scholarly journals Histological and Histomorphometric Evaluation of New Bone Formation after Maxillary Sinus Augmentation with Two Different Osteoconductive Materials: A Randomized, Parallel, Double-Blind Clinical Trial

Materials ◽  
2020 ◽  
Vol 13 (23) ◽  
pp. 5520
Author(s):  
Giuseppe Grasso ◽  
Stefano Mummolo ◽  
Sara Bernardi ◽  
Davide Pietropaoli ◽  
Giuseppe D’Ambrosio ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Lateral Approach ◽  
Bovine Bone ◽  
New Bone Formation ◽  
Short Term ◽  
Sinus Augmentation ◽  
Double Blind ◽  
Double Blind Clinical Trial ◽  
Bone Biopsies

This study aimed to investigate the histological features of deproteinized equine bone mineral (DEBM) and anorganic bovine bone (ABB) after human sinus augmentation with the lateral approach. Twenty-three sinus augmentations were performed in 16 patients (male: 10/female: 6) using DEBM or ABB in a randomized fashion. Healing took place over the next 6 months. Bone core biopsies (N = 23) were obtained for each subject prior to placing the dental implants. The biopsies were processed for both histological descriptions and histomorphometric analysis. Statistical analyses were applied as appropriate, defining statistical significance as p < 0.05. Core bone biopsies revealed no differences in terms of newly formed bone between groups, or differences in terms of tissue inflammation. Both DEBM and ABB appear to be suitable biomaterials for bone augmentation in sinus lift surgery in the short term. However, dedicated studies are required to confirm these results and their stability in the long term.

scholarly journals Histologic and Histomorphometric Comparison between Sintered Nanohydroxyapatite and Anorganic Bovine Xenograft in Maxillary Sinus Grafting: A Split-Mouth Randomized Controlled Clinical Trial

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Claudio Stacchi ◽  
Teresa Lombardi ◽  
Francesco Oreglia ◽  
Andrea Alberghini Maltoni ◽  
Tonino Traini
Keyword(s):  
Maxillary Sinus ◽  
Lateral Approach ◽  
Long Term Results ◽  
Controlled Clinical Trial ◽  
Bovine Bone ◽  
Sinus Augmentation ◽  
Significant Difference ◽  
Bone Biopsies ◽  
Sinus Floor

The presence of vital bone after maxillary sinus augmentation is crucial to enhance the quality of bone-implant interface, ensuring predictable long-term results. The aims of this RCT with split-mouth design were the histologic and histomorphometric comparison of two different biomaterials in sinus elevation after 6 months of healing and the evaluation of the clinical outcomes of implants inserted in the augmented areas after 12 months of prosthetic loading. Twenty-eight patients (10 females, 18 males) were treated with bilateral sinus floor elevation with lateral approach. Pure sintered nanohydroxyapatite (NHA) and anorganic bovine bone (ABB) were used as test and active control, respectively. After six months, 52 bone biopsies were harvested from 26 patients, and 107 implants were inserted in the augmented areas. Histomorphometry showed that, in the two groups, vital bone percentages were 34.9±15% (NHA) and 38.5±17% (ABB) (p=0.428), marrow spaces percentages were 44.5±18% (NHA) and 43.5±23% (ABB) (p=0.866), and residual graft percentages were 20.6±13% (NHA) and 22.3±12% (ABB) (p=0.638). After 6 months of healing, no statistically significant difference was present in histomorphometric outcomes between NHA and ABB groups. Implant survival rate in NHA group after 12 months of loading was 96.4%, showing no statistically significant differences with ABB group.

Histomorphometric Analysis of Sinus Augmentation Using the ICB and MBCP

2007 ◽  
Vol 330-332 ◽  
pp. 1385-1388
Author(s):  
Hyun Seon Jang ◽  
Ju Un Park ◽  
Sang Joun Yu ◽  
Moon Jin Jeong ◽  
Young Sun Kwon ◽  
...  
Keyword(s):  
Bone Formation ◽  
Soft Tissues ◽  
Statistical Significance ◽  
Tissue Bank ◽  
New Bone Formation ◽  
Sinus Augmentation ◽  
Bone Biopsies ◽  
Alternative Materials ◽  
Window Opening ◽  
Study Population

The purpose of this study is to evaluate the new bone formation of sinus augmentation with using ICB (Irradiated Cancellous Bone & Marrow; Rockey Mountain Tissue Bank, Denver, Co) and MBCP (Micro-Macroporous Biphasic Calcium Phosphate;Biomatlante, France). Study population consisted of 4 patients with maxillary posterior edentulous dentition and ridge heights were less than 5 mm. ICB (Rockey Mountain Tissue Bank, Denver, Co) and MBCP (Biomatlante, France) is mixed with 50: 50. After 6 months, the bone biopsies were done with 2mm trephine bur from lateral window opening. Mean new bone formations were 26.84 %, the residual grafts were 4.92 and soft tissues were 67.98 %. The small number of biopsies did not permit analysis of statistical significance. The variability of individual patient factors do not permit definitive conclusions. The mixtures of ICB & MBCP were superior or comparable to another various bone alternative materials in new bone formation of sinus floor elevation.

scholarly journals Spontaneous improvement of carbohydrate-deficient transferrin in PMM2-CDG without mannose observed in CDG natural history study

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Peter Witters ◽  
Andrew C. Edmondson ◽  
Christina Lam ◽  
Christin Johnsen ◽  
Marc C. Patterson ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Natural History ◽  
Randomized Study ◽  
Short Term ◽  
Double Blind ◽  
Natural History Study ◽  
Natural History Studies ◽  
Carbohydrate Deficient Transferrin ◽  
Spontaneous Improvement

AbstractA recent report on long-term dietary mannose supplementation in phosphomannomutase 2 deficiency (PMM2-CDG) claimed improved glycosylation and called for double-blind randomized study of the dietary supplement in PMM2-CDG patients. A lack of efficacy of short-term mannose supplementation in multiple prior reports challenge this study’s conclusions. Additionally, some CDG types have previously been reported to demonstrate spontaneous improvement in glycosylated biomarkers, including transferrin. We have likewise observed improvements in transferrin glycosylation without mannose supplementation. This observation questions the reliability of transferrin as a therapeutic outcome measure in clinical trials for PMM2-CDG. We are concerned that renewed focus on mannose therapy in PMM2-CDG will detract from clinical trials of more promising therapies. Approaches to increase efficiency of clinical trials and ultimately improve patients’ lives requires prospective natural history studies and identification of reliable biomarkers linked to clinical outcomes in CDG. Collaborations with patients and families are essential to identifying meaningful study outcomes.

scholarly journals Long-Term Comparison of Survival and Marginal Bone of Implants with and without Sinus Augmentation in Maxillary Molars within the Same Patients: A 5.8- to 22-Year Retrospective Study

2021 ◽  
Vol 10 (7) ◽  
pp. 1360
Author(s):  
Won-Bae Park ◽  
Ji-Young Han ◽  
Kyung Lhi Kang
Keyword(s):  
Statistical Significance ◽  
Frailty Model ◽  
Implant Failure ◽  
Implant Survival ◽  
Marginal Bone Loss ◽  
Related Factors ◽  
Sinus Augmentation ◽  
Maxillary Molars ◽  
Posterior Maxilla

Maxillary sinus floor augmentation (MSFA) is widely used and considered a predictable procedure for implant placement. However, the influence of MSFA on implant survival and marginal bone loss (MBL) is still inconclusive. The purpose of this retrospective observational study is to evaluate the long-term genuine influence of MSFA on the survival and MBL of implants by comparing those with and without MSFA only in maxillary molars within the same patients. Thirty-eight patients (28 male and 10 female), with a total of 119 implants, received implants with and without MSFA, and were followed up for 5.8 to 22 years. Patient- and implant-related factors were assessed with a frailty model for implant survival and with generalized estimation equations (GEE) for MBL around the implant. No variables showed a statistical significance for implant failure in the frailty model. In GEE analysis for MBL, MSFA did not show any statistical significance. In conclusion, MSFA demonstrated no significant influence on implant failure and MBL in posterior maxilla in this study.

Calcium Carbimide in Alcoholism Treatment. Part 2: medical findings of a short-term, placebo-controlled, double-blind clinical trial

Addiction ◽  
1989 ◽  
Vol 84 (11) ◽  
pp. 1359-1366 ◽  
Author(s):  
JOHN E. PEACHEY ◽  
HELEN M. ANNIS ◽  
EVELYN R. BORNSTEIN ◽  
SILVERIA M. MAGLANA ◽  
KATHY SYKORA
Keyword(s):  
Clinical Trial ◽  
Alcoholism Treatment ◽  
Short Term ◽  
Double Blind ◽  
Double Blind Clinical Trial

scholarly journals Family Burden and Coping among Caregivers of Schizophrenia

2017 ◽  
Vol 4 (4) ◽  
Author(s):  
S. Geetha ◽  
Dr. M. V. Sudhakaran
Keyword(s):  
Human Population ◽  
Statistical Significance ◽  
Subjective Burden ◽  
Short Term ◽  
Care Giving ◽  
Primary Caretakers ◽  
Schizophrenic Patients ◽  
Coping Scale ◽  
And Coping

Schizophrenia is a strict mental disorder affecting about human population. Being chronic and often incapacitating, it extracts tremendous cost from patients, caregivers and society. Caregivers of patients with schizophrenia face stress and emotional hardship and are frequently forced to assume lifelong care-taking roles. Subjective burden refers to the caregivers’ short term and long term reactions to the patient’s symptoms and behaviors, and the care giving task resulting from it. Perceived distress and interpersonal strain are examples. It refers to the extent to which the care giver feels he or she is burdened. This study aims to conducted for analysis the burden and coping among caregivers of schizophrenia. This study conducted with 30 Schizophrenic patients and 30 primary caretakers of the patients, totally 60 samples were studied. The result shows that there is association between burden assessment schedules of caregiver with that of caregivers coping scale. It revealed statistical significance. Low coping score seen in caregiver who had high burden score. Lower burden score seen in caregivers who had high coping level.

scholarly journals A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Using a Low-Frequency Magnetic Field in the Treatment of Musculoskeletal Chronic Pain

2007 ◽  
Vol 12 (4) ◽  
pp. 249-258 ◽  
Author(s):  
Alex W Thomas ◽  
Karissa Graham ◽  
Frank S Prato ◽  
Julia McKay ◽  
Patricia Morley Forster ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Statistical Significance ◽  
Low Frequency ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Sham Treatment ◽  
Double Blind Clinical Trial ◽  
Antinociceptive Effects ◽  
Frequency Magnetic Field ◽  
Pulsed Electromagnetic

Exposure to a specific pulsed electromagnetic field (PEMF) has been shown to produce analgesic (antinociceptive) effects in many organisms. In a randomized, double-blind, sham-controlled clinical trial, patients with either chronic generalized pain from fibromyalgia (FM) or chronic localized musculoskeletal or inflammatory pain were exposed to a PEMF (400 μT) through a portable device fitted to their head during twice-daily 40 min treatments over seven days. The effect of this PEMF on pain reduction was recorded using a visual analogue scale. A differential effect of PEMF over sham treatment was noticed in patients with FM, which approached statistical significance (P=0.06) despite low numbers (n=17); this effect was not evident in those without FM (P=0.93; n=15). PEMF may be a novel, safe and effective therapeutic tool for use in at least certain subsets of patients with chronic, nonmalignant pain. Clearly, however, a larger randomized, double-blind clinical trial with just FM patients is warranted.

scholarly journals Comparison of anti-plaque efficacy between a low and high cost dentifrice: A short term randomized double-blind trial

2014 ◽  
Vol 08 (03) ◽  
pp. 381-388 ◽  
Author(s):  
Rahul Ganavadiya ◽  
B. R. Chandra Shekar ◽  
Pankaj Goel ◽  
Sudheer G. Hongal ◽  
Manish Jain ◽  
...  
Keyword(s):  
Low Cost ◽  
Statistical Significance ◽  
T Test ◽  
Residential Home ◽  
Gingival Inflammation ◽  
Short Term ◽  
Post Intervention ◽  
Double Blind ◽  
Baseline Difference ◽  
Paired T Test

ABSTRACT Objective: The aim of this study was to compare the anti-plaque efficacy of a low and high cost commercially available tooth paste among 13-20 years old adolescents in a Residential Home, Bhopal, India. Materials and Methods: The study was randomized double-blind parallel clinical trial conducted in a Residential Home, Bhopal, India. A total of 65 patients with established dental plaque and gingivitis were randomly assigned to either low cost or high cost dentifrice group for 4 weeks. The plaque and gingival scores at baseline and post-intervention were assessed and compared. Statistical analysis was performed using paired t-test and the independent sample t-test. The statistical significance was fixed at 0.05. Results: Results indicated a significant reduction in plaque and gingival scores in both groups post-intervention compared with the baseline. Difference between the groups was not significant. No adverse events were reported and both the dentifrices were well-tolerated. Conclusion: Low cost dentifrice is equally effective to the high cost dentifrice in reducing plaque and gingival inflammation.

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