scholarly journals Trends in Degradable Mesoporous Organosilica-Based Nanomaterials for Controlling Drug Delivery: A Mini Review

Materials ◽  
2020 ◽  
Vol 13 (17) ◽  
pp. 3668 ◽  
Author(s):  
Vanessa Poscher ◽  
Yolanda Salinas
Keyword(s):  
Drug Delivery ◽  
Clinical Trials ◽  
Potential Application ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cellular Level ◽  
On Demand ◽  
Mesoporous Organosilica ◽  
Molecular Gates ◽  
Potential Use

The last few years of enhancing the design of hybrid mesoporous organosilica nanoparticleshas allowed their degradation under specific pathologic conditions, which finally is showing a lightin their potential use as drug delivery systems towards clinical trials. Nevertheless, the issueof controlling the degradation on-demand at cellular level still remains a major challenge, even if ithas lately been addressed through the incorporation of degradable organo-bridged alkoxysilanesinto the silica framework. On this basis, this mini review covers some of the most recent examplesof dierent degradable organosilica nanomaterials with potential application in nanomedicine,from degradable non-porous to mesoporous organosilica nanoparticles (MONs), functionalized withresponsive molecular gates, and also the very promising degradable periodic mesoporous organosilicamaterials (PMOs) only consisting of organosilica bridges.

scholarly journals Advances in Functional Metal‐Organic Frameworks Based On‐Demand Drug Delivery Systems for Tumor Therapeutics

2021 ◽  
pp. 2100014
Author(s):  
Bhanu Nirosha Yalamandala ◽  
Wei‐Ting Shen ◽  
Sheng‐Hao Min ◽  
Wen‐Hsuan Chiang ◽  
Shing‐Jyh Chang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Metal Organic Frameworks ◽  
Delivery Systems ◽  
On Demand ◽  
Metal Organic

Tough hydrogel module towards an implantable remote and controlled release device

2020 ◽  
Vol 8 (3) ◽  
pp. 960-972 ◽  
Author(s):  
Zhi Wei Kenny Low ◽  
Yifei Luo ◽  
Kangyi Zhang ◽  
Qianyu Lin ◽  
Cally Owh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
On Demand ◽  
Release Device

On-demand controllable drug delivery systems enable the administration of precise dosages and thus have the potential to improve overall healthcare.

scholarly journals New strategy of controlled, stepwise release from novel MBioF and its potential application for drug delivery systems

Adsorption ◽  
2019 ◽  
Vol 25 (3) ◽  
pp. 383-391 ◽  
Author(s):  
Adam Bieniek ◽  
Marek Wiśniewski ◽  
Katarzyna Roszek ◽  
Paulina Bolibok ◽  
Artur P. Terzyk ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Potential Application ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
New Strategy

scholarly journals Stimuli-Responsive Nanofibers Containing Gold Nanorods for On-Demand Drug Delivery Platforms

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1319
Author(s):  
Baljinder Singh ◽  
Nutan Shukla ◽  
Junkee Kim ◽  
Kibeom Kim ◽  
Myoung-Hwan Park
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Gold Nanorods ◽  
Drug Delivery Systems ◽  
Near Infrared ◽  
Resonance Effect ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
On Demand ◽  
Multiple Drugs

On-demand drug delivery systems using nanofibers have attracted significant attention owing to their controllable properties for drug release through external stimuli. Near-infrared (NIR)-responsive nanofibers provide a platform where the drug release profile can be achieved by the on-demand supply of drugs at a desired dose for cancer therapy. Nanomaterials such as gold nanorods (GNRs) exhibit absorbance in the NIR range, and in response to NIR irradiation, they generate heat as a result of a plasmon resonance effect. In this study, we designed poly (N-isopropylacrylamide) (PNIPAM) composite nanofibers containing GNRs. PNIPAM is a heat-reactive polymer that provides a swelling and deswelling property to the nanofibers. Electrospun nanofibers have a large surface-area-to-volume ratio, which is used to effectively deliver large quantities of drugs. In this platform, both hydrophilic and hydrophobic drugs can be introduced and manipulated. On-demand drug delivery systems were obtained through stimuli-responsive nanofibers containing GNRs and PNIPAM. Upon NIR irradiation, the heat generated by the GNRs ensures shrinking of the nanofibers owing to the thermal response of PNIPAM, thereby resulting in a controlled drug release. The versatility of the light-responsive nanofibers as a drug delivery platform was confirmed in cell studies, indicating the advantages of the swelling and deswelling property of the nanofibers and on–off drug release behavior with good biocompatibility. In addition, the system has potential for the combination of chemotherapy with multiple drugs to enhance the effectiveness of complex cancer treatments.

Preparation and characterization of magnetic nanoparticles and their impact on anticancer drug binding and release processes moderated through a 1sttier dendrimer

RSC Advances ◽  
2016 ◽  
Vol 6 (44) ◽  
pp. 37391-37402 ◽  
Author(s):  
Shivani R. Pandya ◽  
Man Singh
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Drug Binding ◽  
Potential Use ◽  
Release Processes

MNPs show superparamagnetic character which moderates the structural ability of TTDMM to bind silibinin (SB) and methotrexate (MTX) anticancer drugs for their potential use in drug delivery systems.

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