scholarly journals Novel Aminoacridine Sensors Based on Molecularly Imprinted Hybrid Polymeric Membranes for Static and Hydrodynamic Drug Quality Control Monitoring

Materials ◽  
2019 ◽  
Vol 12 (20) ◽  
pp. 3327 ◽  
Author(s):  
Saad S. M. Hassan ◽  
Abd El-Galil E. Amr ◽  
Heba Abd El-Naby ◽  
Mohamed El-Naggar ◽  
Ayman H. Kamel ◽  
...  
Keyword(s):  
Quality Control ◽  
Pharmaceutical Preparations ◽  
Thermal Polymerization ◽  
Dioctyl Phthalate ◽  
Polymeric Membranes ◽  
Imprinted Polymer ◽  
Hydrodynamic Mode ◽  
Poly Vinyl Chloride ◽  
Tetraphenyl Borate ◽  
Drug Quality Control

Novel biomimetic potentiometric ion-selective electrodes (ISEs) were fabricated and designed for the assessment of aminoacridine (ACR) based on newly synthesized imprinted polymer (MIP) membranes. Thermal polymerization of methacrylic acid (MAA) or acrylamide (AM) as function monomer, aminoacridine as a template and ethylene glycol dimethacrylate (EGDMA) as across-linker, were utilizedto give the molecular recognition part. The membranes of sensors I andII consist of MIP based MAA and AM, respectively, dispersed in a poly(vinyl chloride) membrane plasticized with dioctyl phthalate (DOP) in the ratio of 3.0 wt%, 32.2 wt% and 64.8 wt%, respectively. Sensors III and IV were similarly prepared with added 1.0 wt% tetraphenyl borate (TPB−) as an anionic discriminator. Sensors I and II exhibited near-Nernstian potential response to ACR+ with slopes of 51.2 ± 1.3 and 50.5 ± 1.4 mV/decade in a 0.01 M phosphate buffer of pH 6.0. The linear response coversthe concentration range of 5.2 × 10−6 to 1.0 × 10−3 M with a detection limit of 0.05 and 0.17 μg/mL for sensors I and II, respectively. The performance characteristics of these sensors were evaluated under static and hydrodynamic mode of operations. They were used for quality control assessment of aminoacridine in some pharmaceutical preparations and biological samples.

scholarly journals Microanalysis of Selected NSAIDs Using the Spectrophotometric Method

Eng ◽  
2020 ◽  
Vol 1 (2) ◽  
pp. 211-221
Author(s):  
Paweł Gumułka ◽  
Monika Dąbrowska ◽  
Małgorzata Starek
Keyword(s):  
Quality Control ◽  
Spectrophotometric Method ◽  
Pharmaceutical Preparations ◽  
Pharmacokinetic Studies ◽  
Over The Counter ◽  
Nsaid Group ◽  
Inflammatory Drugs ◽  
Drug Quality Control ◽  
Uv Range

Non-steroidal anti-inflammatory drugs (NSAIDs) are the group of drugs most commonly used in medicine. They are available over the counter to treat fevers and pains of various origins. The clinical and pharmaceutical analysis of these drugs requires effective analytical procedures for drug quality control, pharmacodynamic and pharmacokinetic studies. This article presents the spectrophotometric method that was used to analyze selected drugs from the NSAID group. The conditions for the determination of selected coxibs and oxicams in the UV range with the use of microplates have been developed. The presented procedure has been validated in accordance with the requirements, guaranteeing reliable results. The obtained results give the basis for the conclusion that the method can be successfully used in the quality control of pharmaceutical preparations with a small amount of available sample.

A Novel Potentiometric PVC-membrane Cysteamine-Selective Electrode Based on Cysteamine-Phosphomolybdate Ion-Pair

2020 ◽  
Vol 16 (2) ◽  
pp. 168-175 ◽  
Author(s):  
Merve Tumur ◽  
Gulsah Saydan Kanberoglu ◽  
Fatih Coldur
Keyword(s):  
Analytical Methods ◽  
Pharmaceutical Preparations ◽  
Life Time ◽  
Ion Pair ◽  
Pharmaceutical Formulation ◽  
Pvc Membrane ◽  
Selective Electrode ◽  
Potentiometric Response ◽  
Drug Quality Control

Background: Cysteamine is used as an orphan drug in the treatment of cystinosis to prevent long-term cystine accumulation in lysosomes. Dosing in cysteamine treatment is extremely important and overdose may cause some side effects. Up to now, various analytical methods have been used for cysteamine determination. Many of these methods require sophisticated instruments, expert operators, time-consuming measurement procedures and manipulation steps, expensive supplies and long analysis time. Aims and Objective: The present study deals with the development of a potentiometric PVC-membrane cysteamine-selective electrode based on an ion-pair of cysteamine and its application in a pharmaceutical formulation. Methods: Cysteamine (Cys)-Phosphomolybdate (PM) ion-pair was synthesized by mixing the equal volumes of 10-2 M Cysteamine HCl and sodium phosphomolybdate aqueous solutions. The obtained precipitate was used as ionophore in the structure of PVC-membrane. Results and Discussion: The electrode exhibited a linear response in the concentration range of 1.0×10- 1-1.0×10-5 M cysteamine with a slope of 51,7 mV per decade and detection limit of 1.0×10-5 M. The potentiometric response of the electrode was very rapid (5 s), adequately repeatable, stable and selective. pH working range and life-time of the electrode were also determined as 3.0-7.0 and 25 days, respectively. Conclusion: A PVC-membrane cysteamine selective electrode was easily prepared. Cysteamine determination in a pharmaceutical formulation was performed. Analysis results indicated that it can be successfully used in drug quality control laboratories for routine analysis of cysteamine in pharmaceutical preparations alternative to more sophisticated, expensive and time-consuming analytical methods.

Some viscoelastic porperties of poly(vinyl chloride)/dioctyl phthalate systems

1985 ◽  
Vol 7 (1) ◽  
pp. 22-25 ◽  
Author(s):  
A. Santamaria ◽  
M. E. Muñoz ◽  
J. J. Peña
Keyword(s):  
Vinyl Chloride ◽  
Dioctyl Phthalate ◽  
Poly Vinyl Chloride

scholarly journals New Approachs in Drug Quality Control: Matrices and Chemometrics

10.5772/50825 ◽  
2012 ◽  
Author(s):  
Sigrid Mennickent ◽  
M. de ◽  
B. Schulz ◽  
M. Vega ◽  
C. G.
Keyword(s):  
Quality Control ◽  
Drug Quality ◽  
Drug Quality Control

Study on the Process of Preparing Microporous Polyvinyl Chloride

2012 ◽  
Vol 174-177 ◽  
pp. 864-869
Author(s):  
Sheng Jun Lu ◽  
Zhi Min Zhou ◽  
Cai Hong Wang ◽  
Jie Yu
Keyword(s):  
Vinyl Chloride ◽  
Polyvinyl Chloride ◽  
Dioctyl Phthalate ◽  
Poly Vinyl Chloride ◽  
Average Size

Microporous Poly (vinyl chloride) (PVC) was prepared by foaming of PVC powders using the solution of 2, 2’-azo-bis-iso-butyronitrile (AIBN) in co-solvent of butanone and cyclohexanone when heated. The effect of composition of solvent and quantity fraction of AIBN also preferred dioctyl phthalate (DOP) on the structure of microporous PVC is discussed. The results indicated that much microporosity with average size of 0.2-2μm can be generated when acetone is selected as solvent, 2% DOP and 10% AIBN are used. The microporous PVC is a potential desirable reactor to prepare CaCO3 nanoparticle.

Sign in / Sign up

Export Citation Format

Share Document