scholarly journals A Facile Synthesis of Core-Shell SiO2@Cu-LBMS Nano-Microspheres for Drug Sustained Release Systems

Materials ◽  
2019 ◽  
Vol 12 (23) ◽  
pp. 3978 ◽  
Author(s):  
Hui Wang ◽  
Haifeng Yang ◽  
Lifang Zhao
Keyword(s):  
Metal Salt ◽  
Drug Loading ◽  
Silica Spheres ◽  
Basic Metal ◽  
Release Behavior ◽  
Facile Synthesis ◽  
Reaction Conditions ◽  
Drug Sustained Release ◽  
Xrd Patterns ◽  
Releasing Time

A well-dispersed SiO2@Layered hydroxide cupric benzoate (SiO2@Cu-LBMS) with a hierarchical structure have been synthesized by a facile method. The layered hydroxide cupric benzoate with a structure of layered basic metal salt (Cu-LBMS) was directly deposited on the surface of silica spheres without any blinder. The morphology of the SiO2@Cu-LBMS nano-microsphere was observed by SEM, and the reaction conditions was also discussed. In addition, the XRD patterns and FTIR spectra provide consistent evidence to the formation of SiO2@Cu-LBMS nano-microspheres. The release behavior and drug loading capability of SiO2@Cu-LBMS microspheres were also investigated by using ibuprofen, aspirin and salicylic acid as model drugs. The results indicated that the drug loading capability of SiO2@Cu-LBMS nano-microspheres was much larger than layered hydroxide cupric benzoate, and the releasing time was significantly prolonged than layered hydroxide cupric benzoate and their physical mixture.

Synthesis of Pyrrolo[1,2-a][1,6]- and [1,8]naphthyridines by Alkyne-Carbonyl Metathesis

Synthesis ◽  
2020 ◽  
Author(s):  
Peter Ehlers ◽  
Peter Langer ◽  
Marian Blanco Ponce ◽  
Silvio Parpart ◽  
Alexander Villinger ◽  
...  
Keyword(s):  
Heterocyclic Compounds ◽  
Metathesis Reaction ◽  
Synthetic Methodology ◽  
Facile Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
Metal Free ◽  
Modular Synthesis

AbstractA concise and modular synthesis of pyrrolo[1,2-a][1,6]- and [1,8]naphthyridines by a one-pot two-step reaction consisting of electrophilic acylation followed by an alkyne-carbonyl-metathesis reaction as the final cyclization step is reported. This developed synthetic methodology allows the facile synthesis of these heterocyclic core structures in mainly high overall yields under metal-free conditions. Reaction conditions are carefully optimized and display a novel supplement to access these tricyclic heterocyclic compounds.

Y(OTf)3-catalyzed Phosphorylation of 2H-Chromene Hemiacetals with P(O)-H compounds to 2-Phosphorylated 2H-Chromenes

2021 ◽  
Author(s):  
Long Chen ◽  
Shi-Lu Zheng ◽  
Yun-Xiang Zou ◽  
Zhong Wen ◽  
Jiafu Lin ◽  
...  
Keyword(s):  
Catalyst Loading ◽  
Facile Synthesis ◽  
Reaction Conditions ◽  
Low Catalyst Loading

Facile synthesis of 2-phosphorylated 2H-chromenes has been accomplished herein via a Y(OTf)3-catalyzed dehydrative coupling of 2H-chromene hemiacetals with P(O)-H compounds. This protocol features low catalyst loading, mild reaction conditions, broad...

scholarly journals Green Synthesis of Copper Nanoparticles Using Cotton

Polymers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 1906
Author(s):  
Marissa Pérez-Alvarez ◽  
Gregorio Cadenas-Pliego ◽  
Odilia Pérez-Camacho ◽  
Víctor E. Comparán-Padilla ◽  
Christian J. Cabello-Alvarado ◽  
...  
Keyword(s):  
Green Synthesis ◽  
Copper Nanoparticles ◽  
Uv Spectroscopy ◽  
Synthesis Method ◽  
Crystallinity Index ◽  
Reaction Conditions ◽  
New Synthesis ◽  
Water As Solvent ◽  
Characterization Studies ◽  
Xrd Patterns

Copper nanoparticles (CuNP) were obtained by a green synthesis method using cotton textile fibers and water as solvent, avoiding the use of toxic reducing agents. The new synthesis method is environmentally friendly, inexpensive, and can be implemented on a larger scale. This method showed the cellulose capacity as a reducing and stabilizing agent for synthetizing Cellulose–Copper nanoparticles (CCuNP). Nanocomposites based on CCuNP were characterized by XRD, TGA, FTIR and DSC. Functional groups present in the CCuNP were identified by FTIR analysis, and XRD patterns disclosed that nanoparticles correspond to pure metallic Cu°, and their sizes are at a range of 13–35 nm. Results demonstrated that CuNPs produced by the new method were homogeneously distributed on the entire surface of the textile fiber, obtaining CCuNP nanocomposites with different copper wt%. Thus, CuNPs obtained by this method are very stable to oxidation and can be stored for months. Characterization studies disclose that the cellulose crystallinity index (CI) is modified in relation to the reaction conditions, and its chemical structure is destroyed when nanocomposites with high copper contents are synthesized. The formation of CuO nanoparticles was confirmed as a by-product, through UV spectroscopy, in the absorbance range of 300–350 nm.

Synthesis of Substituted -N-(5-((7-Methyl-2-Oxo-2H-Chromen-4-yl)-Methyl)-1,3,4-Thiadiazol-2-yl)-Benzamide Derivatives Using TBTU As Coupling Agent And Their Evaluation For Anti Tubercular Activity

2021 ◽  
Vol 18 ◽  
Author(s):  
Monika Kakadiya ◽  
Yunus Pasha ◽  
Malleshappa Noolvi ◽  
Ashish Patel
Keyword(s):  
Antitubercular Activity ◽  
Side Chain ◽  
Antitubercular Agents ◽  
Facile Synthesis ◽  
Aromatic Side Chain ◽  
Reaction Conditions ◽  
Coupling Reagent ◽  
H37rv Strain ◽  
Benzamide Derivatives

: Tuberculosis remains a highly infectious disease across the world. In the identification of new antitubercular agents, coumarin clubbed thiadiazole amides have been synthesized and evaluated for in vitro antitubercular activity. Due to the growing concern about chemicals and their impact on the environment, greener and faster reaction conditions needed to be incorporated. Therefore, we used TBTU as a coupling reagent for efficient and facile synthesis of substituted-N-(5-((7-methyl-2-oxo-2H-chromes-4-yl)-methyl)-1,3, 4 - thiadiazol-2-yl)-benzamide 4a-j with good yields up to 95% in mild reaction condition. All the synthesized compounds were evaluated in vitro for antitubercular activity against the H37Rv strain of M.Tuberculosis. Compounds 4c, 4f, and 4j were found active at 25 µg/mL against M. tb H37Rv. Electron withdrawing substituents present on aromatic side-chain showed promising anti-tubercular activity.

scholarly journals Rational synthesis of an atomically precise carboncone under mild conditions

2019 ◽  
Vol 5 (8) ◽  
pp. eaaw0982 ◽  
Author(s):  
Zheng-Zhong Zhu ◽  
Zuo-Chang Chen ◽  
Yang-Rong Yao ◽  
Cun-Hao Cui ◽  
Shu-Hui Li ◽  
...  
Keyword(s):  
Apex Angle ◽  
Facile Synthesis ◽  
Reaction Conditions ◽  
X Ray ◽  
Carbon Allotropes ◽  
X Ray Crystallography ◽  
Mild Conditions ◽  
Research Opportunity ◽  
Insight Into ◽  
Structural Strain

Carboncones, a special family of all-carbon allotropes, are predicted to have unique properties that distinguish them from fullerenes, carbon nanotubes, and graphenes. Owing to the absence of methods to synthesize atomically well-defined carboncones, however, experimental insight into the nature of pure carboncones has been inaccessible. Herein, we describe a facile synthesis of an atomically well-defined carboncone[1,2] (C70H20) and its soluble penta-mesityl derivative. Identified by x-ray crystallography, the carbon skeleton is a carboncone with the largest possible apex angle. Much of the structural strain is overcome in the final step of converting the bowl-shaped precursor into the rigid carboncone under mild reaction conditions. This work provides a research opportunity for investigations of atomically precise single-layered carboncones having even higher cone walls and/or smaller apex angles.

Facile Synthesis of Silver Nanoparticles by Chemical Reduction Route

2013 ◽  
Vol 756 ◽  
pp. 99-105
Author(s):  
Rajasingam Ratnamalar ◽  
Mustapha Mariatti ◽  
Zulkifli Ahmad ◽  
Sharif Zein Sharif Hussein
Keyword(s):  
Silver Nanoparticles ◽  
Ag Nanoparticles ◽  
Chemical Reduction ◽  
Facile Synthesis ◽  
Cubic Lattice ◽  
Vis Spectroscopy ◽  
Simple Chemical ◽  
The Face ◽  
Fine Control ◽  
Xrd Patterns

This work reports a simple chemical reduction route for the preparation of uniformed Ag nanoparticles whereby a fine control over the sizes of the Ag nanoparticles was studied by varying the concentrations of the reducing agents used. In characterization, UV-Vis spectroscopy showed the changes in optical properties of the Ag nanoparticles with regards to their sizes, where as the XRD patterns of the synthesized Ag nanoparticles confirmed the distinct peaks approximately at 2θ = 38.1°, 44.3°, 64.4°, 77.4°, and 81.5 representing Bragg’s reflections from (111), (200), (220), (311), and (222) planes of the face centred cubic lattice phase. This route of synthesis is feasible to produce Ag nanoparticles with diameters in the range of 30-45 nm.

Drug Loading and Release Behavior Depending on the Induced Porosity of Chitosan/Cellulose Multilayer Nanofilms

2017 ◽  
Vol 14 (10) ◽  
pp. 3322-3330 ◽  
Author(s):  
Sohyeon Park ◽  
Daheui Choi ◽  
Hyejoong Jeong ◽  
Jiwoong Heo ◽  
Jinkee Hong
Keyword(s):  
Drug Loading ◽  
Release Behavior

Facile Synthesis, Morphology Evolution and Tunable Luminescence of NaGdF4:Yb,Er Nanorods with Various Aspect Ratios

NANO ◽  
2018 ◽  
Vol 13 (08) ◽  
pp. 1850093 ◽  
Author(s):  
Shasha Gai ◽  
Jiqing Jiao ◽  
Wei Wei ◽  
Yao Li ◽  
Lihua Liu ◽  
...  
Keyword(s):  
Energy Level ◽  
Hydrothermal Method ◽  
Growth Mechanism ◽  
Morphology Evolution ◽  
Schematic Diagram ◽  
Facile Synthesis ◽  
Reaction Conditions ◽  
Facile Hydrothermal Method ◽  
Aspect Ratios ◽  
Lower Temperature

The well-defined NaGdF4:Yb,Er nanorods (NRs) with various aspect ratios were synthesized using a facile hydrothermal method. The morphology and crystal phase of NRs could be controlled by reaction conditions. NaGdF4:Yb,Er NRs with various aspect ratios could be synthesized and their upconversion (UC) luminescence was tuned. It is displayed that the NRs with aspect ratios about 5 exhibited the strongest UC luminescence among samples. The growth mechanism and morphology transition of NRs had been deduced by schematic diagram. And UC mechanism had been determined by energy level diagrams. Compared with previous reports, the work provided a facial method for UCNRs with various aspect ratios at lower temperature.

scholarly journals Facile synthesis of 1-alkoxy-1H-benzo- and 7-azabenzotriazoles from peptide coupling agents, mechanistic studies, and synthetic applications

2014 ◽  
Vol 10 ◽  
pp. 1919-1932 ◽  
Author(s):  
Mahesh K Lakshman ◽  
Manish K Singh ◽  
Mukesh Kumar ◽  
Raghu Ram Chamala ◽  
Vijayender R Yedulla ◽  
...  
Keyword(s):  
Amide Bond ◽  
Coupling Agents ◽  
Cyclic Ketones ◽  
Substitution Reactions ◽  
Facile Synthesis ◽  
Reaction Conditions ◽  
Peptide Coupling ◽  
Acyclic Nucleoside ◽  
Derivatives Of

(1H-Benzo[d][1,2,3]triazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), 1H-benzo[d][1,2,3]triazol-1-yl 4-methylbenzenesulfonate (Bt-OTs), and 3H-[1,2,3]triazolo[4,5-b]pyridine-3-yl 4-methylbenzenesulfonate (At-OTs) are classically utilized in peptide synthesis for amide-bond formation. However, a previously undescribed reaction of these compounds with alcohols in the presence of a base, leads to 1-alkoxy-1H-benzo- (Bt-OR) and 7-azabenzotriazoles (At-OR). Although BOP undergoes reactions with alcohols to furnish 1-alkoxy-1H-benzotriazoles, Bt-OTs proved to be superior. Both, primary and secondary alcohols undergo reaction under generally mild reaction conditions. Correspondingly, 1-alkoxy-1H-7-azabenzotriazoles were synthesized from At-OTs. Mechanistically, there are three pathways by which these peptide-coupling agents can react with alcohols. From 31P{1H}, [18O]-labeling, and other chemical experiments, phosphonium and tosylate derivatives of alcohols seem to be intermediates. These then react with BtO− and AtO− produced in situ. In order to demonstrate broader utility, this novel reaction has been used to prepare a series of acyclic nucleoside-like compounds. Because BtO− is a nucleofuge, several Bt-OCH2Ar substrates have been evaluated in nucleophilic substitution reactions. Finally, the possible formation of Pd π–allyl complexes by departure of BtO− has been queried. Thus, alpha-allylation of three cyclic ketones was evaluated with 1-(cinnamyloxy)-1H-benzo[d][1,2,3]triazole, via in situ formation of pyrrolidine enamines and Pd catalysis.

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