scholarly journals High Throughput Preparation of Poly(Lactic-Co-Glycolic Acid) Nanoparticles Using Fiber Fluidic Reactor

Materials ◽  
2020 ◽  
Vol 13 (14) ◽  
pp. 3075
Author(s):  
Niloofar Heshmati Aghda ◽  
Emilio J. Lara ◽  
Pulinkumar Patel ◽  
Tania Betancourt
Keyword(s):  
High Throughput ◽  
Self Assembly ◽  
Large Scale ◽  
Glycolic Acid ◽  
Polymeric Nanoparticles ◽  
High Surface ◽  
High Surface Area ◽  
Poly Vinyl Alcohol ◽  
Operational Parameters ◽  
Operational Temperature

Polymeric nanoparticles (NPs) have a variety of biomedical, biotechnology, agricultural and environmental applications. As such, a great need has risen for the fabrication of these NPs in large scales. In this study, we used a high throughput fiber reactor for the preparation of poly(lactic-co-glycolic acid) (PLGA) NPs via nanoprecipitation. The fiber reactor provided a high surface area for the controlled interaction of an organic phase containing the PLGA solution with an aqueous phase, containing poly(vinyl alcohol) (PVA) as a stabilizer. This interaction led to the self-assembly of the polymer into the form of NPs. We studied operational parameters to identify the factors that have the greatest influence on the properties of the resulting PLGA NPs. We found that the concentration of the PLGA solution is the factor that has the greatest effect on NP size, polydispersity index (PDI), and production rate. Increasing PLGA concentration increased NP sizes significantly, while at the same time decreasing the PDI value. The second factor that was found to affect NP properties was the concentration of PVA solution, which resulted in increased NP sizes and decreased production rates. Flowrates of the feed streams also affected NP size to a lesser extent, while changing the operational temperature did not change the product’s features. In general, the results demonstrate that fiber reactors are a suitable method for the large-scale, continuous preparation of polymeric NPs suitable for biomedical applications.

scholarly journals Nanobiotechnology: advances in the use of nanomaterials to increase CO2 biofixation by microalgae

2021 ◽  
Author(s):  
Michele Greque Morais ◽  
Bruna Pereira Vargas ◽  
Bruna Silva Vaz ◽  
Bruna Barcelos Cardias ◽  
Jorge Alberto Vieira Costa
Keyword(s):  
Active Sites ◽  
Large Scale ◽  
Gas Adsorption ◽  
Polymeric Nanoparticles ◽  
Physical Adsorption ◽  
High Surface ◽  
High Surface Area ◽  
Value Added ◽  
Key Points ◽  
Adsorbent Materials

Abstract Microalgae through photosynthesis can convert atmospheric CO2 into biomass to produce biofuels and high value-added bioproducts. the improvement of the cultivation systems helps in the conversion of gases into biomass and, consequently, increase microalgal productivity. Recently, studies involving the technology of physical adsorption with nanomaterials have shown promising results in increasing the CO2 biofixation by microalgae. Polymeric nanoparticles produced by the electrospraying technique stand out as potential adsorbent materials for CO2 capture due to the high surface area per unit volume formed by many active sites that increase the gas adsorption capacity in a liquid medium. The interactions between plant cells and nanomaterials have been revealed the potential of nanobiotechnology to reduce environmental pollution and contribute to sustainability. Moreover, the development of these methodologies can contribute to the viability of large-scale microalgae cultivations for CO2 mitigation. Based on this, the objective of this review is to address the advances of nanobiotechnology to increase CO2 biofixation by microalgae. The potential of adsorbent nanoparticles developed by the electrospraying technique and the key points for applying it for this purpose are also discussed.

scholarly journals Synthesis and self-assembly of curcumin-modified amphiphilic polymeric micelles with antibacterial activity

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Caio H. N. Barros ◽  
Dishon W. Hiebner ◽  
Stephanie Fulaz ◽  
Stefania Vitale ◽  
Laura Quinn ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Self Assembly ◽  
Glycolic Acid ◽  
Extracellular Polymeric Substances ◽  
Polymeric Micelles ◽  
Polymeric Nanoparticles ◽  
Enhanced Resistance ◽  
Antimicrobial Nanoparticles ◽  
Good Penetration ◽  
Antibiofilm Agents

Abstract Background The ubiquitous nature of bacterial biofilms combined with the enhanced resistance towards antimicrobials has led to the development of an increasing number of strategies for biofilm eradication. Such strategies must take into account the existence of extracellular polymeric substances, which obstruct the diffusion of antibiofilm agents and assists in the maintenance of a well-defended microbial community. Within this context, nanoparticles have been studied for their drug delivery efficacy and easily customised surface. Nevertheless, there usually is a requirement for nanocarriers to be used in association with an antimicrobial agent; the intrinsically antimicrobial nanoparticles are most often made of metals or metal oxides, which is not ideal from ecological and biomedical perspectives. Based on this, the use of polymeric micelles as nanocarriers is appealing as they can be easily prepared using biodegradable organic materials. Results In the present work, micelles comprised of poly(lactic-co-glycolic acid) and dextran are prepared and then functionalised with curcumin. The effect of the functionalisation in the micelle’s physical properties was elucidated, and the antibacterial and antibiofilm activities were assessed for the prepared polymeric nanoparticles against Pseudomonas spp. cells and biofilms. It was found that the nanoparticles have good penetration into the biofilms, which resulted in enhanced antibacterial activity of the conjugated micelles when compared to free curcumin. Furthermore, the curcumin-functionalised micelles were efficient at disrupting mature biofilms and demonstrated antibacterial activity towards biofilm-embedded cells. Conclusion Curcumin-functionalised poly(lactic-co-glycolic acid)-dextran micelles are novel nanostructures with an intrinsic antibacterial activity tested against two Pseudomonas spp. strains that have the potential to be further exploited to deliver a secondary bioactive molecule within its core. Graphic Abstract

Facile and large-scale synthesis of poly(m-phenylenediamine) nanobelts with high surface area and superior dye adsorption ability

RSC Advances ◽  
2014 ◽  
Vol 4 (85) ◽  
pp. 45244-45250 ◽  
Author(s):  
Yun Meng ◽  
Liyuan Zhang ◽  
Liyuan Chai ◽  
Wanting Yu ◽  
Ting Wang ◽  
...  
Keyword(s):  
Surface Area ◽  
Large Scale ◽  
High Surface ◽  
High Surface Area ◽  
Dye Adsorption ◽  
High Adsorption ◽  
Adsorption Ability ◽  
Adsorption Performance ◽  
Large Scale Synthesis

PmPD nanobelts with high adsorption performance have been synthesized by using CTAP as oxidants.

scholarly journals Green and facile synthesis of cerium doped Ni3Fe electrocatalyst for efficient oxygen evolution reaction

2020 ◽  
Vol 34 (2) ◽  
pp. 353-363
Author(s):  
F. Kanwal ◽  
A. Batool ◽  
R. Akbar ◽  
S. Asim ◽  
M. Saleem
Keyword(s):  
Oxygen Evolution ◽  
Oxygen Evolution Reaction ◽  
Large Scale ◽  
Low Cost ◽  
High Surface ◽  
High Surface Area ◽  
Three Dimensional ◽  
Alkaline Electrolyte ◽  
Hydrogen Electrode ◽  
Molar Ratios

Electrochemical water splitting is the most promising pathway to produce high-purity hydrogen to alleviate global energy crisis. This reaction demands inexpensive, efficient and robust electrocatalyst for its commercial use. Herein, we demonstrate an effective, facile and scalable method for the synthesis of cerium doped Ni3Fe nanostructures as an electrocatalyst for oxygen evolution reaction (OER) by following simple chemical bath deposition route. The different molar ratios (3, 6 and 12 mM) of cerium in the chemical bath were used to study its effect on the structural and the electrochemical properties of the Ni3Fe nanostructured films. Doping of cerium contents induced variations in the morphology of deposited Ni3Fe nanostructures. The optimized electrocatalyst Ni3Fe/Ce-6 yielded high surface area catalyst nanosheets uniformly deposited on three-dimensional conductive scaffold to ensure increase in the exposure of doped Ni3Fe catalytic sites with high electrical conductivity. As a result, this earth-abundant electrocatalyst affords high OER performance with a small overpotential of 310 mV versus reversible hydrogen electrode (RHE) at 10 mA cm-2 and retains good stability up to ~ 10 h in alkaline electrolyte. This scalable strategy has great potential in future advancement of efficient and low-cost electrocatalysts for their large-scale application in energy conversion systems.                     KEY WORDS: Oxygen evolution, Electrocatalyst, Ni3Fe nanostructures, Cerium, Alkaline electrolyte   Bull. Chem. Soc. Ethiop. 2020, 34(2), 353-363 DOI: https://dx.doi.org/10.4314/bcse.v34i2.12

High-Surface-Area SBA-15 with Enhanced Mesopore Connectivity by the Addition of Poly(vinyl alcohol)

2011 ◽  
Vol 23 (8) ◽  
pp. 2062-2067 ◽  
Author(s):  
Junjiang Zhu ◽  
Kamalakannan Kailasam ◽  
Xiao Xie ◽  
Reinhard Schomaecker ◽  
Arne Thomas
Keyword(s):  
Surface Area ◽  
Vinyl Alcohol ◽  
High Surface ◽  
High Surface Area ◽  
Poly Vinyl Alcohol

Large-scale and facile synthesis of a porous high-entropy alloy CrMnFeCoNi as an efficient catalyst

2020 ◽  
Vol 8 (35) ◽  
pp. 18318-18326 ◽  
Author(s):  
Hailong Peng ◽  
Yangcenzi Xie ◽  
Zicheng Xie ◽  
Yunfeng Wu ◽  
Wenkun Zhu ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Surface Area ◽  
Large Scale ◽  
High Surface ◽  
High Surface Area ◽  
Catalytic Performance ◽  
High Entropy Alloy ◽  
Facile Synthesis ◽  
Efficient Catalyst ◽  
High Entropy

Porous high entropy alloy CrMnFeCoNi exhibited remarkable catalytic activity and stability toward p-nitrophenol hydrogenation. The enhanced catalytic performance not only resulted from the high surface area, but also from exposed high-index facets with terraces.

scholarly journals Anchoring Pd-nanoparticles on dithiocarbamate- functionalized SBA-15 for hydrogen generation from formic acid

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Mustafa Farajzadeh ◽  
Hassan Alamgholiloo ◽  
Fariba Nasibipour ◽  
Reza Banaei ◽  
Sadegh Rostamnia
Keyword(s):  
Formic Acid ◽  
Ultrasonic Irradiation ◽  
Large Scale ◽  
Hydrogen Generation ◽  
High Surface ◽  
High Surface Area ◽  
Pd Nanoparticles ◽  
Metal Nanoparticle ◽  
Catalytic Systems ◽  
Metabolic Products

Abstract Hydrogen (H2) generation from natural biological metabolic products has remained a huge challenge for the energy arena. However, designing a catalytic system with complementary properties including high surface area, high loading, and easy separation offers a promising route for efficient utilization of nanoreactors for prospective H2 suppliers to a fuel cell. Herein, selective dehydrogenation of formic acid (FA) as a natural biological metabolic product to H2 and CO2 gas mixtures has been studied by supporting ultrafine palladium nanoparticles on organosulfur-functionalized SBA-15 nanoreactor under ultrasonic irradiation. The effects of the porous structure as a nanoreactor, and organosulfur groups, which presented around the Pd due to their prominent roles in anchoring and stabilizing of Pd NPs, studied as a superior catalyst for selective dehydrogenation of FA. Whole catalytic systems were utilized in ultrasonic irradiation in the absence of additives to provide excellent TOF/TON values. It was found that propose catalyst is a greener, recyclable, and more suitable option for the large-scale application and provide some new insights into stabilization of ultra-fine metal nanoparticle for a variety of applications.

Precision control of the large-scale green synthesis of biodegradable gold nanodandelions as potential radiotheranostics

2019 ◽  
Vol 7 (11) ◽  
pp. 4720-4729
Author(s):  
Yao-Chen Chuang ◽  
Yu Hsia ◽  
Chia-Hui Chu ◽  
Li-Jie Lin ◽  
Maharajan Sivasubramanian ◽  
...  
Keyword(s):  
Green Synthesis ◽  
Surface Area ◽  
Large Scale ◽  
High Surface ◽  
High Surface Area ◽  
Precision Control ◽  
New Type

Herein, we report a new type of biodegradable, high surface-area gold nanodandelions (GNDs) as potential radiotheranostics.

In Situ and Ex Situ Microscopic Study of Propylene Polymerization With Heterogeneous Mgcl2-Supported Ziegler-Natta Catalysts

2000 ◽  
Vol 6 (S2) ◽  
pp. 33-34
Author(s):  
V. Oleshko ◽  
P. Crozier ◽  
R. Cantrell ◽  
A. Westwood
Keyword(s):  
Large Scale ◽  
Heterogeneous Catalysts ◽  
High Surface ◽  
Light And Electron Microscopy ◽  
High Surface Area ◽  
Propylene Polymerization ◽  
Ex Situ ◽  
Co Catalysts ◽  
Ziegler Natta Catalysts

The large-scale commercial production of polyolefins by catalytic Ziegler-Natta polymerization have stimulated the development of the third, fourth and fifth generation heterogeneous catalysts comprising high surface area defective MgCl2 with TiCl4, electron donors, and AlR3-co-catalysts. In spite of intensive research over the years, the present level of understanding of the catalysts is still incomplete because of their complex composition leading to a multitude of local active site environments. The aim of this work is to provide a new insight into the process via in situ video microscopy of gas phase propylene polymerization over MgCl2-supported Ziegler-Natta catalysts combined with ex situ characterization by light and electron microscopy techniques (SEM, TEM, HRTEM, STEM, PEELS and windowless EDX). Procedures for catalyst synthesis are described elsewhere. The catalysts were stored in a dry box under a He atmosphere (<lppm H2O/O2). Samples were transferred to specimen holders in the dry box and then transferred into the microscopes under high purge N2 conditions to prevent poisoning of the catalysts by air and moisture.

Current Understanding of Formation Mechanisms in Surfactant-Templated Materials

2005 ◽  
Vol 58 (9) ◽  
pp. 627 ◽  
Author(s):  
Karen J. Edler
Keyword(s):  
Self Assembly ◽  
High Surface ◽  
High Surface Area ◽  
Formation Mechanisms ◽  
Surfactant Micelle ◽  
Surfactant Micelles ◽  
Molecular Separation ◽  
Inorganic Species ◽  
Templated Materials ◽  
High Surface Area Materials

Surfactant-templated materials are created through self-assembly in solutions containing both surfactant micelles and an inorganic species. The resulting materials are composites containing an organized surfactant micelle array encapsulated in the inorganic material. Removal of the surfactants generates nanoscale pores which replicate the highly organized micelle phase, producing high surface area materials with uniform pores that have applications in catalysis, molecular separation, encapsulation for sensors and slow release, and thin films for optoelectronics and photoelectrochemical devices. This review looks at recent work aimed at understanding how these materials self-assemble from dilute surfactant solutions to form intricate nanoscale configurations, which also often show complex and highly ordered structures on longer length scales.

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