scholarly journals 3D Printing and NIR Fluorescence Imaging Techniques for the Fabrication of Implants

Materials ◽  
2020 ◽  
Vol 13 (21) ◽  
pp. 4819
Author(s):  
Yong Joon Suh ◽  
Tae Hyeon Lim ◽  
Hak Soo Choi ◽  
Moon Suk Kim ◽  
Sang Jin Lee ◽  
...  

Three-dimensional (3D) printing technology holds great potential to fabricate complex constructs in the field of regenerative medicine. Researchers in the surgical fields have used 3D printing techniques and their associated biomaterials for education, training, consultation, organ transplantation, plastic surgery, surgical planning, dentures, and more. In addition, the universal utilization of 3D printing techniques enables researchers to exploit different types of hardware and software in, for example, the surgical fields. To realize the 3D-printed structures to implant them in the body and tissue regeneration, it is important to understand 3D printing technology and its enabling technologies. This paper concisely reviews 3D printing techniques in terms of hardware, software, and materials with a focus on surgery. In addition, it reviews bioprinting technology and a non-invasive monitoring method using near-infrared (NIR) fluorescence, with special attention to the 3D-bioprinted tissue constructs. NIR fluorescence imaging applied to 3D printing technology can play a significant role in monitoring the therapeutic efficacy of 3D structures for clinical implants. Consequently, these techniques can provide individually customized products and improve the treatment outcome of surgeries.

Author(s):  
Huseyn Elcin

PLGA/HA composite biomaterials are prepared, and 3D printing technology is used to make bone scaffolds that can be implanted in the body. Its performance is tested by in vitro physical and biological methods, and its safety is evaluated by animal experiments. Methods: 3D printing technology was used to print the PLGA/HA composite three-dimensional stent biomaterial, and the tensile strength and bending strength of the stent material were tested with reference to GB/T1040 and GB/T9341 to verify its ability to support the proliferation and differentiation of hMSC. The biological evaluation standard (GB/T16886) evaluates the biocompatibility and biosafety of scaffoldmaterials in vitro and in vivo. Results: The porous 3D scaffold made of PLGA/HA composite material was successfully fabricated; the mechanical tensile strength and flexuralstrength of the composite material were 38 MPa and 42 MPa respectively, which were5.35 times and 5.25 times that of normal human cartilage; in vitro cell test It is proved that the 3D scaffold can support the proliferation and differentiation of hMSC into chondrocytes. The results of the biosafety test show that the scaffold meets the national medical device biological evaluation standards.


Author(s):  
Won Young Kim ◽  
Kishore Pochiraju

As 3D printing technology becomes more ubiquitous and pervasive, printed robot structures are likely to become popular. However, these 3D printed structures have inherent flexibility which causes link deflections and vibrations that lead to difficulties in maintaining gait and produce instabilities during motion. In this paper a biped robot, realized with 3D printing techniques, was modeled and its gait was simulated under position control. Spring and damper elements are used within powered joints to model the link flexibility. Servos were placed at the joints and an open-loop gait trajectory was executed by posing the robot through a series of servo angles. The gait of the printed robot was designed using the model. The printed robot’s stability and accelerations during the motion were characterized with 3-axis accelerometers and gyroscopes mounted on the robot. The acceleration measurements from the printed robot are then compared with the model behavior.


Materials ◽  
2021 ◽  
Vol 14 (18) ◽  
pp. 5177
Author(s):  
Kwang-Sik Jang ◽  
Soon-Jung Park ◽  
Jong-Jin Choi ◽  
Ha-Na Kim ◽  
Kyung-Mi Shim ◽  
...  

The skin protects the body from external barriers. Certain limitations exist in the development of technologies to rapidly prepare skin substitutes that are therapeutically effective in surgeries involving extensive burns and skin transplantation. Herein, we fabricated a structure similar to the skin layer by using skin-derived decellularized extracellular matrix (dECM) with bioink, keratinocytes, and fibroblasts using 3D-printing technology. The therapeutic effects of the produced skin were analyzed using a chimney model that mimicked the human wound-healing process. The 3D-printed skin substitutes exhibited rapid re-epithelialization and superior tissue regeneration effects compared to the control group. These results are expected to aid the development of technologies that can provide customized skin-replacement tissues produced easily and quickly via 3D-printing technology to patients.


2020 ◽  
Vol 6 (23) ◽  
pp. eaba7406 ◽  
Author(s):  
Yuwen Chen ◽  
Jiumeng Zhang ◽  
Xuan Liu ◽  
Shuai Wang ◽  
Jie Tao ◽  
...  

Three-dimensional (3D) printing technology has great potential in advancing clinical medicine. Currently, the in vivo application strategies for 3D-printed macroscale products are limited to surgical implantation or in situ 3D printing at the exposed trauma, both requiring exposure of the application site. Here, we show a digital near-infrared (NIR) photopolymerization (DNP)–based 3D printing technology that enables the noninvasive in vivo 3D bioprinting of tissue constructs. In this technology, the NIR is modulated into customized pattern by a digital micromirror device, and dynamically projected for spatially inducing the polymerization of monomer solutions. By ex vivo irradiation with the patterned NIR, the subcutaneously injected bioink can be noninvasively printed into customized tissue constructs in situ. Without surgery implantation, a personalized ear-like tissue constructs with chondrification and a muscle tissue repairable cell-laden conformal scaffold were obtained in vivo. This work provides a proof of concept of noninvasive in vivo 3D bioprinting.


MRS Advances ◽  
2015 ◽  
Vol 1 (8) ◽  
pp. 521-526 ◽  
Author(s):  
Shannon E. Bakarich ◽  
Robert Gorkin ◽  
Sina Naficy ◽  
Reece Gately ◽  
Marc in het Panhuis ◽  
...  

ABSTRACTThe past few years have seen the introduction of a number of 3D and 4D printing techniques used to process tough hydrogel materials. The use of ‘color’ 3D printing technology where multiple inks are used in the one print allows for the production of composite materials and structures that can further enhance the mechanical performance of the printed hydrogel. This article reviews a number of 3D and 4D printing techniques for fabricating functional hydrogel based devices.


2021 ◽  
pp. 41-44
Author(s):  
Diana-Roxana Viziteu ◽  
Antonela Curteza

The extraordinary thing about the application of 3D printing technology is that it can be used to create accessible items customized to personal needs. In the fashion industry, there is a need for individualized protective equipment. The possibility of applying new technologies such as 3D modelling of protective elements that can be made by using 3D printers is presented in this paper. 3D modelling and additive technologies (3D printing) can be used in the development of protective work clothing. The fabrication process only requires the digital fi le with the 3D model and the right material - we chose to use thermoplastic polyurethane (TPU).The design samples were constructed and modelled using a software program called Rhinoceros. The samples can be integrated into the clothing item, in order to follow the body shape and to provide the necessary protection. Purpose. This paper aims to explore the applicability of 3D printing materials using thermoplastic polyurethane (TPU) for the development of protective gear. Scientifi c novelty. In the fashion industry, three-dimensional (3D) printing has been used by designers and engineers to create everything from accessories to clothing, but only a few studies have investigated its applicability in personal protective equipment. Practical value. One of the most signifi cant technologies of the fourth industrial revolution is 3D printing. Additive manufacturing and 3D printing are the subject of intensive research and development (methods, materials, new techniques, application areas, etc.). The purpose of this study is to develop 3D printing samples and study conditions related to TPU.


2019 ◽  
pp. 417-423
Author(s):  
A. Chiriac ◽  
A. Iencean ◽  
Georgiana Ion ◽  
G. Stan ◽  
S. Munteanu ◽  
...  

Medical implications of 3-dimensional (3D) printing technology have progressed with increasingly used especially in surgical fields. 3D printing techniques are practical and anatomically accurate methods of producing patient specific models for medical education, surgical planning, training and simulation, and implants production for the assessment and treatment of neurosurgical diseases. This article presents the main directions of 3D printing models application in neurosurgery.


Author(s):  
Mohd Nazri Ahmad ◽  
Ahmad Afiq Tarmeze ◽  
Amir Hamzah Abdul Rasib

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