scholarly journals A Numerical Model of a Perforated Microcantilever Covered with Cardiomyocytes to Improve the Performance of the Microcantilever Sensor

Materials ◽  
2020 ◽  
Vol 14 (1) ◽  
pp. 95
Author(s):  
Bin Qiu ◽  
Guangyong Li ◽  
Jianke Du ◽  
Aibing Zhang ◽  
Yuan Jin
Keyword(s):  
Numerical Model ◽  
Cardiac Toxicity ◽  
Simulation Analysis ◽  
Maximum Error ◽  
Contraction Force ◽  
Preliminary Screening ◽  
Microcantilever Sensors ◽  
Bending Effect ◽  
Good Consistency ◽  
Bending Behavior

A few simple polymeric microsystems, such as microcantilever sensors, have recently been developed for the preliminary screening of cardiac toxicity. The microcantilever deflection produced by a change in the cardiomyocyte (CM) contraction force is important for understanding the mechanism of heart failure. In this study, a new numerical model is proposed to analyze the contractile behavior of CMs cultured on a perforated microcantilever surface for improving the performance of the microcantilever sensor. First, the surface traction model is used to investigate the bending displacement of the plain microcantilever. In order to improve the bending effect, a new numerical model is developed to analyze the bending behavior of the perforated microcantilever covered with CMs. Compared with the designed molds, the latter yields better results. Finally, a simulation analysis is proposed based on a finite element method to verify the presence of a preformed mold. Moreover, the effects of various factors on the bending displacement, including microcantilever size, Young’s modulus, and porosity factor, are investigated. Both the simulation and numerical results have good consistency, and the maximum error between the numerical and simulation results is not more than 3.4%, even though the porosity factor reaches 0.147. The results show that the developed mold opens new avenues for CM microcantilever sensors to detect cardiac toxicity.

scholarly journals Polymer-Based Functional Cantilevers Integrated with Interdigitated Electrode Arrays—A Novel Platform for Cardiac Sensing

Micromachines ◽  
2020 ◽  
Vol 11 (4) ◽  
pp. 450 ◽  
Author(s):  
Pooja P. Kanade ◽  
Nomin-Erdene Oyunbaatar ◽  
Dong-Weon Lee
Keyword(s):  
Cardiac Toxicity ◽  
Toxicity Tests ◽  
Dual Function ◽  
Electrode Arrays ◽  
Contraction Force ◽  
Drug Induced ◽  
Cantilever Deflection ◽  
Biomedical Device ◽  
Photosensitive Polymer ◽  
Common Causes

Heart related ailments are some of the most common causes for death in the world, and some of the causes are cardiac toxicity due to drugs. Several platforms have been developed in this regard over the years that can measure electrical or mechanical behavior of cardiomyocytes. In this study, we have demonstrated a biomedical device that can simultaneously measure electrophysiology and contraction force of cardiomyocytes. This dual-function device is composed of a photosensitive polymer-based cantilever, with a pair of metal-based interdigitated electrodes on its surface, such that the cantilever can measure the contraction force of cardiomyocytes and the electrodes can measure the impedance between cells and substrate. The cantilever is patterned with microgrooves so that the cardiomyocytes can align to the cantilever in order to make a higher cantilever deflection in response to contraction force. Preliminary experimental results have identified the potential for use in the drug-induced cardiac toxicity tests, and further optimization is desirable to extend the technique to various bio-sensor areas.

scholarly journals Design and Analysis of Two Piezoelectric Cymbal Transducers with Metal Ring and Add Mass

Sensors ◽  
2019 ◽  
Vol 19 (1) ◽  
pp. 137 ◽  
Author(s):  
Wenjie Wang ◽  
Weihao Shi ◽  
Peter Thomas ◽  
Mingsui Yang
Keyword(s):  
Simulation Analysis ◽  
Low Frequency ◽  
High Strength ◽  
Structural Parameter ◽  
Metal Ring ◽  
Cavity Structure ◽  
Good Consistency ◽  
Frequency Transducer ◽  
Detailed Simulation ◽  
Transducer Design

Based on traditional sandwich structure, two piezoelectric transducers were designed to meet the strict underwater application backgrounds such as high pressure, corrosion resistance, and high strength. Both transducers integrated most of previous researches while one transducer has a multilayer cavity structure which is different from the other structure and previous transducer structures. After a detailed simulation analysis of every structural parameter, key parameters were pointed out to have an obvious influence on its performance. Then, two models were constructed and compared with chosen sets of geometry parameters and manufacturing process, which can also provide a reference for low-frequency transducer design. The simulation results and experimental results of our transducers show a good consistency which indicates the cavity structure can reduce the resonance frequency.

scholarly journals Finite Element Analysis of Deformation and Stress Situation of Triangular Truss Under Different Loads

2018 ◽  
Vol 173 ◽  
pp. 01032
Author(s):  
WL Zeng ◽  
Q Cong ◽  
Y Liu
Keyword(s):  
Finite Element ◽  
Theoretical Calculation ◽  
Simulation Analysis ◽  
Maximum Error ◽  
Equivalent Stiffness ◽  
Element Analysis ◽  
Stress Situation ◽  
Ansys Simulation ◽  
Stiffness Constant ◽  
Comparison Results

In this paper, the two methods for solving finite element problem, theoretical calculation method and ANSYS simulation analysis method, were used to study deformation and stress situation of each node of triangular truss under different distribution loads. The results of theoretical calculation were compared with those of ANSYS simulation, which showed that the counter-acting forces of each node were exactly the same. For the calculation results of the equivalent stiffness constants of each unit could not be accurate, values of each node deformation calculated by theoretical calculation could be error, but the maximum error rate was no more than 3.6%. By the comparison results, conclusion could be made that the results of ANSYS simulation are more intuitive and image, the values are more accurate and reliable, comparing with those of theoretical calculation, the influence of accuracy of equivalent stiffness constant is much more smaller.

Numerical Simulation Analysis of the Groundwater’ Temperature Field in the Concentration Area of the Water Source Heat Pump Engineering

2012 ◽  
Vol 174-177 ◽  
pp. 3027-3030
Author(s):  
Wei Wei ◽  
Ming Zhong Wang ◽  
Jun Pan
Keyword(s):  
Numerical Simulation ◽  
Finite Element Method ◽  
Finite Element ◽  
Temperature Field ◽  
Numerical Model ◽  
Heat Pump ◽  
Simulation Analysis ◽  
Water Source ◽  
Groundwater Temperature ◽  
Change Trend

In order to avoid the heat transfixion among users in the concentration area of the water source heat pump, a suitable layout of pumps for drawing and recharging wells is required. Finite element method is adopted to establish the numerical model of groundwater temperature to predict the change trend of water temperature. The results of the simulation indicate that the groundwater temperature change from 6.3 to 14.2 °C in winter, and from 11.5 to 21.2 °C in summer. These results meet the requirements of the drawing and recharging water in the water source heat pump engineering and are able to avoid the heat transfixion among users. The effect of drawing and recharging water in the water source heat pump engineering to the changes of the groundwater’s temperature field can be analyzed quantitatively through establishing the proper numerical simulation which provides a reference to scientifically design the layout of pumps for drawing and recharging water.

Function Expansion of a Chaotic Logic Unit

2010 ◽  
Vol 171-172 ◽  
pp. 283-287
Author(s):  
Yi Yan Sheng ◽  
Wen Bo Liu
Keyword(s):  
Numerical Model ◽  
Circuit Design ◽  
Simulation Analysis ◽  
Circuit Simulation ◽  
Logic Gate ◽  
Logic Gates ◽  
Control Voltage ◽  
Computing Unit ◽  
Nor Gate ◽  
The Impact

Chaos computing is a new circuit design scheme of using chaos computing units to achieve reconfigurable logic gates. The computing unit can function as different kinds of logic gates by changing external parameters. In this paper, the possibilities of expanding the function of a chaotic NOR gate proposed in the literature is studied. The numerical model for the circuit design was built by constructing differential equations fit for Matlab integration mechanism. Besides, numerical model for integrator saturation was built to make results of numerical simulation conform to that of circuit simulation. Analysis of the impact of integrator saturation was done. With the analysis and by changing the control voltage, NAND function was expanded for the original chaotic logic gate that was only able to function as a NOR gate. By adding the function control signal to the input end and setting the voltage of it to different levels, the computing unit becomes a real time reconfigurable one.

Surface-patterned SU-8 cantilever arrays for preliminary screening of cardiac toxicity

2016 ◽  
Vol 80 ◽  
pp. 456-462 ◽  
Author(s):  
Jong Yun Kim ◽  
Young-Soo Choi ◽  
Bong-Kee Lee ◽  
Dong-Weon Lee
Keyword(s):  
Cardiac Toxicity ◽  
Preliminary Screening ◽  
Cantilever Arrays

Finite Element Analysis, Simulation and Experimental Investigation for Epoxy Laminated Lattice Structure Embedded with SMA Wires

2011 ◽  
Vol 148-149 ◽  
pp. 1413-1418
Author(s):  
Syed Ahmed Ali Tirmizi ◽  
Xing Shen
Keyword(s):  
Deflection Angle ◽  
Simulation Analysis ◽  
Lattice Structure ◽  
Element Analysis ◽  
Practical Applications ◽  
Comparison Results ◽  
Finite Element Analysis Simulation ◽  
Bending Behavior ◽  
Simulation Results ◽  
Increasing Temperature

The simulation analysis for deflection angle of an epoxy laminated lattice structure embedded with varied number of SMA wires with increasing temperature is carried out by using commercial FEM software Ansys. The actual bending behavior of laminated lattice structures is discussed and compared with simulation results. The comparison results obtained in this paper can be used for practical applications of thermo mechanical behavior of laminated SMA actuators.

Effect of Anti-Wear Tape on Behavior of Flexible Risers

2014 ◽  
Author(s):  
Chongyao Zhou ◽  
Naiquan Ye ◽  
Svein Sævik
Keyword(s):  
Numerical Analysis ◽  
Numerical Model ◽  
Cross Section ◽  
Bending Moment ◽  
Laboratory Measurements ◽  
Flexible Riser ◽  
Bending Loads ◽  
Flexible Risers ◽  
Bending Behavior ◽  
The Impact

The service life of a flexible riser is often dominated by the metallic layers under cyclic bending loads, particularly the tensile armor layers. The effect of the anti-wear tapes is normally omitted during cross section modelling, where a plane-remain-plane assumption is usually used for stick condition. Significant differences have been observed between numerical analysis assuming plane surfaces remain plane and laboratory measurements studying the bending moment versus curvature for a flexible riser which has anti-wear tapes between the two tensile armor layers. A new shear interaction algorithm has been developed in the numerical model to improve the modeling of the anti-wear tapes by taking the thickness and shear modulus of the anti-wear material into account. The impact of these parameters on the bending behavior of the flexible riser is demonstrated by comparing the numerical analysis results with the laboratory measurements.

Evaluation of Thermo-Active Foundations for Heating and Cooling Residential Buildings

2016 ◽  
Vol 138 (6) ◽  
Author(s):  
Byung Chang Kwag ◽  
Moncef Krarti
Keyword(s):  
Cost Effectiveness ◽  
Numerical Model ◽  
Simulation Analysis ◽  
Residential Buildings ◽  
Three Dimensional ◽  
Heat Pumps ◽  
Ground Source Heat Pumps ◽  
Heating And Cooling ◽  
Ground Source ◽  
The Cost

The application of thermo-active foundation (TAF) systems to heat and cool residential buildings is evaluated in this paper. First, a transient three-dimensional finite difference numerical model is developed for the analysis of thermo-active foundations. The numerical model predictions are then validated against experimental data obtained from laboratory testing. Using the validated numerical model, G-functions for TAFs are generated and integrated into whole-building simulation analysis program, energyplus. A comparative analysis is carried out to evaluate TAF systems compared to conventional ground-source heat pumps (GSHPs) to provide heating and cooling for multifamily residential buildings. In particular, the analysis compares the cost-effectiveness of TAFs and GSHPs to meet heating and cooling needs for a prototypical multifamily building in three U.S. climates. Due to lower initial costs associated to the reduced excavation costs, it is found that TAFs offer a more cost-effectiveness than GSHP systems to heat and cool multifamily residential buildings.

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