scholarly journals Structural Characterization and Anti-HSV-1 and HSV-2 Activity of Glycolipids from the Marine Algae Osmundaria obtusiloba Isolated from Southeastern Brazilian Coast

Marine Drugs ◽  
2012 ◽  
Vol 10 (12) ◽  
pp. 918-931 ◽  
Author(s):  
Lauro M. de Souza ◽  
Guilherme L. Sassaki ◽  
Maria Teresa Villela Romanos ◽  
Eliana Barreto-Bergter
Keyword(s):  
Structural Characterization ◽  
Marine Algae ◽  
Brazilian Coast ◽  
Hsv 1

Sulfated polysaccharide fraction from marine algae Solieria filiformis : Structural characterization, gastroprotective and antioxidant effects

2016 ◽  
Vol 152 ◽  
pp. 140-148 ◽  
Author(s):  
Willer M. Sousa ◽  
Renan O. Silva ◽  
Francisco F. Bezerra ◽  
Rudy D. Bingana ◽  
Francisco Clark N. Barros ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Marine Algae ◽  
Sulfated Polysaccharide ◽  
Polysaccharide Fraction ◽  
Antioxidant Effects ◽  
Solieria Filiformis

The influence of environmental features in the content of mycosporine-like amino acids in red marine algae along the Brazilian coast

2018 ◽  
Vol 54 (3) ◽  
pp. 380-390 ◽  
Author(s):  
Bruno Briani ◽  
Marina N. Sissini ◽  
Leidson A. Lucena ◽  
Manuela B. Batista ◽  
Iara O. Costa ◽  
...  
Keyword(s):  
Amino Acids ◽  
Marine Algae ◽  
Brazilian Coast ◽  
Environmental Features

scholarly journals Structural characterization and Biological Activity of Sulfolipids from selected Marine Algae

2013 ◽  
Vol 64 (5) ◽  
pp. 561-571 ◽  
Author(s):  
H. H. Abd El Baky ◽  
F. K. El Baz ◽  
G. S. El Baroty ◽  
O. I. Abd El-Salam ◽  
E. A. Ibrahim
Keyword(s):  
Biological Activity ◽  
Structural Characterization ◽  
Marine Algae

scholarly journals Inhibition of Zika Virus by Marine Algae

2017 ◽  
Author(s):  
Claudio Cirne-Santos ◽  
Caroline De Souza Barros ◽  
Caio Cesar Richter Nogueira ◽  
Renata Mendonça Campos ◽  
Valéria Teixeira ◽  
...  
Keyword(s):  
Zika Virus ◽  
Marine Algae ◽  
Kappaphycus Alvarezii ◽  
Strong Association ◽  
Public Health Problem ◽  
Brazilian Coast ◽  
Dependent Manner ◽  
Sulphated Polysaccharides ◽  
Low Concentrations ◽  
Dose Dependent

For many years marine algae has been subject of numerous researches and as a source of natural products with antiviral activity, such as terpenes, alkaloids and sulphated polysaccharides. However, the anti-Zika virus (ZIKV) potential of algae has not been studied. In this study we evaluated extracts seven species of the three major classes of seaweeds (Phaeophyceae, Chlorophyceae and Rhodophyceae) against ZIKV. All seaweeds tested are native of the Brazilian coast, except for Kappaphycus alvarezii that can be cultivated. ZIKV a mosquito-borne flavivirus, has become a public health problem. In recent years there has been an increase in the number of cases and a strong association between ZIKV outbreak and the spread of cases of Guillain-Barré Syndrome and microcephaly. All seaweed extracts tested in this work inhibits ZIKV replication in a dose-dependent manner. Caulerpa racemosa, Kappaphycus alvarezii and Osmundaria obtusiloba extracts were able to inhibit viral replication at low concentrations with EC50 values ranging from 1.38 to 1.98 µg/mL. We observed that O. obtusiloba presented a significant virucidal effect. Our results suggest that extracts of C. racemosa, K. alvarezii and O. obtusiloba presented very promising results, being excellent candidates for further studies, demonstrating that marine algae are an interesting source for the development of novel anti-ZIKV agents.

scholarly journals Benthic marine algae from the insular areas of Paraná, Brazil: new database to support the conservation of marine ecosystems

2014 ◽  
Vol 14 (2) ◽  
Author(s):  
Franciane Maria Pellizzari ◽  
Juliane Bernardi ◽  
Elzi Manoelle Silva ◽  
Michelle Cristine Silva ◽  
Nair S. Yokoya
Keyword(s):  
Urban Area ◽  
Marine Algae ◽  
New Records ◽  
Brazilian Coast ◽  
Sampling Station ◽  
Rocky Shores ◽  
Area Of Interest ◽  
Spatial Differences ◽  
Monitoring Of Biodiversity ◽  
High Concentrations

This study describes the diversity of benthic marine algae from insular areas of the southern Brazilian coast. Algal samples were collected between 2006 and 2010 during the winter and the summer seasons at three sites in the coastal waters of Paraná, Brazil: Ilha do Mel, Currais Archipelago and Ilha do Farol. The samples were collected along parallel transects on the coast. In this survey, Paraná marine phycoflora comprised 139 taxa (90 Rhodophyta, 27 Chlorophyta and 22 Phaeophyceae). Fifty-two species represent new records for the state, and 14 taxa are present at all sampling sites and in both seasons. Higher diversities of rhodophytes and chlorophytes were observed at Ilha do Mel, while phaeophytes were more diverse at Currais Archipelago. Lower algal diversity was observed at Ilha do Farol, a sampling station which is near an urban area. Ceramiaceae, Rhodomelaceae and Corallinaceae were dominant among Rhodophyta, Cladophoraceae and Ulvaceae among Chlorophyta, and Dictyotaceae and Sargassaceae among Phaeophyceae. Seasonal and spatial differences in species composition could be explained by the availability of consolidated substrate, water transparency and proximity to an urban area. Seaweed biodiversity from the Paraná coast also presents low species richness compared to other Brazilian states as a result of the shorter coastline, lower availability of rocky shores, and the location between estuarine systems (Paranaguá and Guaratuba Bays). These bays input a large amount of continental water, resulting in decreased salinity, high concentrations of suspended particulate matter and low transparency in the water column. Knowledge of seaweed diversity is essential for conservation studies. In addition, environmental monitoring programs undertaken during medium- to long-term seasonal changes could be improved to reflect changes detected through new records, the introduction of alien species in the area of interest, or even dominance of opportunistic species over other taxa. Therefore, a database able to support the monitoring of biodiversity is a fundamental step in detecting environmental impacts that could change seaweed biogeography, mainly in urbanized and harbor areas.

scholarly journals Biological activities of marine invertebrates extracts from the northeast brazilian coast

2020 ◽  
Vol 80 (2) ◽  
pp. 393-404 ◽  
Author(s):  
C. Lhullier ◽  
M. I. G. Moritz ◽  
E. O. Tabalipa ◽  
F. N. Sardá ◽  
N. F. Z. Schneider ◽  
...  
Keyword(s):  
Biological Activities ◽  
Ethanolic Extract ◽  
Marine Sponges ◽  
Diffusion Method ◽  
Brazilian Coast ◽  
Isolation And Identification ◽  
Disk Diffusion Method ◽  
Antiproliferative Effects ◽  
Ethanolic Extracts ◽  
Hsv 1

Abstract This paper reports the in vitro antiproliferative effects, antiprotozoal, anti-herpes and antimicrobial activities of 32 organic extracts of 14 marine sponges and 14 corals collected in northeast Brazilian coast. The ethanolic extracts of the sponges Amphimedon compressa and Tedania ignis, and the acetone extract of Dysidea sp. showed relevant results concerning the antiproliferative effects against A549, HCT-8, and PC-3 cell lines by sulforhodamine B assay, but also low specificity. Concerning the antiprotozoal screening, the ethanolic extract of Amphimedon compressa and the acetone and ethanolic extracts of Dysidea sp. were the most active against Leishmania amazonensis and Trypanosoma cruzi expressing β-galactosidase in THP-1 cells. In the preliminary anti-HSV-1 (KOS strain) screening, the ethanolic extracts of the sponges Amphimedon compressa, Haliclona sp. and Chondrosia collectrix inhibited viral replication by more than 50%. The most promising anti-herpes results were observed for the ethanolic extract of Haliclona sp. showing high selective indices against HSV-1, KOS and 29R strains (SI> 50 and >79, respectively), and HSV-2, 333 strain (IS>108). The results of the antibacterial screening indicated that only the ethanolic extract of Amphimedon compressa exhibited a weak activity against Enterococcus faecalis, Pseudomonas aeruginosa and Escherichia coli by the disk diffusion method. In view of these results, the extracts of Amphimedon compressa, Tedania ignis and Dysidea sp. were selected for further studies aiming the isolation and identification of the bioactive compounds with antiproliferative and/or antiprotozoal activities. The relevant anti-herpes activity of the ethanolic extract of Haliclona sp. also deserves special attention, and will be further investigated.

Biotechnological potential of benthic marine algae collected along the Brazilian coast

2018 ◽  
Vol 33 ◽  
pp. 316-327 ◽  
Author(s):  
Aline P. Martins ◽  
Leonardo Zambotti-Villela ◽  
Nair S. Yokoya ◽  
Pio Colepicolo
Keyword(s):  
Marine Algae ◽  
Brazilian Coast ◽  
Biotechnological Potential

Assembly of VP26 in herpes simplex virus-1 capsid implicated by 3-D structure of recombinant capsid

1995 ◽  
Vol 53 ◽  
pp. 840-841
Author(s):  
Z. Hong Zhou ◽  
Jing He ◽  
Joanita Jakana ◽  
J. D. Tatman ◽  
Frazer J. Rixon ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
3D Structure ◽  
Structure Study ◽  
Herpes Simplex Virus 1 ◽  
Shell Proteins ◽  
Life Threatening ◽  
Infected Cells ◽  
Simplex Virus ◽  
Hsv 1

Herpes simplex virus-1 (HSV-1) is a ubiquitous virus which is implicated in diseases ranging from self-curing cold sores to life-threatening infections. The 2500 Å diameter herpes virion is composed of a glycoprotein spike containing, lipid envelope, enclosing a protein layer (the tegument) in which is embedded the capsid (which contains the dsDNA genome). The B-, and A- and C-capsids, representing different morphogenetic stages in HSV-1 infected cells, are composed of 7, and 5 structural proteins respectively. The three capsid types are organized in similar T=16 icosahedral shells with 12 pentons, 150 hexons, and 320 connecting triplexes. Our previous 3D structure study at 26 Å revealed domain features of all these structural components and suggested probable locations for the outer shell proteins, VP5, VP26, VP19c and VP23. VP5 makes up most of both pentons and hexons. VP26 appeared to bind to the VP5 subunit in hexon but not to that in penton.

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