scholarly journals Improvement of the Physical Properties of Guided Bone Regeneration Membrane from Porcine Pericardium by Polyphenols-Rich Pomace Extract

Materials ◽  
2019 ◽  
Vol 12 (16) ◽  
pp. 2564 ◽  
Author(s):  
Nazario Russo ◽  
Clara Cassinelli ◽  
Elisa Torre ◽  
Marco Morra ◽  
Giorgio Iviglia
Keyword(s):  
Physical Properties ◽  
Bone Regeneration ◽  
Enzymatic Degradation ◽  
Guided Bone Regeneration ◽  
Mechanical Stiffness ◽  
Infra Red ◽  
Space Maintenance ◽  
The One ◽  
Porcine Pericardium

To achieve optimal performances, guided bone regeneration membranes should have several properties, in particular, proper stiffness and tear resistance for space maintenance, appropriate resorption time, and non-cytotoxic effect. In this work, polyphenol-rich pomace extract (PRPE), from a selected grape variety (Nebbiolo), rich in proanthocyanidins and flavonols (e.g., quercetin), was used as a rich source of polyphenols, natural collagen crosslinkers, to improve the physical properties of the porcine pericardium membrane. The incorporation of polyphenols in the collagen network of the membrane was clearly identified by infra-red spectroscopy through the presence of a specific peak between 1360–1380 cm−1. Polyphenols incorporated into the pericardium membrane bind to collagen with high affinity and reduce enzymatic degradation by 20% compared to the native pericardium. The release study shows a release of active molecules from the membrane, suggesting a possible use in patients affected by periodontitis, considering the role of polyphenols in the control of this pathology. Mechanical stiffness is increased making the membrane easier to handle. Young’s modulus of pericardium treated with PRPE was three-fold higher than the one measured on native pericardium. Tear and suture retention strength measurement suggest favorable properties in the light of clinical practice requirements.

scholarly journals Evaluation of 1-Ethyl-3-(3-Dimethylaminopropyl) Carbodiimide Cross-Linked Collagen Membranes for Guided Bone Regeneration in Beagle Dogs

Materials ◽  
2020 ◽  
Vol 13 (20) ◽  
pp. 4599
Author(s):  
Jong-Ju Ahn ◽  
Hyung-Joon Kim ◽  
Eun-Bin Bae ◽  
Won-Tak Cho ◽  
YunJeong Choi ◽  
...  
Keyword(s):  
Tensile Strength ◽  
Physical Properties ◽  
Bone Regeneration ◽  
Enzymatic Degradation ◽  
Test Group ◽  
Guided Bone Regeneration ◽  
Control Group ◽  
Collagen Membrane ◽  
Micro Computed Tomography ◽  
Collagen Membranes

The purpose of this study was to evaluate the bone regeneration efficacy of an 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)-cross-linked collagen membrane for guided bone regeneration (GBR). A non-cross-linked collagen membrane (Control group), and an EDC-cross-linked collagen membrane (Test group) were used in this study. In vitro, mechanical, and degradation testing and cell studies were performed. In the animal study, 36 artificial bone defects were formed in the mandibles of six beagles. Implants were inserted at the time of bone grafting, and membranes were assigned randomly. Eight weeks later, animals were sacrificed, micro-computed tomography was performed, and hematoxylin-eosin stained specimens were prepared. Physical properties (tensile strength and enzymatic degradation rate) were better in the Test group than in the Control group. No inflammation or membrane collapse was observed in either group, and bone volumes (%) in defects around implants were similar in the two groups (p > 0.05). The results of new bone areas (%) analysis also showed similar values in the two groups (p > 0.05). Therefore, it can be concluded that cross-linking the collagen membranes with EDC is the method of enhancing the physical properties (tensile strength and enzymatic degradation) of the collagen membranes without risk of toxicity.

The Role of Bone Decortication in Enhancing the Results of Guided Bone Regeneration: A Literature Review

2009 ◽  
Vol 80 (2) ◽  
pp. 175-189 ◽  
Author(s):  
G. Greenstein ◽  
B. Greenstein ◽  
J. Cavallaro ◽  
D. Tarnow
Keyword(s):  
Literature Review ◽  
Bone Regeneration ◽  
Guided Bone Regeneration

scholarly journals Guided Bone Regeneration- A Comprehensive Review

2021 ◽  
Author(s):  
Vineetha Venugopalan ◽  
Anegundi Raghavendra Vamsi ◽  
Santhosh Shenoy ◽  
Karishma Ashok ◽  
Biju Thomas
Keyword(s):  
Bone Regeneration ◽  
Alveolar Bone ◽  
Primary Stability ◽  
Guided Bone Regeneration ◽  
Collagen Membrane ◽  
Bony Defect ◽  
Graft Material ◽  
Bone Augmentation ◽  
Wide Range ◽  
Space Maintenance

Successful implant treatment requires prosthetically driven placement of an implant, primary stability at placement, and careful living bone management. The resorptive changes of alveolar bone are an inevitable process following tooth loss, periodontal disease or trauma which causes bone defects. This results in various aesthetic and functional complications such as soft tissue recession, infection and inflammation. Various methods have been tried and advocated for augmenting these bone deficiencies. Guided Bone Regeneration (GBR) is a successful modality for bone augmentation with a wide range of indications and helps restore the alveolar ridge dimensions. It utilises the principle of Guided Tissue Regeneration (GTR) for space maintenance within a bony defect. Different types of barrier membranes are being utilised along with various bone grafts in GBR. Thorough knowledge regarding the biology of bone is required before the initiation of any bone augmentation procedure. A combination of Collagen Membrane (CM) and graft material was found successful for GBR. Hence, this review focuses on presentation of best available evidence for various aspects of GBR.

scholarly journals Core/Shell Glycine-Polyvinyl Alcohol/Polycaprolactone Nanofibrous Membrane Intended for Guided Bone Regeneration: Development and Characterization

Coatings ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1130
Author(s):  
Marwa Alazzawi ◽  
Nabeel Kadim Abid Alsahib ◽  
Hilal Turkoglu Sasmazel
Keyword(s):  
Polyvinyl Alcohol ◽  
Physical Properties ◽  
Bone Regeneration ◽  
Degradation Rate ◽  
Guided Bone Regeneration ◽  
Nanofibrous Membrane ◽  
Core Shell ◽  
The Core ◽  
Barrier Membrane ◽  
Shell Membrane

Glycine (Gly), which is the simplest amino acid, induces the inflammation response and enhances bone mass density, and particularly its β polymorph has superior mechanical and piezoelectric properties. Therefore, electrospinning of Gly with any polymer, including polyvinyl alcohol (PVA), has a great potential in biomedical applications, such as guided bone regeneration (GBR) application. However, their application is limited due to a fast degradation rate and undesirable mechanical and physical properties. Therefore, encapsulation of Gly and PVA fiber within a poly(ε-caprolactone) (PCL) shell provides a slower degradation rate and improves the mechanical, chemical, and physical properties. A membrane intended for GBR application is a barrier membrane used to guide alveolar bone regeneration by preventing fast-proliferating cells from growing into the bone defect site. In the present work, a core/shell nanofibrous membrane, composed of PCL as shell and PVA:Gly as core, was developed utilizing the coaxial electrospinning technique and characterized morphologically, mechanically, physically, chemically, and thermally. Moreover, the characterization results of the core/shell membrane were compared to monolithic electrospun PCL, PVA, and PVA:Gly fibrous membranes. The results showed that the core-shell membrane appears to be a good candidate for GBR application with a nano-scale fiber of 412 ± 82 nm and microscale pore size of 6.803 ± 0.035 μm. Moreover, the wettability of 47.4 ± 2.2° contact angle (C.A) and mechanical properties of 135 ± 3.05 MPa average modulus of elasticity, 4.57 ± 0.04 MPa average ultimate tensile stress (UTS), and 39.43% ± 0.58% average elongation at break are desirable and suitable for GBR application. Furthermore, the X-ray diffraction (XRD) and transmission electron microscopy (TEM) results exhibited the formation of β-Gly.

The Role of Two Different Collagen Membranes for Dehiscence Defect Around Implants in Humans

2015 ◽  
Vol 41 (4) ◽  
pp. 445-448 ◽  
Author(s):  
Dong-Woon Lee ◽  
Kyeong-Taek Kim ◽  
Yon-Soo Joo ◽  
Mi-Kyung Yoo ◽  
Jeoung-A Yu ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Allogenic Bone ◽  
The Mean ◽  
Collagen Membranes ◽  
Dehiscence Defect ◽  
Result Analysis ◽  
Bone Particles

The aim of this study was to elucidate the role of 2 types of collagen membranes (cross-linked vs noncross-linked) used in conjunction with autogenous or allogenic bone followed by xenogeneic bone particles for dehiscence defect around implants in humans. Experimental groups were divided into 2 groups: Group CL (cross-linked, Ossix Plus, n = 24 implants, 16 patients) and Group NCL (noncross-linked, Bio-Gide, n = 25 implants, 18 patients). At the time of implant insertion and uncovery surgery, measurements of the dehiscence bony height, width, and surface area were made. Before applying the membrane to defects, guided bone regeneration was performed. Because it is difficult to measure the degree of exposure, early exposed cases were excluded from the result analysis. The mean percentage gain of the dehiscence defect and the mean marginal bone reduction value of follow-up radiograph did not show statistically significant differences between the 2 groups. Both membranes exhibited satisfactory results on dehiscence defects. As a result, our authors concluded the success of guided bone regeneration was performed simultaneously for dehiscence defects around the implant, regardless whether collagen membranes were cross-linked or noncross-linked.

scholarly journals PRGF-Modified Collagen Membranes for Guided Bone Regeneration: Spectroscopic, Microscopic and Nano-Mechanical Investigations

2019 ◽  
Vol 9 (5) ◽  
pp. 1035 ◽  
Author(s):  
Cristian Ratiu ◽  
Marcel Brocks ◽  
Traian Costea ◽  
Liviu Moldovan ◽  
Simona Cavalu
Keyword(s):  
Mechanical Properties ◽  
Bone Regeneration ◽  
Enzymatic Degradation ◽  
Young Modulus ◽  
Guided Bone Regeneration ◽  
Fiber Density ◽  
New Approach ◽  
Before And After ◽  
Collagen Membranes ◽  
Membrane Type

The aim of our study was to evaluate the properties of different commercially available resorbable collagen membranes for guided bone regeneration, upon addition of plasma rich in growth factors (PRGF). The structural and morphological details, mechanical properties, and enzymatic degradation were investigated in a new approach, providing clinicians with new data in order to help them in a successful comparison and better selection of membranes with respect to their placement and working condition. Particular characteristics such as porosity, fiber density, and surface topography may influence the mechanical behavior and performances of the membranes, as revealed by SEM/AFM and nanoindentation measurements. The mechanical properties and enzymatic degradation of the membranes were analyzed in a comparative manner, before and after PRGF-modification. The changes in Young modulus values are correlated with the ultrastructural properties of each membrane type. The enzymatic (trypsin) degradation test also emphasized that PRGF-modified membranes exhibit a slower degradation compared to the native ones.

The role of rhFGF-2 soaked polymer membrane for enhancement of guided bone regeneration

2017 ◽  
Vol 29 (7-9) ◽  
pp. 825-843 ◽  
Author(s):  
Sang-Hoon Lee ◽  
Young-Bum Park ◽  
Hong-Seok Moon ◽  
June-Sung Shim ◽  
Han-Sung Jung ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Polymer Membrane

scholarly journals The Role of Blood Clot in Guided Bone Regeneration: Biological Considerations and Clinical Applications with Titanium Foil

Materials ◽  
2021 ◽  
Vol 14 (21) ◽  
pp. 6642
Author(s):  
Lucio Milillo ◽  
Fabrizio Cinone ◽  
Federico Lo Presti ◽  
Dorina Lauritano ◽  
Massimo Petruzzi
Keyword(s):  
Bone Regeneration ◽  
Blood Clot ◽  
Strength Properties ◽  
Guided Bone Regeneration ◽  
Titanium Foil ◽  
Filler Materials ◽  
Clinical Settings ◽  
Fundamental Properties ◽  
Blood Clots

In Guided Bone Regeneration (GBR) materials and techniques are essential to achieve the expected results. Thanks to their properties, blood clots induce bone healing, maturation, differentiation and organization. The preferred material to protect the clot in Guided Bone Regeneration is the titanium foil, as it can be shaped according to the bone defect. Furthermore, its exposition in the oral cavity does not impair the procedure. We report on five clinical cases in order to explain the management of blood clots in combination with titanium foil barriers in different clinical settings. Besides being the best choice to protect the clot, the titanium foil represents an excellent barrier that is useful in GBR due to its biocompatibility, handling, and mechanical strength properties. The clot alone is the best natural scaffold to obtain the ideal bone quality and avoid the persistence of not-resorbed granules of filler materials in the newly regenerated bone. Even though clot contraction still needs to be improved, as it impacts the volume of the regenerated bone, future studies in GBR should be inspired by the clot and its fundamental properties.

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