scholarly journals Impact of Particle Size of Ceramic Granule Blends on Mechanical Strength and Porosity of 3D Printed Scaffolds

Materials ◽  
2015 ◽  
Vol 8 (8) ◽  
pp. 4720-4732 ◽  
Author(s):  
Sebastian Spath ◽  
Philipp Drescher ◽  
Hermann Seitz
Keyword(s):  
Particle Size ◽  
Mechanical Strength ◽  
3D Printed

scholarly journals 3D Printing of Drug Nanocrystals for Film Formulations

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3941
Author(s):  
Giorgia Germini ◽  
Leena Peltonen
Keyword(s):  
Particle Size ◽  
3D Printing ◽  
Polymer Films ◽  
Film Studies ◽  
Polymer Concentration ◽  
Physicochemical Characterization ◽  
Methyl Cellulose ◽  
Polymeric Film ◽  
Content Uniformity ◽  
3D Printed

The aim of the study was to prepare indomethacin nanocrystal-loaded, 3D-printed, fast-dissolving oral polymeric film formulations. Nanocrystals were produced by the wet pearl milling technique, and 3D printing was performed by the semi-solid extrusion method. Hydroxypropyl methyl cellulose (HPMC) was the film-forming polymer, and glycerol the plasticizer. In-depth physicochemical characterization was made, including solid-state determination, particle size and size deviation analysis, film appearance evaluation, determination of weight variation, thickness, folding endurance, drug content uniformity, and disintegration time, and drug release testing. In drug nanocrystal studies, three different stabilizers were tested. Poloxamer F68 produced the smallest and most homogeneous particles, with particle size values of 230 nm and PI values below 0.20, and was selected as a stabilizer for the drug-loaded film studies. In printing studies, the polymer concentration was first optimized with drug-free formulations. The best mechanical film properties were achieved for the films with HPMC concentrations of 2.85% (w/w) and 3.5% (w/w), and these two HPMC levels were selected for further drug-loaded film studies. Besides, in the drug-loaded film printing studies, three different drug levels were tested. With the optimum concentration, films were flexible and homogeneous, disintegrated in 1 to 2.5 min, and released the drug in 2–3 min. Drug nanocrystals remained in the nano size range in the polymer films, particle sizes being in all film formulations from 300 to 500 nm. When the 3D-printed polymer films were compared to traditional film-casted polymer films, the physicochemical behavior and pharmaceutical performance of the films were very similar. As a conclusion, 3D printing of drug nanocrystals in oral polymeric film formulations is a very promising option for the production of immediate-release improved- solubility formulations.

Developments in the Field of Rapid Prototype Production

2008 ◽  
Vol 589 ◽  
pp. 421-425 ◽  
Author(s):  
Norbert Krisztián Kovács ◽  
József Gábor Kovács
Keyword(s):  
Mechanical Strength ◽  
Porous Structure ◽  
Epoxy Resin ◽  
Rapid Prototype ◽  
Post Treatment ◽  
3D Printer ◽  
Infiltration Depth ◽  
3D Printed ◽  
The Common ◽  
Polymer Engineering

Characteristics of 3D printed specimens are porous structure and low mechanical strength. Due to porous structure post treatment is possible, and in most cases infiltration with an epoxy resin, wax or cyanoacrylate material takes place. As a result of post treatment, the mechanical strength can be increased by 100%, although this is strongly influenced by the infiltration depth that depends on the porous structure and the resin viscosity. In the framework of the common research of the Department of Polymer Engineering, BME and Varinex Zrt. the applicability of a 3D printer is examined in the field of direct tool making. As the first step, the resin uptake ability of specimens prepared with a Z810 3D printer is examined.

scholarly journals Suture Fiber Reinforcement of a 3D Printed Gelatin Scaffold for Its Potential Application in Soft Tissue Engineering

2021 ◽  
Vol 22 (21) ◽  
pp. 11600
Author(s):  
Dong Jin Choi ◽  
Kyoung Choi ◽  
Sang Jun Park ◽  
Young-Jin Kim ◽  
Seok Chung ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Mechanical Strength ◽  
Physical Properties ◽  
Dimensional Stability ◽  
3D Structure ◽  
Biological Properties ◽  
Dermal Fibroblasts ◽  
3D Scaffolds ◽  
3D Printed

Gelatin has excellent biological properties, but its poor physical properties are a major obstacle to its use as a biomaterial ink. These disadvantages not only worsen the printability of gelatin biomaterial ink, but also reduce the dimensional stability of its 3D scaffolds and limit its application in the tissue engineering field. Herein, biodegradable suture fibers were added into a gelatin biomaterial ink to improve the printability, mechanical strength, and dimensional stability of the 3D printed scaffolds. The suture fiber reinforced gelatin 3D scaffolds were fabricated using the thermo-responsive properties of gelatin under optimized 3D printing conditions (−10 °C cryogenic plate, 40–80 kPa pneumatic pressure, and 9 mm/s printing speed), and were crosslinked using EDC/NHS to maintain their 3D structures. Scanning electron microscopy images revealed that the morphologies of the 3D printed scaffolds maintained their 3D structure after crosslinking. The addition of 0.5% (w/v) of suture fibers increased the printing accuracy of the 3D printed scaffolds to 97%. The suture fibers also increased the mechanical strength of the 3D printed scaffolds by up to 6-fold, and the degradation rate could be controlled by the suture fiber content. In in vitro cell studies, DNA assay results showed that human dermal fibroblasts’ proliferation rate of a 3D printed scaffold containing 0.5% suture fiber was 10% higher than that of a 3D printed scaffold without suture fibers after 14 days of culture. Interestingly, the supplement of suture fibers into gelatin biomaterial ink was able to minimize the cell-mediated contraction of the cell cultured 3D scaffolds over the cell culture period. These results show that advanced biomaterial inks can be developed by supplementing biodegradable fibers to improve the poor physical properties of natural polymer-based biomaterial inks.

Numerical analysis of mechanical properties of 3D printed aluminium components with variable core infill values

2020 ◽  
Vol 1 (103) ◽  
pp. 16-24
Author(s):  
P. Baras ◽  
J. Sawicki
Keyword(s):  
Numerical Analysis ◽  
Mechanical Strength ◽  
Reference Model ◽  
Reaction Force ◽  
Solid Material ◽  
Solid Core ◽  
Compression Tests ◽  
Element Analysis ◽  
Static Compression ◽  
3D Printed

Purpose: The purpose of this paper is to present numerical modelling results for 3D-printed aluminium components with different variable core infill values. Information published in this paper will guide engineers when designing the components with core infill regions. Design/methodology/approach: During this study 3 different core types (Gyroid, Schwarz P and Schwarz D) and different combinations of their parameters were examined numerically, using FEM by means of the software ANSYS Workbench 2019 R2. Influence of core type as well as its parameters on 3D printed components strength was studied. The “best” core type with the “best” combination of parameters was chosen. Findings: Results obtained from the numerical static compression tests distinctly showed that component strength is highly influenced by the type infill choice selected. Specifically, infill parameters and the coefficient (force reaction/volumetric percentage solid material) were investigated. Resulting total reaction force and percentage of solid material in the component were compared to the fully solid reference model. Research limitations/implications: Based on the Finite Element Analysis carried out in this work, it was found that results highlighted the optimal infill condition defined as the lowest amount of material theoretically used, whilst assuring sufficient mechanical strength. The best results were obtained by Schwarz D core type samples. Practical implications: In the case of the aviation or automotive industry, very high strength of manufactured elements along with a simultaneous reduction of their wight is extremely important. As the viability of additively manufactured parts continues to increase, traditionally manufactured components are continually being replaced with 3D-printed components. The parts produced by additive manufacturing do not have the solid core, they are rather filled with specific geometrical patterns. The reason of such operation is to save the material and, in this way, also weight. Originality/value: The conducted numerical analysis allowed to determine the most favourable parameters for optimal core infill configurations for aluminium 3D printed parts, taking into account the lowest amount of material theoretically used, whilst assuring sufficient mechanical strength.

Effects of post-curing conditions on mechanical properties of 3D printed clear dental aligners

2020 ◽  
Vol 26 (8) ◽  
pp. 1337-1344 ◽  
Author(s):  
Prashant Jindal ◽  
Mamta Juneja ◽  
Divya Bajaj ◽  
Francesco Luke Siena ◽  
Philip Breedon
Keyword(s):  
Mechanical Properties ◽  
3D Printing ◽  
Mechanical Strength ◽  
Financial Burden ◽  
Experimental Studies ◽  
Cost Savings ◽  
Time Duration ◽  
Content Type ◽  
Curing Conditions ◽  
3D Printed

Purpose 3D printing techniques have been widely used for manufacturing complex parts for various dental applications. For achieving suitable mechanical strength, post-cure processing is necessary, where the relative time duration and temperature specification also needs to be defined. The purpose of this study/paper is to assess the effects of post curing conditions and mechanical properties of 3D printed clear dental aligners Design/methodology/approach Dental long-term clear resin material has been used for 3D printing of dental aligners using a Formlabs 3D printer for direct usage on patients. Post-curing conditions have been varied, all of which have been subjected to mechanical compression loading of 1,000 N to evaluate the curing effects on the mechanical strength of the aligners. Findings The experimental studies provide significant insight into both temperatures and time durations that could provide sufficient compressive mechanical strength to the 3D printed clear dental aligners. It was observed that uncured aligners deformed plastically with large deformations under the loading conditions, whereas aligners cured between 400°C–800°C for 15–20 min deformed elastically before fragmenting into pieces after safely sustaining higher compressive loads between 495 N and 666 N. The compressive modulus ratio for cured aligners ranged between 4.46 and 5.90 as compared to uncured aligners. For shorter cure time durations and lower temperature conditions, an appropriate elevated compressive strength was also achieved. Originality/value Based on initial assessments by dental surgeons, suitable customised clear aligners can be designed, printed and cured to the desired levels based on patient’s requirements. This could result in time, energy and unit production cost savings, which ultimately would help to alleviate the financial burden placed on both the health service and their patients.

scholarly journals Patterned nanofiber air filters with high optical transparency, robust mechanical strength, and effective PM2.5 capture capability

RSC Advances ◽  
2020 ◽  
Vol 10 (34) ◽  
pp. 20155-20161 ◽  
Author(s):  
Jinshan Cao ◽  
Zhiqiang Cheng ◽  
Lijuan Kang ◽  
Meng Lin ◽  
Lihao Han
Keyword(s):  
Particle Size ◽  
Mechanical Strength ◽  
Human Health ◽  
Residence Time ◽  
Small Particle ◽  
Toxic Substances ◽  
Small Particle Size ◽  
Daily Production ◽  
Air Filters ◽  
Strong Activity

PM2.5, due to its small particle size, strong activity, ease of the attachment of toxic substances and long residence time in the atmosphere, has a great impact on human health and daily production.

MPT Influence on the Rheological Behaviour of Self-Flow Refractory Castables

2008 ◽  
Vol 587-588 ◽  
pp. 133-137 ◽  
Author(s):  
Abílio P. Silva ◽  
Ana M. Segadães ◽  
Tessaleno C. Devezas
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Mechanical Strength ◽  
Size Distribution ◽  
Fine Particles ◽  
Rheological Behaviour ◽  
Response Surfaces ◽  
Coarse Particles ◽  
Aggregate Particle ◽  
Refractory Castables

The success of a refractory castable is largely due to the quality of its properties and ease of application. Self-flow refractory castables (SFRC), with high flowability index (>130%), can be easily accommodated in a mould without the application of external energy, being ideal for the manufacture of monolithic linings. SFRC castables without cement require a matrix of very fine particles, which guarantees improved rheological behaviour and performs the role of the binder in the absence of the refractory cement. The presence of the aggregate (coarse particles) hinders the flowability index, but improves the castable mechanical strength and reduces firing shrinkage, and also contributes to the reduction of the castable costs. The control of the maximum paste thickness (MPT) allows the reduction of the coarse particles interference, minimizing the number of contact points among the grains and avoiding the formation of an aggregate skeleton that impairs the flowability of the mixture. In the present work, 100% alumina SFRCs without cement were produced with a fixed matrix of fine particles, whose particle size distribution was optimized using statistical techniques (mixtures design and triangular response surfaces). Different aggregate particle size distributions were used, with several MPT values, with the objective of evaluating which was the mean distance that maximized the flowability index, simultaneously ensuring good mechanical strength for the refractory castable. Ensuring a minimum surface area of 2.22m2/g, the mixtures reach the self-flow turning point with a minimum water content and the maximum flowability is obtained for an aggregate particle size distribution modulus of q=0.22, and consequently an optimized MPT value. SFRC with high mechanical strength (>60MPa) were obtained.

Effect of the Particle Size of the Grog on the Properties and Microstructure of Bricks

2006 ◽  
Vol 530-531 ◽  
pp. 438-443 ◽  
Author(s):  
Carlos Maurício Fontes Vieira ◽  
Sérgio Neves Monteiro
Keyword(s):  
Particle Size ◽  
Mechanical Strength ◽  
Red Ceramics

Crushed fired brick waste, known as grog, screened at two different particle size, 840 (20 mesh) and 420 μm (80 mesh), was used in mixtures with clayey body to make typical red ceramics for bricks. The effect of the grog addition up to 20 wt.% on the properties and microstructure of bricks fired at 700oC was evaluated. The results indicated that both the particle size and the amount of grog addition changed the fired properties of the clayey body. Additions above 5 wt.% of grog, with a coarser particle size, decreased the mechanical strength of both the dry body and the fired ceramic pieces. By contrast, grog with a finer particle size may be used up to 10% wt. without deteriorate the properties and corresponding microstructure of the clayey body.

scholarly journals Filtration efficiency of face masks and veils as protective measures during COVID-19 pandemic

2021 ◽  
Author(s):  
Khaled S. Al-Hadyan ◽  
◽  
Ghazi A. Alsbeih Alsbeih ◽  
Najla M. Al-Harbi ◽  
Sara S. Bin Judia ◽  
...  
Keyword(s):  
Particle Size ◽  
Control Measure ◽  
Filtration Efficiency ◽  
Experimental Conditions ◽  
Surgical Masks ◽  
Significant Difference ◽  
Comparable Performance ◽  
The Face ◽  
3D Printed ◽  
The Mean

Wearing face masks have been implemented as a public and personal health control measure against the spread of coronavirus disease (COVID-19). However, the protection level of nonmedical face masks, such as women face veils, is still uncertain. This study aimed to assess the filtration efficiency (FE; percentage of particles retained by a mask) of different types of medical masks (either as sealed or unsealed, single or doubled), non-medical masks (cloth masks) and face veils. FE of face masks was evaluated using an in-house 3D-printed air duct connected to the Aerotrak particle counter with a capability of counting particle sizes of 0.3, 0.5, 0.7, 1, 2 and 5 μm. A set of 10 earloop surgical masks,10 tie-on surgical masks, 3 triple-layers reusable cloth masks and 3 types (short, medium and long) of traditional face veils were included in the study. The unsealed surgical masks showed intermediate FE (36.54-80.58%), with no observed differences between tie-on and earloop or single and doubled masks. For each mask type, the mean FE values of sealed surgical masks (FE≥99.16%) was significantly higher (P<0.001) than the unsealed ones (FE≤80.58%). No significant difference was observed in the mean FE values between unsealed surgical masks and either cloth masks (FE=23.19-75.35%, P=0.26) or face veils (FE=19.10- 70.68%, P=0.14). However, a mockup experiment showed that wearing a surgical mask under the face veil significantly improve the FE (33.73-79.18%; P<0.001). We conclude that besides sealed surgical masks that ensure optimal filtration under the experimental conditions, the unsealed surgical and cloth masks and face veils showed comparable performance and acceptable protection at 5 μm particle size, which is the most relevant particle size associated with COVID-19 infectious droplets. Wearing a surgical mask under the face veil significantly improves the FE compared to wearing a face veil alone.

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