scholarly journals A Lactose-Binding Lectin from the Marine Sponge Cinachyrella Apion (Cal) Induces Cell Death in Human Cervical Adenocarcinoma Cells

Marine Drugs ◽  
2012 ◽  
Vol 10 (12) ◽  
pp. 727-743 ◽  
Author(s):  
Luciana Rabelo ◽  
Norberto Monteiro ◽  
Raphael Serquiz ◽  
Paula Santos ◽  
Ruth Oliveira ◽  
...  
Keyword(s):  
Cell Death ◽  
Marine Sponge ◽  
Cervical Adenocarcinoma ◽  
Adenocarcinoma Cells ◽  
Binding Lectin

scholarly journals Apoptosis Induction of Agave lechuguilla Torrey Extract on Human Lung Adenocarcinoma Cells (SK-LU-1)

2018 ◽  
Vol 19 (12) ◽  
pp. 3765 ◽  
Author(s):  
Luis Anguiano-Sevilla ◽  
Eugenia Lugo-Cervantes ◽  
Cynthia Ordaz-Pichardo ◽  
Jorge Rosas-Trigueros ◽  
María Jaramillo-Flores
Keyword(s):  
Cell Death ◽  
Caspase 3 ◽  
Ethanol Extract ◽  
Fragmentation Pattern ◽  
Intrinsic Pathway ◽  
Adenocarcinoma Cells ◽  
Human Lung Adenocarcinoma Cells ◽  
Caspase 7 ◽  
Mcf 7 ◽  
Apoptotic Signal

In this study, an ethanol extract of Agave lechuguilla was evaluated against six carcinogenic cell lines (HCT-15, MCF-7, PC-3, U-251, SK-LU-1 and K-562) with an inhibition of 75.7 ± 2.3% against the SK-LU-1 line. Based on the previous result, the extract was hydrolyzed and fractionated, to which the IC50 was determined; the cell line was more sensitive to the fractionated extract with an IC50 6.96 ± 0.15 µg/mL. Characterization by mass spectrometry showed the presence of kaempferol, quercetin and a flavonoid dimer formed by afzelechin-4β-8-quercetin, according to the generated fragmentation pattern. The fractionated extract presented cell death by apoptosis with 39.8% at 24 h. Molecular docking was performed with the molecules found to try to describe cell death by apoptosis through death receptors such as FasCD95, TNF-R1, DR4/5 and blocking signaling on the EGFR and K-Ras MAPK/ERK pathway, as well as through the intrinsic pathway activating tBID, which promotes the amplification of the apoptotic signal due to the activation of caspase-3, and consequently caspase-7. In addition to the activation of the IIb complex associated with cell death due to necroptosis.

W1954 Sulforaphane, An Antioxidant Derived from Broccoli, Induces Apoptotic Cell Death in Barrett's Esophageal Adenocarcinoma Cells

2008 ◽  
Vol 134 (4) ◽  
pp. A-741
Author(s):  
Masood A. Shammas ◽  
Christopher S. Bryant ◽  
Sanjeev Kumar ◽  
Madhu Prasad ◽  
Christopher P. Steffes ◽  
...  
Keyword(s):  
Cell Death ◽  
Esophageal Adenocarcinoma ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Adenocarcinoma Cells ◽  
Barrett’S Esophageal Adenocarcinoma

Evaluation of DNA Damage, DNA Repair, Oxidative Stress, and Cell Death Caused by Helicobacter pylori in Human Adenocarcinoma Cells

2021 ◽  
Author(s):  
DİDEM ORAL ◽  
ÜNZİLE SUR ◽  
gizem özkemahlı ◽  
Anıl Yirüna ◽  
N. DİLARA ZEYBEK ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Cell Death ◽  
Dna Repair ◽  
Helicobacter Pylori ◽  
Adenocarcinoma Cells

Knockdown of integrin β4-induced autophagic cell death associated with P53 in A549 lung adenocarcinoma cells

FEBS Journal ◽  
2008 ◽  
Vol 275 (22) ◽  
pp. 5725-5732 ◽  
Author(s):  
Qiuxia He ◽  
Bin Huang ◽  
Jing Zhao ◽  
Yun Zhang ◽  
Shangli Zhang ◽  
...  
Keyword(s):  
Cell Death ◽  
Lung Adenocarcinoma ◽  
Autophagic Cell Death ◽  
Adenocarcinoma Cells ◽  
Integrin Β4 ◽  
Lung Adenocarcinoma Cells ◽  
A549 Lung

Abstract B43: Alisertib (MLN8237), an Aurora Kinase A inhibitor, enhances Docetaxel-induced cell death in Upper Gastrointestinal Adenocarcinoma cells

2012 ◽  
Vol 18 (10 Supplement) ◽  
pp. B43-B43
Author(s):  
Vikas Sehdev ◽  
Frank Revetta ◽  
Abbes Belkhiri ◽  
Jeffrey Ecsedy ◽  
Alexander Zaika ◽  
...  
Keyword(s):  
Cell Death ◽  
Aurora Kinase ◽  
Aurora Kinase A ◽  
Adenocarcinoma Cells ◽  
Upper Gastrointestinal ◽  
Kinase A
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