scholarly journals Lateral Ridge Augmentation with Guided Bone Regeneration Using Particulate Bone Substitutes and Injectable Platelet-Rich Fibrin in a Digital Workflow: 6 Month Results of a Prospective Cohort Study Based on Cone-Beam Computed Tomography Data

Materials ◽  
2021 ◽  
Vol 14 (21) ◽  
pp. 6430
Author(s):  
Maoxia Wang ◽  
Xiaoqing Zhang ◽  
Yazhen Li ◽  
Anchun Mo
Keyword(s):  
Wound Closure ◽  
Test Group ◽  
Bone Substitutes ◽  
Control Group ◽  
Hard Tissue ◽  
Digital Workflow ◽  
Platelet Rich Fibrin ◽  
Ridge Augmentation ◽  
Post Surgery ◽  
Lateral Ridge

This study aimed to test whether or not a digital workflow for GBR with particulate bone substitutes and injectable platelet-rich fibrin improved the thickness of the hard tissue compared to the conventional workflow. 26 patients in need of lateral bone augmentation were enrolled. GBR with particulate bone substitutes and injectable platelet-rich fibrin was performed in all patients. Patients were divided into two groups: control (conventional workflow; n = 14) and test (digital workflow; n = 12). CBCT scans were performed before surgery, immediately after wound closure, and 6 months post-surgery, and the labial thickness of the hard tissue (LT) was assessed at 0–5 mm apical to the implant shoulder (LT0–LT5) at each time point. A total of 26 patients were included in this study. After wound closure, the test group showed significantly greater thickness in LT0–LT2 than the control group (LT0: test: 4.31 ± 0.73 mm, control: 2.99 ± 1.02 mm; LT1: test: 4.55 ± 0.69 mm, control: 3.60 ± 0.96 mm; LT2: test: 4.76 ± 0.54 mm, control: 4.05 ± 1.01 mm; p < 0.05). At 6 months, significant differences in LT0–LT1 were detected between the groups (LT0: test: 1.88 ± 0.57 mm, control: 1.08 ± 0.60 mm; LT1: test: 2.36 ± 0.66 mm, control: 1.69 ± 0.58 mm; p < 0.05). Within the limitations of this study, the use of digital workflow in GBR with particulate bone substitutes and i-PRF exerted a positive effect on the labial thickness of hard tissue in the coronal portion of the implant after wound closure and at 6 months.

scholarly journals Efficacy of a New-generation Platelet-rich Fibrin in the Treatment of Periodontal Intrabony Defects: a Randomized Clinical Trial

2021 ◽  
Author(s):  
Boroka Klara Csifo-Nagy ◽  
Eleonora Solyom ◽  
Vera Lili Bognar ◽  
Annamaria Nevelits ◽  
Ferenc Dori
Keyword(s):  
Positive Impact ◽  
Test Group ◽  
Gingival Recession ◽  
Control Group ◽  
Intrabony Defects ◽  
Pocket Depth ◽  
Platelet Rich Fibrin ◽  
Registration Number ◽  
Enamel Matrix Derivatives ◽  
New Generation

Abstract Background: The aim of the study was to clinically evaluate the healing of intrabony defects after treatment with a new generation of platelet-rich fibrin (A-PRF+) respect to enamel matrix derivatives (EMD). Methods: Thirty (30) intrabony defects of 18 patients (9 males, 9 females) were randomly treated with A-PRF+ (test, n=15) or EMD (control, n=15). The following clinical parameters were recorded at baseline and 6 months after surgery: pocket depth (PD), gingival recession (GR) and clinical attachment level (CAL). After debridement the intrabony defects were filled with A-PRF+ in the test group, respectively with EMD in the control group, and fixed with sutures to ensure wound closure and stability.Results: Both treatment methods resulted in statistically significant PD reductions, respectively CAL gains six months post-operatively. No statistically significant differences were found between the two groups as the mean CAL gain was 2.33±1.58 mm in the A-PRF+ group, respectively 2.60±1.18 mm in the EMD group (p < 0.001).Conclusion: Within the limits of this study the new-generation platelet-rich fibrin seems to be as clinically effective as EMD in the surgical treatment of intrabony defects. Treatment with A-PRF+ or EMD resulted in reliable clinical outcomes. The use of A-PRF+ as a human autologous product can give a positive impact on periodontal healing.Clinical Relevance: A-PRF+ may be suitable for the treatment of intrabony periodontal defects. Trial registration number (TRN): NCT04404374 (ClinicalTrials.gov ID)Date of registration: 19.05.2020., retrospectively registered

Platelet Derived Growth Factor Secretion and Bone Healing After Er:YAG Laser Bone Irradiation

2011 ◽  
Vol 37 (sp1) ◽  
pp. 195-204 ◽  
Author(s):  
Gavriel Kesler ◽  
Dana Kesler Shvero ◽  
Yariv Siman Tov ◽  
George Romanos
Keyword(s):  
Growth Factor ◽  
Laser Irradiation ◽  
Bone Healing ◽  
Er:Yag Laser ◽  
Test Group ◽  
Significant Rise ◽  
Platelet Derived Growth Factor ◽  
Control Group ◽  
Saline Irrigation ◽  
Post Surgery

Er:YAG laser irradiation has been reported to enhance wound healing. However, no studies have evaluated the synthesis of growth factors after laser irradiation. The present study investigated the effects of laser irradiation on the amount of secretion of platelet derived growth factor (PDGF) in the wound, clarifying the effects of the Er:YAG laser on the bone healing. Osteotomies were prepared in the tibiae of 28 rats using an Er:YAG laser (test group). Maximum power of 8 watts, energy per pulse of 700 mJ, and frequency up to 50 Hz were used. The laser was used with external water irrigation, a spot size of 2 mm, energy per pulse of 500 to 1000 mJ/pulse, and energy density of 32 J/cm2. Twenty eight additional rats served as a control group and their osteotomies were prepared with a drill 1.3 mm in diameter at 1000 rpm, with simultaneous saline irrigation. Two rats from the tested group and 2 from the control group were sacrificed on each day following surgery (1–14 days), and the tissue specimens were prepared for histologic evaluation. Immunohistochemical staining with anti-PDGF was performed after histologic examination. The difference between the PDGF staining intensities of the 2 treatment groups was analyzed using a multivariate logistic regression test. A significant rise in PDGF staining occurred in both groups 2–3 days following surgery. However, while high PDGF counts remained for the 2-week experimental period in the laser group, PDGF levels in the control group returned to baseline levels 8 days post surgery. The 2 groups (laser and control) were found to be different throughout the experiment, and the rat type was found to be a significant predictor (P  =  .000011). The present study demonstrated that Er:YAG laser irradiation seems to stimulate the secretion of PDGF in osteotomy sites in a rat model. It is possible that the high levels of PDGF are part of the mechanism that Er:YAG irradiation enhances and improves the healing of osteotomy sites.

scholarly journals Use of Platelet-Rich Fibrin Associated with Xenograft in Critical Bone Defects: Histomorphometric Study in Rabbits

Symmetry ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1293
Author(s):  
Paulo Wilson Maia ◽  
Marcelo Lucchesi Teixeira ◽  
Luís Guilherme Scavone de Macedo ◽  
Antonio Carlos Aloise ◽  
Celio Amaral Passos Junior ◽  
...  
Keyword(s):  
Bone Formation ◽  
Saline Solution ◽  
Healing Process ◽  
Test Group ◽  
The Other ◽  
Control Group ◽  
Collagen Membrane ◽  
Platelet Rich Fibrin ◽  
Histomorphometric Study ◽  
Significant Difference

Platelet-rich fibrin (PRF) is an autologous material used to improve bone regeneration when associated with bone grafts. It affects tissue angiogenesis, increasing the healing process and, theoretically, presenting potential to increase bone neoformation. The aim of this study was to verify, histomorphometrically, the effects of the association of PRF to a xenograft. Twelve adult white New Zealand rabbits were randomly assigned into two groups containing six animals each. After general anesthesia of the animals, two critical defects of 12 mm were created in the rabbit calvaria, one on each side of the sagittal line. Each defect was filled with the following biomaterials: in the control group (CG), xenograft hydrated with saline solution filling one defect and xenograft hydrated with saline solution covered with collagen membrane on the other side; in the test group (TG), xenograft associated with PRF filling the defect of one side and xenograft associated with PRF covered with collagen membrane on the other side. After eight weeks the animals were euthanized and a histomorphometric analysis was performed. The results showed that in the sites that were covered with collagen membrane, there was no statistically significant difference for all the analyzed parameters. However, when comparing the groups without membrane coverage, a statistically significant difference could be observed for the vital mineralized tissue (VMT) and nonmineralized tissue (NMT) parameters, with more VMT in the test group and more NMT in the control group. Regarding the intragroup comparison, the use of the membrane coverage presented significant outcomes in both groups. Therefore, in this experimental model, PRF did not affect the levels of bone formation when a membrane coverage technique was used. However, higher levels of bone formation were observed in the test group when membrane coverage was not used.

New Method of Sedation in Oral Surgery

2005 ◽  
Vol 31 (6) ◽  
pp. 304-308 ◽  
Author(s):  
Gintaras Juodzbalys ◽  
Rimvydas Giedraitis ◽  
Vita Mačhiulskienė ◽  
Luc W. J. Huys ◽  
Ricardas Kubilius
Keyword(s):  
Local Anesthesia ◽  
Oral Surgery ◽  
Test Group ◽  
Anterograde Amnesia ◽  
Control Group ◽  
Alveolar Ridge ◽  
Alveolar Ridge Augmentation ◽  
Ridge Augmentation ◽  
Dental Implantation ◽  
Experienced Pain

Abstract Local anesthesia, the well-known method of sedation, usually is insufficient for dental implantation and the augmentation of the alveolar ridge, because the operations last for 1 to 2 hours and patients may experience fear and strain. This article examines a new complex sedation method using ketorolac, midazolam, and a local anesthetic 4% solution of articaine hydrochloride and epinephrine (Septanest) in combination with a vasoconstrictor. This method was applied to 67 patients operated on for dental implantation with screw implants or for the alveolar ridge augmentation with biocompatible materials. The control group, which consisted of 20 patients, received local anesthesia with articaine-epinephrine only. Most of the control patients were found to have experienced fear and strain during the aforementioned surgical procedures; their blood pressure and pulse rate increased, and more than half of them experienced pain. No disorders of hemodynamics or the psychoemotional status of the patients were observed during sedation with ketorolac, midazolam, and articaine-epinephrine. Furthermore, anterograde amnesia was determined for the 80% of the patients in the test group.

Comparison of Autogenous Block Bone Graft and Screw Tent-Pole Techniques for Vertical Bone Augmentation in the Posterior Mandible: A Split-Mouth Randomized Controlled Study

2020 ◽  
pp. 232020682097601
Author(s):  
Gözde Işık ◽  
Tayfun Günbay ◽  
Yig˘it Uyanıkgil ◽  
Hüseyin Kısaog˘lu ◽  
Meltem Özden Yüce
Keyword(s):  
Bone Graft ◽  
Test Group ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Control Group ◽  
Bone Augmentation ◽  
Implant Survival ◽  
Platelet Rich Fibrin ◽  
Randomized Controlled ◽  
Block Bone Graft

Aim: To evaluate the effect on vertical bone augmentation of the screw tent-pole technique using particulate allograft in combination with injectable platelet-rich fibrin, and to compare this with autogenous block bone graft. Materials and Methods: This split-mouth randomized controlled study involved patients with bilateral partial edentulism and vertical bone loss in the posterior mandible. In each patient, the control side was treated with autogenous block bone graft harvested from the mandibular ramus and, on the test side, the screw tent-pole technique was employed, using particulate allograft in combination with injectable platelet-rich fibrin. All augmented sites were covered by leukocyte and platelet-rich fibrin membrane. The primary outcome variable of this study was the radiographic changes to bone height 6 months after augmentation. The secondary outcome variables were the percentage of newly formed bone and the implant survival rate. The data were analyzed with a significance level of α = 0.05. Results: Of the 13 patients included, a total of 11 patients (7 females, 4 males; mean age 50.92) completed the study. The mean values of vertical bone gain were 1.72 ± 0.78 mm for the test group and 2.83 ± 0.89 mm for the control group, which constitutes a significant difference ( P = .008). The percentage of newly formed bone was 18.08% ± 2.17% for the test group and 14.26% ± 1.76% for the control group. The difference between the groups was statistically significant ( P < .001). The implant survival rates were 100% for both study groups. Conclusions: Based on the study results, screw tent-pole can be considered a feasible technique for bone augmentation. Further randomized studies will be necessary to fully evaluate vertical bone augmentation using the screw tent-pole technique, with different graft materials and with larger samples.

COMPARISON OF POST EXTRACTION SOCKET HEALING WITH AND WITHOUT USING PLATELET RICH FIBRIN (PRF) – A CLINICAL AND RADIOGRAPHIC STUDY

2021 ◽  
pp. 62-65
Author(s):  
S.P. Indra Kumar ◽  
Kavin T ◽  
Narendar R ◽  
E. Gayathri Priyadharshini ◽  
Akshaya murugan ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Maxillofacial Surgery ◽  
Test Group ◽  
Control Group ◽  
Oral And Maxillofacial Surgery ◽  
Soft Tissue Healing ◽  
Extraction Socket ◽  
Platelet Rich Fibrin ◽  
Tissue Healing ◽  
Socket Healing

AIM: The aim of this study is to comparatively evaluate the post extraction socket healing clinically and radiographically with and without using Platelet Rich Fibrin (PRF). MATERIALS AND METHODS: Fifty, otherwise healthy individuals undergoing dental treatment in the department of Oral and Maxillofacial surgery, Vivekananda Dental College for women, Thiruchengode, were randomly selected and the participants were divided into two groups – test group(PRF, n=25) and control group (Blood clot, n=25). Blood was freshly obtained from the participants of the test group and PRF was prepared. PRF was placed in the sockets of the test group and followed by the pressure application and suturing. Control group were allowed to heal naturally. Clinically, soft tissue healing and socket closure were assessed. Radiographic analysis of socket healing done by comparison of pre- and post-operative radiographs. The clinical follow-up assessments were done at an interval of 3 days, 1 week and 4 weeks and the data obtained were assessed. The patients were aged above 18 years, i RESULT: ncluding 33 females and 17 males. The soft tissue and socket healing were higher in the test group when compared with the control group clinically and the mean proportion of radiographic bone ll was signicantly higher in the test group in all the time intervals of 3 days, 1 week and 4 weeks, respectively. Outcome of the study CONCLUSION: demonstrate that the PRF placement in the extraction socket accelerates soft tissue healing and socket healing and increases the bone ll and reduces the bone resorption using clinical and radiographic methods.

scholarly journals Dimensional changes of hard and soft tissue after immediate implantation in comparison with conventional tooth extraction

2016 ◽  
Vol 15 (3) ◽  
pp. 335-342 ◽  
Author(s):  
Mehrdad Radvar ◽  
Kazem Fatemi ◽  
Reihane Abrishamchi ◽  
Amir Moeintaghavi ◽  
Sara Mohammadzade
Keyword(s):  
Soft Tissue ◽  
Tooth Extraction ◽  
Soft Tissues ◽  
Medical Science ◽  
Test Group ◽  
Control Group ◽  
Hard Tissue ◽  
Single Root ◽  
Vertical Changes ◽  
Immediate Implantation

Introduction: Immediate implantation in single-root teeth has been claimed to possess some benefits, especially bone preservation. The aim of this study was to evaluate ridge changes after immediate implantation in comparison with tooth extraction and dental socket healing.Methods and Materials: In this study, 21 patients with hopeless single-root teeth were selected. After impression and cast making, the patients were divided into test and control groups. Each group included twelve dental sockets. For all teeth the extraction was performed atraumatically. Measurements included bucco-lingual ridge dimensions at 3mm and 7mm apical to an imaginary line connecting the CEJs of the two adjacent teeth (CEJ line) as well as vertical distance between the mentioned line and bone crest at the misobuccal, midbuccal, distobuccal, mesiopalatal, midpalatal, and distopalatal aspects. In addition, soft tissue measurements similar to hard tissue ones were taken using stone casts and acrylic stents. In test group immediate implantation was carried out following extraction whereas in the control group dental sockets were left for natural healing. Four months after the operation, in both groups, the flap was reflected and measurements taken at baseline were repeated.Results: Vertical changes of soft tissues in test group were significantly less than control group at all points except in mid-buccal aspect (p=0.033 for mesiobuccal, p=0.026 for distobuccal, p=0.004 for midpalatal, p=0.002 mesiopalatal, p=0.022 for distopalatal, p=0.016 for distal, p=0.048 for mesial). Horizontal dimension change of soft tissue at 7mm apical to the CEJ line in test group, were also significantly less than control group (p= 0.051). Vertical changes of hard tissue, measured in all points, in test group were less than those of control group. These changes were significant in mid-buccal, mid-palatal, mesiopalatal and distopalatal points (p= 0.046, 0.029, 0.020 and 0.026 respectively). Horizontal changes of hard tissue at 3mm and 7mm apical to the CEJ line in test group were also less than control group. However, this was significant only at the 3mm point (p=0.028).Conclusion: According to the results of this study, it can be concluded that immediate implantation is to some extent effective in reducing the expected vertical and horizontal bone and soft tissue changes occurring following conventional tooth extraction and natural socket healing. Further investigation is warranted to determine the optimum method of preventing these changes.Bangladesh Journal of Medical Science Vol.15(3) 2016 p.335-342

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