scholarly journals CaCO3–Chitosan Composites Granules for Instant Hemostasis and Wound Healing

Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3350
Author(s):  
Wei He ◽  
Xiaodong Huang ◽  
Jun Zhang ◽  
Yue Zhu ◽  
Yajun Liu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Composite Material ◽  
Traffic Accidents ◽  
Low Cost ◽  
Wet Granulation ◽  
Excessive Bleeding ◽  
Accelerate Wound Healing ◽  
Risk Of Death ◽  
Porous Chitosan

Excessive bleeding induces a high risk of death and is a leading cause of deaths that result from traffic accidents and military conflict. In this paper, we developed a novel porous chitosan–CaCO3 (CS–CaCO3) composite material and investigated its hemostatic properties and wound healing performance. The CS–CaCO3 composites material was prepared via a wet-granulation method. Granulation increases the infiltrating ability of the CS–CaCO3 composites material. The improved water absorption ability was enhanced to 460% for the CS–CaCO3 composites material compared to the CaCO3 or chitosan with only one single component. The coagulation studies in vivo illustrated that the blood clotting time was greatly reduced from 31 s for CaCO3 to 16 s for the CS–CaCO3 composite material. According to the results of the wound healing experiments in rats, it was found that the CS–CaCO3 composite material can promote wound healing. The CS–CaCO3 composite material could accelerate wound healing to a rate of 9 days, compared with 12 days for the CaCO3. The hemostatic activity, biocompatibility, and low cost of CS–CaCO3 composite material make it a potential agent for effective hemostatic and wound healing materials.

scholarly journals Fish Collagen Surgical Compress Repairing Characteristics on Wound Healing Process In Vivo

Marine Drugs ◽  
2019 ◽  
Vol 17 (1) ◽  
pp. 33 ◽  
Author(s):  
Jingjing Chen ◽  
Kaili Gao ◽  
Shu Liu ◽  
Shujun Wang ◽  
Jeevithan Elango ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Collagen Sponge ◽  
Wound Healing Process ◽  
Inflammatory Infiltration ◽  
Accelerate Wound Healing ◽  
Soluble Collagen ◽  
Bovine Collagen ◽  
Lower Effect

The development of biomaterials with the potential to accelerate wound healing is a great challenge in biomedicine. In this study, four types of samples including pepsin soluble collagen sponge (PCS), acid soluble collagen sponge (ACS), bovine collagen electrospun I (BCE I) and bovine collagen electrospun II (BCE II) were used as wound dressing materials. We showed that the PCS, ACS, BCE I and BCE II treated rats increased the percentage of wound contraction, reduced the inflammatory infiltration, and accelerated the epithelization and healing. PCS, ACS, BCE I, and BCE II significantly enhanced the total protein and hydroxyproline level in rats. ACS could induce more fibroblasts proliferation and differentiation than PCS, however, both PCS and ACS had a lower effect than BCE I and BCE II. PCS, ACS, BCE I, and BCE II could regulate deposition of collagen, which led to excellent alignment in the wound healing process. There were similar effects on inducing the level of cytokines including EGF, FGF, and vascular endothelial marker CD31 among these four groups. Accordingly, this study disclosed that collagens (PCS and ACS) from tilapia skin and bovine collagen electrospun (BCE I and BCE II) have significant bioactivity and could accelerate wound healing rapidly and effectively in rat model.

scholarly journals Bioinspired mechanically active adhesive dressings to accelerate wound closure

2019 ◽  
Vol 5 (7) ◽  
pp. eaaw3963 ◽  
Author(s):  
S. O. Blacklow ◽  
J. Li ◽  
B. R. Freedman ◽  
M. Zeidi ◽  
C. Chen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Closure ◽  
Healing Process ◽  
Skin Wound ◽  
Wound Management ◽  
In Vivo Studies ◽  
Skin Wound Healing ◽  
Accelerate Wound Healing

Inspired by embryonic wound closure, we present mechanically active dressings to accelerate wound healing. Conventional dressings passively aid healing by maintaining moisture at wound sites. Recent developments have focused on drug and cell delivery to drive a healing process, but these methods are often complicated by drug side effects, sophisticated fabrication, and high cost. Here, we present novel active adhesive dressings consisting of thermoresponsive tough adhesive hydrogels that combine high stretchability, toughness, tissue adhesion, and antimicrobial function. They adhere strongly to the skin and actively contract wounds, in response to exposure to the skin temperature. In vitro and in vivo studies demonstrate their efficacy in accelerating and supporting skin wound healing. Finite element models validate and refine the wound contraction process enabled by these active adhesive dressings. This mechanobiological approach opens new avenues for wound management and may find broad utility in applications ranging from regenerative medicine to soft robotics.

scholarly journals Characteristics of Gel Emulsion Formulation of Snakehead (Channa Micropeltes) As Wound Healer

Omni-Akuatika ◽  
2018 ◽  
Vol 14 (2) ◽  
Author(s):  
Firlianty Firlianty ◽  
Choirul Anwar ◽  
Anang Najamuddin ◽  
Silvester B. Pratasik
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Control Treatment ◽  
Wound Healing Process ◽  
In Vivo Test ◽  
Accelerate Wound Healing ◽  
Randomized Design ◽  
Speed Up ◽  
Emulsion Formulation

This study is aimed to know the characteristics and the effectivity of gel emulsion of snakehead (Channa micropeltes) extract in accelerating wound healing process. It used experimental method with Complete Randomized Design. Four treatments with 3 replications were employed, i.e. 1%, 2%, and 4% gel emulsion of snakehead Channa micropeltes extract and a control treatment. Results showed that C. micropeltes extract formulated in gel emulsion had white colour, typical aroma of gel emulsion, soft texture with mean dispersion ability of 3 cm, and pH 6. In vivo test on male mices that gel emulsion of C. micropeltes extract was highly effective (P≤0.05) to accelerate wound healing, in which the treatment of 1% gel emulsion gave the highest effect with 98.5% wound healing at day-14, followed with that of control treatment, 95% healing, then 2%, 90% healing and 4%, 90% healing, respectively. Snakehead (Channa micrpeltes) extract formulated in gel emulsion can speed up the wound healing process.

scholarly journals Topical Thyroid Hormone Accelerates Wound Healing in Mice

Endocrinology ◽  
2005 ◽  
Vol 146 (10) ◽  
pp. 4425-4430 ◽  
Author(s):  
Joshua D. Safer ◽  
Tara M. Crawford ◽  
Michael F. Holick
Keyword(s):  
Wound Healing ◽  
Thyroid Hormone ◽  
Topical Application ◽  
Dependent Manner ◽  
Accelerate Wound Healing ◽  
Previous Hypothesis ◽  
Dose Dependent ◽  
Physiologic Role

Although the physiologic role of thyroid hormone in skin is not well understood, mounting evidence suggests that T3 plays an important role in epidermal proliferation. The goal of this project was to evaluate whether the topical application of supraphysiologic doses of T3 could accelerate wound healing. We evaluated mice treated with topical T3vs. the same mice receiving vehicle alone (Novasome A). Ten-millimeter diameter (79 mm2) dorsal skin wounds were established in all animals, and wounds were remeasured 4 d after injury. All animals were evaluated twice: once with the T3 treatment and once with the vehicle alone. Daily topical application of 150 ng T3 resulted in 58% greater wound closure relative to wounds on the same animals receiving vehicle alone (P < 0.001). Furthermore, we determined that wound healing-associated keratin 6 protein expression in hair follicle keratinocytes increased in a dose-dependent manner in vivo during topical T3 treatment. The data support our previous hypothesis that T3 is necessary for optimal wound healing. Now, we further suggest that topical thyroid hormone may be an inexpensive agent to hasten healing of certain wounds.

scholarly journals Come together: bioelectric healing-on-a-chip

2020 ◽  
Author(s):  
Tom J. Zajdel ◽  
Gawoon Shim ◽  
Daniel J. Cohen
Keyword(s):  
Wound Healing ◽  
Cost Model ◽  
Low Cost ◽  
Experimental System ◽  
Model Systems ◽  
Device Development ◽  
Wound Healing Response ◽  
Field Geometry ◽  
On Chip

AbstractThere is a growing interest in bioelectric wound treatment and electrotaxis, the process by which cells detect an electric field and orient their migration along its direction, has emerged as a potential cornerstone of the endogenous wound healing response. Despite recognition of the importance of electrotaxis in wound healing, no experimental system to date demonstrates that the actual closing of a wound can be accelerated solely by the electrotaxis response itself, and in vivo systems are too complex to resolve cell migration from other healing stages such as proliferation and inflammation. This uncertainty has led to a lack of standardization between stimulation methods, model systems, and electrode technology required for device development. In this paper, we present a ‘healing-on-chip’ approach that is a standardized, low-cost, model for investigating electrically accelerated wound healing. Our device provides the first convergent field geometry used in a stimulation device. We validate this device by using electrical stimulation to close a 1.5 mm gap between two large (30 mm2) primary skin keratinocyte layers to double the rate of healing over an unstimulated tissue. This proves that convergent electrotaxis is both possible and can accelerate healing, and offers a new ‘healing-on-a-chip’ platform to explore future bioelectric interfaces.

Accelerated Wound Healing Induced by a Novel Amphibian Peptide (OA-FF10)

2019 ◽  
Vol 26 (4) ◽  
pp. 261-270 ◽  
Author(s):  
Naixin Liu ◽  
Zhe Li ◽  
Buliang Meng ◽  
Wenxin Bian ◽  
Xiaojie Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Low Cost ◽  
Financial Burden ◽  
Human Keratinocytes ◽  
Critical Issue ◽  
Disulfide Bridge ◽  
Toxic Activity

Background: Despite the continued development of modern medicine, chronic wounds are still a critical issue in clinical treatment, placing a great physiological, psychological, and financial burden on patients. Researchers have investigated many methods to solve this problem, with bioactive peptides gaining increasing attention due to their considerable advantages and diverse functions, as well as low cost, simple storage, and easy transportation. Methods: In this research, a novel peptide (named OA-FF10) was identified from the skin secretions of the odorous frog species Odorrana andersonii. The sequence of mature OA-FF10 was “FFTTSCRSGC”, which was produced by the post-translational processing of a 61-residue prepropeptide. Results: Similar to most frog peptides, OA-FF10 showed an intramolecular disulfide bridge at the C-terminus. OA-FF10 demonstrated no antibacterial, antioxidant, hemolytic, or acute toxic activity, but promoted wound healing and proliferation of human keratinocytes (HaCaT) both time- and dose-dependently. Furthermore, while OA-FF10 had no effect on wound healing of Human Skin Fibroblasts (HSF), it did accelerate healing in a full-thickness skin-wound mouse model. Conclusion: Our research revealed the strong wound-healing activity of OA-FF10 in vivo and in vitro, thus providing a new candidate for the development of novel wound-healing drugs.

Green light emitting diodes accelerate wound healing: Characterization of the effect and its molecular basis in vitro and in vivo

2012 ◽  
Vol 20 (2) ◽  
pp. 226-235 ◽  
Author(s):  
Tomohiro Fushimi ◽  
Shigeki Inui ◽  
Takeshi Nakajima ◽  
Masahiro Ogasawara ◽  
Ko Hosokawa ◽  
...  
Keyword(s):  
Wound Healing ◽  
Molecular Basis ◽  
Light Emitting Diodes ◽  
Green Light ◽  
Light Emitting ◽  
Accelerate Wound Healing

scholarly journals Saliva Exosomes-Derived UBE2O Promotes Angiogenesis in Cutaneous Wounds by Targeting SMAD6

2020 ◽  
Author(s):  
Guohui Liu ◽  
Bobin Mi ◽  
Lang Chen ◽  
Yuan Xiong ◽  
Chenchen Yan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Repair ◽  
Cutaneous Wounds ◽  
Accelerate Wound Healing ◽  
Ubiquitin Conjugating Enzyme ◽  
Novel Strategy ◽  
Underlying Mechanisms ◽  
Main Components

Abstract Background Enhancing angiogenesis is critical for accelerating wound healing. Application of different types of exosomes (Exos) to promote angiogenesis represents a novel strategy for enhanced wound repair. Saliva is known to accelerate wound healing, but the underlying mechanisms remain unclear. Results Our results have demonstrated that saliva-derived exosomes (saliva-Exos) induce HUVEC proliferation, migration, and angiogenesis in vitro, and promote cutaneous wound healing in vivo. Further experiments documented that Ubiquitin-conjugating enzyme E2O (UBE2O) is one of the main components of saliva-Exos, and activation of UBE2O has effects similar to those of saliva-Exos, both in vitro and in vivo. Mechanistically, UBE2O decreases the level of SMAD6, thereby activating BMP2, which, in turn, induces angiogenesis. Conclusions The present work suggests that administration of saliva-Exos and UBE2O represents a promising strategy for enhancing wound healing through promotion of angiogenesis.

scholarly journals Sulfated Polysaccharides From Sea Algae as the Basis of Modern Biotechnologies for Creating Wound Coverings: Current Achievements and Coming Prospects

2020 ◽  
Author(s):  
Boris Andryukov ◽  
Natalya Besednova ◽  
Tatyana Kuznetsova ◽  
Tatyana Zaporozhets ◽  
Svetlana Ermakova ◽  
...  
Keyword(s):  
Wound Healing ◽  
Clinical Trial Data ◽  
Biological Properties ◽  
Biologically Active ◽  
Wound Dressings ◽  
Sulfated Polysaccharides ◽  
Accelerate Wound Healing ◽  
In Vivo Experiments

Wound healing involves a complex cascade of cellular, molecular, and biochemical responses and signaling processes. It consists of successive interrelated phases, the duration of which depends on multifactorial processes. Wound treatment is a major healthcare issue that can be resolved by development of effective and affordable wound dressings based on natural materials and biologically active substances. Proper use of modern wound dressings can significantly accelerate wound healing with minimal cosmetic defects. The innovative biotechnologies for creating modern natural interactive dressings are based on sulfated polysaccharides from seaweeds with their unique structures and biological properties, the availability of their sources in the form of wild bushes, and in the form of aquaculture, as well as with a high potential for participation in process control wound healing. These natural biopolymers are a novel and promising biologically active source for designing wound dressings based on alginates, fucoidans, carrageenans, and ulvans, which serve as active and effective therapeutic tools. The aim of this review is to summarize available information about the modern wound dressing’s technologies based on seaweed-derived polysaccharides, including those successfully implemented in commercial products, with the emphasis on promising and innovative designs. The further prospect of using marine biopolymers is related to the need to analyze the results of numerous in vitro and in vivo experiments, summarize clinical trial data, develop a scientifically based approach and relevant practical recommendations for the treatment of wounds.

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