scholarly journals Fabrication of Polyurethane/Polylactide (PU/PLDL) Nanofibers Using Electrospinning Method

Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2459
Author(s):  
Marta Lech ◽  
Joanna Mastalska-Popławska ◽  
Jadwiga Laska
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Synthetic Polymers ◽  
Electrospinning Process ◽  
Rheological Parameters ◽  
Electrospun Fibers ◽  
Lower Viscosity ◽  
Electrospinning Method ◽  
Aligned Fibers ◽  
Pure Acetone

Polylactide and aliphatic polyurethane are biodegradable synthetic polymers which are broadly used as biomaterials in regenerative medicine for implants and scaffolds for tissue engineering. In this paper, the detailed studies of the fabrication of the electrospun fibers of polyurethane/polylactide mixtures were described. The influence of the used solvent (dimethylformamide (DMF)) and diluents (acetone and dichloromethane (DCM)) on the rheological parameters and electrospinning of the described mixtures was examined. Rheological studies showed that polyure-thane/polylactide mixtures have mostly non-Newtonian character, strongly influenced by the diluent. Solutions containing 50 wt.% or more of polyurethane became less viscous after the addition of DCM or acetone, whereas those with bigger amount of polylactide showed higher viscosity after the addition of DCM and lower viscosity after the addition of acetone. Optimized electrospinning process has been elaborated. Fibers with diameters from 250 nm up to 1 µm have been produced and compared. Pure acetone worsened the electrospinning process, but the more DCM was in the mixture, the thinner and more aligned fibers were produced.

Study of Preparation Metallocene Based LLDPE Extra-Fibers by Melt Electrospinning Process

2012 ◽  
Vol 512-515 ◽  
pp. 2424-2427
Author(s):  
Na Zhao ◽  
Tai Qi Liu ◽  
Rui Xue Liu
Keyword(s):  
Field Strength ◽  
High Viscosity ◽  
Electrospinning Process ◽  
Electrospun Fibers ◽  
Optimal Parameters ◽  
Common Solution ◽  
Melt Electrospinning ◽  
Fine Fiber ◽  
Electrospinning Method ◽  
Solution Electrospinning

In this paper, metallocene based LLDPE (mLLDPE) extra-fine fiber , which can not be processed by a common solution electrospinning method.was successfully prepared via a melt electrospinning method. First, a self-designed melt electrospinning device was manufctured and it was used to produce mLLDPE fibers . Then LLDPE extra-fine fiber was successfully prepared by addition of viscosity-reducing additive such as wax, and the resulted fiber was charctered by SEM. Last, the optimal parameters for the preparation of mLLDPE fiber was determined. The experimental results show that commercial mLLDPE can hardly be processed to fibers because of its high viscosity. The diameter and morphology of resulted mLLDPE electrospun fibers depend on the electrospinning parameters such as electric field strength and collecting distance.

scholarly journals Architectured helically coiled scaffolds from elastomeric poly(butylene succinate)(PBS) copolyester via wet electrospinning

2018 ◽  
Author(s):  
Agueda Sonseca ◽  
Rahul Sahay ◽  
Karolina Stepien ◽  
Julia Bukała ◽  
Aleksandra Wcislek ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Thermoplastic Elastomer ◽  
Solvent System ◽  
High Specific Surface Area ◽  
Electrospinning Process ◽  
Coagulation Bath ◽  
High Porosity ◽  
Butylene Succinate ◽  
Smooth Muscle Tissue ◽  
Electrospinning Method

<div><div><div><p>Electrospinning is one of the most investigated methods used to produce polymeric fiber structures that mimic the morphology of native extracellular matrix. These structures have been extensively studied in the context of scaffolds for tissue regeneration. However, the compactness of materials obtained by traditional electrospinning, collected as two-dimensional non-woven scaffolds, can limit cell infiltration and tissue ingrowth. In addition, for applications in smooth muscle tissue engineering, highly elastic scaffolds capable of withstanding cyclic mechanical strains without suffering significant permanent deformations are preferred. In order to address these challenges, we report the fabrication of microscale 3D helically coiled structures (referred as 3D-HCS) by wet-electrospinning method, a modification of the traditional electrospinning process in which a coagulation bath (non-solvent system for the electrospun material) is used as the collector. The present study, for the first time, successfully demonstrates the feasibility of using this method to produce various architectures of 3D-HCS from segmented copolyester of poly(butylene succinate-co- dilinoleic succinate) (PBS-DLS), a thermoplastic elastomer. A mechanism for the HCS formation is proposed and verified with experimental data. Fabricated 3D-HCS showed high specific surface area, high porosity, and good elasticity. Further, the marked increase in cell proliferation on 3D-HCS confirmed the suitability of these materials as scaffolds for soft tissue engineering.</p></div></div></div>

scholarly journals Architectured Helically Coiled 3D Structures from Elastomeric Poly(butylene succinate)(PBS) Copolyester

2018 ◽  
Author(s):  
Agueda Sonseca ◽  
Rahul Sahay ◽  
Karolina Stepien ◽  
Julia Bukała ◽  
Aleksandra Wcislek ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Thermoplastic Elastomer ◽  
Solvent System ◽  
High Specific Surface Area ◽  
Electrospinning Process ◽  
Coagulation Bath ◽  
High Porosity ◽  
Butylene Succinate ◽  
Smooth Muscle Tissue ◽  
Electrospinning Method

<div><div><div><p>Electrospinning is one of the most investigated methods used to produce polymeric fiber structures that mimic the morphology of native extracellular matrix. These structures have been extensively studied in the context of scaffolds for tissue regeneration. However, the compactness of materials obtained by traditional electrospinning, collected as two-dimensional non-woven scaffolds, can limit cell infiltration and tissue ingrowth. In addition, for applications in smooth muscle tissue engineering, highly elastic scaffolds capable of withstanding cyclic mechanical strains without suffering significant permanent deformations are preferred. In order to address these challenges, we report the fabrication of microscale 3D helically coiled structures (referred as 3D-HCS) by wet-electrospinning method, a modification of the traditional electrospinning process in which a coagulation bath (non-solvent system for the electrospun material) is used as the collector. The present study, for the first time, successfully demonstrates the feasibility of using this method to produce various architectures of 3D helically coiled structures (HCS) from segmented copolyester of poly(butylene succinate-co-dilinoleic succinate) (PBS-DLS), a thermoplastic elastomer. A mechanism for the HCS formation is proposed and verified with experimental data. Fabricated 3D-HCS showed high specific surface area, high porosity, and good elasticity. Further, the marked increase in cell proliferation on 3D-HCS confirmed the suitability of these materials as scaffolds for soft tissue engineering.</p></div></div></div>

scholarly journals Architectured helically coiled scaffolds from elastomeric poly(butylene succinate) (PBS) copolyester via wet electrospinning

2019 ◽  
Author(s):  
Agueda Sonseca ◽  
Rahul Sahay ◽  
Karolina Stepien ◽  
Julia Bukała ◽  
Aleksandra Wcislek ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Thermoplastic Elastomer ◽  
Solvent System ◽  
High Specific Surface Area ◽  
Electrospinning Process ◽  
Coagulation Bath ◽  
High Porosity ◽  
Butylene Succinate ◽  
Smooth Muscle Tissue ◽  
Electrospinning Method

<div><div><div><p>Electrospinning is one of the most investigated methods used to produce polymeric fiber structures that mimic the morphology of native extracellular matrix. These structures have been extensively studied in the context of scaffolds for tissue regeneration. However, the compactness of materials obtained by traditional electrospinning, collected as two-dimensional non-woven scaffolds, can limit cell infiltration and tissue ingrowth. In addition, for applications in smooth muscle tissue engineering, highly elastic scaffolds capable of withstanding cyclic mechanical strains without suffering significant permanent deformations are preferred. In order to address these challenges, we report the fabrication of microscale 3D helically coiled structures (referred as 3D-HCS) by wet-electrospinning method, a modification of the traditional electrospinning process in which a coagulation bath (non-solvent system for the electrospun material) is used as the collector. The present study, for the first time, successfully demonstrates the feasibility of using this method to produce various architectures of 3D-HCS from segmented copolyester of poly(butylene succinate-co- dilinoleic succinate) (PBS-DLS), a thermoplastic elastomer. A mechanism for the HCS formation is proposed and verified with experimental data. Fabricated 3D-HCS showed high specific surface area, high porosity, and good elasticity. Further, the marked increase in cell proliferation on 3D-HCS confirmed the suitability of these materials as scaffolds for soft tissue engineering.</p></div></div></div>

scholarly journals A review of electrospinning manipulation techniques to direct fiber deposition and maximize pore size

2017 ◽  
Vol 2 (1) ◽  
pp. 46-61 ◽  
Author(s):  
Kevin P. Feltz ◽  
Emily A. Growney Kalaf ◽  
Chengpeng Chen ◽  
R. Scott Martin ◽  
Scott A. Sell
Keyword(s):  
Magnetic Field ◽  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Regenerative Medicine ◽  
Electrospinning Process ◽  
Electrospun Scaffolds ◽  
Alternative Techniques ◽  
Fiber Deposition ◽  
Medicine Community ◽  
Field Manipulation

Abstract Electrospinning has been widely accepted for several decades by the tissue engineering and regenerative medicine community as a technique for nanofiber production. Owing to the inherent flexibility of the electrospinning process, a number of techniques can be easily implemented to control fiber deposition (i.e. electric/ magnetic field manipulation, use of alternating current, or air-based fiber focusing) and/or porosity (i.e. air impedance, sacrificial porogen/sacrificial fiber incorporation, cryo-electrospinning, or alternative techniques). The purpose of this review is to highlight some of the recent work using these techniques to create electrospun scaffolds appropriate for mimicking the structure of the native extracellular matrix, and to enhance the applicability of advanced electrospinning techniques in the field of tissue engineering.

scholarly journals Architectured helically coiled scaffolds from elastomeric poly(butylene succinate) (PBS) copolyester via wet electrospinning

2019 ◽  
Author(s):  
Agueda Sonseca ◽  
Rahul Sahay ◽  
Karolina Stepien ◽  
Julia Bukała ◽  
Aleksandra Wcislek ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Thermoplastic Elastomer ◽  
Solvent System ◽  
High Specific Surface Area ◽  
Electrospinning Process ◽  
Coagulation Bath ◽  
High Porosity ◽  
Butylene Succinate ◽  
Smooth Muscle Tissue ◽  
Electrospinning Method

<div><div><div><p>Electrospinning is one of the most investigated methods used to produce polymeric fiber structures that mimic the morphology of native extracellular matrix. These structures have been extensively studied in the context of scaffolds for tissue regeneration. However, the compactness of materials obtained by traditional electrospinning, collected as two-dimensional non-woven scaffolds, can limit cell infiltration and tissue ingrowth. In addition, for applications in smooth muscle tissue engineering, highly elastic scaffolds capable of withstanding cyclic mechanical strains without suffering significant permanent deformations are preferred. In order to address these challenges, we report the fabrication of microscale 3D helically coiled structures (referred as 3D-HCS) by wet-electrospinning method, a modification of the traditional electrospinning process in which a coagulation bath (non-solvent system for the electrospun material) is used as the collector. The present study, for the first time, successfully demonstrates the feasibility of using this method to produce various architectures of 3D-HCS from segmented copolyester of poly(butylene succinate-co- dilinoleic succinate) (PBS-DLS), a thermoplastic elastomer. A mechanism for the HCS formation is proposed and verified with experimental data. Fabricated 3D-HCS showed high specific surface area, high porosity, and good elasticity. Further, the marked increase in cell proliferation on 3D-HCS confirmed the suitability of these materials as scaffolds for soft tissue engineering.</p></div></div></div>

Mechanical Behavior of PCL Nanofibers

2016 ◽  
Vol 696 ◽  
pp. 196-201
Author(s):  
M. Kagan Keler ◽  
Sibel Daglilar ◽  
Oguzhan Gunduz ◽  
Metin Yuksek ◽  
Yesim Muge Sahin ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Tensile Testing ◽  
Biomedical Applications ◽  
Cartilage Defects ◽  
Special Programme ◽  
Electrospinning Method ◽  
Fiber Scaffolds ◽  
Usage Area

The biomedical applications of Poly (e-caprolactone) (PCL) have an extensive usage area such as tissue engineering, regenerative medicine, cartilage defects and biomedical implants. Because of the PCL’s high biocompatibility and excellent mechanical features some implants have been designed for getting remarkable results. Clinically approved fibers ranging from 500 nm to 750 nm were produced by electrospinning method. The mechanical properties of the fiber scaffolds were performed via tensile testing and results were measured by special programme. Five different fiber scaffolds which they produced in various compositions have been used for this research.

Tissue engineering in regenerative medicine

2015 ◽  
Vol 6 (5) ◽  
pp. 291-298
Author(s):  
Barbara Różalska ◽  
Bartłomiej Micota ◽  
Małgorzata Paszkiewicz ◽  
Beata Sadowska
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine

Graphene and Graphene-Based Materials in Biomedical Applications

2019 ◽  
Vol 26 (38) ◽  
pp. 6834-6850 ◽  
Author(s):  
Mohammad Omaish Ansari ◽  
Kalamegam Gauthaman ◽  
Abdurahman Essa ◽  
Sidi A. Bencherif ◽  
Adnan Memic
Keyword(s):  
Tissue Engineering ◽  
Thermal Properties ◽  
Gene Delivery ◽  
Regenerative Medicine ◽  
Biomedical Research ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Two Dimensional ◽  
Drug And Gene Delivery ◽  
Biomedical Fields

: Nanobiotechnology has huge potential in the field of regenerative medicine. One of the main drivers has been the development of novel nanomaterials. One developing class of materials is graphene and its derivatives recognized for their novel properties present on the nanoscale. In particular, graphene and graphene-based nanomaterials have been shown to have excellent electrical, mechanical, optical and thermal properties. Due to these unique properties coupled with the ability to tune their biocompatibility, these nanomaterials have been propelled for various applications. Most recently, these two-dimensional nanomaterials have been widely recognized for their utility in biomedical research. In this review, a brief overview of the strategies to synthesize graphene and its derivatives are discussed. Next, the biocompatibility profile of these nanomaterials as a precursor to their biomedical application is reviewed. Finally, recent applications of graphene-based nanomaterials in various biomedical fields including tissue engineering, drug and gene delivery, biosensing and bioimaging as well as other biorelated studies are highlighted.

2D, 3D and 4D Active Compound Delivery in Tissue Engineering and Regenerative Medicine

2015 ◽  
Vol 21 (12) ◽  
pp. 1506-1516 ◽  
Author(s):  
Nicolas Hanauer ◽  
Pierre Latreille ◽  
Shaker Alsharif ◽  
Xavier Banquy
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Active Compound
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