scholarly journals Dendrimers: Amazing Platforms for Bioactive Molecule Delivery Systems

Materials ◽  
2020 ◽  
Vol 13 (3) ◽  
pp. 570 ◽  
Author(s):  
Claudia Sandoval-Yañez ◽  
Cristian Castro Rodriguez
Keyword(s):  
Drug Delivery Systems ◽  
Structural Modification ◽  
Physicochemical Characteristics ◽  
Therapeutic Strategies ◽  
Delivery Systems ◽  
Bioactive Molecules ◽  
Target Tissue ◽  
Bioactive Molecule ◽  
Low Solubility ◽  
Low Solubility Drugs

Today, dendrimers are the main nanoparticle applied to drug delivery systems. The physicochemical characteristics of dendrimers and their versatility structural modification make them attractive to applied as a platform to bioactive molecules transport. Nanoformulations based on dendrimers enhance low solubility drugs, arrival to the target tissue, drugs bioavailability, and controlled release. This review describes the latter approaches on the transport of bioactive molecules based on dendrimers. The review focus is on the last therapeutic strategies addressed by dendrimers conjugated with bioactive molecules. A brief review of the latest studies in therapies against cancer and cardiovascular diseases, as well as future projections in the area, are addressed.

scholarly journals Food-Derived Nanoscopic Drug Delivery Systems for Treatment of Rheumatoid Arthritis

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3506
Author(s):  
Dong Han ◽  
Qilei Chen ◽  
Hubiao Chen
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Bioactive Molecules ◽  
Research Orientation ◽  
Therapeutic Outcomes ◽  
Systemic Inflammatory Disease ◽  
Recent Developments

Rheumatoid arthritis (RA) is a severe systemic inflammatory disease with no cure at present. Recent developments in the understanding of inflammation and nanomaterial science have led to increased applications of nanostructured drug delivery systems in the treatment of RA. The present review summarizes novel fabrications of nanoscale drug carriers using food components as either the delivered drugs or carrier structures, in order to achieve safe, effective and convenient drug administration. Polyphenols and flavonoids are among the most frequently carried anti-RA therapeutics in the nanosystems. Fatty substances, polysaccharides, and peptides/proteins can function as structuring agents of the nanocarriers. Frequently used nanostructures include nanoemulsions, nanocapsules, liposomes, and various nanoparticles. Using these nanostructures has improved drug solubility, absorption, biodistribution, stability, targeted accumulation, and release. Joint vectorization, i.e., using a combination of bioactive molecules, can bring elevated therapeutic outcomes. Utilization of anti-arthritic chemicals that can self-assemble into nanostructures is a promising research orientation in this field.

scholarly journals Single-Walled Carbon Nanohorns as Promising Nanotube-Derived Delivery Systems to Treat Cancer

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 850 ◽  
Author(s):  
Alazne Moreno-Lanceta ◽  
Mireia Medrano-Bosch ◽  
Pedro Melgar-Lesmes
Keyword(s):  
Drug Delivery ◽  
Anticancer Agents ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Physicochemical Characteristics ◽  
Delivery Systems ◽  
Preclinical Research ◽  
Carbon Nanohorns ◽  
Single Walled Carbon

Cancer has become one of the most prevalent diseases worldwide, with increasing incidence in recent years. Current pharmacological strategies are not tissue-specific therapies, which hampers their efficacy and results in toxicity in healthy organs. Carbon-based nanomaterials have emerged as promising nanoplatforms for the development of targeted delivery systems to treat diseased cells. Single-walled carbon nanohorns (SWCNH) are graphene-based horn-shaped nanostructure aggregates with a multitude of versatile features to be considered as suitable nanosystems for targeted drug delivery. They can be easily synthetized and functionalized to acquire the desired physicochemical characteristics, and no toxicological effects have been reported in vivo followed by their administration. This review focuses on the use of SWCNH as drug delivery systems for cancer therapy. Their main applications include their capacity to act as anticancer agents, their use as drug delivery systems for chemotherapeutics, photothermal and photodynamic therapy, gene therapy, and immunosensing. The structure, synthesis, and covalent and non-covalent functionalization of these nanoparticles is also discussed. Although SWCNH are in early preclinical research yet, these nanotube-derived nanostructures demonstrate an interesting versatility pointing them out as promising forthcoming drug delivery systems to target and treat cancer cells.

scholarly journals Interpenetrating Polymer Networks as Innovative Drug Delivery Systems

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Alka Lohani ◽  
Garima Singh ◽  
Shiv Sankar Bhattacharya ◽  
Anurag Verma
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymer Networks ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
Interpenetrating Polymer Networks ◽  
Bioactive Molecules ◽  
Polymer Science ◽  
Natural Polymers ◽  
Innovative Drug

Polymers have always been valuable excipients in conventional dosage forms, also have shown excellent performance into the parenteral arena, and are now capable of offering advanced and sophisticated functions such as controlled drug release and drug targeting. Advances in polymer science have led to the development of several novel drug delivery systems. Interpenetrating polymer networks (IPNs) have shown superior performances over the conventional individual polymers and, consequently, the ranges of applications have grown rapidly for such class of materials. The advanced properties of IPNs like swelling capacity, stability, biocompatibility, nontoxicity and biodegradability have attracted considerable attention in pharmaceutical field especially in delivering bioactive molecules to the target site. In the past few years various research reports on the IPN based delivery systems showed that these carriers have emerged as a novel carrier in controlled drug delivery. The present review encompasses IPNs, their types, method of synthesis, factors which affects the morphology of IPNs, extensively studied IPN based drug delivery systems, and some natural polymers widely used for IPNs.

Delivery Systems for Birch-bark Triterpenoids and their Derivatives in Anticancer Research

2020 ◽  
Vol 27 (8) ◽  
pp. 1308-1336 ◽  
Author(s):  
Inese Mierina ◽  
Reinis Vilskersts ◽  
Māris Turks
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Biological Activities ◽  
Delivery Systems ◽  
Chemotherapeutic Agents ◽  
Birch Bark ◽  
Self Assembling ◽  
Wide Range ◽  
Synthetic Derivatives ◽  
Low Solubility

Birch-bark triterpenoids and their semi-synthetic derivatives possess a wide range of biological activities including cytotoxic effects on various tumor cell lines. However, due to the low solubility and bioavailability, their medicinal applications are rather limited. The use of various nanotechnology-based drug delivery systems is a rapidly developing approach to the solubilization of insufficiently bioavailable pharmaceuticals. Herein, the drug delivery systems deemed to be applicable for birch-bark triterpenoid structures are reviewed. The aforementioned disadvantages of birch-bark triterpenoids and their semi-synthetic derivatives can be overcome through their incorporation into organic nanoparticles, which include various dendrimeric systems, as well as embedding the active compounds into polymer matrices or complexation with carbohydrate nanoparticles without covalent bonding. Some of the known triterpenoid delivery systems consist of nanoparticles featuring inorganic cores covered with carbohydrates or other polymers. Methods for delivering the title compounds through encapsulation and emulsification into lipophilic media are also suitable. Besides, the birch-bark triterpenoids can form self-assembling systems with increased bio-availability. Even more, the self-assembling systems are used as carriers for delivering other chemotherapeutic agents. Another advantage besides increased bioavailability and anticancer activity is the reduced overall systemic toxicity in most of the cases, when triterpenoids are delivered with any of the carriers.

Therapeutic Efficacy of Herbal Formulations Through Novel Drug Delivery Systems

2021 ◽  
pp. 1-42
Author(s):  
Arvind Kumar Singh Chandel ◽  
Nutan Bhingradiya
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Herbal Medicines ◽  
Bioactive Compound ◽  
Delivery Systems ◽  
Bioactive Molecules ◽  
Therapeutic Molecules ◽  
Dose Accuracy ◽  
The Many ◽  
Novel Drug

The herbal-based drugs have been getting wide attention over the last few decades. The herbal drugs have been used from the ancient times, but the dose accuracy, efficacy, and treatment was just based on symptomatic observatory. Modern research is focused on pure bioactive compound instead of crude. The researchers are trying to apply the current advanced nanotechnology-based knowledge on the herbal medicines to improve efficacy and reduces the unwanted pharmacological actions' adverse effects of the therapeutic molecules. The many novel drug delivery systems available used for the herbal bioactive molecules include polymeric micelle, injectable hydrogel, nano gel, nano emulsions, microsphere, polymeric nanoparticles, nano capsules, liposomes, phytosomes, transferosomes, dendrimer, and ethosomes. This chapter highlights the existing research and development of current standing of the of various novel formulations especially for the herbal bioactive molecules and summarizes their active ingredients, commercial formulations, route of drug administration, and pharmacological activity.

Multi-physics study of acoustofluidic delivery agents' clustering behavior

2021 ◽  
Author(s):  
Hussain AlSadiq ◽  
Karnaker Reddy Tupally ◽  
Robert Vogel ◽  
Harendra S Parekh ◽  
Martin Veidt
Keyword(s):  
Drug Delivery ◽  
Brownian Motion ◽  
Drug Delivery Systems ◽  
Cluster Formation ◽  
Radiation Force ◽  
Delivery Systems ◽  
Electrostatic Repulsion ◽  
Clear Understanding ◽  
Target Tissue ◽  
Zeta Potentials

Abstract Acoustofluidicly manipulated microbubbles (MBs) and echogenic liposomes (ELIPs) have been suggested as drug delivery systems for the ‘on demand’ release of drug in target tissue. This requires a clear understanding of their behaviour during ultrasonication and after ultrasonication stops. The main focus of this study is to investigate the behaviour of MBs and ELIPs clusters after ultrasonication stops and the underlaying cause of cluster diffusion considering electrostatic repulsion, steric repulsion and Brownian motion. It also examines the capability of existing models used to predict MBs’ attraction velocity due to secondary radiation force, on predicting ELIPs’ attraction velocity. Tunable resistive pulse sensing (TRPS) and phase analysis light scattering (PALS) techniques were used to measure zeta potentials of the agents and the size distributions were measured using TRPS. The zeta potentials were found to be -2.43 mV and -0.62 mV for Definity™ MBs, and -3.62 mV and -2.35 mV for ELIPs using TRPS and PALS, respectively. Both agents were shown to have significant cluster formation at pressures as low as 6 kPa. Clusters of both agents were shown to diffuse as sonication stops at a rate that approximately equals the sum of the diffusion coefficients of the agents forming them. The de-clustering behaviours are due to Brownian motion as no sign of electrostatic repulsion was observed and particles movements were observed to be faster for smaller diameters. These findings are important to design and optimise effective drug delivery systems using acoustofluidically manipulated MBs and ELIPs.

A Wide-Ranging Analysis on Ethosomes

2015 ◽  
Vol 2 (2) ◽  
pp. 1-4
Author(s):  
Matilda K ◽  
Charlotte G
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
High Efficiency ◽  
Delivery Systems ◽  
Bioactive Molecules ◽  
Cationic Drugs ◽  
Delivery Service ◽  
Future Improvement ◽  
Challenges And Opportunities ◽  
And Training

Ethosomes are noninvasive release carriers that facilitate drugs to attain the deep skin layers and the universal movement. Though ethosomal systems are theoretically complicated, they are effortless in their training, safe for use an arrangement that can highly enlarge their relevance. Ethosomes are soft, compliant vesicles tailored for improved liberation of vigorous agents. Because of their exclusive organization, ethosomes are able to encapsulate and deliver during the skin highly lipophilic molecules such as cannabinoids, testosterone, and minoxidil, as well as cationic drugs such as propranolol, trihexaphenidyl, Cyclosporine, insulin, salbutamol etc. Improved release of bioactive molecules during the skin and cellular membranes by means of an ethosomal delivery service opens numerous challenges and opportunities for the research and future improvement of novel improved therapies. Ethosomes are gaining reputation in designing drug delivery systems for topical and transdermal use for their ability to reach deep skin layers and universal circulation. Although ethosomes are theoretically complicated, they are simple in training and safe for use. Although with their high efficiency, the ethosomes show possible for development of their applications. The aim of the review to make a inclusive description on properties and training of ethosomes followed by the classification and the list of drugs encapsulated in ethosomes.

Ionic liquids as a potential tool for drug delivery systems

MedChemComm ◽  
2016 ◽  
Vol 7 (10) ◽  
pp. 1881-1897 ◽  
Author(s):  
Noorul Adawiyah ◽  
Muhammad Moniruzzaman ◽  
Siti Hawatulaila ◽  
Masahiro Goto
Keyword(s):  
Drug Delivery ◽  
Ionic Liquids ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Drug Molecules ◽  
Pharmaceutical Industries ◽  
Low Solubility ◽  
Potential Tool

The pharmaceutical industries face a series of challenges in the delivery of many newly developed drug molecules because of their low solubility, bioavailability, stability and polymorphic conversion.

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