scholarly journals Effects of BMP-2 Delivery in Calcium Phosphate Bone Graft Materials with Different Compositions on Bone Regeneration

Materials ◽  
2016 ◽  
Vol 9 (11) ◽  
pp. 954 ◽  
Author(s):  
Jin-Chul Park ◽  
Eun-Bin Bae ◽  
Se-Eun Kim ◽  
So-Yun Kim ◽  
Kyung-Hee Choi ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Graft ◽  
Bone Regeneration

scholarly journals Calcium Phosphate Bone Graft Substitutes with High Mechanical Load Capacity and High Degree of Interconnecting Porosity

Materials ◽  
2019 ◽  
Vol 12 (21) ◽  
pp. 3471 ◽  
Author(s):  
Hettich ◽  
Schierjott ◽  
Epple ◽  
Gbureck ◽  
Heinemann ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Graft ◽  
Bone Regeneration ◽  
Mechanical Stability ◽  
Mechanical Load ◽  
Load Capacity ◽  
Virtual Object ◽  
Acetabular Bone Defect ◽  
Scaffold Structure ◽  
Bone Graft Substitutes

Bone graft substitutes in orthopedic applications have to fulfill various demanding requirements. Most calcium phosphate (CaP) bone graft substitutes are highly porous to achieve bone regeneration, but typically lack mechanical stability. This study presents a novel approach, in which a scaffold structure with appropriate properties for bone regeneration emerges from the space between specifically shaped granules. The granule types were tetrapods (TEPO) and pyramids (PYRA), which were compared to porous CaP granules (CALC) and morselized bone chips (BC). Bulk materials of the granules were mechanically loaded with a peak pressure of 4 MP; i.e., comparable to the load occurring behind an acetabular cup. Mechanical loading reduced the volume of CALC and BC considerably (89% and 85%, respectively), indicating a collapse of the macroporous structure. Volumes of TEPO and PYRA remained almost constant (94% and 98%, respectively). After loading, the porosity was highest for BC (46%), lowest for CALC (25%) and comparable for TEPO and PYRA (37%). The pore spaces of TEPO and PYRA were highly interconnected in a way that a virtual object with a diameter of 150 µm could access 34% of the TEPO volume and 36% of the PYRA volume. This study shows that a bulk of dense CaP granules in form of tetrapods and pyramids can create a scaffold structure with load capacities suitable for the regeneration of an acetabular bone defect.

Integrating silicon/zinc dual elements with PLGA microspheres in calcium phosphate cement scaffolds synergistically enhances bone regeneration

2020 ◽  
Vol 8 (15) ◽  
pp. 3038-3049 ◽  
Author(s):  
Weiwei Liang ◽  
Min Gao ◽  
Jingsheng Lou ◽  
Yunyang Bai ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Graft ◽  
Bone Regeneration ◽  
Calcium Phosphate Cement ◽  
Bone Repair ◽  
Plga Microspheres ◽  
Bone Graft Substitutes ◽  
Osteogenic Factors

Integrating multiple pro-osteogenic factors into bone graft substitutes is a practical and effective approach to improve bone repair efficacy.

scholarly journals The Effect of Bisphasic Calcium Phosphate Block Bone Graft Materials with Polysaccharides on Bone Regeneration

Materials ◽  
2017 ◽  
Vol 10 (1) ◽  
pp. 17 ◽  
Author(s):  
Hyun-Sang Yoo ◽  
Ji-Hyeon Bae ◽  
Se-Eun Kim ◽  
Eun-Bin Bae ◽  
So-Yeun Kim ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Graft ◽  
Bone Regeneration ◽  
Block Bone Graft

Application of BMP-2 for bone graft in Dentistry

RSBO ◽  
2016 ◽  
Vol 12 (1) ◽  
pp. 88
Author(s):  
Lídia Audrey Rocha Valadas Marques ◽  
Edvan Alves da Costa Júnior ◽  
Mara Assef Leitão Lotif ◽  
Edilson Martins Rodrigues Neto ◽  
Francisco Filipe Carvalho da Silva ◽  
...  
Keyword(s):  
Life Expectancy ◽  
Bone Graft ◽  
Bone Regeneration ◽  
Tooth Loss ◽  
Clinical Use ◽  
Increase Life Expectancy ◽  
Bone Replacement ◽  
Morphogenetic Protein ◽  
The Face ◽  
Global Increase

Introduction: The global increase life expectancy and the resulting tooth loss has required searching for new rehabilitation alternatives in Dentistry. Biomaterials can be defined as any material that acts replacing a lost bone defect and its function. In Dentistry, many studies have aimed to improve bone regeneration through the use of BMPs for bone replacement. Objective: To review the literature on the use and clinical viability of human morphogenetic protein for the jaws reconstruction. Material and methods: The following databases were searched: Pubmed, Bireme, Lilacs, and Scielo and 30 articles published between 1965 and 2013 were found using the following descriptors: “dental implants”, “maxillary sinus”, and “biocompatible materials”. Results: Several studies demonstrate the biological advantages of rhBMP-2 on bone regeneration of the jaws. In recent years, morphogenetic protein has presented a large clinical use. Conclusion: Despite being a high-cost biomaterial, rhBMP-2 is a viable and very effective alternative for reconstruction of defects of the face.

Direct 3D Printing of Seashell Precursor toward Engineering a Multiphasic Calcium Phosphate Bone Graft

2021 ◽  
Author(s):  
Prabhash Dadhich ◽  
Pavan Kumar Srivas ◽  
Bodhisatwa Das ◽  
Pallabi Pal ◽  
Joy Dutta ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
3D Printing ◽  
Bone Graft
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