093500 ◽

2013 ◽

Vol 11 (9) ◽

pp. 3500-3516 ◽

Cited By ~ 35

Author(s):

Georgios Kallifatidis ◽

Dominic Hoepfner ◽

Tiphaine Jaeg ◽

Esther Guzmán ◽

Amy Wright

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Natural Product ◽

Marine Natural Product ◽

Manzamine A ◽

Pancreatic Cancer Cells ◽

Vacuolar Atpases

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Abstract A39: The marine natural product manzamine A targets vacuolar ATPases and autophagy in pancreatic cancer cells.

10.1158/1538-7445.panca2012-a39 ◽

2012 ◽

Author(s):

Georgios Kallifatidis ◽

Dominic Hoepfner ◽

Sven Schuierer ◽

Nicole Hartmann ◽

Esther Guzmán ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Natural Product ◽

Marine Natural Product ◽

Manzamine A ◽

Pancreatic Cancer Cells ◽

Vacuolar Atpases

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Correction: Kallifatidis, G. et al. The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells. Mar. Drugs 2013, 11, 3500–3516

Marine Drugs ◽

10.3390/md12042305 ◽

2014 ◽

Vol 12 (4) ◽

pp. 2305-2307 ◽

Cited By ~ 1

Author(s):

Georgios Kallifatidis ◽

Dominic Hoepfner ◽

Tiphaine Jaeg ◽

Esther Guzmán ◽

Amy Wright

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Natural Product ◽

Marine Natural Product ◽

Manzamine A ◽

Pancreatic Cancer Cells ◽

Vacuolar Atpases

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The marine natural product microsclerodermin A is a novel inhibitor of the nuclear factor kappa B and induces apoptosis in pancreatic cancer cells

Investigational New Drugs ◽

10.1007/s10637-014-0185-3 ◽

2014 ◽

Vol 33 (1) ◽

pp. 86-94 ◽

Cited By ~ 19

Author(s):

Esther A. Guzmán ◽

Kelly Maers ◽

Jill Roberts ◽

Hilaire V. Kemami-Wangun ◽

Dedra Harmody ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Natural Product ◽

Nuclear Factor Kappa B ◽

Marine Natural Product ◽

Nuclear Factor ◽

Nuclear Factor Kappa ◽

Pancreatic Cancer Cells

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Farnesyl Pyrophosphate Synthase as a Target for Drug Development: Discovery of Natural-Product-Derived Inhibitors and Their Activity in Pancreatic Cancer Cells

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.9b01405 ◽

2019 ◽

Vol 62 (23) ◽

pp. 10867-10896

Author(s):

Shuai Han ◽

Xin Li ◽

Yun Xia ◽

Zhengsen Yu ◽

Ningning Cai ◽

...

Keyword(s):

Pancreatic Cancer ◽

Drug Development ◽

Cancer Cells ◽

Natural Product ◽

Farnesyl Pyrophosphate ◽

Farnesyl Pyrophosphate Synthase ◽

Pancreatic Cancer Cells

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A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis

Investigational New Drugs ◽

10.1007/s10637-010-9422-6 ◽

2010 ◽

Vol 29 (5) ◽

pp. 777-785 ◽

Cited By ~ 24

Author(s):

Esther A. Guzmán ◽

Jacob D. Johnson ◽

Patricia A. Linley ◽

Sarath E. Gunasekera ◽

Amy E. Wright

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Metastatic Potential ◽

Manzamine A ◽

Pancreatic Cancer Cells ◽

Induced Apoptosis

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From a Natural Product Lead to the Identification of Potent and Selective Benzofuran-3-yl-(indol-3-yl)maleimides as Glycogen Synthase Kinase 3β Inhibitors That Suppress Proliferation and Survival of Pancreatic Cancer Cells

Journal of Medicinal Chemistry ◽

10.1021/jm801317h ◽

2009 ◽

Vol 52 (7) ◽

pp. 1853-1863 ◽

Cited By ~ 74

Author(s):

Irina N. Gaisina ◽

Franck Gallier ◽

Andrei V. Ougolkov ◽

Ki H. Kim ◽

Toru Kurome ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Natural Product ◽

Glycogen Synthase ◽

Glycogen Synthase Kinase ◽

Glycogen Synthase Kinase 3Β ◽

Pancreatic Cancer Cells

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Sa1785 Synthetic Prenylflavonoid Natural Product Panduratin a Possesses Cytotoxic Activities Against Pancreatic Cancer Cells and Inhibits Cysteine Cathepsin Proteases In Vitro

Gastroenterology ◽

10.1016/s0016-5085(12)61222-0 ◽

2012 ◽

Vol 142 (5) ◽

pp. S-325

Author(s):

Benjamin Fox ◽

Ishita D. Majumdar ◽

Arvind Devanabanda ◽

Huan Cong ◽

John A. Porco ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Natural Product ◽

Cytotoxic Activities ◽

Pancreatic Cancer Cells ◽

Cathepsin Proteases ◽

Cysteine Cathepsin ◽

Panduratin A

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Synergistic effects of retrovirus IFN-α gene transfer and gemcitabine on apoptosis of pancreatic cancer cells

Gastroenterology ◽

10.1016/s0016-5085(01)83058-4 ◽

2001 ◽

Vol 120 (5) ◽

pp. A615-A615

Author(s):

M GORSCHLUETER ◽

B SCHOETTKER ◽

A MAERTEN ◽

C ZISKE

Keyword(s):

Pancreatic Cancer ◽

Gene Transfer ◽

Cancer Cells ◽

Synergistic Effects ◽

Pancreatic Cancer Cells

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Standardized herbal extracts of Japanese Kampo medicine and their effects on human and murine pancreatic cancer cells

10.1055/s-0039-3399710 ◽

2019 ◽

Author(s):

K Kuchta ◽

K Weimer ◽

L Frank ◽

H Rausch ◽

V Ellenrieder ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Kampo Medicine ◽

Herbal Extracts ◽

Pancreatic Cancer Cells

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IKK1 promotes G1 phase progression of pancreatic cancer cells by the transcriptional regulation of the F-box protein skp2

Zeitschrift für Gastroenterologie ◽

10.1055/s-2005-920118 ◽

2005 ◽

Vol 43 (05) ◽

Author(s):

G Schneider ◽

D Saur ◽

J Siveke ◽

R Fritsch ◽

RM Schmid

Keyword(s):

Pancreatic Cancer ◽

Transcriptional Regulation ◽

Cancer Cells ◽

G1 Phase ◽

Pancreatic Cancer Cells ◽

Phase Progression ◽

F Box Protein

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