scholarly journals Marine Bioactives: Pharmacological Properties and Potential Applications against Inflammatory Diseases

Marine Drugs ◽  
2012 ◽  
Vol 10 (12) ◽  
pp. 812-833 ◽  
Author(s):  
Nicolantonio D’Orazio ◽  
Maria Alessandra Gammone ◽  
Eugenio Gemello ◽  
Massimo De Girolamo ◽  
Salvatore Cusenza ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Pharmacological Properties ◽  
Potential Applications ◽  
Marine Bioactives

An Overview of the Pharmacological Properties and Potential Applications of Lavender and Cumin

2020 ◽  
pp. 83-115
Author(s):  
Muneeb U Rehman ◽  
Sheikh Bilal Ahmad ◽  
Aazima Shah ◽  
Bismah Kashani ◽  
Anas Ahmad ◽  
...  
Keyword(s):  
Pharmacological Properties ◽  
Potential Applications

scholarly journals Σύνθεση και μελέτη αναστολέων λιπολυτικών ενζύμων

2016 ◽  
Author(s):  
Αικατερίνη Νικολάου
Keyword(s):  
Fatty Acids ◽  
Lysophosphatidic Acid ◽  
Inhibitory Activity ◽  
Functional Group ◽  
Inflammatory Diseases ◽  
Hydroxamic Acids ◽  
Pharmacological Properties ◽  
Ester Bond ◽  
Phospholipases A2 ◽  
Inflammatory Conditions

Phospholipases A2 (PLA2) are enzymes that hydrolyze the sn-2 ester bond of phospholipids releasing free fatty acids and lysophospholipids. Among them, arachidonic acid can be converted into a variety of eicosanoids by metabolic enzymes, while lysophosphatidylcholine (LPC), the most abundant lysophospholipid in plasma and tissues, can be converted into lysophosphatidic acid (LPA) by a secreted enzyme that exhibits lysophospholipase D activity, known as autotaxin (ATX). Both enzymes are involved in inflammatory conditions and, as a consequence, constitute attractive targets for the development of novel agents for the treatment of inflammatory diseases. Due to the fact that molecules which bear the 2-oxoamide functional group and long aliphatic chains exhibit inhibitory activity against cytosolic GIVA cPLA2, 2-oxoamideswith reduced lipophilicity were designed and synthesized. Taking into consideration that in recent years hydroxamic acids have attracted considerable attention due to their pharmacological properties, hydroxamic acids and derivatives there of were designed and synthesized, so as to evaluate their inhibitory activity against ATX.

Updates and advances on pharmacological properties of Taraxacum mongolicum Hand.-Mazz and its potential applications

2021 ◽  
pp. 131380
Author(s):  
Yan Zhang ◽  
Ying-Fan Hu ◽  
Wei Li ◽  
Guang-Ya Xu ◽  
Kun-Rong Wang ◽  
...  
Keyword(s):  
Pharmacological Properties ◽  
Potential Applications

scholarly journals Potential Applications of PET/CT/MR Imaging in Inflammatory Diseases

PET Clinics ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. 547-558
Author(s):  
Sanaz Katal ◽  
Ali Gholamrezanezhad ◽  
Moozhan Nikpanah ◽  
Thomas Q. Christensen ◽  
Thomas J. Werner ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Inflammatory Diseases ◽  
Pet Ct ◽  
Potential Applications

Prostatic bioregulatory polypeptide prostatilen: pharmacological properties and 30-year experience of clinical application in urology

2020 ◽  
Vol 10 (3) ◽  
pp. 243-258
Author(s):  
Igor V. Kuzmin ◽  
Sergey Yu. Borovets ◽  
Anatoliy G. Gorbachev ◽  
Salman Kh. Al-Shukri
Keyword(s):  
Clinical Application ◽  
Chronic Prostatitis ◽  
Inflammatory Diseases ◽  
Experimental Studies ◽  
Prostatic Hyperplasia ◽  
Pharmacological Properties ◽  
Therapeutic Action ◽  
High Biological Activity ◽  
Saint Petersburg ◽  
Medical University

The review summarizes the results of 30-year clinical application of the prostatic bioregulatory peptide Prostatilen. The data from experimental studies, testifying for the high biological activity of the drug is shown, the mechanisms of its therapeutic action are described. The review presents the results of clinical studies demonstrating the effectiveness and pathogenetic justification of the prescription of Prostatilen in the treatment of chronic prostatitis, benign prostatic hyperplasia, infectious and inflammatory diseases of the kidneys and urinary bladder, as well as of several other diseases. The experience of Prostatilen application in the urological clinic of First Pavlov Saint Petersburg State Medical University is shown.

Major Techniques of Biotechnology

1998 ◽  
Vol 11 (1) ◽  
pp. 28-37
Author(s):  
Joseph A. Tami
Keyword(s):  
Messenger Rna ◽  
Recombinant Dna ◽  
Inflammatory Diseases ◽  
Diagnostic Testing ◽  
Yeast Cells ◽  
Recombinant Dna Technology ◽  
Potential Applications ◽  
Foreign Dna ◽  
Immuno Globulins ◽  
And Function

Since the discovery of the structure and function of DNA over 40 years ago, the established knowledge of molecular biology has increased dramatically, and many new tools have been discovered and utilized by scientists to develop new therapeutic agents. Important tools that are used in recombinant DNA technology include restriction endonucleases (cleave DNA), DNA ligase (link DNA molecules together), and cloning vectors (place foreign DNA into an organism such as bacterial or yeast cells in order to mass produce the protein encoded by that foreign DNA). The development of hybridoma technology provided a method to produce virtually unlimited quantities of pure antibody with a single specificity. These immuno-globulins are known as monoclonal antibodies, and have provided both therapeutic and diagnostic agents. Antisense molecules are oligonucleotides which bind to the messenger RNA (mRNA) of a target gene and selectively inhibit the production of specific proteins. Potential applications for these molecules include cancer and viral and inflammatory diseases. The more recent development of the polymerase chain reaction (PCR) has provided a tool that has revolutionized diagnostic testing in diverse areas such as infectious diseases, genetic abnormalities, and cancer.

A Focus on Phytochemical and Pharmacological Profile of Prunus lycioides (=Amygdalus lycioides)

2020 ◽  
Vol 20 ◽  
Author(s):  
Valeria Cavalloro ◽  
Francesco Bracco ◽  
Simona Collina ◽  
Emanuela Martino
Keyword(s):  
Soil Erosion ◽  
Endemic Species ◽  
Inflammatory Diseases ◽  
Antioxidant Properties ◽  
Oil Extraction ◽  
Native People ◽  
Pharmacological Properties ◽  
Pharmacological Profile ◽  
Domestic Species ◽  
Microbial Infections

: Prunus lycioides (Spach) C.K. Schneid. (= Amygdalus lycioides Spach.), popularly recognized as “Badam Talkh kuhi”, is an endemic species of Iran. It is widely distributed in Central and West Asia, where it plays a role in preventing and controlling soil erosion. Although domestic species of Prunus genus are well known and widely used in food, pharmaceutical, and cosmetic industries, poor information about wild species is available so far. As far as Prunus lycioides, it is commonly used by native people in traditional medicine for treating diabetes, inflammatory diseases, and microbial infections. The wild almonds are traditionally exploited for oil extraction, due to their antioxidant properties. This review summarizes advances in the studies regarding of Prunus lycioides and its pharmacological properties. The aim of the review is to renew the interest in this promising plant, thus stimulating researchers to go further with the study for discovering new bioactive compounds.

An Overview of the Pharmacological Properties and Potential Applications of Natural Monoterpenes

2015 ◽  
Vol 14 (14) ◽  
pp. 1156-1168 ◽  
Author(s):  
Agata Koziol ◽  
Agnieszka Stryjewska ◽  
Tadeusz Librowski ◽  
Kinga Salat ◽  
Magdalena Gawel ◽  
...  
Keyword(s):  
Pharmacological Properties ◽  
Potential Applications
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