scholarly journals Utilization of Finite Element Analysis for Articular Cartilage Tissue Engineering

Materials ◽  
2019 ◽  
Vol 12 (20) ◽  
pp. 3331 ◽  
Author(s):  
Chaudhry R. Hassan ◽  
Yi-Xian Qin ◽  
David E. Komatsu ◽  
Sardar M.Z. Uddin
Keyword(s):  
Tissue Engineering ◽  
Finite Element Analysis ◽  
Finite Element ◽  
Articular Cartilage ◽  
Material Properties ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Scaffold Design ◽  
Element Analysis ◽  
In Vivo Models

Scaffold design plays an essential role in tissue engineering of articular cartilage by providing the appropriate mechanical and biological environment for chondrocytes to proliferate and function. Optimization of scaffold design to generate tissue-engineered cartilage has traditionally been conducted using in-vitro and in-vivo models. Recent advances in computational analysis allow us to significantly decrease the time and cost of scaffold optimization using finite element analysis (FEA). FEA is an in-silico analysis technique that allows for scaffold design optimization by predicting mechanical responses of cells and scaffolds under applied loads. Finite element analyses can potentially mimic the morphology of cartilage using mesh elements (tetrahedral, hexahedral), material properties (elastic, hyperelastic, poroelastic, composite), physiological loads by applying loading conditions (static, dynamic), and constitutive stress–strain equations (linear, porous–elastic, biphasic). Furthermore, FEA can be applied to the study of the effects of dynamic loading, material properties cell differentiation, cell activity, scaffold structure optimization, and interstitial fluid flow, in isolated or combined multi-scale models. This review covers recent studies and trends in the use of FEA for cartilage tissue engineering and scaffold design.

Articular cartilage: from formation to tissue engineering

2016 ◽  
Vol 4 (5) ◽  
pp. 734-767 ◽  
Author(s):  
Sandra Camarero-Espinosa ◽  
Barbara Rothen-Rutishauser ◽  
E. Johan Foster ◽  
Christoph Weder
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Scaffold Design ◽  
Current State ◽  
Biological Aspects

A summary of the current state of cartilage tissue engineering underlying the relevant biological aspects that are important for scaffold design.

scholarly journals Experimental and finite element analysis of articular cartilage

2021 ◽  
Author(s):  
Abdolreza Karami
Keyword(s):  
Finite Element Analysis ◽  
Finite Element ◽  
Cervical Spine ◽  
Articular Cartilage ◽  
Material Properties ◽  
Testing Machine ◽  
Published Data ◽  
Test Protocol ◽  
Element Analysis ◽  
The Finite Element Analysis

In the clinical field, articular cartilage has an important role in performance of most joints in the human body. In the present study, articular cartilage was excised from the knee joint of a bovine and tested in a tensile testing machine. The data obtained from the test was used to calculate the material properties of the cartilage. The material properites obtained from the experimental work were validated against the published experimental results in the literature. As the values from the experiment were in satisfactory agreement with the published data, it was concluded that the test protocol used in the experiment provides reliable data. Next, the material properties were implemented in finite element model of C3-C4 of cervical spine to examine if the finite element analysis can provide an accurate prediction of the behavior of the cervical spine. The stress and displacement results of the finite element analysis were consistent with the reported data in the literature. The location and the amount of the maximum stresses were examined and compared with the failure point of the materials.

scholarly journals Experimental and finite element analysis of articular cartilage

2021 ◽  
Author(s):  
Abdolreza Karami
Keyword(s):  
Finite Element Analysis ◽  
Finite Element ◽  
Cervical Spine ◽  
Articular Cartilage ◽  
Material Properties ◽  
Testing Machine ◽  
Published Data ◽  
Test Protocol ◽  
Element Analysis ◽  
The Finite Element Analysis

In the clinical field, articular cartilage has an important role in performance of most joints in the human body. In the present study, articular cartilage was excised from the knee joint of a bovine and tested in a tensile testing machine. The data obtained from the test was used to calculate the material properties of the cartilage. The material properites obtained from the experimental work were validated against the published experimental results in the literature. As the values from the experiment were in satisfactory agreement with the published data, it was concluded that the test protocol used in the experiment provides reliable data. Next, the material properties were implemented in finite element model of C3-C4 of cervical spine to examine if the finite element analysis can provide an accurate prediction of the behavior of the cervical spine. The stress and displacement results of the finite element analysis were consistent with the reported data in the literature. The location and the amount of the maximum stresses were examined and compared with the failure point of the materials.

scholarly journals On the Design of a Biodegradable POC-HA Polymeric Cardiovascular Stent

2012 ◽  
Author(s):  
Joonas Ponkala ◽  
Mohsin Rizwan ◽  
Panos S. Shiakolas
Keyword(s):  
Finite Element Analysis ◽  
Finite Element ◽  
Material Properties ◽  
Three Dimensional ◽  
Polymeric Composite ◽  
Coronary Stent ◽  
Element Analysis ◽  
Material Models ◽  
Solid Models ◽  
Biodegradable Stents

The current state of the art in coronary stent technology, tubular structures used to keep the lumen open, is mainly populated by metallic stents coated with certain drugs to increase biocompatibility, even though experimental biodegradable stents have appeared in the horizon. Biodegradable polymeric stent design necessitates accurate characterization of time dependent polymer material properties and mechanical behavior for analysis and optimization. This manuscript presents the process for evaluating material properties for biodegradable biocompatible polymeric composite poly(diol citrate) hydroxyapatite (POC-HA), approaches for identifying material models and three dimensional solid models for finite element analysis and fabrication of a stent. The developed material models were utilized in a nonlinear finite element analysis to evaluate the suitability of the POC-HA material for coronary stent application. In addition, the advantages of using femtosecond laser machining to fabricate the POC-HA stent are discussed showing a machined stent. The methodology presented with additional steps can be applied in the development of a biocompatible and biodegradable polymeric stents.

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