scholarly journals A Chronic Oral Toxicity Study of Marine Collagen Peptides Preparation from Chum Salmon (Oncorhynchus keta) Skin Using Sprague-Dawley Rat

Marine Drugs ◽  
2011 ◽  
Vol 10 (12) ◽  
pp. 20-34 ◽  
Author(s):  
Jiang Liang ◽  
Xin-Rong Pei ◽  
Zhao-Feng Zhang ◽  
Nan Wang ◽  
Jun-Bo Wang ◽  
...  
Keyword(s):  
Chum Salmon ◽  
Toxicity Study ◽  
Oncorhynchus Keta ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Chum Salmon Oncorhynchus Keta ◽  
Collagen Peptides ◽  
Sprague Dawley Rat

scholarly journals A 13-week repeated dose oral toxicity study on a water extract of Artemisia annua in Sprague-Dawley rat

2020 ◽  
Vol 21 (1) ◽  
pp. 30-37
Author(s):  
Su-Jin Park ◽  
Seong-Hyun Ho ◽  
Seon-Hee Kim ◽  
Chanyoung Park ◽  
Eun-Young Cho ◽  
...  
Keyword(s):  
Artemisia Annua ◽  
Water Extract ◽  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rat ◽  
Dose Oral

Safety Assessment of a Hydroethanolic Extract of Caralluma fimbriata

2013 ◽  
Vol 32 (5) ◽  
pp. 385-394 ◽  
Author(s):  
Antoinette Y. Odendaal ◽  
Narendra S. Deshmukh ◽  
Tennille K. Marx ◽  
Alexander G. Schauss ◽  
John R. Endres ◽  
...  
Keyword(s):  
Developmental Toxicity ◽  
Toxicity Study ◽  
Developmental Study ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Toxicological Assessment ◽  
Sprague Dawley Rats ◽  
Chromosomal Aberration Test ◽  
Hydroethanolic Extract

This toxicological assessment evaluated the safety of a hydroethanolic extract prepared from Caralluma fimbriata (CFE), a dietary supplement marketed worldwide as an appetite suppressant. Studies included 2 in vitro genotoxicity assays, a repeated dose oral toxicity study, and a developmental study in rats. No evidence of in vitro mutagenicity or clastogenicity surfaced in the in vitro studies at concentrations up to 5000 μg of extract/plate (Ames test) or 5000 μg of extract/mL (chromosomal aberration test). No deaths or treatment-related toxicity were seen in the 6-month chronic oral toxicity study in Sprague-Dawley rats conducted at 3 doses (100, 300, and 1000 mg/kg body weight (bw)/d). The no observed effect level for CFE in this study was considered to be 1000 mg/kg bw/d. A prenatal developmental toxicity study conducted at 3 doses (250, 500, and 1000 mg/kg bw/d) in female Sprague-Dawley rats resulted in no treatment-related external, visceral, or skeletal fetal abnormalities, and no treatment-related maternal or pregnancy alterations were seen at and up to the maximum dose tested. CFE was not associated with any toxicity or adverse events.

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