scholarly journals Electrospun PCL Fiber Mats Incorporating Multi-Targeted B and Co Co-Doped Bioactive Glass Nanoparticles for Angiogenesis

Materials ◽  
2020 ◽  
Vol 13 (18) ◽  
pp. 4010 ◽  
Author(s):  
Si Chen ◽  
Dagmar Galusková ◽  
Hana Kaňková ◽  
Kai Zheng ◽  
Martin Michálek ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Bioactive Glass ◽  
Sol Gel ◽  
Spherical Shape ◽  
Biologically Active ◽  
Ion Release ◽  
Fiber Mats ◽  
Young’S Moduli ◽  
Co Doped

Vascularization is necessary in tissue engineering to keep adequate blood supply in order to maintain the survival and growth of new tissue. The synergy of biologically active ions with multi-target activity may lead to superior angiogenesis promotion in comparison to single-target approaches but it has been rarely investigated. In this study, polycaprolactone (PCL) fiber mats embedded with B and Co co-doped bioactive glass nanoparticles (BCo.BGNs) were fabricated as a tissue regeneration scaffold designed for promoting angiogenesis. BCo.NBGs were successfully prepared with well-defined spherical shape using a sol-gel method. The PCL fiber mats embedding co-doped bioactive glass nanoparticles were fabricated by electrospinning using benign solvents. The Young’s moduli of the nanoparticle containing PCL fiber mats were similar to those of the neat fiber mats and suitable for scaffolds utilized in soft tissue repair approaches. The mats also showed non-cytotoxicity to ST-2 cells. PCL fiber mats containing BCo.BGNs with a relatively high content of B and Co promoted the secretion of vascular endothelial growth factor to a greater extent than PCL fiber mats with a relatively low B and Co contents, which demonstrates the potential of dual ion release (B and Co) from bioactive glasses to enhance angiogenesis in soft tissue engineering.

Assessment of polyglycolic acid mesh and bioactive glass for soft-tissue engineering scaffolds

Biomaterials ◽  
2004 ◽  
Vol 25 (27) ◽  
pp. 5857-5866 ◽  
Author(s):  
Richard M. Day ◽  
Aldo R. Boccaccini ◽  
Sandra Shurey ◽  
Judith A. Roether ◽  
Alastair Forbes ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Bioactive Glass ◽  
Polyglycolic Acid ◽  
Tissue Engineering Scaffolds ◽  
Polyglycolic Acid Mesh ◽  
Soft Tissue Engineering

Sol–gel derived nanoscale bioactive glass (NBG) particles reinforced poly(ε-caprolactone) composites for bone tissue engineering

2013 ◽  
Vol 33 (3) ◽  
pp. 1102-1108 ◽  
Author(s):  
Bo Lei ◽  
Kwan-Ha Shin ◽  
Da-Young Noh ◽  
In-Hwan Jo ◽  
Young-Hag Koh ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Sol Gel

Luminescence Properties of Sm3+/Eu3+ Co-Doped ZnO Quantum Dots

2016 ◽  
Vol 16 (4) ◽  
pp. 3597-3601
Author(s):  
Fengyi Liu ◽  
Hong Li ◽  
Yajing Hu ◽  
Na Jin ◽  
Yun Mou ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Sol Gel ◽  
Spherical Shape ◽  
Hexagonal Wurtzite Structure ◽  
Luminescence Properties ◽  
Transmission Electron ◽  
Doped Zno ◽  
Zno Quantum Dots ◽  
Zno Qds ◽  
Co Doped

In order to improve luminescence properties of semiconductor ZnO quantum dots (QDs), Sm3+/Eu3+ co-doped ZnO QDs have been controllably synthesized by sol–gel method in this paper. ZnO QDs have a spherical shape with mean diameter at about 5–6 nm, which was characterized by high-resolution transmission electron microscopy (HRTEM). ZnO QDs have hexagonal wurtzite structure with parts of Sm3+ and Eu3+ incorporated into the lattice, which was demonstrated by X-ray Diffraction (XRD). Luminescence properties at room temperature (RT) of different amount of Sm3+ and 2 mol% Eu3+ doped ZnO QDs were examined in-depth by optical spectra. In contrast to the Pr3+/Eu3+ co-doped fluorescent performance researched in our previous study, the photoluminescence (PL) spectra indicates the unique luminescence properties of Sm3+/Eu3+ co-doped ZnO QDs. In addition, fluorescence lifetimes were obtained to illustrate the luminous mechanism.

scholarly journals Comparison of the Effect of Sol-Gel and Coprecipitation Routes on the Properties and Behavior of Nanocomposite Chitosan-Bioactive Glass Membranes for Bone Tissue Engineering

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Elke M. F. Lemos ◽  
Sandhra M. Carvalho ◽  
Patrícia S. O. Patrício ◽  
Claudio L. Donnici ◽  
Marivalda M. Pereira
Keyword(s):  
Tissue Engineering ◽  
Cell Viability ◽  
Bioactive Glass ◽  
Bone Regeneration ◽  
Sol Gel ◽  
Composite Films ◽  
Maximum Tensile Stress ◽  
Control Group ◽  
Nanoparticle Dispersion

Recent studies in tissue engineering have highlighted the importance of the development of composite materials based on biodegradable polymers containing bioactive glasses, in particular, composites for high load support and excellent cell viability for potential application in bone regeneration. In this work, hybrid composite films were obtained by combining chitosan with bioactive glass in solution form and in nanoparticle dispersion form obtained by the two different synthesis routes: the sol-gel method and coprecipitation. The bioactive glass served both as a mechanical reinforcing agent and as a triggering agent with high bioactivity. The results ofin vitroassays with simulated body fluid demonstrated the formation of a significant layer of fibrils on the surface of the film, with a typical morphology of carbonated hydroxyapatite, reflecting induction of a favorable bioactivity. Maximum tensile stress increased from 42 to 80 MPa to the sample with 5% wt bioactive glass. In addition, samples containing 5% and 10% wt bioactive glass showed a significant increase in cell viability, 18 and 30% increase compared to the control group. The samples showed significant response, indicating that they could be a potential material for use in bone regeneration through tissue engineering.

Sol–gel-derived manganese-releasing bioactive glass as a therapeutic approach for bone tissue engineering

2017 ◽  
Vol 52 (15) ◽  
pp. 8904-8927 ◽  
Author(s):  
Breno Rocha Barrioni ◽  
Ana Celeste Oliveira ◽  
Maria de Fátima Leite ◽  
Marivalda de Magalhães Pereira
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Therapeutic Approach ◽  
Sol Gel

Preparation and mineralization of 13-93 bioactive glass-containing electrospun poly-epsilon-caprolactone composite nanofibrous mats

2018 ◽  
Vol 32 (5) ◽  
pp. 690-709
Author(s):  
Rabia Konyalı ◽  
Aylin M Deliormanlı
Keyword(s):  
Bioactive Glass ◽  
Fibrous Composite ◽  
Glass Particle ◽  
Ion Release ◽  
Composite Scaffolds ◽  
Fiber Mats ◽  
Nanocomposite Fiber ◽  
Static Conditions ◽  
Hydroxyapatite Formation

In this study, silicate- based 13-93 bioactive glass (BG) /poly-ε-caprolactone (PCL) nanocomposite fiber mats were fabricated through electrospinning. To prepare composites, amorphous electrospun bioactive glass nanofibers (BGFs) or melt-derived microscale bioactive glass particles (BGPs) were incorporated into the PCL matrix. In vitro mineralization ability of the prepared fibrous mats was assessed in simulated body fluid under static conditions. The results revealed that it is possible to prepare bead-free continuous nanofibers using PCL-acetone solution at specified PCL concentrations (8 and 10 wt%). Nanofibers with almost uniform diameters were produced using 10 wt% PCL solution. Incorporation of BG in the form of particle or fiber into the PCL matrix was made between 1 wt% and 10 wt%. The results showed that the diameter of BGP-containing composite fibers was higher compared to BGF-containing composite scaffolds. The addition of BG to the PCL matrix both in the form of powder and fiber enhanced hydroxyapatite formation in the fibrous scaffolds. The amount of calcium phosphate–based material formation was higher in glass particle–containing samples compared to glass fiber–containing PCL scaffolds. Additionally, the degradation rate in phosphate buffer and silicium ion release amount of BGP-containing PCL fibers was higher compared to BGF-containing PCL fibers. It was concluded that fibrous composite scaffolds prepared in this study could have potential in tissue engineering applications.

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