scholarly journals Improved Corrosion Behavior and Biocompatibility of Porous Titanium Samples Coated with Bioactive Chitosan-Based Nanocomposites

Materials ◽  
2021 ◽  
Vol 14 (21) ◽  
pp. 6322
Author(s):  
Cristina García-Cabezón ◽  
Vanda Godinho ◽  
Coral Salvo-Comino ◽  
Yadir Torres ◽  
Fernando Martín-Pedrosa
Keyword(s):  
Corrosion Resistance ◽  
Stress Shielding ◽  
Porous Titanium ◽  
Substrate Material ◽  
Titanium Implants ◽  
Potential Candidate ◽  
Protection Efficiency ◽  
Cellular Behavior ◽  
One Step ◽  
Current Densities

Porous titanium implants can be a good solution to solve the stress shielding phenomenon. However, the presence of pores compromises mechanical and corrosion resistance. In this work, porous titanium samples obtained using a space-holder technique are coated with Chitosan, Chitosan/AgNPs and Chitosan/Hydroxyapatite using only one step and an economic electrodeposition method. The coatings’ topography, homogeneity and chemical composition were analyzed. A study of the effect of the porosity and type of coating on corrosion resistance and cellular behavior was carried out. The electrochemical studies reveal that porous samples show high current densities and an unstable oxide film; therefore, there is a need for surface treatments to improve corrosion resistance. The Chitosan coatings provide a significant improvement in the corrosion resistance, but the Chitosan/AgNPs and Chitosan/HA coatings showed the highest protection efficiency, especially for the more porous samples. Furthermore, these coatings have better adherence than the chitosan coatings, and the higher surface roughness obtained favors cell adhesion and proliferation. Finally, a combination of coating and porous substrate material with the best biomechanical balance and biofunctional behavior is proposed as a potential candidate for the replacement of small, damaged bone tissues.

scholarly journals Osteogenic Differentiation of Human Mesenchymal Stem Cells Modulated by Surface Manganese Chemistry in SLA Titanium Implants

2022 ◽  
Vol 2022 ◽  
pp. 1-13
Author(s):  
Jin-Woo Park ◽  
Yusuke Tsutsumi ◽  
Eui-Kyun Park
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Corrosion Resistance ◽  
Osteogenic Differentiation ◽  
Chemical Treatment ◽  
Human Mesenchymal Stem Cells ◽  
Titanium Implants ◽  
Potential Candidate ◽  
Implant Surface ◽  
Wet Chemical

The manganese (Mn) ion has recently been probed as a potential candidate element for the surface chemistry modification of titanium (Ti) implants in order to develop a more osteogenic surface with the expectation of taking advantage of its strong binding affinity to the integrins on bone-forming cells. However, the exact mechanism of how Mn enhances osteogenesis when introduced into the surface of Ti implants is not clearly understood. This study investigated the corrosion resistance and potential osteogenic capacity of a Mn-incorporated Ti surface as determined by electrochemical measurement and examining the behaviors of human mesenchymal stem cells (MSCs) in a clinically available sandblasted/acid-etched (SLA) oral implant surface intended for future biomedical applications. The surface that resulted from wet chemical treatment exhibited the formation of a Mn-containing nanostructured TiO2 anatase thin film in the SLA implant and improved corrosion resistance. The Mn-incorporated SLA surface displayed sustained Mn ion release and enhanced osteogenesis-related MSC function, which enhanced early cellular events such as spreading, focal adhesion, and mRNA expression of critical adhesion-related genes and promoted full human MSC differentiation into mature osteoblasts. Our findings indicate that surface Mn modification by wet chemical treatment is an effective approach to produce a Ti implant surface with increased osteogenic capacity through the promotion of the osteogenic differentiation of MSCs. The improved corrosion resistance of the resultant surface is yet another important benefit of being able to provide favorable osseointegration interface stability with an increased barrier effect.

scholarly journals Use of Impedance Spectroscopy for the Characterization of In-Vitro Osteoblast Cell Response in Porous Titanium Bone Implants

Metals ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1077
Author(s):  
Mercè Giner ◽  
Alberto Olmo ◽  
Miguel Hernández ◽  
Paloma Trueba ◽  
Ernesto Chicardi ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Impedance Spectroscopy ◽  
Cell Viability ◽  
Cellular Response ◽  
Stress Shielding ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Size And Morphology ◽  
Porous Substrates

The use of titanium implants with adequate porosity (content, size and morphology) could solve the stress shielding limitations that occur in conventional titanium implants. Experiments to assess the cellular response (adhesion, proliferation and differentiation of osteoblasts) on implants are expensive, time-consuming and delicate. In this work, we propose the use of impedance spectroscopy to evaluate the growth of osteoblasts on porous titanium implants. Osteoblasts cells were cultured on fully-dense and 40 vol.% porous discs with two ranges of pore size (100–200 μm and 355–500 μm) to study cell viability, proliferation, differentiation (Alkaline phosphatase activity) and cell morphology. The porous substrates 40 vol.% (100–200 µm) showed improved osseointegration response as achieved more than 80% of cell viability and higher levels of Cell Differentiation by Alkaline Phosphatase (ALP) at 21 days. This cell behavior was further evaluated observing an increase in the impedance modulus for all study conditions when cells were attached. However, impedance levels were higher on fully-dense due to its surface properties (flat surface) than porous substrates (flat and pore walls). Surface parameters play an important role on the global measured impedance. Impedance is useful for characterizing cell cultures in different sample types.

scholarly journals Complete Osseointegration of a Retrieved 3-D Printed Porous Titanium Cervical Cage

2020 ◽  
Vol 7 ◽  
Author(s):  
Wimar van den Brink ◽  
Nancy Lamerigts
Keyword(s):  
Animal Studies ◽  
Bone Ingrowth ◽  
Fibrous Tissue ◽  
Case Series ◽  
Stress Shielding ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Histological Evaluation ◽  
Anterior Plate ◽  
Bone Apposition

Introduction: Porous 3D-printed titanium has only recently been introduced for spinal applications. Evidence around its use is currently limited to animal studies and only few human case series. This study describes the histological findings of a retrieved EIT cervical cage, explanted 2 years after insertion.Materials and Methods: The patient underwent a double level C4/C5 & C5/C6 anterior cervical decompression using EIT cervical cages without an anterior plate. Two years later the C6/7 level degenerated and began to cause myelopathic symptoms. In order to address the kyphotic imbalance of the cervical spine and fix the C6/7 level, the surgeon decided to remove the C5/6 cervical cage and bridge the fusion from C4 to C7 inclusive. The retrieved cage was histologically evaluated for bone ingrowth and signs of inflammation.Results: MRI demonstrated spinal canal stenosis at C6/C7. Plain radiographs confirmed well-integrated cervical cages at 2 years postoperative. The peroperative surgical need to use a chisel to remove the implant at C5/C6 reconfirmed the solid fusion of the segment. Macroscopically white tissue, indicative of bone, was present at both superior and inferior surfaces of the explanted specimen. Histological evaluation revealed complete osseointegration of the 5 mm high EIT Cellular Titanium® cervical cage, displaying mature lamellar bone in combination with bone marrow throughout the cage. Furthermore, a pattern of trabecular bone apposition (without fibrous tissue interface) and physiological remodeling activity was observed directly on the cellular titanium scaffold.Conclusion: This histological retrieval study of a radiologically fused cervical EIT cage clearly demonstrates complete osseointegration within a 2-year time frame. The scaffold exhibits a bone in growth pattern and maturation of bone tissue similar of what has been demonstrated in animal studies evaluating similar porous titanium implants. The complete osseointegration throughout the cage indicates physiological loading conditions even in the central part of the cage. This pattern suggests the absence, or at least the minimization, of stress-shielding in this type of porous titanium cage.

One-step plasma deposited thin SiO x C y films for corrosion resistance of low carbon steel

2020 ◽  
pp. 1-19
Author(s):  
Alaa Fahmy ◽  
Mansour El Sabbagh ◽  
Mahmoud Bedair ◽  
Amr Gangan ◽  
Mohsen El-Sabbah ◽  
...  
Keyword(s):  
Corrosion Resistance ◽  
Carbon Steel ◽  
Low Carbon Steel ◽  
Low Carbon ◽  
One Step

scholarly journals Understanding long-term silver release from surface modified porous titanium implants

2017 ◽  
Vol 58 ◽  
pp. 550-560 ◽  
Author(s):  
Anish Shivaram ◽  
Susmita Bose ◽  
Amit Bandyopadhyay
Keyword(s):  
Porous Titanium ◽  
Titanium Implants ◽  
Silver Release ◽  
Surface Modified

BIO-CORROSION RESISTANCE AND BIOCOMPATIBILITY OF A ZrTi-BASED BMGMC AS POTENTIAL HARD TISSUE IMPLANTS

2013 ◽  
Vol 27 (19) ◽  
pp. 1341029
Author(s):  
XIAOBO HUANG ◽  
JIAOJUAN ZOU ◽  
CHAN WANG ◽  
RUIQIANG HANG ◽  
JUNWEI QIAO ◽  
...  
Keyword(s):  
Cell Culture ◽  
Corrosion Resistance ◽  
Reference Material ◽  
Corrosion Current ◽  
Electrochemical Measurements ◽  
Ti Alloy ◽  
Cellular Viability ◽  
Hard Tissue ◽  
Cellular Behaviors ◽  
Current Densities

In this study, we compared the bio-corrosion resistance and biocompatibility of a ZrTi -based BMGMC ( Zr 58.5 Ti 14.3 Ni 4.9 Cu 6.1 Nb 5.2 Be 11.0). The Ti - 6Al - 4V alloy was used as a reference material. By utilizing the electrochemical measurements and M3T3 cell culture, the corrosion resistance and biocompatibility of this BMGMC were evaluated. The BMGMC displayed high positive corrosion potentials and low corrosion current densities, which indicated that this material exhibited a highly improved corrosion resistance than the Ti alloy. The cells could adhere on the surface of this BMGMC and exhibited improved cellular behaviors, such as cellular viability and cytoskeketal structure. In summary, the ZrTi -based BMGMC showed great potential for applications in the hard tissue implants.

scholarly journals Tribo-mechanical and cellular behavior of superficially modified porous titanium samples using femtosecond laser

2021 ◽  
pp. 127555
Author(s):  
Paloma Trueba ◽  
Mercè Giner ◽  
Ángel Rodríguez ◽  
Ana M. Beltrán ◽  
José M. Amado ◽  
...  
Keyword(s):  
Femtosecond Laser ◽  
Porous Titanium ◽  
Cellular Behavior

Increasing of Corrosion Resistance for Metal Products of Livestock Premises

2021 ◽  
Vol 316 ◽  
pp. 758-764
Author(s):  
M.Yu. Karelina ◽  
S.M. Gaidar ◽  
D.I. Petrovskiy
Keyword(s):  
Corrosion Resistance ◽  
Low Carbon Steel ◽  
Industrial Complex ◽  
Low Carbon ◽  
Inhibitor Concentration ◽  
Complex Action ◽  
Protection Efficiency ◽  
Degree Of Protection ◽  
Metal Products ◽  
Increase Corrosion Resistance

The purpose of the work was to identify and analyze the causes of corrosion destruction of metal products, used in conditions of animal keeping on farms of the agro-industrial complex, and to find effective methods of combating it. In order to increase corrosion resistance of metal products of livestock farms and complexes, it is proposed to use the developed preparation, which has fungicidal and anticorrosive properties simultaneously. The rate of metal products corrosion during the experiment was evaluated by the museum strain of Aspergillus niger fungi. The article describes the causes of fungal corrosion, the principle of its effect on metals; proposes an inhibitor of complex action for the control of electrochemical and bio-corrosion. The protection efficiency of metal products by the inhibitor was evaluated by the corrosion braking coefficient and the degree of protection. The effect of inhibitor concentration on the rate of low carbon steel bio-corrosion has been studied. It has been proven that the rate of corrosion processes decreased by 50 times, when exposed to a medium, contaminated with fungus spores, on metal samples treated with an inhibitor.

Corrosion resistance of porous titanium in some aggressive media

1968 ◽  
Vol 7 (12) ◽  
pp. 977-981 ◽  
Author(s):  
D. S. Arensburger ◽  
V. S. Pugin ◽  
I. M. Fedorchenko
Keyword(s):  
Corrosion Resistance ◽  
Porous Titanium

scholarly journals Electrical Impedance of Surface Modified Porous Titanium Implants with Femtosecond Laser

Materials ◽  
2022 ◽  
Vol 15 (2) ◽  
pp. 461
Author(s):  
Paula Navarro ◽  
Alberto Olmo ◽  
Mercè Giner ◽  
Marleny Rodríguez-Albelo ◽  
Ángel Rodríguez ◽  
...  
Keyword(s):  
Cell Culture ◽  
Femtosecond Laser ◽  
Laser Treatment ◽  
Electrical Impedance ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Electrical Impedance Spectroscopy ◽  
Wide Range ◽  
Titanium Surfaces ◽  
Surface Modified

The chemical composition and surface topography of titanium implants are essential to improve implant osseointegration. The present work studies a non-invasive alternative of electrical impedance spectroscopy for the characterization of the macroporosity inherent to the manufacturing process and the effect of the surface treatment with femtosecond laser of titanium discs. Osteoblasts cell culture growths on the titanium surfaces of the laser-treated discs were also studied with this method. The measurements obtained showed that the femtosecond laser treatment of the samples and cell culture produced a significant increase (around 50%) in the absolute value of the electrical impedance module, which could be characterized in a wide range of frequencies (being more relevant at 500 MHz). Results have revealed the potential of this measurement technique, in terms of advantages, in comparison to tiresome and expensive techniques, allowing semi-quantitatively relating impedance measurements to porosity content, as well as detecting the effect of surface modification, generated by laser treatment and cell culture.

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